CA3157428A1 - Sigma-1 receptor ligands and uses thereof - Google Patents

Sigma-1 receptor ligands and uses thereof Download PDF

Info

Publication number
CA3157428A1
CA3157428A1 CA3157428A CA3157428A CA3157428A1 CA 3157428 A1 CA3157428 A1 CA 3157428A1 CA 3157428 A CA3157428 A CA 3157428A CA 3157428 A CA3157428 A CA 3157428A CA 3157428 A1 CA3157428 A1 CA 3157428A1
Authority
CA
Canada
Prior art keywords
hydrochloride
methyl
benzylpiperidin
aryl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3157428A
Other languages
English (en)
French (fr)
Inventor
Jean-Jacques Bourguignon
Martine Schmitt
Jacques BRICARD
Tanguy MAURICE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Institut National de la Sante et de la Recherche Medicale INSERM
Universite de Strasbourg
Universite de Montpellier
Ecole Pratique des Hautes Etudes SAS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Universite de Strasbourg
Universite de Montpellier
Ecole Pratique des Hautes Etudes SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS, Universite de Strasbourg, Universite de Montpellier, Ecole Pratique des Hautes Etudes SAS filed Critical Centre National de la Recherche Scientifique CNRS
Publication of CA3157428A1 publication Critical patent/CA3157428A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA3157428A 2019-12-19 2020-12-18 Sigma-1 receptor ligands and uses thereof Pending CA3157428A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19306705.5 2019-12-19
EP19306705 2019-12-19
PCT/EP2020/086996 WO2021123145A1 (en) 2019-12-19 2020-12-18 Sigma-1 receptor ligands and uses thereof

Publications (1)

Publication Number Publication Date
CA3157428A1 true CA3157428A1 (en) 2021-06-24

Family

ID=69232740

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3157428A Pending CA3157428A1 (en) 2019-12-19 2020-12-18 Sigma-1 receptor ligands and uses thereof

Country Status (6)

Country Link
US (1) US20230049619A1 (https=)
EP (1) EP4077310B1 (https=)
JP (1) JP7725475B2 (https=)
CN (1) CN114981260A (https=)
CA (1) CA3157428A1 (https=)
WO (1) WO2021123145A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12612371B2 (en) 2019-12-19 2026-04-28 Universite De Strasbourg Sigma-1 receptor ligands and therapeutic uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB858792A (en) * 1958-02-10 1961-01-18 Sandoz Ltd New pyridazine derivatives and processes for their manufacture
GB0204252D0 (en) 2002-02-23 2002-04-10 Oxford Glycosciences Uk Ltd Novel compounds
US8404852B2 (en) * 2003-01-31 2013-03-26 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
AR042956A1 (es) * 2003-01-31 2005-07-13 Vertex Pharma Inhibidores de girasa y usos de los mismos
ATE522249T1 (de) 2007-07-26 2011-09-15 Novartis Ag Organische verbindungen
WO2010131145A1 (en) 2009-05-12 2010-11-18 Pfizer Limited Cyclobutenedione derivatives
CA2761279A1 (en) 2009-05-20 2010-11-25 F. Hoffmann-La Roche Ag Heterocyclic antiviral compounds
CN102241667B (zh) * 2010-05-14 2013-10-23 中国人民解放军军事医学科学院毒物药物研究所 1-[(4-羟基哌啶-4基)甲基]吡啶-2(1h)-酮衍生物及其制备方法和用途
BR112014015197A8 (pt) 2011-12-21 2017-06-13 Novira Therapeutics Inc agentes antivirais de hepatite b
AR098215A1 (es) * 2013-10-29 2016-05-18 Takeda Pharmaceuticals Co Compuesto heterocíclico
WO2017222952A1 (en) * 2016-06-23 2017-12-28 Merck Sharp & Dohme Corp. 3- heteroaryl substituted 5-trifluoromethyl oxadiazoles as histone deacetylase 6 (hdac6) inhibitors
WO2019068771A1 (en) * 2017-10-04 2019-04-11 Esteve Pharmaceuticals, S.A. USE OF SIGMA RECEPTOR LIGANDS AGAINST AGE-RELATED COGNITIVE DISORDERS

Also Published As

Publication number Publication date
JP2023507508A (ja) 2023-02-22
US20230049619A1 (en) 2023-02-16
EP4077310B1 (en) 2024-05-01
WO2021123145A1 (en) 2021-06-24
EP4077310A1 (en) 2022-10-26
CN114981260A (zh) 2022-08-30
EP4077310C0 (en) 2024-05-01
JP7725475B2 (ja) 2025-08-19

Similar Documents

Publication Publication Date Title
CN108349936B (zh) 作为毒蕈碱性受体4拮抗剂的化合物
JP6530764B2 (ja) ＲＯＲγ調節因子としてのピロリジニルスルホン誘導体およびその使用
AU2015230127B2 (en) Novel compounds as histone deacetylase 6 inhibitors and pharmaceutical compositions comprising the same
AU2002321669B2 (en) Novel 2H-pyridazine-3-one derivatives, pharmaceutical compositions containing the same and a process for the preparation of the active ingredient
KR20180039657A (ko) 무스카린성 작용제
ES2678770T3 (es) Derivados de amida de compuestos de 1-oxa-4,9-diazaespiro undecano que tienen actividad multimodal contra el dolor
CA3072926A1 (en) Spirocycle compounds and methods of making and using same
PT1499589E (pt) Derivados de n- fenil ( piperidin-2-il ) metilbenzamida, sua preparação e sua aplicação em terapêutica
PT1558579E (pt) N-alquil-4-metilenoamino-3-hidróxi-2-piridonas como antimicrobiais.
CA2779178A1 (en) Analgesic that binds filamin a
WO2017016669A1 (en) Substituted amide derivatives having multimodal activity against pain
CZ362599A3 (cs) Indazolamidové sloučeniny jako serotoninergní přípravky
CA3179059A1 (en) Collagen 1 translation inhibitors and methods of use thereof
WO2019241751A1 (en) Ssao inhibitors and uses thereof
JPWO2018021447A1 (ja) ドーパミンｄ３受容体拮抗作用を有する含窒素縮環化合物
EP4077310B1 (en) Sigma-1 receptor ligands and uses thereof
BR112020008050A2 (pt) composto modulador alostérico positivo de receptor muscarínico m1, composição farmacêutica compreendendo o referido composto, uso dos mesmos e combinação
US12503463B2 (en) Aliphatic acid amide derivative
CA3090788A1 (en) Heterocyclic p2y14 receptor antagonists
KR20220079921A (ko) M4 작용제로서의 2-아자스피로[3.4]옥탄 유도체
JP7646873B2 (ja) アデノシンＡ２ａ受容体アンタゴニストとしての化合物およびこれを含む薬学的組成物
EP4076456B1 (en) Sigma-1 receptor ligands and therapeutic uses thereof
JP2009523747A (ja) α７ニコチン性アセチルコリン受容体のモジュレーターおよびその治療上の使用
KR20240115832A (ko) 헌팅턴병을 치료하기 위한 htt 조절제
TWI917344B (zh) 脂肪族酸醯胺衍生物

Legal Events

Date Code Title Description
D11 Substantive examination requested

Free format text: ST27 STATUS EVENT CODE: A-1-1-D10-D11-D117 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: REQUEST FOR EXAMINATION RECEIVED

Effective date: 20241113

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-1-1-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT

Effective date: 20241113

MFA Maintenance fee for application paid

Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 4TH ANNIV.) - STANDARD

Year of fee payment: 4

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-1-1-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20241127

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-1-1-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT

Effective date: 20241127

Free format text: ST27 STATUS EVENT CODE: A-1-1-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20241127

D00 Search and/or examination requested or commenced

Free format text: ST27 STATUS EVENT CODE: A-1-1-D10-D00-D118 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: REQUEST FOR EXAMINATION REQUIREMENTS DETERMINED COMPLIANT

Effective date: 20241220

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-1-1-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT

Effective date: 20250424

D11 Substantive examination requested

Free format text: ST27 STATUS EVENT CODE: A-1-2-D10-D11-D155 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: ALL REQUIREMENTS FOR EXAMINATION DETERMINED COMPLIANT

Effective date: 20250507

MFA Maintenance fee for application paid

Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 5TH ANNIV.) - STANDARD

Year of fee payment: 5

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20251125

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20251125

D15 Examination report completed

Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D15-D126 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: EXAMINER'S REPORT

Effective date: 20260105