CA3233052A1 - Controlled lesion and immune response to pulsed electric field therapy - Google Patents

Controlled lesion and immune response to pulsed electric field therapy Download PDF

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Publication number
CA3233052A1
CA3233052A1 CA3233052A CA3233052A CA3233052A1 CA 3233052 A1 CA3233052 A1 CA 3233052A1 CA 3233052 A CA3233052 A CA 3233052A CA 3233052 A CA3233052 A CA 3233052A CA 3233052 A1 CA3233052 A1 CA 3233052A1
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CA
Canada
Prior art keywords
energy
energy delivery
pef
electric field
tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3233052A
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English (en)
French (fr)
Inventor
Timothy J. O'brien
William S. Krimsky
Matthew T. Silvestrini
Chiara PASTORI
Robert E. Ii Neal
Jonathan R. WALDSTREICHER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Galvanize Therapeutics Inc
Original Assignee
Galvanize Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galvanize Therapeutics Inc filed Critical Galvanize Therapeutics Inc
Publication of CA3233052A1 publication Critical patent/CA3233052A1/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/1206—Generators therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00577—Ablation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00613—Irreversible electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B2018/1405—Electrodes having a specific shape
    • A61B2018/1425—Needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Otolaryngology (AREA)
  • Plasma & Fusion (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Surgical Instruments (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Radiation-Therapy Devices (AREA)
CA3233052A 2021-09-20 2022-09-19 Controlled lesion and immune response to pulsed electric field therapy Pending CA3233052A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US202163246239P 2021-09-20 2021-09-20
US63/246,239 2021-09-20
US202163290529P 2021-12-16 2021-12-16
US63/290,529 2021-12-16
US202263322319P 2022-03-22 2022-03-22
US63/322,319 2022-03-22
US202263351562P 2022-06-13 2022-06-13
US63/351,562 2022-06-13
PCT/US2022/044021 WO2023044124A1 (en) 2021-09-20 2022-09-19 Controlled lesion and immune response to pulsed electric field therapy

Publications (1)

Publication Number Publication Date
CA3233052A1 true CA3233052A1 (en) 2023-03-23

Family

ID=85603549

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3233052A Pending CA3233052A1 (en) 2021-09-20 2022-09-19 Controlled lesion and immune response to pulsed electric field therapy

Country Status (5)

Country Link
EP (1) EP4404857A4 (cg-RX-API-DMAC7.html)
JP (1) JP2024534500A (cg-RX-API-DMAC7.html)
AU (1) AU2022348518A1 (cg-RX-API-DMAC7.html)
CA (1) CA3233052A1 (cg-RX-API-DMAC7.html)
WO (1) WO2023044124A1 (cg-RX-API-DMAC7.html)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3474760B1 (en) 2016-06-27 2023-01-11 Galvanize Therapeutics, Inc. Generator and a catheter with an electrode for treating a lung passageway
US12564440B2 (en) 2021-04-26 2026-03-03 Pulse Biosciences, Inc. Multi-strut ablation and sensing catheter devices and methods
CA3215962A1 (en) 2021-04-26 2022-11-03 Roman Turovskiy Circumferential ablation devices and methods
US12446944B2 (en) 2021-04-26 2025-10-21 Pulse Biosciences, Inc. Mapping and ablation applicators
WO2025043024A2 (en) * 2023-08-22 2025-02-27 Galvanize Therapeutics, Inc. Quantification of immunological status and treatment planning
JP2025050034A (ja) * 2023-09-22 2025-04-04 日本ライフライン株式会社 電源装置およびアブレーションシステム
CN117982802B (zh) * 2024-04-07 2024-06-18 浙江大学 一种闭环肺部肿瘤电场治疗系统

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0810066A2 (pt) * 2007-04-19 2015-05-05 The Foundry Inc Sistemas e métodos para criação de um efeito utilizando energia de microondas à tecido específico
WO2015085162A1 (en) * 2013-12-05 2015-06-11 Rfemb Holdings, Llc Cancer immunotherapy by radiofrequency electrical membrane breakdown (rf-emb)
JP7461881B2 (ja) * 2017-12-26 2024-04-04 ガルヴァナイズ セラピューティクス，インコーポレイテッド 疾患状態および障害の治療のための方法、装置、およびシステム
DK3731771T3 (da) * 2017-12-26 2023-08-28 Galvanize Therapeutics Inc V462033dk00
US11311329B2 (en) * 2018-03-13 2022-04-26 Virginia Tech Intellectual Properties, Inc. Treatment planning for immunotherapy based treatments using non-thermal ablation techniques
EP3852868B1 (en) 2018-09-18 2025-02-12 Virginia Tech Intellectual Properties, Inc. Treatment planning system for immunotherapy enhancement via non-thermal ablation
CN118203401A (zh) 2019-04-18 2024-06-18 盖能适治疗股份有限公司 用于治疗异常组织的装置、系统和方法
EP3998973A4 (en) 2019-07-16 2023-07-26 Galvanize Therapeutics, Inc. TREATMENT OF THE REPRODUCTIVE TRACT WITH PULSED ELECTRIC FIELDS
EP4065005A4 (en) * 2019-11-27 2023-12-27 North Carolina State University METHOD FOR CONTROLLING TREATMENT VOLUME, HEAT GRADIENTS, MUSCLE STIMULATION AND IMMUNE RESPONSES IN PULSED ELECTRICAL FIELD TREATMENTS
WO2021127558A1 (en) 2019-12-18 2021-06-24 Galary, Inc. Treatment of cardiac tissue with pulsed electric fields
CN115348844A (zh) 2020-04-08 2022-11-15 盖能适治疗股份有限公司 脉冲电场波形操作和使用
WO2023172773A1 (en) 2022-03-11 2023-09-14 Virginia Tech Intellectual Properties, Inc. Systems and methods of using pulsed electric fields to spatially control cell death mechanisms

Also Published As

Publication number Publication date
EP4404857A4 (en) 2025-07-16
WO2023044124A1 (en) 2023-03-23
JP2024534500A (ja) 2024-09-20
EP4404857A1 (en) 2024-07-31
AU2022348518A1 (en) 2024-04-04

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