CA3218112A1 - Reprogramming of cells to type 1 conventional dendritic cells or antigen-presenting cells - Google Patents

Reprogramming of cells to type 1 conventional dendritic cells or antigen-presenting cells Download PDF

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Publication number
CA3218112A1
CA3218112A1 CA3218112A CA3218112A CA3218112A1 CA 3218112 A1 CA3218112 A1 CA 3218112A1 CA 3218112 A CA3218112 A CA 3218112A CA 3218112 A CA3218112 A CA 3218112A CA 3218112 A1 CA3218112 A1 CA 3218112A1
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cell
vector
construct
cancer
batf3
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CA3218112A
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English (en)
French (fr)
Inventor
Fabio FIUZA ROSA
Olga ZIMMERMANNOVA
Alexandra Gabriela BARROS FERREIRA
Ervin ASCIC
Cristiana FERREIRA PIRES
Carlos Filipe RIBEIRO LEMOS PEREIRA
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Asgard Therapeutics AB
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Asgard Therapeutics AB
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Publication of CA3218112A1 publication Critical patent/CA3218112A1/en
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/19—Dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24—Antigen-presenting cells [APC]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/41—Vertebrate antigens
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    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
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    • A61K40/4213—CD74, Ii, MHC class II invariant chain or MHC class II gamma chain
    • A—HUMAN NECESSITIES
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    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/46—Viral antigens
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
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    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • A61K2239/57—Skin; melanoma
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
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CA3218112A 2021-05-19 2022-05-19 Reprogramming of cells to type 1 conventional dendritic cells or antigen-presenting cells Pending CA3218112A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP21174802.5 2021-05-19
EP21174802 2021-05-19
EP22158117 2022-02-23
EP22158117.6 2022-02-23
PCT/EP2022/063606 WO2022243448A1 (en) 2021-05-19 2022-05-19 Reprogramming of cells to type 1 conventional dendritic cells or antigen-presenting cells

Publications (1)

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CA3218112A1 true CA3218112A1 (en) 2022-11-24

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CA3218112A Pending CA3218112A1 (en) 2021-05-19 2022-05-19 Reprogramming of cells to type 1 conventional dendritic cells or antigen-presenting cells

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US (1) US20250186489A1 (cg-RX-API-DMAC10.html)
EP (1) EP4341384A1 (cg-RX-API-DMAC10.html)
JP (1) JP2024522074A (cg-RX-API-DMAC10.html)
KR (1) KR20240008332A (cg-RX-API-DMAC10.html)
CA (1) CA3218112A1 (cg-RX-API-DMAC10.html)
IL (1) IL308291A (cg-RX-API-DMAC10.html)
WO (1) WO2022243448A1 (cg-RX-API-DMAC10.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025120097A1 (en) * 2023-12-05 2025-06-12 Asgard Therapeutics Ab Rna-based strategies for dendritic cell reprogramming and uses thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025198857A1 (en) * 2024-03-20 2025-09-25 The Regents Of The University Of California Irf8-mediated reprogramming of the immune microenvironment in glioblastoma
WO2026003067A1 (en) * 2024-06-25 2026-01-02 Asgard Therapeutics Ab Transcription factors and reprogramming modulators for reprogramming cells to cdc1 cells, compositions and methods thereof
WO2026003071A2 (en) * 2024-06-25 2026-01-02 Asgard Therapeutics Ab Novel transcription factor combinations for immune cell reprogramming and related methods
WO2026009883A1 (ja) * 2024-07-03 2026-01-08 慶應義塾 心筋ダイレクトリプログラミングのための組換えアデノ随伴ウイルスベクター

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Publication number Priority date Publication date Assignee Title
AU2011377617B2 (en) * 2011-09-23 2018-03-08 Bluebird Bio, Inc. Improved gene therapy methods
US11345891B2 (en) * 2017-04-05 2022-05-31 Asgard Therapeutics Ab Compositions for reprogramming cells into dendritic cells or antigen presenting cells, methods and uses thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025120097A1 (en) * 2023-12-05 2025-06-12 Asgard Therapeutics Ab Rna-based strategies for dendritic cell reprogramming and uses thereof

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IL308291A (en) 2024-01-01
EP4341384A1 (en) 2024-03-27
JP2024522074A (ja) 2024-06-11
KR20240008332A (ko) 2024-01-18
WO2022243448A1 (en) 2022-11-24
US20250186489A1 (en) 2025-06-12

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