CA3229447A1 - Anticorps ciblant des complexes peptidiques hla-e-hote et leurs utilisations - Google Patents
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
Abstract
La présente invention concerne des anticorps monoclonaux recombinants à maturation d'affinité (mAb) et des fragments qui se lient spécifiquement à un complexe HLA-E-peptide, y compris des complexes HLA-E-VL9, et régulent la fonction de cellule effectrice de cytotoxicité de cellules NK et/ou de lymphocytes T CD8 + positives pour l'expression en surface cellulaire de NKG2A ("NKG2A+"). Des anticorps monoclonaux ont été dérivés de manière recombinante de MAb spécifiques de HLA-E-VL9 fonctionnels isolés issus de souris transgéniques HLA-B immunisées contre un peptide HLA-E-VL9 et du répertoire des lymphocytes B humains naïfs. De tels anticorps sont peuvent réguler la cytotoxicité des cellules effectrices et peuvent de préférence reconnaître des complexes peptidiques HLA-E-VL9 exprimés sur la surface de cellules tumorales. Les anticorps monoclonaux ont été soumis à un ou à plusieurs cycles de maturation d'affinité. L'invention concerne des méthodes d'utilisation de mAb HLA-E-VL9 à maturation d'affinité pour moduler la fonction de cellules NK et/ou de lymphocytes CD8+ dans le cadre de stratégies immunothérapeutiques.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163235535P | 2021-08-20 | 2021-08-20 | |
| US63/235,535 | 2021-08-20 | ||
| PCT/US2021/050537 WO2022060893A1 (fr) | 2020-09-15 | 2021-09-15 | Anticorps ciblant des complexes peptidiques hla-e-host et leurs utilisations |
| USPCT/US2021/050537 | 2021-09-15 | ||
| PCT/US2022/075241 WO2023023663A1 (fr) | 2021-08-20 | 2022-08-19 | Anticorps ciblant des complexes peptidiques hla-e-hôte et leurs utilisations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3229447A1 true CA3229447A1 (fr) | 2023-02-23 |
Family
ID=85241120
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3229447A Pending CA3229447A1 (fr) | 2021-08-20 | 2022-08-19 | Anticorps ciblant des complexes peptidiques hla-e-hote et leurs utilisations |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP4388012A1 (fr) |
| CA (1) | CA3229447A1 (fr) |
| WO (1) | WO2023023663A1 (fr) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9725764D0 (en) * | 1997-12-04 | 1998-02-04 | Isis Innovation | HLA-E binding |
| EP3362475B1 (fr) * | 2015-10-12 | 2023-08-30 | Innate Pharma | Agents de blocage de cd73 |
| CN111434688A (zh) * | 2019-01-11 | 2020-07-21 | 上海开拓者生物医药有限公司 | Cd73抗体及其制备方法和应用 |
-
2022
- 2022-08-19 EP EP22859437.0A patent/EP4388012A1/fr active Pending
- 2022-08-19 WO PCT/US2022/075241 patent/WO2023023663A1/fr active Application Filing
- 2022-08-19 CA CA3229447A patent/CA3229447A1/fr active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP4388012A1 (fr) | 2024-06-26 |
| WO2023023663A1 (fr) | 2023-02-23 |
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