CA3217079A1 - Fusion polypeptides - Google Patents

Fusion polypeptides Download PDF

Info

Publication number
CA3217079A1
CA3217079A1 CA3217079A CA3217079A CA3217079A1 CA 3217079 A1 CA3217079 A1 CA 3217079A1 CA 3217079 A CA3217079 A CA 3217079A CA 3217079 A CA3217079 A CA 3217079A CA 3217079 A1 CA3217079 A1 CA 3217079A1
Authority
CA
Canada
Prior art keywords
fusion polypeptide
polypeptide
hydroxide
metal
complex
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3217079A
Other languages
English (en)
French (fr)
Inventor
Michael Schmidt
Grigorios Zarbis-Papastoitsis
Karl Dane Wittrup
Darrell Irvine
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ankyra Therapeutics Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA3217079A1 publication Critical patent/CA3217079A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5434—IL-12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/11001—Non-specific serine/threonine protein kinase (2.7.11.1), i.e. casein kinase or checkpoint kinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA3217079A 2021-05-05 2022-05-04 Fusion polypeptides Pending CA3217079A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163184620P 2021-05-05 2021-05-05
US63/184,620 2021-05-05
PCT/US2022/027617 WO2022235755A2 (en) 2021-05-05 2022-05-04 Fusion polypeptides

Publications (1)

Publication Number Publication Date
CA3217079A1 true CA3217079A1 (en) 2022-11-10

Family

ID=82020825

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3217079A Pending CA3217079A1 (en) 2021-05-05 2022-05-04 Fusion polypeptides

Country Status (8)

Country Link
US (3) US12454695B2 (https=)
EP (1) EP4334337A2 (https=)
JP (1) JP2024517855A (https=)
KR (1) KR20240028341A (https=)
AU (1) AU2022269602A1 (https=)
CA (1) CA3217079A1 (https=)
IL (1) IL308240A (https=)
WO (1) WO2022235755A2 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4334337A2 (en) 2021-05-05 2024-03-13 Ankyra Therapeutics, Inc. Fusion polypeptides
CA3234552A1 (en) 2021-10-20 2023-04-27 Synthekine, Inc. Heterodimeric fc cytokines and uses thereof
JP2025540624A (ja) * 2022-11-09 2025-12-16 アンキラ セラピューティクス，インコーポレイテッド 融合ポリペプチドを作製する方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019346335B2 (en) * 2018-09-28 2024-07-25 Massachusetts Institute Of Technology Collagen-localized immunomodulatory molecules and methods thereof
WO2020263399A1 (en) 2019-06-26 2020-12-30 Massachusetts Institute Of Technology Immunomodulatory fusion protein-metal hydroxide complexes and methods thereof
EP4334337A2 (en) 2021-05-05 2024-03-13 Ankyra Therapeutics, Inc. Fusion polypeptides

Also Published As

Publication number Publication date
US20260035706A1 (en) 2026-02-05
WO2022235755A3 (en) 2022-12-29
EP4334337A2 (en) 2024-03-13
KR20240028341A (ko) 2024-03-05
US20220372495A1 (en) 2022-11-24
US20250327085A1 (en) 2025-10-23
JP2024517855A (ja) 2024-04-23
IL308240A (en) 2024-01-01
AU2022269602A1 (en) 2023-11-09
WO2022235755A2 (en) 2022-11-10
US12454695B2 (en) 2025-10-28

Similar Documents

Publication Publication Date Title
TWI906278B (zh) 經遮蔽之il-12細胞激素及其裂解產物
KR102355950B1 (ko) Tigit에 대한 항체
CN111320695B (zh) 治疗或预防认知障碍的人源化抗体、其生产方法及使用其用于治疗或预防认识障碍的剂
KR20220050971A (ko) 신규 항-cd39 항체
KR102773428B1 (ko) Il10 수용체 결합 분자 및 사용 방법
US20250327085A1 (en) Fusion polypeptides
CN111032688A (zh) 用于延长的血清半衰期的工程化抗体fc变体
KR20170101311A (ko) 항-ｃｄ3 항체, 항-ｃｄ123 항체, 및 ｃｄ3 및/또는 ｃｄ123에 특이적으로 결합하는 이중특이적 항체
KR20190140943A (ko) 항-cd33 항체 제제
AU2016209324A1 (en) Tumor necrosis factor (TNF) superfamily receptor binding molecules and uses thereof
US20230416394A1 (en) Novel conjugate molecules targeting cd39 and tgfbeta
TW202311291A (zh) 抗ctla-4抗體的用途
KR20220050166A (ko) Igm 글리코변이체
FR3075200A1 (fr) Variants avec fragment fc ayant une affinite augmentee pour fcrn et une affinite augmentee pour au moins un recepteur du fragment fc
KR20210095781A (ko) 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물
CN118076638A (zh) 新型抗sirpa抗体
TW202440647A (zh) 經工程改造之pd-1抗體及其用途
JP2024509501A (ja) 新規活性を持つｈｈｌａ２結合剤
JP2026063000A (ja) Ｇｐ１３０結合分子および使用方法
EP3882271A2 (en) Ifn-gamma-inducible regulatory t cell convertible anti-cancer (irtca) antibody and uses thereof
JP7837873B2 (ja) ヒト化抗ＴｒｋＡ抗体及びその使用
CA3170750A1 (en) Serum albumin binding nanobody compositions and methods for using the same
WO2026046399A1 (en) Anti-dll3 antibodies and use thereof
WO2025150556A1 (ja) 環境応答性ペプチドを利用したタンパク質の製造方法
KR20260038311A (ko) 인간화 il-10 수용체 결합 분자 및 사용 방법

Legal Events

Date Code Title Description
MFA Maintenance fee for application paid

Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 3RD ANNIV.) - STANDARD

Year of fee payment: 3

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-1-1-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20250428

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-1-1-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20250428