CA3229493A1 - Modified immune cells expressing tlr receptors - Google Patents

Modified immune cells expressing tlr receptors Download PDF

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Publication number
CA3229493A1
CA3229493A1 CA3229493A CA3229493A CA3229493A1 CA 3229493 A1 CA3229493 A1 CA 3229493A1 CA 3229493 A CA3229493 A CA 3229493A CA 3229493 A CA3229493 A CA 3229493A CA 3229493 A1 CA3229493 A1 CA 3229493A1
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Canada
Prior art keywords
domain
cell
tlr
polypeptide
modified immune
Prior art date
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Pending
Application number
CA3229493A
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English (en)
French (fr)
Inventor
Yanliang ZHU
Qingling JIANG
Zhongyuan TU
Yafeng Zhang
Shu Wu
Xiaohu FAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Legend Biotech Ireland Ltd
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Legend Biotech Ireland Ltd
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Application filed by Legend Biotech Ireland Ltd filed Critical Legend Biotech Ireland Ltd
Publication of CA3229493A1 publication Critical patent/CA3229493A1/en
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C—CHEMISTRY; METALLURGY
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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CA3229493A 2021-08-18 2022-08-18 Modified immune cells expressing tlr receptors Pending CA3229493A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
CN2021113239 2021-08-18
CNPCT/CN2021/113239 2021-08-18
CNPCT/CN2021/122129 2021-09-30
CN2021122129 2021-09-30
CNPCT/CN2021/133061 2021-11-25
CN2021133061 2021-11-25
CNPCT/CN2022/112578 2022-08-15
CN2022112578 2022-08-15
PCT/CN2022/113170 WO2023020558A1 (en) 2021-08-18 2022-08-18 Modified immune cells expressing tlr receptors

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CA3229493A1 true CA3229493A1 (en) 2023-02-23

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CA3229493A Pending CA3229493A1 (en) 2021-08-18 2022-08-18 Modified immune cells expressing tlr receptors

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US (1) US20240350545A1 (enExample)
EP (1) EP4392463A4 (enExample)
JP (1) JP2024534783A (enExample)
KR (1) KR20240055733A (enExample)
CN (1) CN117580870A (enExample)
AU (1) AU2022330883A1 (enExample)
CA (1) CA3229493A1 (enExample)
TW (1) TW202328435A (enExample)
WO (1) WO2023020558A1 (enExample)

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WO2024251225A1 (en) * 2023-06-07 2024-12-12 Nanjing Legend Biotech Co., Ltd. Rapamycin resistant cells and methods of use thereof
JP2026523614A (ja) * 2023-07-07 2026-07-14 オーバーランド セラピューティクス （ユーエス） インコーポレイテッド Ｇｐｒｃ５ｄに対する単一ドメイン抗体
WO2026158639A1 (en) * 2025-01-26 2026-07-30 Nanjing Legend Biotech Co., Ltd. Bcma binding moieties and uses thereof

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GB201513540D0 (en) * 2015-07-31 2015-09-16 King S College London Therapeutic agents
CN107207613B (zh) * 2015-08-07 2020-06-09 深圳市体内生物医药科技有限公司 含Toll样受体胞内结构域的嵌合抗原受体
CN106220736B (zh) * 2016-07-20 2020-01-10 深圳市体内生物医药科技有限公司 一种嵌合抗原受体、表达其的细胞及其制备方法和用途
US11654158B2 (en) * 2016-11-17 2023-05-23 2Seventy Bio, Inc. TGFBeta signal convertor
CN106749675B (zh) * 2016-12-27 2022-05-27 深圳市体内生物医药科技有限公司 一种重组慢病毒及其应用
DK3688032T3 (da) * 2017-09-26 2025-12-15 Cero Therapeutics Holdings Inc Kimære engulfment-receptormolekyler og anvendelsesfremgangsmåder
WO2020052543A1 (en) * 2018-09-10 2020-03-19 Nanjing Legend Biotech Co., Ltd. Single-domain antibodies against cd33 and constructs thereof
US20220096547A1 (en) * 2019-01-03 2022-03-31 Nanjing Legend Biotech Co., Ltd. Modified immune cells expressing flagellin polypeptide
EP3937974A1 (en) * 2019-03-11 2022-01-19 Leucid Bio Ltd Muc1 parallel car (pcar) therapeutic agents
CN110904048A (zh) * 2019-12-04 2020-03-24 合肥中科干细胞再生医学有限公司 一种car-cd123t2嵌合抗原受体t细胞及其应用
CN111875710A (zh) * 2020-07-31 2020-11-03 广东昭泰体内生物医药科技有限公司 异质性肿瘤治疗用免疫细胞及其应用
CN112210018A (zh) * 2020-10-12 2021-01-12 广东昭泰体内生物医药科技有限公司 一种靶向gpc3的嵌合抗原受体及其应用

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