CA3174217A1 - Insert oculaire contenant un glucocorticoide - Google Patents
Insert oculaire contenant un glucocorticoide Download PDFInfo
- Publication number
- CA3174217A1 CA3174217A1 CA3174217A CA3174217A CA3174217A1 CA 3174217 A1 CA3174217 A1 CA 3174217A1 CA 3174217 A CA3174217 A CA 3174217A CA 3174217 A CA3174217 A CA 3174217A CA 3174217 A1 CA3174217 A1 CA 3174217A1
- Authority
- CA
- Canada
- Prior art keywords
- insert
- sustained release
- dexamethasone
- release biodegradable
- hydrogel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000002250 progressing effect Effects 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 230000010349 pulsation Effects 0.000 description 1
- 150000003220 pyrenes Chemical class 0.000 description 1
- MIXMJCQRHVAJIO-TZHJZOAOSA-N qk4dys664x Chemical compound O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O MIXMJCQRHVAJIO-TZHJZOAOSA-N 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 239000012713 reactive precursor Substances 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 230000029964 regulation of glucose metabolic process Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229960001487 rimexolone Drugs 0.000 description 1
- QTTRZHGPGKRAFB-OOKHYKNYSA-N rimexolone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CC)(C)[C@@]1(C)C[C@@H]2O QTTRZHGPGKRAFB-OOKHYKNYSA-N 0.000 description 1
- 238000007151 ring opening polymerisation reaction Methods 0.000 description 1
- 238000011125 single therapy Methods 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229960001922 sodium perborate Drugs 0.000 description 1
- 239000012064 sodium phosphate buffer Substances 0.000 description 1
- YKLJGMBLPUQQOI-UHFFFAOYSA-M sodium;oxidooxy(oxo)borane Chemical compound [Na+].[O-]OB=O YKLJGMBLPUQQOI-UHFFFAOYSA-M 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 229940063675 spermine Drugs 0.000 description 1
- 239000012798 spherical particle Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000003270 steroid hormone Substances 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000003319 supportive effect Effects 0.000 description 1
- 238000013269 sustained drug release Methods 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 229960001967 tacrolimus Drugs 0.000 description 1
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 description 1
- 238000004885 tandem mass spectrometry Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000004797 therapeutic response Effects 0.000 description 1
- FYOWZTWVYZOZSI-UHFFFAOYSA-N thiourea dioxide Chemical compound NC(=N)S(O)=O FYOWZTWVYZOZSI-UHFFFAOYSA-N 0.000 description 1
- 231100000816 toxic dose Toxicity 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 229960002117 triamcinolone acetonide Drugs 0.000 description 1
- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
- 229920001664 tyloxapol Polymers 0.000 description 1
- MDYZKJNTKZIUSK-UHFFFAOYSA-N tyloxapol Chemical compound O=C.C1CO1.CC(C)(C)CC(C)(C)C1=CC=C(O)C=C1 MDYZKJNTKZIUSK-UHFFFAOYSA-N 0.000 description 1
- 229960004224 tyloxapol Drugs 0.000 description 1
- 238000002562 urinalysis Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Dans certains modes de réalisation, l'invention concerne un insert intracanaliculaire biodégradable à libération prolongée contenant un glucocorticoïde dispersé dans un hydrogel pour le traitement d'une kératoconjonctivite sèche.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063052646P | 2020-07-16 | 2020-07-16 | |
| US63/052,646 | 2020-07-16 | ||
| US202063124176P | 2020-12-11 | 2020-12-11 | |
| US63/124,176 | 2020-12-11 | ||
| US202163181720P | 2021-04-29 | 2021-04-29 | |
| US63/181,720 | 2021-04-29 | ||
| PCT/US2021/041761 WO2022015940A1 (fr) | 2020-07-16 | 2021-07-15 | Insert oculaire contenant un glucocorticoïde |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3174217A1 true CA3174217A1 (fr) | 2022-01-20 |
Family
ID=77300995
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3174217A Pending CA3174217A1 (fr) | 2020-07-16 | 2021-07-15 | Insert oculaire contenant un glucocorticoide |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP4181930A1 (fr) |
| JP (1) | JP2023534952A (fr) |
| KR (1) | KR20230041708A (fr) |
| CN (1) | CN116133664A (fr) |
| AU (1) | AU2021309965A1 (fr) |
| BR (1) | BR112023000669A2 (fr) |
| CA (1) | CA3174217A1 (fr) |
| IL (1) | IL299769A (fr) |
| MX (1) | MX2023000628A (fr) |
| WO (1) | WO2022015940A1 (fr) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2043698A2 (fr) | 2006-07-20 | 2009-04-08 | Sicor, Inc. | Procédé de préparation d'un ingrédient pharmaceutique actif stérile solide |
| EP2156823A1 (fr) | 2008-08-14 | 2010-02-24 | Pharmatex Italia Srl | Processus de préparation de composés pharmaceutiques poudrés stériles sous la forme de micro et nano particules |
| CA2750242C (fr) * | 2009-02-12 | 2018-05-22 | Incept, Llc | Delivrance de medicament par bouchons d'hydrogels |
| EP3294212B1 (fr) | 2015-05-12 | 2023-10-25 | Incept, LLC | Administration de médicament à partir d'hydrogels |
| CN109982683A (zh) * | 2016-09-23 | 2019-07-05 | 因赛普特有限责任公司 | 前房内药物递送储库 |
-
2021
- 2021-07-15 KR KR1020237002637A patent/KR20230041708A/ko active Search and Examination
- 2021-07-15 AU AU2021309965A patent/AU2021309965A1/en active Pending
- 2021-07-15 IL IL299769A patent/IL299769A/en unknown
- 2021-07-15 CN CN202180060084.6A patent/CN116133664A/zh active Pending
- 2021-07-15 EP EP21752805.8A patent/EP4181930A1/fr active Pending
- 2021-07-15 BR BR112023000669A patent/BR112023000669A2/pt unknown
- 2021-07-15 MX MX2023000628A patent/MX2023000628A/es unknown
- 2021-07-15 JP JP2023502835A patent/JP2023534952A/ja active Pending
- 2021-07-15 CA CA3174217A patent/CA3174217A1/fr active Pending
- 2021-07-15 WO PCT/US2021/041761 patent/WO2022015940A1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP4181930A1 (fr) | 2023-05-24 |
| IL299769A (en) | 2023-03-01 |
| JP2023534952A (ja) | 2023-08-15 |
| MX2023000628A (es) | 2023-02-27 |
| BR112023000669A2 (pt) | 2023-04-25 |
| WO2022015940A1 (fr) | 2022-01-20 |
| AU2021309965A1 (en) | 2023-02-23 |
| CN116133664A (zh) | 2023-05-16 |
| KR20230041708A (ko) | 2023-03-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20220929 |
|
| EEER | Examination request |
Effective date: 20220929 |
|
| EEER | Examination request |
Effective date: 20220929 |
|
| EEER | Examination request |
Effective date: 20220929 |
|
| EEER | Examination request |
Effective date: 20220929 |