CA3228823A1 - Compositions d'arndb modifies de poids moleculaire eleve - Google Patents
Compositions d'arndb modifies de poids moleculaire eleve Download PDFInfo
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- CA3228823A1 CA3228823A1 CA3228823A CA3228823A CA3228823A1 CA 3228823 A1 CA3228823 A1 CA 3228823A1 CA 3228823 A CA3228823 A CA 3228823A CA 3228823 A CA3228823 A CA 3228823A CA 3228823 A1 CA3228823 A1 CA 3228823A1
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- LITQZINTSYBKIU-UHFFFAOYSA-F tetracopper;hexahydroxide;sulfate Chemical compound [OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Cu+2].[Cu+2].[Cu+2].[Cu+2].[O-]S([O-])(=O)=O LITQZINTSYBKIU-UHFFFAOYSA-F 0.000 description 1
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- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- ONCZDRURRATYFI-TVJDWZFNSA-N trifloxystrobin Chemical compound CO\N=C(\C(=O)OC)C1=CC=CC=C1CO\N=C(/C)C1=CC=CC(C(F)(F)F)=C1 ONCZDRURRATYFI-TVJDWZFNSA-N 0.000 description 1
- ZSDSQXJSNMTJDA-UHFFFAOYSA-N trifluralin Chemical compound CCCN(CCC)C1=C([N+]([O-])=O)C=C(C(F)(F)F)C=C1[N+]([O-])=O ZSDSQXJSNMTJDA-UHFFFAOYSA-N 0.000 description 1
- IMEVJVISCHQJRM-UHFFFAOYSA-N triflusulfuron-methyl Chemical group COC(=O)C1=CC=CC(C)=C1S(=O)(=O)NC(=O)NC1=NC(OCC(F)(F)F)=NC(N(C)C)=N1 IMEVJVISCHQJRM-UHFFFAOYSA-N 0.000 description 1
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- 238000010200 validation analysis Methods 0.000 description 1
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- GPPXJZIENCGNKB-UHFFFAOYSA-N vanadium Chemical compound [V]#[V] GPPXJZIENCGNKB-UHFFFAOYSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
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- QAOHCFGKCWTBGC-QHOAOGIMSA-N wybutosine Chemical compound C1=NC=2C(=O)N3C(CC[C@H](NC(=O)OC)C(=O)OC)=C(C)N=C3N(C)C=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O QAOHCFGKCWTBGC-QHOAOGIMSA-N 0.000 description 1
- QAOHCFGKCWTBGC-UHFFFAOYSA-N wybutosine Natural products C1=NC=2C(=O)N3C(CCC(NC(=O)OC)C(=O)OC)=C(C)N=C3N(C)C=2N1C1OC(CO)C(O)C1O QAOHCFGKCWTBGC-UHFFFAOYSA-N 0.000 description 1
- WCNMEQDMUYVWMJ-JPZHCBQBSA-N wybutoxosine Chemical compound C1=NC=2C(=O)N3C(CC([C@H](NC(=O)OC)C(=O)OC)OO)=C(C)N=C3N(C)C=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O WCNMEQDMUYVWMJ-JPZHCBQBSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/60—Isolated nucleic acids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P23/00—Chemosterilants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P7/00—Arthropodicides
- A01P7/02—Acaricides
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P7/00—Arthropodicides
- A01P7/04—Insecticides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/30—Production chemically synthesised
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Plant Pathology (AREA)
- Environmental Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Insects & Arthropods (AREA)
- Biophysics (AREA)
- Dentistry (AREA)
- Virology (AREA)
- Agronomy & Crop Science (AREA)
- Physics & Mathematics (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
L'invention concerne des ARN double brin modifiés (ARNdbm) chimiquement post-transcriptionnellement ayant une modification polyalkyloxy de poids moléculaire élevé en position 2'-OH. Cette modification permet une plus grande biodisponibilité du composé, une meilleure stabilité du composé, et permet une plus grande stabilité contre les nucléases. Les ARNdbm peuvent être produits de manière économique de façon facilement évolutive. L'invention concerne des compositions d'ARNdbm ayant des nucléotides chimiquement modifiés, de telle sorte que les ARNdbm sont modifiés pour contenir des polymères polyalkyloxy de poids moléculaire élevé. L'invention concerne également des procédés de synthèse permettant de fabriquer efficacement ces ARNdbm ainsi que des procédés d'utilisation d'ARNdbm.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163239165P | 2021-08-31 | 2021-08-31 | |
| US63/239,165 | 2021-08-31 | ||
| PCT/US2022/075740 WO2023034849A2 (fr) | 2021-08-31 | 2022-08-31 | Compositions d'arndb modifiés de poids moléculaire élevé |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3228823A1 true CA3228823A1 (fr) | 2023-03-09 |
Family
ID=83508899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3228823A Pending CA3228823A1 (fr) | 2021-08-31 | 2022-08-31 | Compositions d'arndb modifies de poids moleculaire eleve |
Country Status (3)
| Country | Link |
|---|---|
| AR (1) | AR126939A1 (fr) |
| CA (1) | CA3228823A1 (fr) |
| WO (1) | WO2023034849A2 (fr) |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE421583T1 (de) * | 1999-04-30 | 2009-02-15 | Cyclops Genome Sciences Ltd | Isolierung von nukleinsäuren |
| US20040167090A1 (en) * | 2003-02-21 | 2004-08-26 | Monahan Sean D. | Covalent modification of RNA for in vitro and in vivo delivery |
| US20060021087A1 (en) | 2004-04-09 | 2006-01-26 | Baum James A | Compositions and methods for control of insect infestations in plants |
| TW200836762A (en) * | 2006-11-27 | 2008-09-16 | Enzon Pharmaceuticals Inc | Polymeric short interfering RNA conjugates |
| US20130047297A1 (en) | 2010-03-08 | 2013-02-21 | Robert D. Sammons | Polynucleotide molecules for gene regulation in plants |
| US9428791B2 (en) * | 2012-08-14 | 2016-08-30 | The Board Of Trustees Of The Leland Stanford Junior University | Probes of RNA structure and methods for using the same |
| SG10201805197VA (en) | 2013-06-19 | 2018-07-30 | Apse Llc | Compositions and methods using capsids resistant to hydrolases |
| CA2917108A1 (fr) | 2013-07-10 | 2015-01-15 | Basf Se | Arni inhibant l'expression des genes cyp51 pouvant etre utilises en vue de la lutte contre les champignons et les oomycetes phytopathogenes |
| CA2959402A1 (fr) | 2014-09-17 | 2016-03-24 | Pioneer Hi-Bred International, Inc. | Compositions et procedes de lutte contre des insectes nuisibles |
| CN110325540A (zh) | 2016-11-07 | 2019-10-11 | 纳诺索尔公司 | 转录后化学修饰的双链rna |
| BR112019022872A2 (pt) | 2017-05-01 | 2020-05-19 | Donald Danforth Plant Science Center | abordagem de rnai para proteção contra pragas |
| CN111033816B (zh) | 2017-08-28 | 2022-09-13 | 株式会社村田制作所 | 非水电解液电池和通信设备 |
| US11572557B2 (en) * | 2018-01-29 | 2023-02-07 | The Board Of Trustees Of The Leland Stanford Junior University | Photoreversible acylation reagents |
| US20220380418A1 (en) | 2018-08-13 | 2022-12-01 | Pioneer Hi-Bred International, Inc. | Novel insecticidal toxin receptors and methods of use |
| EP3983077A4 (fr) * | 2019-06-17 | 2023-12-20 | Alnylam Pharmaceuticals, Inc. | Administration d'oligonucléotides au striatum |
| DE102019212345B4 (de) | 2019-08-19 | 2024-02-08 | Robert Bosch Gmbh | Elektromechanisch antreibbarer Bremsdruckerzeuger |
-
2022
- 2022-08-31 CA CA3228823A patent/CA3228823A1/fr active Pending
- 2022-08-31 WO PCT/US2022/075740 patent/WO2023034849A2/fr active Application Filing
- 2022-08-31 AR ARP220102359A patent/AR126939A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2023034849A3 (fr) | 2023-05-19 |
| WO2023034849A2 (fr) | 2023-03-09 |
| WO2023034849A8 (fr) | 2024-03-07 |
| AR126939A1 (es) | 2023-11-29 |
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