CA3172844A1 - Transglutaminase variants - Google Patents

Transglutaminase variants

Info

Publication number
CA3172844A1
CA3172844A1 CA3172844A CA3172844A CA3172844A1 CA 3172844 A1 CA3172844 A1 CA 3172844A1 CA 3172844 A CA3172844 A CA 3172844A CA 3172844 A CA3172844 A CA 3172844A CA 3172844 A1 CA3172844 A1 CA 3172844A1
Authority
CA
Canada
Prior art keywords
product
enzyme
protein
composition
tgase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3172844A
Other languages
English (en)
French (fr)
Inventor
Will SHINDEL
Erika Milczek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Curie Co Inc
Original Assignee
Curie Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curie Co Inc filed Critical Curie Co Inc
Publication of CA3172844A1 publication Critical patent/CA3172844A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/104—Aminoacyltransferases (2.3.2)
    • C12N9/1044—Protein-glutamine gamma-glutamyltransferase (2.3.2.13), i.e. transglutaminase or factor XIII
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/50—Isolated enzymes; Isolated proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/00041—Use of virus, viral particle or viral elements as a vector
    • C12N2795/00043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/02—Aminoacyltransferases (2.3.2)
    • C12Y203/02013—Protein-glutamine gamma-glutamyltransferase (2.3.2.13), i.e. transglutaminase or factor XIII
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • Birds (AREA)
  • Environmental Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA3172844A 2020-03-13 2021-03-10 Transglutaminase variants Pending CA3172844A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062988918P 2020-03-13 2020-03-13
US62/988,918 2020-03-13
PCT/US2021/021766 WO2021183680A1 (en) 2020-03-13 2021-03-10 Transglutaminase variants

Publications (1)

Publication Number Publication Date
CA3172844A1 true CA3172844A1 (en) 2021-09-16

Family

ID=77671938

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3172844A Pending CA3172844A1 (en) 2020-03-13 2021-03-10 Transglutaminase variants

Country Status (9)

Country Link
US (1) US20230167420A1 (https=)
EP (1) EP4118194A4 (https=)
JP (1) JP2023518714A (https=)
KR (1) KR20220153047A (https=)
CN (1) CN115298306A (https=)
BR (1) BR112022017192A2 (https=)
CA (1) CA3172844A1 (https=)
MX (1) MX2022011077A (https=)
WO (1) WO2021183680A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20250304927A1 (en) 2022-05-20 2025-10-02 Curie Co. Inc. Pro-peptide variants for modulating activity of transglutaminases
CN115487345B (zh) * 2022-08-22 2024-03-12 天津大学 基于丝素蛋白的止血水凝胶和止血海绵及其制备方法和应用
KR20260013477A (ko) 2023-05-19 2026-01-28 큐리 컴퍼니 인코포레이티드 트랜스글루타미나제 및 그의 용도
CN117643311B (zh) * 2023-12-01 2024-09-27 北京舜雷科技有限公司 一种组合物、制备方法及应用
CN121610553B (zh) * 2026-01-30 2026-04-17 四川友联味业食品有限公司 一种鲜味肽提取物复配取代味精的加工工艺

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2090001T3 (es) * 1994-02-14 1998-08-01 Univ Leiden Un metodo para seleccionar por la presencia de un defecto genetico asociado con trombosis y/o una pobre respuesta anticoagulante a la proteina c activada.
BR0014059B1 (pt) * 1999-09-30 2013-02-05 processo para produzir transglutaminase.
KR100575394B1 (ko) * 2000-08-17 2006-05-03 아지노모토 가부시키가이샤 미생물 유래 트랜스글루타미나제의 변이 방법
US20090117640A1 (en) * 2005-08-18 2009-05-07 Novo Nordisk Health Care Ag Transglutaminase Variants with Improved Specificity
JP2008194004A (ja) * 2007-02-15 2008-08-28 Ajinomoto Co Inc 変異体トランスグルタミナーゼ
AU2008215422B2 (en) * 2007-02-15 2011-07-14 Ajinomoto Co., Inc. Transglutaminase having disulfide bond introduced therein
EP2251421B1 (en) * 2008-02-13 2016-11-16 Amano Enzyme Inc. Stabilized transglutaminase and process for production thereof
CN102341497B (zh) * 2009-03-06 2013-11-06 味之素株式会社 放线菌来源的耐热性转谷氨酰胺酶
WO2019014118A1 (en) * 2017-07-09 2019-01-17 Igc Bio, Inc. PROSS OPTIMIZED ENZYMES
CN107739734B (zh) * 2017-10-26 2020-07-07 江南大学 一种酶活提高的谷氨酰胺转氨酶突变体
EP3706780A4 (en) * 2017-11-07 2021-12-22 Codexis, Inc. TRANSGLUTAMINASE VARIANTS
BR112020009793A2 (pt) * 2017-11-30 2020-11-03 Amano Enzyme Inc. transglutaminase modificada
CN113473856B (zh) * 2019-03-06 2024-03-19 居里公司 防腐剂组合物及其使用方法
MX2023002744A (es) * 2020-09-08 2023-04-03 Curie Co Inc Composiciones y metodos de uso de las mismas.

Also Published As

Publication number Publication date
EP4118194A4 (en) 2024-08-21
MX2022011077A (es) 2022-09-23
US20230167420A1 (en) 2023-06-01
JP2023518714A (ja) 2023-05-08
EP4118194A1 (en) 2023-01-18
KR20220153047A (ko) 2022-11-17
BR112022017192A2 (pt) 2022-10-18
CN115298306A (zh) 2022-11-04
WO2021183680A1 (en) 2021-09-16

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