CA3146290A1 - Methods of identifying t cell receptors - Google Patents

Methods of identifying t cell receptors Download PDF

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Publication number
CA3146290A1
CA3146290A1 CA3146290A CA3146290A CA3146290A1 CA 3146290 A1 CA3146290 A1 CA 3146290A1 CA 3146290 A CA3146290 A CA 3146290A CA 3146290 A CA3146290 A CA 3146290A CA 3146290 A1 CA3146290 A1 CA 3146290A1
Authority
CA
Canada
Prior art keywords
amino acid
dpb1
dqb1
seq
position corresponding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3146290A
Other languages
English (en)
French (fr)
Inventor
Naoto Hirano
Munehide Nakatsugawa
Yuki Yamashita
Kenji SUGATA
Muhammed Aashiq RAHMAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University Health Network
Original Assignee
University Health Network
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Health Network filed Critical University Health Network
Publication of CA3146290A1 publication Critical patent/CA3146290A1/en
Pending legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56977—HLA or MHC typing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/554—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being a biological cell or cell fragment, e.g. bacteria, yeast cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/7051—T-cell receptor (TcR)-CD3 complex
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70539—MHC-molecules, e.g. HLA-molecules

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Mycology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA3146290A 2019-07-30 2020-07-29 Methods of identifying t cell receptors Pending CA3146290A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962880492P 2019-07-30 2019-07-30
US62/880,492 2019-07-30
US202063029103P 2020-05-22 2020-05-22
US63/029,103 2020-05-22
PCT/IB2020/057176 WO2021019476A1 (en) 2019-07-30 2020-07-29 Methods of identifying t cell receptors

Publications (1)

Publication Number Publication Date
CA3146290A1 true CA3146290A1 (en) 2021-02-04

Family

ID=74228602

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3146290A Pending CA3146290A1 (en) 2019-07-30 2020-07-29 Methods of identifying t cell receptors

Country Status (11)

Country Link
US (1) US20220291215A1 (cg-RX-API-DMAC10.html)
EP (1) EP4004546A4 (cg-RX-API-DMAC10.html)
JP (2) JP7724203B2 (cg-RX-API-DMAC10.html)
KR (1) KR102985224B1 (cg-RX-API-DMAC10.html)
CN (1) CN114761802B (cg-RX-API-DMAC10.html)
AU (1) AU2020321710A1 (cg-RX-API-DMAC10.html)
CA (1) CA3146290A1 (cg-RX-API-DMAC10.html)
IL (1) IL290226A (cg-RX-API-DMAC10.html)
MX (1) MX2022001204A (cg-RX-API-DMAC10.html)
TW (1) TW202118779A (cg-RX-API-DMAC10.html)
WO (1) WO2021019476A1 (cg-RX-API-DMAC10.html)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2020231693A1 (en) 2019-03-04 2021-09-30 University Health Network T cell receptors and methods of use thereof
TWI881991B (zh) * 2019-07-30 2025-05-01 大學健康網絡 Ｉｉ類ｍｈｃ分子及其使用方法
TW202116797A (zh) 2019-07-30 2021-05-01 大學健康網絡 Ｉｉ類ｍｈｃ分子及其使用方法
CN118662607B (zh) * 2023-03-15 2026-07-07 中国科学院上海药物研究所 抑制过激炎性反应的蛋白及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012120488A (ja) * 2010-12-09 2012-06-28 Univ Of Tokyo 新規安定化組換えｍｈｃタンパク質
AU2018335274B2 (en) * 2017-09-20 2025-02-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services HLA class II–restricted T cell receptors against mutated RAS
TW202116797A (zh) * 2019-07-30 2021-05-01 大學健康網絡 Ｉｉ類ｍｈｃ分子及其使用方法

Also Published As

Publication number Publication date
CN114761802A (zh) 2022-07-15
CN114761802B (zh) 2026-04-28
WO2021019476A1 (en) 2021-02-04
JP2025166836A (ja) 2025-11-06
KR20220052941A (ko) 2022-04-28
JP7724203B2 (ja) 2025-08-15
EP4004546A1 (en) 2022-06-01
MX2022001204A (es) 2022-05-03
JP2022542445A (ja) 2022-10-03
US20220291215A1 (en) 2022-09-15
IL290226A (en) 2022-03-01
TW202118779A (zh) 2021-05-16
KR102985224B1 (ko) 2026-07-02
EP4004546A4 (en) 2024-10-09
AU2020321710A1 (en) 2022-03-03

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