CA3228509A1 - Treatment of jak-inhibition-responsive disorders with prodrugs of jak inhibitors - Google Patents
Treatment of jak-inhibition-responsive disorders with prodrugs of jak inhibitors Download PDFInfo
- Publication number
- CA3228509A1 CA3228509A1 CA3228509A CA3228509A CA3228509A1 CA 3228509 A1 CA3228509 A1 CA 3228509A1 CA 3228509 A CA3228509 A CA 3228509A CA 3228509 A CA3228509 A CA 3228509A CA 3228509 A1 CA3228509 A1 CA 3228509A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- pharmaceutically acceptable
- deuterium
- formula
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163232538P | 2021-08-12 | 2021-08-12 | |
| US63/232,538 | 2021-08-12 | ||
| US202163233059P | 2021-08-13 | 2021-08-13 | |
| US63/233,059 | 2021-08-13 | ||
| PCT/US2022/040190 WO2023018954A1 (en) | 2021-08-12 | 2022-08-12 | Treatment of jak-inhibition-responsive disorders with prodrugs of jak inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3228509A1 true CA3228509A1 (en) | 2023-02-16 |
Family
ID=83188710
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3228509A Pending CA3228509A1 (en) | 2021-08-12 | 2022-08-12 | Treatment of jak-inhibition-responsive disorders with prodrugs of jak inhibitors |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20240307401A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP4384173A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2024532765A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2022328282A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3228509A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2023018954A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116870012A (zh) * | 2023-07-26 | 2023-10-13 | 北京大学宁波海洋药物研究院 | 一类甾体硫酸酯化合物在制备jak激酶抑制剂中的应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9925962D0 (en) | 1999-11-02 | 1999-12-29 | Novartis Ag | Organic compounds |
| CZ20033211A3 (cs) | 2001-05-03 | 2004-09-15 | F. Hoffmann-La Roche Ag | Farmaceutická léková forma amorfního nelfinavir mesylátu |
| WO2006039237A1 (en) | 2004-09-29 | 2006-04-13 | Cordis Corporation | Pharmaceutical dosage forms of stable amorphous rapamycin like compounds |
| LT1993360T (lt) | 2005-12-28 | 2017-06-12 | Vertex Pharmaceuticals Incorporated | N-[2,4-bis(1,1-dimetiletil)-5-hidroksifenil]-1,4-dihidro-4-oksochinolin-3-karboksamido kieta forma |
| WO2010083283A2 (en) | 2009-01-15 | 2010-07-22 | Incyte Corporation | Processes for preparing jak inhibitors and related intermediate compounds |
| EP3450434B1 (en) | 2012-06-15 | 2021-02-24 | CoNCERT Pharmaceuticals, Inc. | Deuterated derivatives of ruxolitinib |
| US10561659B2 (en) | 2016-05-04 | 2020-02-18 | Concert Pharmaceuticals, Inc. | Treatment of hair loss disorders with deuterated JAK inhibitors |
| CN107759601B (zh) * | 2016-08-23 | 2020-09-11 | 苏州旺山旺水生物医药有限公司 | 一种jak抑制剂及其盐的制备方法 |
| BR112019024509A2 (pt) * | 2017-05-23 | 2020-06-23 | Theravance Biopharma R&D Ip, Llc | Glicuronídeo de pró-fármacos dos inibidores da janus quinase |
| CN107915738B (zh) | 2017-11-14 | 2019-07-26 | 海化生命(厦门)科技有限公司 | 用于合成巴瑞替尼的关键中间体2的制备方法 |
| EP3921318A1 (en) | 2019-02-06 | 2021-12-15 | Concert Pharmaceuticals Inc. | Process for preparing enantiomerically enriched jak inhibitors |
| EP4172147A1 (en) | 2020-06-29 | 2023-05-03 | Concert Pharmaceuticals Inc. | Methods and intermediates for preparing jak inhibitors |
-
2022
- 2022-08-12 AU AU2022328282A patent/AU2022328282A1/en not_active Abandoned
- 2022-08-12 US US18/682,339 patent/US20240307401A1/en active Pending
- 2022-08-12 JP JP2024508389A patent/JP2024532765A/ja active Pending
- 2022-08-12 EP EP22764557.9A patent/EP4384173A1/en active Pending
- 2022-08-12 WO PCT/US2022/040190 patent/WO2023018954A1/en not_active Ceased
- 2022-08-12 CA CA3228509A patent/CA3228509A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20240307401A1 (en) | 2024-09-19 |
| JP2024532765A (ja) | 2024-09-10 |
| WO2023018954A1 (en) | 2023-02-16 |
| AU2022328282A1 (en) | 2024-02-22 |
| EP4384173A1 (en) | 2024-06-19 |
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