CA3147744C - System and method to modulate phrenic nerve to prevent sleep apnea - Google Patents

System and method to modulate phrenic nerve to prevent sleep apnea Download PDF

Info

Publication number
CA3147744C
CA3147744C CA3147744A CA3147744A CA3147744C CA 3147744 C CA3147744 C CA 3147744C CA 3147744 A CA3147744 A CA 3147744A CA 3147744 A CA3147744 A CA 3147744A CA 3147744 C CA3147744 C CA 3147744C
Authority
CA
Canada
Prior art keywords
stimulation
medical device
respiration
patient
control logic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3147744A
Other languages
English (en)
French (fr)
Other versions
CA3147744A1 (en
Inventor
Mark Gelfand
Howard R. Levin
Andrew Halpert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zoll Respicardia Inc
Original Assignee
Zoll Respicardia Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zoll Respicardia Inc filed Critical Zoll Respicardia Inc
Publication of CA3147744A1 publication Critical patent/CA3147744A1/en
Application granted granted Critical
Publication of CA3147744C publication Critical patent/CA3147744C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/3611—Respiration control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3601—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of respiratory organs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/0816—Measuring devices for examining respiratory frequency
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/0826—Detecting or evaluating apnoea events
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36135—Control systems using physiological parameters
    • A61N1/3614—Control systems using physiological parameters based on impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4806—Sleep evaluation
    • A61B5/4818—Sleep apnoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36135—Control systems using physiological parameters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/3615—Intensity

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Physiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Electrotherapy Devices (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
CA3147744A 2005-11-18 2006-11-17 System and method to modulate phrenic nerve to prevent sleep apnea Active CA3147744C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US73780805P 2005-11-18 2005-11-18
US60/737,808 2005-11-18
US74306205P 2005-12-21 2005-12-21
US60/743,062 2005-12-21
US74332606P 2006-02-21 2006-02-21
US60/743,326 2006-02-21
CA2865410A CA2865410C (en) 2005-11-18 2006-11-17 System and method to modulate phrenic nerve to prevent sleep apnea

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2865410A Division CA2865410C (en) 2005-11-18 2006-11-17 System and method to modulate phrenic nerve to prevent sleep apnea

Publications (2)

Publication Number Publication Date
CA3147744A1 CA3147744A1 (en) 2007-05-31
CA3147744C true CA3147744C (en) 2024-04-23

Family

ID=38067802

Family Applications (3)

Application Number Title Priority Date Filing Date
CA3147744A Active CA3147744C (en) 2005-11-18 2006-11-17 System and method to modulate phrenic nerve to prevent sleep apnea
CA2865410A Active CA2865410C (en) 2005-11-18 2006-11-17 System and method to modulate phrenic nerve to prevent sleep apnea
CA2630211A Active CA2630211C (en) 2005-11-18 2006-11-17 System and method to modulate phrenic nerve to prevent sleep apnea

Family Applications After (2)

Application Number Title Priority Date Filing Date
CA2865410A Active CA2865410C (en) 2005-11-18 2006-11-17 System and method to modulate phrenic nerve to prevent sleep apnea
CA2630211A Active CA2630211C (en) 2005-11-18 2006-11-17 System and method to modulate phrenic nerve to prevent sleep apnea

Country Status (5)

Country Link
US (5) US8244359B2 (https=)
EP (2) EP1960038B8 (https=)
JP (1) JP2009515670A (https=)
CA (3) CA3147744C (https=)
WO (1) WO2007061902A2 (https=)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7073501B2 (en) * 1999-02-04 2006-07-11 Univerity Technologies International Inc. Ventilatory stabilization technology
US20050085874A1 (en) * 2003-10-17 2005-04-21 Ross Davis Method and system for treating sleep apnea
US20070044669A1 (en) * 2005-08-24 2007-03-01 Geise Gregory D Aluminum can compacting mechanism with improved actuation handle assembly
US9050005B2 (en) 2005-08-25 2015-06-09 Synapse Biomedical, Inc. Method and apparatus for transgastric neurostimulation
US7775983B2 (en) * 2005-09-16 2010-08-17 Cardiac Pacemakers, Inc. Rapid shallow breathing detection for use in congestive heart failure status determination
US12179014B2 (en) 2005-11-18 2024-12-31 Zoll Respicardia, Inc. Transvenous phrenic nerve stimulation system
EP1960038B8 (en) * 2005-11-18 2021-04-07 Respicardia, Inc. System to modulate phrenic nerve to prevent sleep apnea
US7766840B2 (en) * 2005-12-01 2010-08-03 Cardiac Pacemakers, Inc. Method and system for heart failure status evaluation based on a disordered breathing index
EP1957150A4 (en) * 2005-12-02 2009-12-02 Synapse Biomedical Inc TRANSVISCERAL NEUROSTIMULATION MAPPING DEVICE AND METHOD
US7662105B2 (en) 2005-12-14 2010-02-16 Cardiac Pacemakers, Inc. Systems and methods for determining respiration metrics
WO2007103585A2 (en) 2006-03-09 2007-09-13 Synapse Biomedical, Inc. Ventilator assist system and method to improve respiratory function
US7819816B2 (en) * 2006-03-29 2010-10-26 Cardiac Pacemakers, Inc. Periodic disordered breathing detection
US8909341B2 (en) * 2007-01-22 2014-12-09 Respicardia, Inc. Device and method for the treatment of breathing disorders and cardiac disorders
ES2430613T3 (es) 2007-01-29 2013-11-21 Simon Fraser University Aparato de neuroestimulación transvascular
US9079016B2 (en) 2007-02-05 2015-07-14 Synapse Biomedical, Inc. Removable intramuscular electrode
US8052611B2 (en) 2007-03-14 2011-11-08 Cardiac Pacemakers, Inc. Method and apparatus for management of heart failure hospitalization
US9943234B2 (en) * 2007-04-17 2018-04-17 Cardiac Pacemakers, Inc. Using respiration distress manifestations for heart failure detection
US9820671B2 (en) * 2007-05-17 2017-11-21 Synapse Biomedical, Inc. Devices and methods for assessing motor point electromyogram as a biomarker
US8983609B2 (en) 2007-05-30 2015-03-17 The Cleveland Clinic Foundation Apparatus and method for treating pulmonary conditions
US9987488B1 (en) 2007-06-27 2018-06-05 Respicardia, Inc. Detecting and treating disordered breathing
CN101765401B (zh) * 2007-07-26 2013-09-25 优特埃合伙有限公司 用于调整患者呼吸的瞬时介入
US8135471B2 (en) * 2007-08-28 2012-03-13 Cardiac Pacemakers, Inc. Method and apparatus for inspiratory muscle stimulation using implantable device
WO2009052631A1 (en) * 2007-10-26 2009-04-30 Uti Limited Partnership Ventilation stabilization system
US8428726B2 (en) 2007-10-30 2013-04-23 Synapse Biomedical, Inc. Device and method of neuromodulation to effect a functionally restorative adaption of the neuromuscular system
WO2009059033A1 (en) * 2007-10-30 2009-05-07 Synapse Biomedical, Inc. Method of improving sleep disordered breathing
US8155744B2 (en) 2007-12-13 2012-04-10 The Cleveland Clinic Foundation Neuromodulatory methods for treating pulmonary disorders
US9079033B2 (en) * 2008-01-22 2015-07-14 Cardiac Pacemakers, Inc. Respiration as a trigger for therapy optimization
US9199075B1 (en) 2008-02-07 2015-12-01 Respicardia, Inc. Transvascular medical lead
DE102008022924A1 (de) * 2008-05-09 2009-11-12 Siemens Aktiengesellschaft Vorrichtung und Verfahren für einen medizinischen Eingriff
JP5547200B2 (ja) 2008-10-01 2014-07-09 インスパイア・メディカル・システムズ・インコーポレイテッド 睡眠時無呼吸を治療する経静脈法
WO2010059839A2 (en) 2008-11-19 2010-05-27 Inspire Medical Systems, Inc. Method of treating sleep disordered breathing
US8870773B2 (en) * 2009-02-09 2014-10-28 The Cleveland Clinic Foundation Ultrasound-guided delivery of a therapy delivery device to a nerve target
US20100204567A1 (en) * 2009-02-09 2010-08-12 The Cleveland Clinic Foundation Ultrasound-guided delivery of a therapy delivery device to a phrenic nerve
US20110009760A1 (en) * 2009-07-10 2011-01-13 Yi Zhang Hospital Readmission Alert for Heart Failure Patients
US8233987B2 (en) * 2009-09-10 2012-07-31 Respicardia, Inc. Respiratory rectification
EP2512330B1 (en) 2009-12-14 2024-08-14 Mayo Foundation For Medical Education And Research Device for treating cardiac disorders by modulating autonomic response
US20110208175A1 (en) * 2010-02-24 2011-08-25 Medtronic Vascular, Inc. Methods for Treating Sleep Apnea Via Renal Denervation
EP2667934B1 (en) 2011-01-25 2020-05-27 Apellis Holdings, LLC Apparatus and methods for assisting breathing
FR2971418B1 (fr) * 2011-02-14 2014-02-14 Univ Paris Curie Borne d'assistance permettant la surveillance a distance d'une personne connectee a un dispositif medical d'assistance et de surveillance
US8504158B2 (en) 2011-05-09 2013-08-06 Medtronic, Inc. Phrenic nerve stimulation during cardiac refractory period
US8706235B2 (en) * 2011-07-27 2014-04-22 Medtronic, Inc. Transvenous method to induce respiration
US8509902B2 (en) * 2011-07-28 2013-08-13 Medtronic, Inc. Medical device to provide breathing therapy
US9861817B2 (en) 2011-07-28 2018-01-09 Medtronic, Inc. Medical device to provide breathing therapy
US9724018B2 (en) 2011-10-27 2017-08-08 Medtronic Cryocath Lp Method for monitoring phrenic nerve function
CN104271195B (zh) 2012-03-05 2017-04-19 西蒙·弗雷瑟大学 经血管神经刺激设备及方法
US20130289636A1 (en) * 2012-04-30 2013-10-31 Mustafa Karamanoglu Timed implantable therapy delivery device
WO2013188965A1 (en) 2012-06-21 2013-12-27 Simon Fraser University Transvascular diaphragm pacing systems and methods of use
US10335592B2 (en) 2012-12-19 2019-07-02 Viscardia, Inc. Systems, devices, and methods for improving hemodynamic performance through asymptomatic diaphragm stimulation
EP2934668B1 (en) 2012-12-19 2018-08-22 VisCardia, Inc. Hemodynamic performance enhancement through asymptomatic diaphragm stimulation
CN103142400B (zh) * 2013-03-20 2014-12-31 张栋 一种膈肌康复刺激信号的产生方法及一种膈肌功能康复器
JP2016515904A (ja) * 2013-04-05 2016-06-02 ワシーム アハマド， 空気流の診断および回復のためのデバイスおよび方法
EP2986243B1 (en) 2013-04-15 2020-06-17 Mayo Foundation for Medical Education and Research Apparatus for percutaneous epicardial ablation of cardiac ganglionated plexi without myocardial injury
CN105451648A (zh) 2013-08-05 2016-03-30 心脏起搏器股份公司 基于浅快呼吸指数检测心力衰竭的恶化的系统和方法
US10064564B2 (en) 2013-08-23 2018-09-04 Medtronic Cryocath Lp Method of CMAP monitoring
CN105873630B (zh) 2013-11-22 2020-01-03 隆佩瑟尔医疗公司 用于通过经血管神经刺激辅助呼吸的装置和方法
EP3096835B1 (en) 2014-01-21 2019-08-07 Lungpacer Medical Inc. Systems for optimization of multi-electrode nerve pacing
US12070601B2 (en) 2014-03-28 2024-08-27 Pinnacle Bionics. Inc. Stimulation system for exercising diaphragm and method of operation thereof
JP5636129B1 (ja) * 2014-05-16 2014-12-03 株式会社テクノリンク 呼吸異常改善装置
WO2016033245A1 (en) * 2014-08-26 2016-03-03 Rmx, Llc Devices and methods for reducing intrathoracic pressure
EP3377168B1 (en) 2015-11-17 2023-06-21 Inspire Medical Systems, Inc. Microstimulation sleep disordered breathing (sdb) therapy device
US10369361B2 (en) 2016-04-29 2019-08-06 Viscardia, Inc. Leads for implantable medical device that affects pressures within the intrathoracic cavity through diaphragmatic stimulation
US10765359B2 (en) 2016-12-16 2020-09-08 Medtronic, Inc. Device-based detection and monitoring of sleep apnea conditions
US10293164B2 (en) 2017-05-26 2019-05-21 Lungpacer Medical Inc. Apparatus and methods for assisted breathing by transvascular nerve stimulation
JP7184370B2 (ja) 2017-06-30 2022-12-06 ラングペーサー メディカル インコーポレイテッド 認知障害の予防、緩和、及び／または治療のための装置
US10195429B1 (en) 2017-08-02 2019-02-05 Lungpacer Medical Inc. Systems and methods for intravascular catheter positioning and/or nerve stimulation
US10940308B2 (en) 2017-08-04 2021-03-09 Lungpacer Medical Inc. Systems and methods for trans-esophageal sympathetic ganglion recruitment
US20190175908A1 (en) 2017-12-11 2019-06-13 Lungpacer Medical Inc. Systems and methods for strengthening a respiratory muscle
WO2020097331A1 (en) 2018-11-08 2020-05-14 Lungpacer Medical Inc. Stimulation systems and related user interfaces
WO2020102193A1 (en) 2018-11-13 2020-05-22 Inspire Medical Systems, Inc. Multiple type sleep apnea
US11471683B2 (en) 2019-01-29 2022-10-18 Synapse Biomedical, Inc. Systems and methods for treating sleep apnea using neuromodulation
US11357979B2 (en) 2019-05-16 2022-06-14 Lungpacer Medical Inc. Systems and methods for sensing and stimulation
WO2020252037A1 (en) 2019-06-12 2020-12-17 Lungpacer Medical Inc. Circuitry for medical stimulation systems
US11266838B1 (en) 2019-06-21 2022-03-08 Rmx, Llc Airway diagnostics utilizing phrenic nerve stimulation device and method
US11998303B2 (en) * 2019-06-24 2024-06-04 Medtronic, Inc. Sensing respiration parameters based on an impedance signal
JP7558992B2 (ja) * 2019-06-28 2024-10-01 レズメド ピーティーワイ リミテッド 刺激装置を内蔵したバンド
US11324954B2 (en) 2019-06-28 2022-05-10 Covidien Lp Achieving smooth breathing by modified bilateral phrenic nerve pacing
US11925803B2 (en) 2019-09-26 2024-03-12 Viscardia, Inc. Implantable medical systems, devices, and methods for affecting cardiac function through diaphragm stimulation, and for monitoring diaphragmatic health
EP4126191A1 (en) 2020-03-27 2023-02-08 VisCardia, Inc. Implantable medical systems, devices and methods for delivering asymptomatic diaphragmatic stimulation
US12414709B2 (en) 2021-02-11 2025-09-16 Zoll Respicardia, Inc. Monitoring system and user interface for monitoring implantable disordered breathing treatment systems
PL4056135T3 (pl) 2021-03-09 2023-10-02 Circle Safe Stymulacja nerwu przeponowego
WO2024206904A1 (en) 2023-03-31 2024-10-03 Zoll Medical Corporation Systems for sleep disorder detection, analysis, and/or treatment
WO2024243331A1 (en) 2023-05-22 2024-11-28 Lunair Medical, Inc. Methods and systems for implanting percutaneous electrode assemblies for phrenic nerve stimulation to treat sleep apnea
CN120361421B (zh) * 2025-06-06 2025-10-24 广州雪利昂生物科技有限公司 呼吸同步的体外膈神经电刺激器
CN121196535B (zh) * 2025-11-28 2026-03-06 中国人民解放军陆军军医大学第一附属医院 可植入式纳米发电机驱动的智能呼吸训练监测贴片

Family Cites Families (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4129125A (en) * 1976-12-27 1978-12-12 Camin Research Corp. Patient monitoring system
US4169479A (en) 1977-02-24 1979-10-02 Rudolph Muto Elongated, tapered flexible front guide for electrical catheters and method of use
US4827935A (en) * 1986-04-24 1989-05-09 Purdue Research Foundation Demand electroventilator
US4830008A (en) * 1987-04-24 1989-05-16 Meer Jeffrey A Method and system for treatment of sleep apnea
US5056519A (en) * 1990-05-14 1991-10-15 Vince Dennis J Unilateral diaphragmatic pacer
US5265604A (en) * 1990-05-14 1993-11-30 Vince Dennis J Demand - diaphragmatic pacing (skeletal muscle pressure modified)
US5170802A (en) * 1991-01-07 1992-12-15 Medtronic, Inc. Implantable electrode for location within a blood vessel
US5211173A (en) * 1991-01-09 1993-05-18 Medtronic, Inc. Servo muscle control
US5146918A (en) * 1991-03-19 1992-09-15 Medtronic, Inc. Demand apnea control of central and obstructive sleep apnea
US5174287A (en) * 1991-05-28 1992-12-29 Medtronic, Inc. Airway feedback measurement system responsive to detected inspiration and obstructive apnea event
US5184621A (en) 1991-05-29 1993-02-09 C. R. Bard, Inc. Steerable guidewire having electrodes for measuring vessel cross-section and blood flow
FR2698871B1 (fr) * 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5531781A (en) 1993-11-02 1996-07-02 Alferness; Clifton A. Implantable lead having a steering distal guide tip
US5485851A (en) * 1994-09-21 1996-01-23 Medtronic, Inc. Method and apparatus for arousal detection
US5483969A (en) * 1994-09-21 1996-01-16 Medtronic, Inc. Method and apparatus for providing a respiratory effort waveform for the treatment of obstructive sleep apnea
US6449507B1 (en) * 1996-04-30 2002-09-10 Medtronic, Inc. Method and system for nerve stimulation prior to and during a medical procedure
US7269457B2 (en) * 1996-04-30 2007-09-11 Medtronic, Inc. Method and system for vagal nerve stimulation with multi-site cardiac pacing
US6006134A (en) * 1998-04-30 1999-12-21 Medtronic, Inc. Method and device for electronically controlling the beating of a heart using venous electrical stimulation of nerve fibers
US6532388B1 (en) 1996-04-30 2003-03-11 Medtronic, Inc. Method and system for endotracheal/esophageal stimulation prior to and during a medical procedure
US7225019B2 (en) * 1996-04-30 2007-05-29 Medtronic, Inc. Method and system for nerve stimulation and cardiac sensing prior to and during a medical procedure
USRE38705E1 (en) * 1996-04-30 2005-02-22 Medtronic, Inc. Method and device for electronically controlling the beating of a heart using venous electrical stimulation of nerve fibers
US5642774A (en) * 1996-06-05 1997-07-01 Touchstone, Inc. Heat exchanger mounting system
US6132384A (en) * 1996-06-26 2000-10-17 Medtronic, Inc. Sensor, method of sensor implant and system for treatment of respiratory disorders
US6078830A (en) 1997-10-01 2000-06-20 Ep Technologies, Inc. Molded catheter distal end assembly and process for the manufacture thereof
US6714823B1 (en) 1998-04-29 2004-03-30 Emory University Cardiac pacing lead and delivery system
AUPP366398A0 (en) * 1998-05-22 1998-06-18 Resmed Limited Ventilatory assistance for treatment of cardiac failure and cheyne-stokes breathing
US6463327B1 (en) * 1998-06-11 2002-10-08 Cprx Llc Stimulatory device and methods to electrically stimulate the phrenic nerve
EP1087697A1 (en) * 1998-06-19 2001-04-04 Cas Medical Systems, Inc. Apnea detector with artifact rejection
SE9803508D0 (sv) * 1998-10-14 1998-10-14 Siemens Elema Ab System for assisted breathing
US6356788B2 (en) * 1998-10-26 2002-03-12 Birinder Bob Boveja Apparatus and method for adjunct (add-on) therapy for depression, migraine, neuropsychiatric disorders, partial complex epilepsy, generalized epilepsy and involuntary movement disorders utilizing an external stimulator
US6212435B1 (en) * 1998-11-13 2001-04-03 Respironics, Inc. Intraoral electromuscular stimulation device and method
US6415183B1 (en) * 1999-12-09 2002-07-02 Cardiac Pacemakers, Inc. Method and apparatus for diaphragmatic pacing
US6589188B1 (en) * 2000-05-05 2003-07-08 Pacesetter, Inc. Method for monitoring heart failure via respiratory patterns
JP4873816B2 (ja) 2000-05-16 2012-02-08 アトリオニックス・インコーポレイテッド ガイドワイヤトラッキング機構を備えた先端部可撓性カテーテル
US6584362B1 (en) 2000-08-30 2003-06-24 Cardiac Pacemakers, Inc. Leads for pacing and/or sensing the heart from within the coronary veins
US8086314B1 (en) 2000-09-27 2011-12-27 Cvrx, Inc. Devices and methods for cardiovascular reflex control
US6684101B2 (en) * 2001-04-25 2004-01-27 Cardiac Pacemakers, Inc. Implantable medical device employing single drive, dual sense impedance measuring
US6641542B2 (en) * 2001-04-30 2003-11-04 Medtronic, Inc. Method and apparatus to detect and treat sleep respiratory events
US6934583B2 (en) * 2001-10-22 2005-08-23 Pacesetter, Inc. Implantable lead and method for stimulating the vagus nerve
FR2833496B1 (fr) * 2001-12-14 2004-02-13 Ela Medical Sa Dispositif medical actif comprenant des moyens perfectionnes de diagnostic du syndrome d'apnee du sommeil
US6928324B2 (en) * 2002-02-14 2005-08-09 Pacesetter, Inc. Stimulation device for sleep apnea prevention, detection and treatment
WO2003083475A1 (en) 2002-04-03 2003-10-09 Mitsubishi Rayon Co., Ltd. Gel having biosubstance fixed thereto and microarray utilizing the gel
US7162303B2 (en) 2002-04-08 2007-01-09 Ardian, Inc. Renal nerve stimulation method and apparatus for treatment of patients
US20030195571A1 (en) * 2002-04-12 2003-10-16 Burnes John E. Method and apparatus for the treatment of central sleep apnea using biventricular pacing
US6881192B1 (en) * 2002-06-12 2005-04-19 Pacesetter, Inc. Measurement of sleep apnea duration and evaluation of response therapies using duration metrics
US7277757B2 (en) 2002-10-31 2007-10-02 Medtronic, Inc. Respiratory nerve stimulation
US7025730B2 (en) * 2003-01-10 2006-04-11 Medtronic, Inc. System and method for automatically monitoring and delivering therapy for sleep-related disordered breathing
JP4089493B2 (ja) * 2003-04-14 2008-05-28 株式会社デンソー 電子制御装置
US7155278B2 (en) * 2003-04-21 2006-12-26 Medtronic, Inc. Neurostimulation to treat effects of sleep apnea
MXPA05012169A (es) * 2003-05-16 2006-05-19 Science Medicus Inc Control respiratorio mediante senales codificadas neuro-electricas.
EP1633434B1 (en) 2003-06-04 2014-11-19 Synecor Intravascular electrophysiological system
US7840270B2 (en) * 2003-07-23 2010-11-23 Synapse Biomedical, Inc. System and method for conditioning a diaphragm of a patient
US7359755B2 (en) 2003-08-08 2008-04-15 Advanced Neuromodulation Systems, Inc. Method and apparatus for implanting an electrical stimulation lead using a flexible introducer
US7591265B2 (en) * 2003-09-18 2009-09-22 Cardiac Pacemakers, Inc. Coordinated use of respiratory and cardiac therapies for sleep disordered breathing
US7787946B2 (en) 2003-08-18 2010-08-31 Cardiac Pacemakers, Inc. Patient monitoring, diagnosis, and/or therapy systems and methods
US7979128B2 (en) * 2003-10-15 2011-07-12 Rmx, Llc Device and method for gradually controlling breathing
US8467876B2 (en) 2003-10-15 2013-06-18 Rmx, Llc Breathing disorder detection and therapy delivery device and method
US8265759B2 (en) * 2003-10-15 2012-09-11 Rmx, Llc Device and method for treating disorders of the cardiovascular system or heart
US8160711B2 (en) * 2003-10-15 2012-04-17 Rmx, Llc Multimode device and method for controlling breathing
US8140164B2 (en) * 2003-10-15 2012-03-20 Rmx, Llc Therapeutic diaphragm stimulation device and method
US20080161878A1 (en) * 2003-10-15 2008-07-03 Tehrani Amir J Device and method to for independently stimulating hemidiaphragms
US8244358B2 (en) * 2003-10-15 2012-08-14 Rmx, Llc Device and method for treating obstructive sleep apnea
US7970475B2 (en) * 2003-10-15 2011-06-28 Rmx, Llc Device and method for biasing lung volume
US20060167523A1 (en) * 2003-10-15 2006-07-27 Tehrani Amir J Device and method for improving upper airway functionality
US9259573B2 (en) * 2003-10-15 2016-02-16 Rmx, Llc Device and method for manipulating exhalation
US6964641B2 (en) * 2003-12-24 2005-11-15 Medtronic, Inc. Implantable medical device with sleep disordered breathing monitoring
US7519425B2 (en) * 2004-01-26 2009-04-14 Pacesetter, Inc. Tiered therapy for respiratory oscillations characteristic of Cheyne-Stokes respiration
US7225021B1 (en) * 2004-01-30 2007-05-29 Pacesetter, Inc. Differentiation of central sleep apnea and obstructive sleep apnea using an implantable cardiac device
US7094207B1 (en) * 2004-03-02 2006-08-22 Pacesetter, Inc. System and method for diagnosing and tracking congestive heart failure based on the periodicity of cheyne-stokes respiration using an implantable medical device
US7070568B1 (en) * 2004-03-02 2006-07-04 Pacesetter, Inc. System and method for diagnosing and tracking congestive heart failure based on the periodicity of Cheyne-Stokes Respiration using an implantable medical device
US20050197588A1 (en) * 2004-03-04 2005-09-08 Scott Freeberg Sleep disordered breathing alert system
US7179229B1 (en) * 2004-04-07 2007-02-20 Pacesetter, Inc. System and method for apnea detection using blood pressure detected via an implantable medical system
US7245971B2 (en) 2004-04-21 2007-07-17 Pacesetter, Inc. System and method for applying therapy during hyperpnea phase of periodic breathing using an implantable medical device
US7082331B1 (en) * 2004-04-21 2006-07-25 Pacesetter, Inc. System and method for applying therapy during hyperpnea phase of periodic breathing using an implantable medical device
US7357775B1 (en) * 2004-05-11 2008-04-15 Pacesetter, Inc. System and method for providing demand-based Cheyne-Stokes Respiration therapy using an implantable medical device
US7223244B1 (en) * 2004-05-18 2007-05-29 Pacesetter, Inc. System and method for monitoring hypercapnic ventilatory response
US7747323B2 (en) 2004-06-08 2010-06-29 Cardiac Pacemakers, Inc. Adaptive baroreflex stimulation therapy for disordered breathing
US7596413B2 (en) * 2004-06-08 2009-09-29 Cardiac Pacemakers, Inc. Coordinated therapy for disordered breathing including baroreflex modulation
US7371220B1 (en) * 2004-06-30 2008-05-13 Pacesetter, Inc. System and method for real-time apnea/hypopnea detection using an implantable medical system
US7200442B1 (en) * 2004-09-10 2007-04-03 Pacesetter, Inc. Implantable cardiac device with impedance monitoring control and method
US7340302B1 (en) * 2004-09-27 2008-03-04 Pacesetter, Inc. Treating sleep apnea in patients using phrenic nerve stimulation
US7361146B1 (en) * 2004-11-24 2008-04-22 Pacesetter, Inc. System and method for detecting abnormal respiration via respiratory parameters derived from intracardiac electrogram signals
US7269459B1 (en) * 2005-02-08 2007-09-11 Pacesetter, Inc. Implantable cardiac device with selectable tiered sleep apnea therapies and method
US7363086B1 (en) * 2005-03-21 2008-04-22 Pacesetter, Inc. Capture verification in respiratory diaphragm stimulation
US7499748B2 (en) * 2005-04-11 2009-03-03 Cardiac Pacemakers, Inc. Transvascular neural stimulation device
US20060247750A1 (en) 2005-04-28 2006-11-02 Seifert Kevin R Guide catheters for accessing cardiac sites
WO2007058938A2 (en) * 2005-11-10 2007-05-24 Inspiration Medical, Inc. Diaphragm stimulation device
US10406366B2 (en) 2006-11-17 2019-09-10 Respicardia, Inc. Transvenous phrenic nerve stimulation system
EP1960038B8 (en) 2005-11-18 2021-04-07 Respicardia, Inc. System to modulate phrenic nerve to prevent sleep apnea
US7766840B2 (en) * 2005-12-01 2010-08-03 Cardiac Pacemakers, Inc. Method and system for heart failure status evaluation based on a disordered breathing index
US8005543B2 (en) 2006-05-08 2011-08-23 Cardiac Pacemakers, Inc. Heart failure management system
US8280513B2 (en) * 2006-12-22 2012-10-02 Rmx, Llc Device and method to treat flow limitations
ES2430613T3 (es) 2007-01-29 2013-11-21 Simon Fraser University Aparato de neuroestimulación transvascular
US20080183264A1 (en) * 2007-01-30 2008-07-31 Cardiac Pacemakers, Inc. Electrode configurations for transvascular nerve stimulation

Also Published As

Publication number Publication date
CA2865410A1 (en) 2007-05-31
EP1960038A4 (en) 2009-09-23
US8244359B2 (en) 2012-08-14
WO2007061902A2 (en) 2007-05-31
EP1960038B8 (en) 2021-04-07
US11305119B2 (en) 2022-04-19
CA2865410C (en) 2022-04-26
US20200086118A1 (en) 2020-03-19
US20160001072A1 (en) 2016-01-07
CA2630211A1 (en) 2007-05-31
EP2371416B1 (en) 2018-08-22
EP2371416A1 (en) 2011-10-05
CA2630211C (en) 2016-11-01
JP2009515670A (ja) 2009-04-16
US20070118183A1 (en) 2007-05-24
WO2007061902A3 (en) 2007-10-11
EP1960038A2 (en) 2008-08-27
EP1960038B1 (en) 2018-08-22
US10518090B2 (en) 2019-12-31
CA3147744A1 (en) 2007-05-31
US20220176119A1 (en) 2022-06-09
US20130165989A1 (en) 2013-06-27

Similar Documents

Publication Publication Date Title
US20220176119A1 (en) System and method to modulate phrenic nerve to prevent sleep apnea
US12420092B2 (en) Systems for treating disordered breathing by comparing stimulated and unstimulated breathing
US8412331B2 (en) Breathing therapy device and method
US8265759B2 (en) Device and method for treating disorders of the cardiovascular system or heart
US10300270B2 (en) Device and method for the treatment of breathing disorders and cardiac disorders
US8121692B2 (en) Method and apparatus for neural stimulation with respiratory feedback
US9216291B2 (en) Method and apparatus for controlling neural stimulation during disordered breathing
WO2016033245A1 (en) Devices and methods for reducing intrathoracic pressure
JP2019506960A (ja) 神経調整デバイス

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20220204

MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 18TH ANNIV.) - STANDARD

Year of fee payment: 18

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20241108

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT

Effective date: 20241108

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20241108

MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 19TH ANNIV.) - STANDARD

Year of fee payment: 19

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20251107

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20251107