CA3159436A1 - Utilisation d'un agent d'ouverture du canal potassique kv7 pour le traitement de la douleur - Google Patents
Utilisation d'un agent d'ouverture du canal potassique kv7 pour le traitement de la douleur Download PDFInfo
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- CA3159436A1 CA3159436A1 CA3159436A CA3159436A CA3159436A1 CA 3159436 A1 CA3159436 A1 CA 3159436A1 CA 3159436 A CA3159436 A CA 3159436A CA 3159436 A CA3159436 A CA 3159436A CA 3159436 A1 CA3159436 A1 CA 3159436A1
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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- A61K31/13—Amines
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- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
Abstract
Selon certains modes de réalisation, la présente invention concerne des méthodes et des utilisations pour traiter la douleur chez un sujet, les méthodes comprenant l'administration par voie orale d'une quantité thérapeutiquement efficace de N-[4-(6-fluoro-3,4-dihydro-1H-isoquinolin-2-yl)-2,6-diméthylphényl]-3,3-diméthylbutanamide (Composé A), au sujet nécessitant un tel traitement. La présente invention concerne également diverses méthodes améliorées de thérapie et d'administration du composé A.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962945093P | 2019-12-06 | 2019-12-06 | |
| US62/945,093 | 2019-12-06 | ||
| US201962948010P | 2019-12-13 | 2019-12-13 | |
| US62/948,010 | 2019-12-13 | ||
| PCT/US2020/063471 WO2021113757A1 (fr) | 2019-12-06 | 2020-12-04 | Utilisation d'un agent d'ouverture du canal potassique kv7 pour le traitement de la douleur |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3159436A1 true CA3159436A1 (fr) | 2021-06-10 |
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Family Applications (1)
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|---|---|---|---|
| CA3159436A Pending CA3159436A1 (fr) | 2019-12-06 | 2020-12-04 | Utilisation d'un agent d'ouverture du canal potassique kv7 pour le traitement de la douleur |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP4069211A1 (fr) |
| JP (1) | JP2023504166A (fr) |
| KR (1) | KR20220113411A (fr) |
| CN (1) | CN114786658A (fr) |
| AU (1) | AU2020397173A1 (fr) |
| BR (1) | BR112022010733A2 (fr) |
| CA (1) | CA3159436A1 (fr) |
| CL (1) | CL2022001477A1 (fr) |
| CR (1) | CR20220318A (fr) |
| IL (1) | IL293504A (fr) |
| MX (1) | MX2022006877A (fr) |
| PE (1) | PE20221169A1 (fr) |
| TW (1) | TW202133847A (fr) |
| WO (1) | WO2021113757A1 (fr) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113698345B (zh) * | 2021-10-27 | 2022-02-01 | 上海挚盟医药科技有限公司 | 作为钾通道调节剂的化合物及其制备和应用 |
| JP7294734B2 (ja) * | 2021-10-27 | 2023-06-20 | シャンハイ ジムン バイオファーマ，インコーポレーテッド | カリウムチャネル調節剤としての化合物ならびにその調製および応用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2061465T3 (da) * | 2006-08-23 | 2013-07-08 | Valeant Pharmaceuticals Int | Derivater af 4-(N-azacycloalkyl)anilider som kaliumkanalmodulatorer |
| US8993593B2 (en) * | 2006-08-23 | 2015-03-31 | Valeant Pharmaceuticals International | N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators |
| WO2013067591A1 (fr) * | 2011-11-10 | 2013-05-16 | Relevare Australia Pty Ltd | Formulations topiques pour gestion de la douleur |
| US9248122B2 (en) * | 2012-11-28 | 2016-02-02 | Grünenthal GmbH | Heteroquinoline-3-carboxamides as KCNQ2/3 modulators |
| RS64922B1 (sr) * | 2018-05-11 | 2023-12-29 | Xenon Pharmaceuticals Inc | Postupci za povećanje bioraspoloživosti i izloženosti otvaraču naponom kontrolisanih kalijumskih kanala |
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2020
- 2020-12-04 IL IL293504A patent/IL293504A/en unknown
- 2020-12-04 CN CN202080084722.3A patent/CN114786658A/zh active Pending
- 2020-12-04 BR BR112022010733A patent/BR112022010733A2/pt unknown
- 2020-12-04 CA CA3159436A patent/CA3159436A1/fr active Pending
- 2020-12-04 KR KR1020227021509A patent/KR20220113411A/ko active Search and Examination
- 2020-12-04 CR CR20220318A patent/CR20220318A/es unknown
- 2020-12-04 AU AU2020397173A patent/AU2020397173A1/en active Pending
- 2020-12-04 MX MX2022006877A patent/MX2022006877A/es unknown
- 2020-12-04 WO PCT/US2020/063471 patent/WO2021113757A1/fr unknown
- 2020-12-04 EP EP20828491.9A patent/EP4069211A1/fr active Pending
- 2020-12-04 JP JP2022532695A patent/JP2023504166A/ja active Pending
- 2020-12-04 TW TW109142937A patent/TW202133847A/zh unknown
- 2020-12-04 PE PE2022001015A patent/PE20221169A1/es unknown
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2022
- 2022-06-03 CL CL2022001477A patent/CL2022001477A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL293504A (en) | 2022-08-01 |
| CR20220318A (es) | 2022-10-07 |
| MX2022006877A (es) | 2022-07-11 |
| CN114786658A (zh) | 2022-07-22 |
| CL2022001477A1 (es) | 2023-04-28 |
| KR20220113411A (ko) | 2022-08-12 |
| BR112022010733A2 (pt) | 2022-08-23 |
| EP4069211A1 (fr) | 2022-10-12 |
| WO2021113757A1 (fr) | 2021-06-10 |
| PE20221169A1 (es) | 2022-07-25 |
| JP2023504166A (ja) | 2023-02-01 |
| AU2020397173A1 (en) | 2022-06-23 |
| TW202133847A (zh) | 2021-09-16 |
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