CA3154828A1 - A cold form laminate with high barrier to cross migration of water vapor and oxygen - Google Patents
A cold form laminate with high barrier to cross migration of water vapor and oxygen Download PDFInfo
- Publication number
- CA3154828A1 CA3154828A1 CA3154828A CA3154828A CA3154828A1 CA 3154828 A1 CA3154828 A1 CA 3154828A1 CA 3154828 A CA3154828 A CA 3154828A CA 3154828 A CA3154828 A CA 3154828A CA 3154828 A1 CA3154828 A1 CA 3154828A1
- Authority
- CA
- Canada
- Prior art keywords
- cold form
- aluminium foil
- form laminate
- layer
- film
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 40
- 238000013508 migration Methods 0.000 title claims abstract description 34
- 230000005012 migration Effects 0.000 title claims abstract description 34
- 230000004888 barrier function Effects 0.000 title claims abstract description 21
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title abstract description 38
- 239000001301 oxygen Substances 0.000 title abstract description 38
- 229910052760 oxygen Inorganic materials 0.000 title abstract description 38
- 239000005030 aluminium foil Substances 0.000 claims abstract description 111
- 239000010410 layer Substances 0.000 claims description 114
- 230000001070 adhesive effect Effects 0.000 claims description 59
- 239000000853 adhesive Substances 0.000 claims description 58
- 239000004922 lacquer Substances 0.000 claims description 44
- 239000011248 coating agent Substances 0.000 claims description 27
- 238000000576 coating method Methods 0.000 claims description 27
- 239000011888 foil Substances 0.000 claims description 19
- -1 polypropylene Polymers 0.000 claims description 19
- 239000012790 adhesive layer Substances 0.000 claims description 16
- 239000011347 resin Substances 0.000 claims description 14
- 229920005989 resin Polymers 0.000 claims description 14
- 239000011247 coating layer Substances 0.000 claims description 11
- 239000004800 polyvinyl chloride Substances 0.000 claims description 11
- 239000004952 Polyamide Substances 0.000 claims description 10
- 229920001577 copolymer Polymers 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 10
- 229920002647 polyamide Polymers 0.000 claims description 10
- 229920000915 polyvinyl chloride Polymers 0.000 claims description 10
- 229920000554 ionomer Polymers 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 229920000728 polyester Polymers 0.000 claims description 8
- 229920000642 polymer Polymers 0.000 claims description 8
- 239000004698 Polyethylene Substances 0.000 claims description 7
- 229920001328 Polyvinylidene chloride Polymers 0.000 claims description 7
- 150000001336 alkenes Chemical class 0.000 claims description 7
- 239000010408 film Substances 0.000 claims description 7
- 229920000573 polyethylene Polymers 0.000 claims description 7
- 239000005033 polyvinylidene chloride Substances 0.000 claims description 7
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 6
- 239000004925 Acrylic resin Substances 0.000 claims description 5
- 229920000178 Acrylic resin Polymers 0.000 claims description 5
- 229920005678 polyethylene based resin Polymers 0.000 claims description 5
- 239000004743 Polypropylene Substances 0.000 claims description 4
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 claims description 4
- 239000011230 binding agent Substances 0.000 claims description 4
- 239000006185 dispersion Substances 0.000 claims description 4
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 4
- 229920000139 polyethylene terephthalate Polymers 0.000 claims description 4
- 239000005020 polyethylene terephthalate Substances 0.000 claims description 4
- 239000004626 polylactic acid Substances 0.000 claims description 4
- 229920000098 polyolefin Polymers 0.000 claims description 4
- 229920001155 polypropylene Polymers 0.000 claims description 4
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 claims description 3
- 239000003822 epoxy resin Substances 0.000 claims description 3
- 229920006226 ethylene-acrylic acid Polymers 0.000 claims description 3
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 claims description 3
- 229920000647 polyepoxide Polymers 0.000 claims description 3
- 229920001225 polyester resin Polymers 0.000 claims description 3
- 239000004645 polyester resin Substances 0.000 claims description 3
- 229920002050 silicone resin Polymers 0.000 claims description 3
- JHPBZFOKBAGZBL-UHFFFAOYSA-N (3-hydroxy-2,2,4-trimethylpentyl) 2-methylprop-2-enoate Chemical compound CC(C)C(O)C(C)(C)COC(=O)C(C)=C JHPBZFOKBAGZBL-UHFFFAOYSA-N 0.000 claims description 2
- LGXVIGDEPROXKC-UHFFFAOYSA-N 1,1-dichloroethene Chemical compound ClC(Cl)=C LGXVIGDEPROXKC-UHFFFAOYSA-N 0.000 claims description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
- 229910000838 Al alloy Inorganic materials 0.000 claims description 2
- 229920000089 Cyclic olefin copolymer Polymers 0.000 claims description 2
- 239000004713 Cyclic olefin copolymer Substances 0.000 claims description 2
- 239000002033 PVDF binder Substances 0.000 claims description 2
- 229910045601 alloy Inorganic materials 0.000 claims description 2
- 239000000956 alloy Substances 0.000 claims description 2
- XYLMUPLGERFSHI-UHFFFAOYSA-N alpha-Methylstyrene Chemical compound CC(=C)C1=CC=CC=C1 XYLMUPLGERFSHI-UHFFFAOYSA-N 0.000 claims description 2
- DQXBYHZEEUGOBF-UHFFFAOYSA-N but-3-enoic acid;ethene Chemical compound C=C.OC(=O)CC=C DQXBYHZEEUGOBF-UHFFFAOYSA-N 0.000 claims description 2
- 239000000839 emulsion Substances 0.000 claims description 2
- QHZOMAXECYYXGP-UHFFFAOYSA-N ethene;prop-2-enoic acid Chemical compound C=C.OC(=O)C=C QHZOMAXECYYXGP-UHFFFAOYSA-N 0.000 claims description 2
- 239000005038 ethylene vinyl acetate Substances 0.000 claims description 2
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims description 2
- 229920001179 medium density polyethylene Polymers 0.000 claims description 2
- 239000004701 medium-density polyethylene Substances 0.000 claims description 2
- 150000002735 metacrylic acids Chemical class 0.000 claims description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 2
- 239000003960 organic solvent Substances 0.000 claims description 2
- 229920006287 phenoxy resin Polymers 0.000 claims description 2
- 239000013034 phenoxy resin Substances 0.000 claims description 2
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims description 2
- 229920002239 polyacrylonitrile Polymers 0.000 claims description 2
- 239000005023 polychlorotrifluoroethylene (PCTFE) polymer Substances 0.000 claims description 2
- 229920005673 polypropylene based resin Polymers 0.000 claims description 2
- 229920002981 polyvinylidene fluoride Polymers 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 229920006395 saturated elastomer Polymers 0.000 claims description 2
- 239000000243 solution Substances 0.000 claims description 2
- 239000000725 suspension Substances 0.000 claims description 2
- 229920001897 terpolymer Polymers 0.000 claims description 2
- 229920005992 thermoplastic resin Polymers 0.000 claims description 2
- 229920006305 unsaturated polyester Polymers 0.000 claims description 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 238000007789 sealing Methods 0.000 description 18
- 238000010276 construction Methods 0.000 description 11
- 239000004411 aluminium Substances 0.000 description 8
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 8
- 229910052782 aluminium Inorganic materials 0.000 description 8
- 230000005540 biological transmission Effects 0.000 description 8
- 238000000034 method Methods 0.000 description 6
- 239000013047 polymeric layer Substances 0.000 description 6
- 239000007789 gas Substances 0.000 description 4
- 238000004806 packaging method and process Methods 0.000 description 4
- 238000013459 approach Methods 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 239000008186 active pharmaceutical agent Substances 0.000 description 2
- 229920006233 biaxially oriented polyamide Polymers 0.000 description 2
- 229920006378 biaxially oriented polypropylene Polymers 0.000 description 2
- 239000011127 biaxially oriented polypropylene Substances 0.000 description 2
- 229920005549 butyl rubber Polymers 0.000 description 2
- 239000002274 desiccant Substances 0.000 description 2
- 238000010030 laminating Methods 0.000 description 2
- 238000003475 lamination Methods 0.000 description 2
- 239000005022 packaging material Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- OJOWICOBYCXEKR-UHFFFAOYSA-N 5-ethylidenebicyclo[2.2.1]hept-2-ene Chemical compound C1C2C(=CC)CC1C=C2 OJOWICOBYCXEKR-UHFFFAOYSA-N 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 241000364051 Pima Species 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000003570 air Substances 0.000 description 1
- 230000003466 anti-cipated effect Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 230000032798 delamination Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000009820 dry lamination Methods 0.000 description 1
- 229920006242 ethylene acrylic acid copolymer Polymers 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000003116 impacting effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
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- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/50—Properties of the layers or laminate having particular mechanical properties
- B32B2307/514—Oriented
- B32B2307/516—Oriented mono-axially
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/50—Properties of the layers or laminate having particular mechanical properties
- B32B2307/514—Oriented
- B32B2307/518—Oriented bi-axially
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/70—Other properties
- B32B2307/724—Permeability to gases, adsorption
- B32B2307/7242—Non-permeable
- B32B2307/7244—Oxygen barrier
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/70—Other properties
- B32B2307/724—Permeability to gases, adsorption
- B32B2307/7242—Non-permeable
- B32B2307/7246—Water vapor barrier
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/70—Other properties
- B32B2307/732—Dimensional properties
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2553/00—Packaging equipment or accessories not otherwise provided for
Abstract
The present disclosure provides a cold form laminate comprising of an oriented polymeric film; a first aluminium foil; a second aluminium foil; and a heat seal layer to provide high barrier to cross migration of water vapor and oxygen through sealed seam and sealed area into cavities when formed into a blister pack. The certain cold form laminates optionally comprise polymeric film(s) positioned between the oriented polymeric film and the first aluminium foil, or the first aluminium foil and the second aluminium foil, or at both the positions.
Description
A COLD FORM LAMINATE WITH HIGH BARRIER TO CROSS MIGRATION
OF WATER VAPOR AND OXYGEN
FIELD OF THE INVENTION
[0001] The present disclosure relates to a broad field of cold form laminateswith bather to cross migration in a blister pack. More particularly the present disclosure relates to a cold form laminate with high bather to cross migration of water vaporandoxygen through sealed area or seam of a blister pack.
BACKGROUND OF THE INVENTION
OF WATER VAPOR AND OXYGEN
FIELD OF THE INVENTION
[0001] The present disclosure relates to a broad field of cold form laminateswith bather to cross migration in a blister pack. More particularly the present disclosure relates to a cold form laminate with high bather to cross migration of water vaporandoxygen through sealed area or seam of a blister pack.
BACKGROUND OF THE INVENTION
[0002] Background description includes information that may be useful in understanding the present invention. It is not an admission that any of the information provided herein is prior art or relevant to the present invention, or that any publication specifically or implicitly referenced is prior art.
[0003] Cold forming packaging materials with effective bather properties still remains challenge for pharmaceutical packaging. Over the time migration of water vapors from environment into the pack and eventually into the product can adversely influence the product like pharmaceutical formulation, more specifically active pharmaceutical ingredient (API). To reduce the influence of environment and migration of water vapors and oxygen many approaches have been tried. For moisture sensitive products such as solid formulations of pharmaceutical products, laminates with aluminium as barrier layer are used mainly. When such laminates with aluminium layer are used for blister packaging, one of the risks still remains that renders such packaging ineffective is migration of water vapors through the sealed seam (Figure 1) of the final pack. In order to improve barrier properties laminates with multiple layers are provided comprising of polymeric layers in addition to the aluminium film. With a view to increase barrier,sealing layers are used to provide a better bather compared with PVC film of 60 or 100 pm (standard for cold form laminate).1n such cases increase inthe thickness of bather layer is considered responsible to get a better barrier.
However, despite the use of such multilayer laminatefor cold form blisterpack it is generally observed that after packaging, over a period of time these laminates do not offer adequate barrier to the water vapor and oxygen cross migration. Other approaches attemptedto provide high bather to humidity and oxygen include incorporating chemical desiccant like calcium carbonate in one of the cavitiesof the blister pack commonly known as "fish bone blister" or integrating desiccant in the sealing layer. However, such approaches require additional machinery, more materials and complex processing making the laminate highly costly.
However, despite the use of such multilayer laminatefor cold form blisterpack it is generally observed that after packaging, over a period of time these laminates do not offer adequate barrier to the water vapor and oxygen cross migration. Other approaches attemptedto provide high bather to humidity and oxygen include incorporating chemical desiccant like calcium carbonate in one of the cavitiesof the blister pack commonly known as "fish bone blister" or integrating desiccant in the sealing layer. However, such approaches require additional machinery, more materials and complex processing making the laminate highly costly.
[0004] Cold form laminatesto overcome such challenges are generally used with much thicker polymeric layer, for example the base laminate comprises of 25 pima oriented polyamide (oPA)film, 40 to 80 pmaluminium, adhesive about 4 pm, 60 or 100 pm PVC and the same is sealed with lid foil of hard or soft temper aluminiumwith lacquer coating with minimum total thickness of about 28 pm for push through and peel/peel-push with 91 ¨ 96 pm thickness, and 5.6pm heat seal lacquer. Such cold form laminates are provided with a view to prevent failure or deformities during sealing and forming, such as pinholes or crack in the formed cold form film laminate.
[0005] However, such cold form laminate is notfound to ensure protection against migration of humidity and oxygenthrough the land areathat is adistance from edge of blister pack to beginning of cavity, or in case of no secure sealing could be afforded during the sealing with such cold form laminateallowing entry of humidity and oxygen into the cavity and therebyadversely impacting shelf life of the packed product.Thus, there exists an unmet demand to provide packaging materials like cold form laminates with high bather to cross migration of water vapor and reduced ingress of oxygen through sealed seam of an Alu-Alublister pack.
OBJECTS OF THE INVENTION
OBJECTS OF THE INVENTION
[0006] It is an object of the present disclosure to provide a cold form laminate with high barrier to cross migration of water vapor and reduced ingress of oxygen through sealed seam of a blister pack.
[0007] It is a further object of the present disclosure to provide a cold form laminate comprising an oriented polymeric film;double layers ofaluminium foils;and a heat seal layer to provide a cold form laminate withhigh bather to cross migration of water vapor and oxygen through sealed area into cavities when formed into a blister pack.
[0008] It is a further object of the present disclosure to provide a cold form laminate comprising of an oriented polymeric film; twoaluminium foils; and a heat seal layer to provide barrier to cross migration of water vapor and ingress of oxygen through sealed area into cavities when formed into a blister pack_
[0009] It is a further object of the present disclosure to provide a cold form laminate comprising of an oriented polymeric film; a first aluminium foil; a secondaluminium foil; a heat seal layer; and optionally a polymeric film between one or both of, the oriented polymeric filmand the first aluminium foil, and the first aluminium foil and the second aluminium foil.
SUMMARY OF THE INVENTION'
SUMMARY OF THE INVENTION'
[0010] Accordingly, in a general aspect the present disclosure provides a cold form laminate with high barrier to cross migration of water vapor and oxygen through sealed seam and sealed area when formed into a blister pack.
[0011] In an aspect the present disclosure provides a cold form laminate comprising an additional aluminium foil to the standard cold form laminate known in the art (Fig. 1) and with reduced overall thicknessof the sealing layerto provide high barrier to cross migration of water vapor and oxygen through sealed seam and sealed area into cavities when formed into a blister pack.
[0012] In one aspect the present disclosure provides a cold form laminate comprising of an oriented polymeric film; two aluminium foils; and a heat seal layerto provide high bather to cross migration of water vapor and oxygen through sealed seam and sealed area into cavities when formed into a blister pack.
[0013] In one aspect the present disclosure provides a cold form laminate with high barrier to cross migration of water vapor and oxygen, said cold form laminate comprising an oriented polymeric film; a first aluminium foil; a second aluminium foil; and a heat seal layer.
[0014] In one aspect the present disclosure provides a cold form laminate comprising an oriented polymeric film; a first aluminium foil; a second aluminium foil; a heat seal layer;and one or more layer(s)of an adhesive layer, a coating layer, a tie layer anda lacquer layer disposed in between each of the oriented polymeric film, the first aluminium foil, and the second aluminium foil.
[0015] In one aspect the present disclosure provides a cold form laminate comprising an oriented polymeric film; a first aluminium foil; a second aluminium foil; a heat seal layer;
and an optional polymeric film(s) positioned between the oriented polymeric film and the first aluminium foil, or the first aluminium foil and the second aluminium foil, or at both the positions.
and an optional polymeric film(s) positioned between the oriented polymeric film and the first aluminium foil, or the first aluminium foil and the second aluminium foil, or at both the positions.
[0016] In one aspect the present disclosure provides a cold form laminate comprising an oriented polymeric film; a first aluminium foil; a second aluminium foil; a heat seal layer;optional polymeric film(s); and one or more layer(s)of an adhesive layer, a coating layer, a tie layer anda lacquer layer disposed in between each of the oriented polymeric film, the first aluminium foil, the second aluminium foil, and optional polymeric film(s).
[0017] Various objects, features, aspects and advantages of the inventive subject matter will become more apparent from the following detailed description of preferred embodiments.
BRIEF DESCRIPTION OF DRAWINGS THE INVENTION
BRIEF DESCRIPTION OF DRAWINGS THE INVENTION
[0018] The following drawings form part of the present specification and are included to further illustrate aspects of the present disclosure. The disclosure may be better understood by reference to the drawings in combination with the detailed description of the specific embodiments presented herein.
[0019] Figure 1: It is representative cross-sectional view of a conventional blister pack 100 showing a passage or cross migration of water vapor and ingress of oxygen through the laminate in the cavity area 120, over the cavity area 130, and across the sealed seam 140 when the blister pack is made froma conventional cold form laminate 110.
[0020] Figure 2 is Table 1 showing exemplary construction of cold form laminate with high barrier to cross migration of water vapor and oxygen in accordance with the present disclosure comprisingtwo aluminium foils.
[0021] Figure 3: Figures 3a-3f are Tables 2-7 showing exemplary constructions of cold form laminate with high barrier to cross migration of water vapor and oxygen in accordance with the present disclosure with two aluminium foils; and a single coating layer (Fig. 3a), two coating layers in combination with different arrangements of adhesive and lacquer layers(Fig.
3b-3d), two coating layers in combination with different arrangements of tie layers, an adhesive layer and a lacquer layer.
3b-3d), two coating layers in combination with different arrangements of tie layers, an adhesive layer and a lacquer layer.
[0022] Figure 4: Figures 4a-4c are Tables 8-10 showing exemplary constructions of cold form laminate with high bather to cross migration of water vapor and oxygen in accordance with the present disclosure with two layers of aluminium foil; and a single polymeric layer in combination with different arrangements of a polymeric layer, adhesive layers and a lacquer layer (Fig. 4a-4b), and two polymeric layers in combination with adhesive layers and a lacquer layer (Fig. 4c).
[0023] Figure 5: Is a graph showing water vapor transmission rate in gram per cavity per day through a conventional cold form laminate as per Fig. 1 and the cold form laminate as per one of the exemplaryembodiments of the present disclosure.
[0024] Figure 6: Is a graph showing oxygen transmission rate in gram per cavity per day through a conventional cold form laminate as per Fig 1 and the cold form laminate as per one of the exemplary embodiments of the present disclosure.
[0025] The following is a detailed description of embodiments of the disclosure. The embodiments are in such detail as to clearly communicate the disclosure.
However, the amount of detail offered is not intended to limit the anticipated variations of embodiments; on the contrary, the intention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the present disclosure as defined by the appended claims.
However, the amount of detail offered is not intended to limit the anticipated variations of embodiments; on the contrary, the intention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the present disclosure as defined by the appended claims.
[0026] All publications herein are incorporated by reference to the same extent as if each individual publication or patent application were specifically and individually indicated to be incorporated by reference. Where a definition or use of a term in an incorporated reference is inconsistent or contrary to the definition of that term provided herein, the definition of that term provided herein applies and the definition of that term in the reference does not apply.
[0027] Reference throughout this specification to "one embodiment" or "an embodiment" means that a particular feature, structure or characteristic described in connection with the embodiment is included in at least one embodiment. Thus, the appearances of the phrases "in one embodiment" or "in an embodiment" in various places throughout this specification are not necessarily all referring to the same embodiment.
Furthermore, the particular features, structures, or characteristics may be combined in any suitable manner in one or more embodiments.
Furthermore, the particular features, structures, or characteristics may be combined in any suitable manner in one or more embodiments.
[0028] In some embodiments, the numbers expressing quantities of ingredients, properties such as concentration, reaction conditions, and so forth, used to describe and claim certain embodiments of the invention are to be understood as being modified in some instances by the term "about."Accordingly, in some embodiments, the numerical parameters set forth in the written description and attached claims are approximations that can vary depending upon the desired properties sought to be obtained by a particular embodiment.ln some embodiments, the numerical parameters should be construed in light of the number of reported significant digits and by applying ordinary rounding techniques.Notwithstanding that the numerical ranges and parameters setting forth the broad scope of some embodiments of the invention are approximations, the numerical values set forth in the specific examples are reported as precisely as practicable.The numerical values presented in some embodiments of the invention may contain certain errors necessarily resulting from the standard deviation found in their respective testing measurements.
[0029] As used in the description herein and throughout the claims that follow, the meaning of "a," "an," and "the" includes plural reference unless the context clearly dictates otherwiseAlso, as used in the description herein, the meaning of "in" includes "in" and "on"
unless the context clearly dictates otherwise.
unless the context clearly dictates otherwise.
[0030] Unless the context requires otherwise, throughout the specification which follow, the word "comprise" and variations thereof, such as, "comprises" and "comprising" are to be construed in an open, inclusive sense that is as "including, but not limited to."
[0031] The recitation of ranges of values herein is merely intended to serve as a shorthand method of referring individually to each separate value falling within the range.Unless otherwise indicated herein, each individual value is incorporated into the specification as if it were individually recited herein.All methods described herein can be performed in any suitable order unless otherwise indicated herein or otherwise clearly contradicted by context.The use of any and all examples, or exemplary language (e.g. "such as") provided with respect to certain embodiments herein is intended merely to better illustrate the invention and does not pose a limitation on the scope of the invention otherwise claimed.No language in the specification should be construed as indicating any non-claimed element essential to the practice of the invention.
[0032] Groupings of alternative elements or embodiments of the invention disclosed herein are not to be construed as limitations.Each group member can be referred to and claimed individually or in any combination with other members of the group or other elements found herein.One or more members of a group can be included in, or deleted from, a group for reasons of convenience and/or patentability.
[0033] The description that follows, and the embodiments described therein, is provided by way of illustration of an example, or examples, of particular embodiments of the principles and aspects of the present disclosure. These examples are provided for the purposes of explanation, and not of limitation, of those principles and of the disclosure.
[0034] It should also be appreciated that the present disclosure can be implementedin numerous ways, including as a system, a method or a device. In this specification, these implementations, or any other form that the invention may take, may be referred to as processes. In general, the order of the steps of the disclosed processes may be altered within the scope of the invention.
[0035] The headings and abstract of the invention provided herein are for convenience only and do not interpret the scope or meaning of the embodiments.
[0036] The following discussion provides many example embodiments of the inventive subject matter. Although each embodiment represents a single combination of inventive elements, the inventive subject matter is considered to include all possible combinations of the disclosed elements. Thus, if one embodiment comprises elements A, B, and C, and a second embodiment comprises elements B and D, then the inventive subject matter is also considered to include other remaining combinations of A, B, C, or D, even if not explicitly disclosed.
[0037] Various terms as used herein are shown below. To the extent a term used in a claim is not defined below, it should be given the broadest definition persons in the pertinent art have given that term as reflected in printed publications and issued patents at the time of filing.
[0038] The term, "water vapors", "moisture" and "humidity" as used herein interchangeably refers to the moisture content which can be in the surrounding atmosphere on the outside and inside of the cavity/cavities of a blister pack.
[0039] The terms, "oxygen", "air", and "gas" are used interchangeably herein and refers to the air, gas or oxygen in the atmosphere as well as inside the cavity/cavities of a blister pack.
[0040] The present disclosure relates to a cold form laminate with high barrier to cross migration of water vapor and reduced ingress of oxygen through sealed seam or sealed area into cavitiesof a formed blister pack.
[0041] The standard known cold forming laminate used conventionally includes 25 pm oriented polyamide (oPA) film, 45 to 80 gmaluminium foil, sealing layer usually made of 60gm or 100 pm PVC film. Al foil and PVC films are laminated with each other with the help of adhesive usually 3 to 5 p.m thick layer. The standard laminate usually has total thickness of sealing layer about108 to 185 m sealed with 5.6 gm thick heat seal lacquer applied on the aluminium of lid foil.Despite such construction, conventional cold forming laminates do not provide desired effective barrierto cross migration to humidity and oxygen.
[0042] Accordingly, the present disclosure provides a cold form laminate comprising an additional aluminium foil as compared to the standard cold form laminate known in the art (Fig. 1). The present disclosure provides a cold form laminate with the reduced thickness of sealing layer and with two aluminium foilsto provide high barrier to cross migration of water vapor and oxygen through sealed areasinto cavities when formed into a blister.
Such construction is provided to minimize or avoid likelihood of failure during the sealing and cross migration of water vapor or oxygen through sealed seam and sealed areas.
The construction of the cold form laminate in accordance with the present disclosure is provided to afford high bather to cross migration of water vapor and oxygen through pin holes present in the aluminium foil and any cracks that may be formed either during the forming or storage.
Such construction is provided to minimize or avoid likelihood of failure during the sealing and cross migration of water vapor or oxygen through sealed seam and sealed areas.
The construction of the cold form laminate in accordance with the present disclosure is provided to afford high bather to cross migration of water vapor and oxygen through pin holes present in the aluminium foil and any cracks that may be formed either during the forming or storage.
[0043]
In one embodiment the present disclosure provides a cold form laminate comprising of an oriented polymeric film; two aluminium foils; and a heat seal layerto provide high barrier to cross migration of water vapor and oxygen through sealed seam and sealed area into cavities when formed into a blister pack.
In one embodiment the present disclosure provides a cold form laminate comprising of an oriented polymeric film; two aluminium foils; and a heat seal layerto provide high barrier to cross migration of water vapor and oxygen through sealed seam and sealed area into cavities when formed into a blister pack.
[0044]
In one embodiment the present disclosure provides a cold form laminate with high barrier to cross migration of water vapor and oxygen, said cold form laminate comprising an oriented polymeric film; a first aluminium foil; a second aluminium foil; and a heat seal layer.
15 [0045]
In one embodiment the present disclosure provides a cold form laminate comprising an oriented polymeric film; a first aluminium foil; a second aluminium foil; a heat seal layer;and one or more layer(s)of an adhesive layer, a coating layer, a tie layer anda lacquer layer disposed in between each of the oriented polymeric film, the first aluminium foil, and the second aluminium foil.
20 [0046]
In one embodiment the present disclosure provides a cold form laminate comprising an oriented polymeric film; a first aluminium foil; a second aluminium foil; a heat seal layer; and an optional polymeric film(s) positioned between the oriented polymeric film and the first aluminium foil, or the first aluminium foil and the second aluminium foil, or at both the positions.
25 [0047]
In one embodiment the present disclosure provides a cold form laminate comprising an oriented polymeric film; a first aluminium foil; a second aluminium foil; a heat seal layer;optional polymeric film(s); and one or more layer(s)of an adhesive layer, a coating layer, a tie layer anda lacquer layer disposed in between each of the oriented polymeric film, the first aluminium foil, the second aluminium foil, and optional polymeric film(s).
30 [0048]
An oriented polymeric film to form the cold form laminate can be selected from oriented film of polyamide, polyester, polypropylene, polyethylene, or the race or the combination thereof. In one embodiment the oriented film used is oriented film of polyamide (oPA). An oriented polymeric film can be biaxial oriented or monoaxial oriented. The biaxially oriented film for example can be biaxially oriented polyamide (BOPA) film, biaxially oriented polypropylene film (BOPP), polyethylene terephthalate (PET), or the like, or combination thereof.
[0049] The cold form laminate with high bather to cross migration of water vapor and reduced ingress of oxygen comprises the oriented polymeric film, for example, anoriented film of polyamide (oPA) with the thickness of about 15 pm to about 40 pm. In certain embodiments, the oriented film of polyarnide (oPA) can be of the thickness of about 15 pm to about 30 pm.
[0050] The aluminium foil used is of aluminium alloy selected from grade 8011, 8111, and 8021 and 8079. The aluminium foil layer used can be of the thickness of from about 4 pm to about 150 pm. The first and second aluminium layer can be from different or the same alloy. The first layer of aluminium foil can be of the thickness ranging from about 20 pm to about 100 pm. In certain embodiments, the first layer of aluminium foil can be of the thickness ranging from about 30 pm to about 80 pm. The second layer of aluminium foil can be of the thickness ranging from about 8 pm to about 80 pm. In certain embodiments, the second layer of aluminium foil can be ofthe thickness ranging from about 10 pm to about 60 pm.
[0051] In one embodiment, the polymeric film can be cast, biaxial oriented or monoaxial oriented, said polymeric film can be selected from the group consisting of polyethylene film, polyethylene terephthalate, cyclic olefin copolymer film, polyacrylonitrile, polylactic acid, polyamide,cyclo-olefinic polymer, cyclo-olefmic copolymer, polyvinyl chloride, polypropylene, polyester,polyvinylidene chloride,poly-chloro-tri-fluoro-ethylene, polylactic acid or the like. The polymeric film can be of the thickness ranging from about6 pm to about 100 pm. In certain embodiments the polymeric film can be of the thickness ranging from about 8pm to about 60 pm.
[0052] The adhesive is used to bond or laminate the two layers of similar or different materials. The adhesive for the adhesive layer isselected from polyethylene-based resin, urethane-based adhesives, olefin-based adhesives, butyl rubber-based adhesives, acrylic resin-based adhesives, polyester resin-based adhesives, epoxy resin-based adhesives and silicone resin-based. The adhesive that may be used in the adhesive layer include polyethylene-based resins in the case of adhering by sandwich lamination, or urethane-based adhesives, olefin-based adhesives, butyl rubber-based adhesives, acrylic resin-based adhesives, polyester resin-based adhesives, epoxy resin-based adhesives and silicone resin-based adhesives in the case of adhering by dry lamination. The adhesive layer can be of the thickness ranging from about 0.4 gsm to about 7 gsm. In certain embodiments, the adhesive layer can be of the thickness ranging from about 2 gsm to about 6 gsm.
[0053] The lacquer can be based on nitro cellulose-, vinyl-, acrylate-, epoxy-, acetate-, polyurethane-, polyester-, latices- resins, or mixture thereof.The lacquer used can be selected 5 from the group consisting of the lacquer is selected from the group consisting of phenoxy resins; blends of copolymers of methacrylic ester, olefins and ethylidennorbornen as binder;
blends of polybutylmetacrylate, polybutyl-ethacrylate and acrylic resins as binder; tackifier based on alphamethylstyrene, maleic acid anhydride modified copolymers of vinylacetat and vinylchloride; water-based dispersions based on ethylenevinylacetate, polyvinylidene-10 chloride, ethylene acrylic acid and metacrylic acid and salts thereof.
The lacquer layer can be of the thickness ranging from about 0.2 gsm to about 10 gsm. In certain embodiments, the lacquer layer can be of the thickness ranging from about 0.3 gsm to about 5.0 gsm.
[0054] The coating material may bea layer of a resin or polymeric film. The resin may be for example an ionomer, a thermoplastic resin, an easy peelable resin such as a polyolefin-based polymers or any other resinused to adhere to the aluminium foil to form a laminate, or itcan be in a form adopted in which the aluminium foil is coated with an easy peeling resin.
The resin that may be used include polyethylene-based resin, polypropylene-based resin, saturated or unsaturated polyester, ionomers, polyvinyl chloride (PVC), polystyrene, derivatives thereof and mixtures thereof. The polymeric film that may be used as a coating material may include for example polyethylene, polyvinylidene chloride, a polyvinylidene fluoride coating film. The coating film or layer can be of the thickness ranging from about 2 gsm to about 50 gsm. In certain embodiments, the coating layer can be of the thickness ranging from about 5 gsm to about 50gsm. In certain embodiments, the coating layer can be of the thickness ranging from about 10 gsm to about 30 gsm.
[0055] The tie layer is the layer which is applied in between two layers to increase the adhesion between said two layers, especially two layers of dissimilar materials that otherwise would have poor adhesion to each other. The tie layer in accordance with the present disclosurecan be of an ionomer resin, or ethylene-acrylic acid copolymer, in combination with polyethylene. In certain embodiments, the tie layer can be an adhesive layer of polymeric composition for example ethylene/butyl acrylate copolymer composition, or ethylene-butylene-propylene terpolymer layer, ethylene propylene copolymer layer, medium density polyethylene layer.The tie layer can be of the thickness ranging from about 1 gsm to about 50 gsm. In certain embodiments, the coating layer can be of the thickness ranging from about 3 gsm to about 30 gsm.
[0056] The heat seal layercan be based on water or organic solvent, solution, suspension, emulsion, dispersion; based on vinyl chloride, vinylidene dichloride, vinyl acetate, acrylate, compatible with the sealing layer of lid foil. The heat seal layer can be a coating of resins, based on poly olefins, ionomers, polyester, vinyl acetate, cyclo-olefinic polymer, with or without a tie layer.The heat seal layer can be a film, based on poly vinyl chloride, poly vinylidene chloride, poly-olefins, polyester, cyclo-olefmic polymer, ionomers, as cast film or oriented film, bonded by adhesive. The combination of heat seal layer from cold form laminate and lid foil can allow opening of the produced blister pack by push through, tearing, peel-push or peel. The heat seal layer can preferably bea heat seal lacqueror coating or filmin the thickness ranging from about 2 gsm to about 45 gsm. In certain embodiments, the heat seal lacquer or coating or film can be in the thickness ranging from about 3 gsm to about30 gsm.
[0057] The cold form laminate may be formed by connecting individual layers for example oriented polymeric layer, aluminium foils, polymeric layer by laminating with solvent-based, solvent-free or aqueous adhesives and/or by extrusion lamination or coated to the other films, foils, and layers with the help of suitable adhesive, lacquer,coating or tie layer to provide the minimum bonding strength of film to foil and film to film (inner and outer side).
[0058] The oriented polymeric film (oPA), the first and second aluminium foils and optional polymeric foils are laminated to each other by means of an application of a layer of an adhesive between the film and foil, or foil and foil, or film and film. In certain embodiment, prior to applying the adhesive on the aluminium foil, a thin layer of lacquer can be applied to bond the aluminium foil with the oriented polymeric film or optional polymeric film to reduce the tendency of delamination of film(s) during and/or after forming. In few embodiments, a layer of a coating material may be applied to the aluminium foil before or after applying the layer of the adhesive or the lacquer to bond the aluminium foil with another aluminium foil or the oriented polymeric film. In certain embodiments two aluminium foils can be bonded together by application of a layer of a coating material arid a tie layer. The tie layer can be required for laminating the aluminium foil with the film, especially certain type of film such as non-polar polymeric films.
[0059] In certain embodiments the cold form laminate comprises an oPA, the first aluminium foil; the second aluminium foil; and the heat seal layer; wherein the oriented polymeric film, the first aluminium foil and the second aluminium foil are laminated with each other by application of one or more layers of an adhesive, lacquer, coating material and tie layer. Such cold form laminate can comprise of following construction:
¨ oPA/adhesive/first aluminium foil/adhesive/second aluminium foil/heat seal layer.
¨ oPA/adhesive/lacquer/first aluminium foil/adhesive/second aluminium foil/heat seal layer.
¨ oPA/adhesive/lacquer/first aluminium foil/coating/adhesive/second aluminium foil/heat seal layer.
¨ oPAJadhesive/coating/fffst aluminium foil/lacquer/coating/second aluminium foil/heat seal layer.
¨ oPA/adhesive/coating/lacquer/first aluminium foil/lacquer/coating/second aluminium foil/heat seal layer.
¨ oPA/adhesive/coating/lacquer/first aluminium foil/coating/adhesive/second aluminium foil/heat seal layer.
¨ oPA/adhesive/coating/tieffirst aluminium foil/tie/coating/second aluminium foil/heat seal layer.
¨ oPA/adhesive/coating/lacquer/first aluminium foil/tie/coating/second aluminium foil/heat seal layer.
[0060]
In certain other embodiments the cold form laminate comprises an oPA, the first aluminium foil; the polymeric film in between the oPA and the first aluminium foil, the first and second aluminium foils, or both; and the heat seal layer; wherein the oriented polymeric film, the first aluminium foil, the second aluminium foil, and polymeric film(s) are laminated with each other by application of one or more layers of an adhesive, and lacquer. Such cold form laminate can comprise of following construction:
¨ oPA/adhesive/lacquer/first aluminium foil/adhesive/polymeric layer/adhesive/second aluminium foil/heat seal layer.
¨ oPA/adhesive/polymeric film/adhesive/lacquer/first aluminium foil/adhesive/second aluminium foil/heat seal layer.
¨ oPA/adhesive/polymeric film/adhesive/lacquer/first aluminium foil/adhesive/polymeric film/adhesive/second aluminium foil/heat seal layer.
[0061]
The exemplary constructions of the cold form laminate with specific thickness of individual layers to provide high bather to cross migration of water vapor and oxygen are shown in Fig. 2, Figs. 3a-3f, and Figs. 4a-4c as represented in Tables 1-10.
[0062]
The cold form laminate in accordance with the present disclosure can be usedas a blister base part that may be produced in the known manner.
[0063] The cold form laminate in accordance with the present disclosure can be used on flat forming flat sealing machine, rotary forming and flat sealing, rotary forming and rotary sealing, as well as on flat forming rotary sealing machines.
[0064] In some embodiments the present disclosure provides a blister pack formed from the cold form laminate provided in accordance with the present disclosure as a base part for packing of the product, especially those requiring protection from longer exposure of humidity/moisture and gas/air/oxygen, more particularly requiring cross bather to water vapor and ingress of oxygen. The blister pack further includes lid layer comprising aluminium and a sealing layer. The lid layer comprises of for example aluminium foil with the thickness of about 6 pm to about 60 pm, preferably about 15 pm to 38 pm with minimum 0.5 pm thick heat seal layer of lacquer. Lid foil can be configured to open by tear, push through, rupture, peel, peel push or any suitable mechanism.
[0065] Such blister pack with the cold form laminates provide multifold better cross diffusion barrier to water vapor and also reduce ingress of gases or oxygen, or both as compared to the blister packs with the standard cold form laminateshaving much thicker constructions. At the same time such a blister construction drastically reduces a fast-gaseous migration of substances out of the blisteras needed in some of the products.
[0066] The invention is described in the following by way of examples and with reference to the accompanying drawing.
Example 1A
Blister pack with base made from convention cold form laminate [0067] A standard blister pack was formed from the typical cold form laminate as a base laminate comprising of 25 pm of oriented polyamide (oPA) film, 40pm aluminium, adhesive about 4 pm, 60 pm PVC and the same was sealed with a lid foil of hard temper proofa1um1nium28pm with lacquer coating for push through blisterpack with sealing layer of 5.6pm heat seal lacquer. The totalthickness of the blister pack was about 162.6pm Example 1 Blister pack with base made from the cold form laminate in accordance with the present disclosure comprising double layers of aluminium foil [0068] A blister pack was formed from the cold form laminate in accordance with the present disclosure as per Table 11 as a base laminate and the same was sealed with a lid foil of hard temper proofaluminium28 pm with lacquer coating for push through blisterpack with sealing layer of 5.6pm heat seal lacquer.
Table 11 oPA Adhesive Lacquer Al -1 Adhesive Al -2 HSL
(11m) (pm) (pm) (11 (pm) (1(m) 4 25 5.6 Example 2 Determination of Water vapor transmission rate and Oxygen transmission rate of cold form laminates of Example 1A and Example 1 [0069] The water vapor transmission rate (WVTR) and oxygen transmission rate (OTR) were studies of the blister packs made from the conventional cold form laminate as per Example lA and the cold form laminate in accordance with the present disclosure as per Example 1. The WVTR and OTR were determined of the blister packs middle cavities and the edge cavities having distance of 4mm from the edge after 1 year, 2 years, 3 years and 4 years of packaging by calculating the values with a specially developed software. The input data for the transmission of oxygen and humidity were measured with standard test equipment, e.g. from company MOCON and the data were used for the calculation.
The results of the WVTR and OTR determination studies are provided in below Table 12 and Table 13 as well as Figure 5 and Figure 6 respectively:
Table 12: WVTR results (g/cavity) After 1 year After 2 year After 3 year After 4 year Example 1A Middle cavity 0.1571 0.3142 0.4713 0.7855 Example 1 Middle cavity 0.0542 0.1084 0.1626 0.271 Example 1A Edge cavity 0.2757 0.5514 0.8272 1.3786 Example 1 Edge cavity 0.0951 0.1903 0.2854 0.4757 Table 13: OTR results (g/cavity) After 1 year After 2 year After 3 year After 4 year Example 1A Middle cavity 0.0001 0.0004 0.0006 0.0009 Example 1 Middle cavity 0.0001 0.0003 0.0004 0.0007 Example 1A Edge cavity 0.0002 0.0007 0.0011 0.0018 Example 1 Edge cavity 0.0002 0.0006 0.0009 0.0015 [0070] As can be seen from the above Tables 12 and 13 and Figs. 5 and 6, it is very clear that the cold form laminate according to the present disclosure was unexpectedly able to provide significantly much higher bather to the cross migration of the water vapor transmission and ingress of oxygen over longer duration of over four years as compared to the conventional cold form laminate.
[0071] While the foregoing describes various embodiments of the disclosure, other and further embodiments of the disclosure may be devised without departing from the basic scope 5 thereof. The scope of the disclosure is determined by the claims that follow. The disclosure is not limited to the described embodiments, versions or examples, which are included to enable a person having ordinary skill in the art to make and use the invention when combined with information and knowledge available to the person having ordinary skill in the art.
In one embodiment the present disclosure provides a cold form laminate with high barrier to cross migration of water vapor and oxygen, said cold form laminate comprising an oriented polymeric film; a first aluminium foil; a second aluminium foil; and a heat seal layer.
15 [0045]
In one embodiment the present disclosure provides a cold form laminate comprising an oriented polymeric film; a first aluminium foil; a second aluminium foil; a heat seal layer;and one or more layer(s)of an adhesive layer, a coating layer, a tie layer anda lacquer layer disposed in between each of the oriented polymeric film, the first aluminium foil, and the second aluminium foil.
20 [0046]
In one embodiment the present disclosure provides a cold form laminate comprising an oriented polymeric film; a first aluminium foil; a second aluminium foil; a heat seal layer; and an optional polymeric film(s) positioned between the oriented polymeric film and the first aluminium foil, or the first aluminium foil and the second aluminium foil, or at both the positions.
25 [0047]
In one embodiment the present disclosure provides a cold form laminate comprising an oriented polymeric film; a first aluminium foil; a second aluminium foil; a heat seal layer;optional polymeric film(s); and one or more layer(s)of an adhesive layer, a coating layer, a tie layer anda lacquer layer disposed in between each of the oriented polymeric film, the first aluminium foil, the second aluminium foil, and optional polymeric film(s).
30 [0048]
An oriented polymeric film to form the cold form laminate can be selected from oriented film of polyamide, polyester, polypropylene, polyethylene, or the race or the combination thereof. In one embodiment the oriented film used is oriented film of polyamide (oPA). An oriented polymeric film can be biaxial oriented or monoaxial oriented. The biaxially oriented film for example can be biaxially oriented polyamide (BOPA) film, biaxially oriented polypropylene film (BOPP), polyethylene terephthalate (PET), or the like, or combination thereof.
[0049] The cold form laminate with high bather to cross migration of water vapor and reduced ingress of oxygen comprises the oriented polymeric film, for example, anoriented film of polyamide (oPA) with the thickness of about 15 pm to about 40 pm. In certain embodiments, the oriented film of polyarnide (oPA) can be of the thickness of about 15 pm to about 30 pm.
[0050] The aluminium foil used is of aluminium alloy selected from grade 8011, 8111, and 8021 and 8079. The aluminium foil layer used can be of the thickness of from about 4 pm to about 150 pm. The first and second aluminium layer can be from different or the same alloy. The first layer of aluminium foil can be of the thickness ranging from about 20 pm to about 100 pm. In certain embodiments, the first layer of aluminium foil can be of the thickness ranging from about 30 pm to about 80 pm. The second layer of aluminium foil can be of the thickness ranging from about 8 pm to about 80 pm. In certain embodiments, the second layer of aluminium foil can be ofthe thickness ranging from about 10 pm to about 60 pm.
[0051] In one embodiment, the polymeric film can be cast, biaxial oriented or monoaxial oriented, said polymeric film can be selected from the group consisting of polyethylene film, polyethylene terephthalate, cyclic olefin copolymer film, polyacrylonitrile, polylactic acid, polyamide,cyclo-olefinic polymer, cyclo-olefmic copolymer, polyvinyl chloride, polypropylene, polyester,polyvinylidene chloride,poly-chloro-tri-fluoro-ethylene, polylactic acid or the like. The polymeric film can be of the thickness ranging from about6 pm to about 100 pm. In certain embodiments the polymeric film can be of the thickness ranging from about 8pm to about 60 pm.
[0052] The adhesive is used to bond or laminate the two layers of similar or different materials. The adhesive for the adhesive layer isselected from polyethylene-based resin, urethane-based adhesives, olefin-based adhesives, butyl rubber-based adhesives, acrylic resin-based adhesives, polyester resin-based adhesives, epoxy resin-based adhesives and silicone resin-based. The adhesive that may be used in the adhesive layer include polyethylene-based resins in the case of adhering by sandwich lamination, or urethane-based adhesives, olefin-based adhesives, butyl rubber-based adhesives, acrylic resin-based adhesives, polyester resin-based adhesives, epoxy resin-based adhesives and silicone resin-based adhesives in the case of adhering by dry lamination. The adhesive layer can be of the thickness ranging from about 0.4 gsm to about 7 gsm. In certain embodiments, the adhesive layer can be of the thickness ranging from about 2 gsm to about 6 gsm.
[0053] The lacquer can be based on nitro cellulose-, vinyl-, acrylate-, epoxy-, acetate-, polyurethane-, polyester-, latices- resins, or mixture thereof.The lacquer used can be selected 5 from the group consisting of the lacquer is selected from the group consisting of phenoxy resins; blends of copolymers of methacrylic ester, olefins and ethylidennorbornen as binder;
blends of polybutylmetacrylate, polybutyl-ethacrylate and acrylic resins as binder; tackifier based on alphamethylstyrene, maleic acid anhydride modified copolymers of vinylacetat and vinylchloride; water-based dispersions based on ethylenevinylacetate, polyvinylidene-10 chloride, ethylene acrylic acid and metacrylic acid and salts thereof.
The lacquer layer can be of the thickness ranging from about 0.2 gsm to about 10 gsm. In certain embodiments, the lacquer layer can be of the thickness ranging from about 0.3 gsm to about 5.0 gsm.
[0054] The coating material may bea layer of a resin or polymeric film. The resin may be for example an ionomer, a thermoplastic resin, an easy peelable resin such as a polyolefin-based polymers or any other resinused to adhere to the aluminium foil to form a laminate, or itcan be in a form adopted in which the aluminium foil is coated with an easy peeling resin.
The resin that may be used include polyethylene-based resin, polypropylene-based resin, saturated or unsaturated polyester, ionomers, polyvinyl chloride (PVC), polystyrene, derivatives thereof and mixtures thereof. The polymeric film that may be used as a coating material may include for example polyethylene, polyvinylidene chloride, a polyvinylidene fluoride coating film. The coating film or layer can be of the thickness ranging from about 2 gsm to about 50 gsm. In certain embodiments, the coating layer can be of the thickness ranging from about 5 gsm to about 50gsm. In certain embodiments, the coating layer can be of the thickness ranging from about 10 gsm to about 30 gsm.
[0055] The tie layer is the layer which is applied in between two layers to increase the adhesion between said two layers, especially two layers of dissimilar materials that otherwise would have poor adhesion to each other. The tie layer in accordance with the present disclosurecan be of an ionomer resin, or ethylene-acrylic acid copolymer, in combination with polyethylene. In certain embodiments, the tie layer can be an adhesive layer of polymeric composition for example ethylene/butyl acrylate copolymer composition, or ethylene-butylene-propylene terpolymer layer, ethylene propylene copolymer layer, medium density polyethylene layer.The tie layer can be of the thickness ranging from about 1 gsm to about 50 gsm. In certain embodiments, the coating layer can be of the thickness ranging from about 3 gsm to about 30 gsm.
[0056] The heat seal layercan be based on water or organic solvent, solution, suspension, emulsion, dispersion; based on vinyl chloride, vinylidene dichloride, vinyl acetate, acrylate, compatible with the sealing layer of lid foil. The heat seal layer can be a coating of resins, based on poly olefins, ionomers, polyester, vinyl acetate, cyclo-olefinic polymer, with or without a tie layer.The heat seal layer can be a film, based on poly vinyl chloride, poly vinylidene chloride, poly-olefins, polyester, cyclo-olefmic polymer, ionomers, as cast film or oriented film, bonded by adhesive. The combination of heat seal layer from cold form laminate and lid foil can allow opening of the produced blister pack by push through, tearing, peel-push or peel. The heat seal layer can preferably bea heat seal lacqueror coating or filmin the thickness ranging from about 2 gsm to about 45 gsm. In certain embodiments, the heat seal lacquer or coating or film can be in the thickness ranging from about 3 gsm to about30 gsm.
[0057] The cold form laminate may be formed by connecting individual layers for example oriented polymeric layer, aluminium foils, polymeric layer by laminating with solvent-based, solvent-free or aqueous adhesives and/or by extrusion lamination or coated to the other films, foils, and layers with the help of suitable adhesive, lacquer,coating or tie layer to provide the minimum bonding strength of film to foil and film to film (inner and outer side).
[0058] The oriented polymeric film (oPA), the first and second aluminium foils and optional polymeric foils are laminated to each other by means of an application of a layer of an adhesive between the film and foil, or foil and foil, or film and film. In certain embodiment, prior to applying the adhesive on the aluminium foil, a thin layer of lacquer can be applied to bond the aluminium foil with the oriented polymeric film or optional polymeric film to reduce the tendency of delamination of film(s) during and/or after forming. In few embodiments, a layer of a coating material may be applied to the aluminium foil before or after applying the layer of the adhesive or the lacquer to bond the aluminium foil with another aluminium foil or the oriented polymeric film. In certain embodiments two aluminium foils can be bonded together by application of a layer of a coating material arid a tie layer. The tie layer can be required for laminating the aluminium foil with the film, especially certain type of film such as non-polar polymeric films.
[0059] In certain embodiments the cold form laminate comprises an oPA, the first aluminium foil; the second aluminium foil; and the heat seal layer; wherein the oriented polymeric film, the first aluminium foil and the second aluminium foil are laminated with each other by application of one or more layers of an adhesive, lacquer, coating material and tie layer. Such cold form laminate can comprise of following construction:
¨ oPA/adhesive/first aluminium foil/adhesive/second aluminium foil/heat seal layer.
¨ oPA/adhesive/lacquer/first aluminium foil/adhesive/second aluminium foil/heat seal layer.
¨ oPA/adhesive/lacquer/first aluminium foil/coating/adhesive/second aluminium foil/heat seal layer.
¨ oPAJadhesive/coating/fffst aluminium foil/lacquer/coating/second aluminium foil/heat seal layer.
¨ oPA/adhesive/coating/lacquer/first aluminium foil/lacquer/coating/second aluminium foil/heat seal layer.
¨ oPA/adhesive/coating/lacquer/first aluminium foil/coating/adhesive/second aluminium foil/heat seal layer.
¨ oPA/adhesive/coating/tieffirst aluminium foil/tie/coating/second aluminium foil/heat seal layer.
¨ oPA/adhesive/coating/lacquer/first aluminium foil/tie/coating/second aluminium foil/heat seal layer.
[0060]
In certain other embodiments the cold form laminate comprises an oPA, the first aluminium foil; the polymeric film in between the oPA and the first aluminium foil, the first and second aluminium foils, or both; and the heat seal layer; wherein the oriented polymeric film, the first aluminium foil, the second aluminium foil, and polymeric film(s) are laminated with each other by application of one or more layers of an adhesive, and lacquer. Such cold form laminate can comprise of following construction:
¨ oPA/adhesive/lacquer/first aluminium foil/adhesive/polymeric layer/adhesive/second aluminium foil/heat seal layer.
¨ oPA/adhesive/polymeric film/adhesive/lacquer/first aluminium foil/adhesive/second aluminium foil/heat seal layer.
¨ oPA/adhesive/polymeric film/adhesive/lacquer/first aluminium foil/adhesive/polymeric film/adhesive/second aluminium foil/heat seal layer.
[0061]
The exemplary constructions of the cold form laminate with specific thickness of individual layers to provide high bather to cross migration of water vapor and oxygen are shown in Fig. 2, Figs. 3a-3f, and Figs. 4a-4c as represented in Tables 1-10.
[0062]
The cold form laminate in accordance with the present disclosure can be usedas a blister base part that may be produced in the known manner.
[0063] The cold form laminate in accordance with the present disclosure can be used on flat forming flat sealing machine, rotary forming and flat sealing, rotary forming and rotary sealing, as well as on flat forming rotary sealing machines.
[0064] In some embodiments the present disclosure provides a blister pack formed from the cold form laminate provided in accordance with the present disclosure as a base part for packing of the product, especially those requiring protection from longer exposure of humidity/moisture and gas/air/oxygen, more particularly requiring cross bather to water vapor and ingress of oxygen. The blister pack further includes lid layer comprising aluminium and a sealing layer. The lid layer comprises of for example aluminium foil with the thickness of about 6 pm to about 60 pm, preferably about 15 pm to 38 pm with minimum 0.5 pm thick heat seal layer of lacquer. Lid foil can be configured to open by tear, push through, rupture, peel, peel push or any suitable mechanism.
[0065] Such blister pack with the cold form laminates provide multifold better cross diffusion barrier to water vapor and also reduce ingress of gases or oxygen, or both as compared to the blister packs with the standard cold form laminateshaving much thicker constructions. At the same time such a blister construction drastically reduces a fast-gaseous migration of substances out of the blisteras needed in some of the products.
[0066] The invention is described in the following by way of examples and with reference to the accompanying drawing.
Example 1A
Blister pack with base made from convention cold form laminate [0067] A standard blister pack was formed from the typical cold form laminate as a base laminate comprising of 25 pm of oriented polyamide (oPA) film, 40pm aluminium, adhesive about 4 pm, 60 pm PVC and the same was sealed with a lid foil of hard temper proofa1um1nium28pm with lacquer coating for push through blisterpack with sealing layer of 5.6pm heat seal lacquer. The totalthickness of the blister pack was about 162.6pm Example 1 Blister pack with base made from the cold form laminate in accordance with the present disclosure comprising double layers of aluminium foil [0068] A blister pack was formed from the cold form laminate in accordance with the present disclosure as per Table 11 as a base laminate and the same was sealed with a lid foil of hard temper proofaluminium28 pm with lacquer coating for push through blisterpack with sealing layer of 5.6pm heat seal lacquer.
Table 11 oPA Adhesive Lacquer Al -1 Adhesive Al -2 HSL
(11m) (pm) (pm) (11 (pm) (1(m) 4 25 5.6 Example 2 Determination of Water vapor transmission rate and Oxygen transmission rate of cold form laminates of Example 1A and Example 1 [0069] The water vapor transmission rate (WVTR) and oxygen transmission rate (OTR) were studies of the blister packs made from the conventional cold form laminate as per Example lA and the cold form laminate in accordance with the present disclosure as per Example 1. The WVTR and OTR were determined of the blister packs middle cavities and the edge cavities having distance of 4mm from the edge after 1 year, 2 years, 3 years and 4 years of packaging by calculating the values with a specially developed software. The input data for the transmission of oxygen and humidity were measured with standard test equipment, e.g. from company MOCON and the data were used for the calculation.
The results of the WVTR and OTR determination studies are provided in below Table 12 and Table 13 as well as Figure 5 and Figure 6 respectively:
Table 12: WVTR results (g/cavity) After 1 year After 2 year After 3 year After 4 year Example 1A Middle cavity 0.1571 0.3142 0.4713 0.7855 Example 1 Middle cavity 0.0542 0.1084 0.1626 0.271 Example 1A Edge cavity 0.2757 0.5514 0.8272 1.3786 Example 1 Edge cavity 0.0951 0.1903 0.2854 0.4757 Table 13: OTR results (g/cavity) After 1 year After 2 year After 3 year After 4 year Example 1A Middle cavity 0.0001 0.0004 0.0006 0.0009 Example 1 Middle cavity 0.0001 0.0003 0.0004 0.0007 Example 1A Edge cavity 0.0002 0.0007 0.0011 0.0018 Example 1 Edge cavity 0.0002 0.0006 0.0009 0.0015 [0070] As can be seen from the above Tables 12 and 13 and Figs. 5 and 6, it is very clear that the cold form laminate according to the present disclosure was unexpectedly able to provide significantly much higher bather to the cross migration of the water vapor transmission and ingress of oxygen over longer duration of over four years as compared to the conventional cold form laminate.
[0071] While the foregoing describes various embodiments of the disclosure, other and further embodiments of the disclosure may be devised without departing from the basic scope 5 thereof. The scope of the disclosure is determined by the claims that follow. The disclosure is not limited to the described embodiments, versions or examples, which are included to enable a person having ordinary skill in the art to make and use the invention when combined with information and knowledge available to the person having ordinary skill in the art.
Claims (22)
1. A cold form laminate with high barrier to cross migration of water vapor and oxygenthrough sealed seam and sealed area into cavities when formed into a blister pack, said cold form laminate comprising an oriented polymeric film; a first aluminium foil; a second aluminium foil; and a heat seal layer.
2. The cold form laminate as claimed in claim 1, wherein the cold form laminate optionally comprises a polymeric film(s) positioned between the oriented polymeric film and the first aluminium foil, or the first aluminium foil and the second aluminium foil, or both.
3. The cold form laminate as claimed in claim 1 or 2, wherein the cold form laminate comprises one or more layer(s)of an adhesive layer, a coating material, a tie layer and a lacquer layer disposed in between each of the oriented polymeric film, the first aluminium foil, the second aluminium foil, and optional polymeric film(s).
4. The cold form laminate as claimed in claim 1 or 2, wherein the oriented polymeric film is selected from an oriented film of polyamide, polyester, polypropylene, and polyethylene.
5. The cold form laminate as claimed in claim 4, wherein the oriented polymeric film is oriented film of polyamide (oPA)with the thickness of 15 pm to about 40 pm.
6. The cold form laminate as claimed in claim 1 or 2, wherein the first aluminium foil and second aluminium foil are of aluminium alloy selected from grade 8011, 8111, and 8021 and 8079, and the first aluminium foil and the second aluminium foil are of the different or the same alloy.
7. The cold form laminate as claimed in claim 6, wherein the firstaluminium foil and the second aluminium foil are of the thickness ranging from 4 pm to 150 pm.
8. The cold form laminate as claimed claim 7, wherein the first aluminium foil is of the thickness ranging from about 20 pm to 100 pm and the second aluminium foil is of the the thickness ranging from 8 p.tm to 80 pm.
9. The cold form laminate as claimed claim 2, wherein the polymeric film is cast, biaxial oriented or monoaxial oriented selected from the group consisting of polyethylene film, polyethylene terephthalate, cyclic olefin copolymer film, polyacrylonitrile, polylactic acid, polyamide, cyclo-olefinic polymer, cyclo-olefmic copolymer, polyvinyl chloride, polypropylene, polyester, polyvinylidene chloride,poly-chloro-tri-fluoro-ethylene, and polylactic acid.
10. The cold form laminate as claimed claim 2, wherein thepolymeric film is of the thickness ranging from 6 pm to100 pm.
11. The cold form laminate as claimed claim 3, wherein the adhesive in the adhesive layer isselected from polyethylene-based resin, urethane-based adhesives, olefin-based adhesives, butyl nibber-based adhesives, acrylic resin-based adhesives, polyester resin-based adhesives, epoxy resin-based adhesives and silicone resin-based.
12. The cold form laminate as claimed claim 3, wherein the adhesive layer is of the thickness ranging from 0.4 gsm to 7 gsm.
13. The cold form laminate as claimed claim 3, wherein the lacquer layer is of lacquer based on nitro cellulose-, vinyl-, acrylate-, epoxy-, acetate-, polyurethane-, polyester-, or latices- resins.
14. The cold form laminate as claimed claim 3, wherein the lacquer is selected from the group consisting of phenoxy resins; blends of copolymers of methacrylic ester, olefins and ethylidennorbonien as binder; blends of polybutylmetacrylate, polybutyl-ethacrylate and acrylic resins as binder; tackifier based on alphamethylstyrene, maleic acid anhydride modified copolymers of vinylacetat and vinylchloride; water-based dispersions based on ethylenevinylacetate, polyvinylidene-chloride, ethylene acrylic acid and metacrylic acid and salts thereof.
15. The cold form laminate as claimed claim 3, wherein the lacquer layer is of the thickness ranging from 0.2 gsm to 10 gsm.
16. The cold form laminate as claimed claim 3, wherein the coating material is a resin or a polymeric film; wherein the resin is selected from an ionomer resin, a thermoplastic resin, a polyolefin-based polymer, polyethylene-based resin, polypropylene-based resin, saturated or unsaturated polyester, polyvinyl chloride, andpolystyrene; and the polymeric fihn is selected from a polyethylene, polyvinylidene chloride, a polyvinylidene fluoride.
17. The cold form laminate as claimed claim 3, wherein the coating layer is of the thickness ranging from 2 gsm to 50 gsm.
18. The cold form laminate as claimed claim 3, wherein the tie layer is selected from an ionomer resin, ethylene-acrylic acid copolymerin combination with polyethylene, ethylene/butyl acrylate copolymer, ethylene-butylene-propylene terpolymer, ethylene propylene copolymer, and medium density polyethylene.
19. The cold form laminate as claimed claim 3, whereinthe tie layer is of the thickness ranging from 1 gsm to 50 gsm.
20. The cold form laminate as claimed claim 1 or 2, whereinthe heat seal layer is a lacquer based on water or organic solvent, solution, suspension, emulsion, dispersion based on vinyl chloride, vinylidene dichloride, vinyl acetate, acrylate; a resin based on poly olefins, ionomers, polyester, vinyl acetate, cyclo-olefmic polymer, with or without a tie layer; or a film, based on poly vinyl chloride, poly vinylidene chloride, poly-olefins, polyester, cyclo-olefinic polymer, ionomers, as cast film or oriented film, bonded by adhesive.
21. The cold form laminate as claimed claim 1 or 2, whereinthe heat seal layer is of the thickness ranging from 2 gsm to 45 gsm.
22. A blister pack formed from the cold form laminate as claimed in any one of the claims 1-21 as a base part.
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IN201921044189 | 2019-10-31 | ||
PCT/IB2020/059831 WO2021084373A1 (en) | 2019-10-31 | 2020-10-20 | A cold form laminate with high barrier to cross migration of water vapor and oxygen |
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EP1488921A1 (en) * | 2003-06-17 | 2004-12-22 | Alcan Technology & Management Ltd. | Cold-formable laminate |
EP1787800A1 (en) * | 2005-11-17 | 2007-05-23 | Alcan Technology & Management Ltd. | Cold-workable laminate used for the base of a blister pack |
EP2025508A1 (en) * | 2007-08-14 | 2009-02-18 | Alcan Technology & Management Ltd. | Cold forming laminate |
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- 2020-10-20 CA CA3154828A patent/CA3154828A1/en active Pending
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Effective date: 20220413 |
|
EEER | Examination request |
Effective date: 20220413 |
|
EEER | Examination request |
Effective date: 20220413 |
|
EEER | Examination request |
Effective date: 20220413 |