CA3142035A1 - Polymer comprising multiple functionalized sidechains for biomolecule delivery - Google Patents

Polymer comprising multiple functionalized sidechains for biomolecule delivery Download PDF

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Publication number
CA3142035A1
CA3142035A1 CA3142035A CA3142035A CA3142035A1 CA 3142035 A1 CA3142035 A1 CA 3142035A1 CA 3142035 A CA3142035 A CA 3142035A CA 3142035 A CA3142035 A CA 3142035A CA 3142035 A1 CA3142035 A1 CA 3142035A1
Authority
CA
Canada
Prior art keywords
group
polymer
formula
independently
instance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3142035A
Other languages
English (en)
French (fr)
Inventor
Kunwoo Lee
Santanu MAITY
Franco Duarte
Mingchee TAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Breeze Bio Inc
Original Assignee
GenEdit Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GenEdit Inc filed Critical GenEdit Inc
Publication of CA3142035A1 publication Critical patent/CA3142035A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/48—Polymers modified by chemical after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/105—Persulfides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L77/00—Compositions of polyamides obtained by reactions forming a carboxylic amide link in the main chain; Compositions of derivatives of such polymers
    • C08L77/04—Polyamides derived from alpha-amino carboxylic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Psychology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Polyamides (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA3142035A 2019-05-28 2020-05-28 Polymer comprising multiple functionalized sidechains for biomolecule delivery Pending CA3142035A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962853658P 2019-05-28 2019-05-28
US62/853,658 2019-05-28
US201962907458P 2019-09-27 2019-09-27
US62/907,458 2019-09-27
PCT/US2020/035007 WO2020243370A1 (en) 2019-05-28 2020-05-28 Polymer comprising multiple functionalized sidechains for biomolecule delivery

Publications (1)

Publication Number Publication Date
CA3142035A1 true CA3142035A1 (en) 2020-12-03

Family

ID=71094892

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3142035A Pending CA3142035A1 (en) 2019-05-28 2020-05-28 Polymer comprising multiple functionalized sidechains for biomolecule delivery

Country Status (7)

Country Link
US (1) US20220340712A1 (https=)
EP (1) EP3976015A1 (https=)
JP (1) JP7805789B2 (https=)
KR (1) KR20220013570A (https=)
AU (1) AU2020282798A1 (https=)
CA (1) CA3142035A1 (https=)
WO (1) WO2020243370A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3788094A2 (en) 2018-04-27 2021-03-10 Genedit Inc. Cationic polymer and use for biomolecule delivery
WO2020067142A1 (en) 2018-09-25 2020-04-02 The University Of Tokyo Amphiphilic poly(amino acid), block copolymer using the amphiphilic poly(amino acid), and complex including the amphiphilic poly(amino acid) or the block copolymer and nucleic acid
US20240285781A1 (en) 2021-06-11 2024-08-29 GenEdit, Inc. Biodegradable polymer comprising side chains with polyamine and polyalkylene oxide groups
WO2024020332A1 (en) * 2022-07-18 2024-01-25 Bridgeway Innovations, Llc Oxidatively degrading and ros scavenging polymers for medical applications

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9811059D0 (en) * 1998-05-23 1998-07-22 Univ Strathclyde Polyamino acid vesicles
IL131074A0 (en) * 1999-07-23 2001-03-19 Polygene Ltd A biodegradable polycation composition for delivery of an anionic macromolecule
WO2010075303A1 (en) 2008-12-23 2010-07-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Splicing factors with a puf protein rna-binding domain and a splicing effector domain and uses of same
ES2477416T3 (es) * 2009-02-13 2014-07-16 The University Of Tokyo Poliamino�cidos cati�nicos y usos de los mismos
JP5661626B2 (ja) * 2009-07-23 2015-01-28 国立大学法人 東京大学 アニオン性ポリマー、該アニオン性ポリマーを用いたポリイオンコンプレックスおよび三元系ポリマー複合体、ならびに薬学組成物
JP4655298B1 (ja) * 2010-02-23 2011-03-23 ナノキャリア株式会社 短鎖のカチオン性ポリアミノ酸およびその使用
WO2012068627A1 (en) 2010-11-24 2012-05-31 The University Of Western Australia Peptides for the specific binding of rna targets
US20120237565A1 (en) * 2011-03-14 2012-09-20 Intezyne Technologies, Incorporated Pegylated polyplexes containing two or more different polymers for polynucleotide delivery
AU2013248928A1 (en) 2012-04-16 2014-12-04 The State Board Of Higher Education On Behalf Of The University Of Oregon Peptides for the binding of nucleotide targets
CN113355357B (zh) 2012-12-12 2024-12-03 布罗德研究所有限公司 对用于序列操纵的改进的系统、方法和酶组合物进行的工程化和优化
EP2840140B2 (en) 2012-12-12 2023-02-22 The Broad Institute, Inc. Crispr-Cas based method for mutation of prokaryotic cells
US20140310830A1 (en) 2012-12-12 2014-10-16 Feng Zhang CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes
US8697359B1 (en) 2012-12-12 2014-04-15 The Broad Institute, Inc. CRISPR-Cas systems and methods for altering expression of gene products
WO2014093655A2 (en) 2012-12-12 2014-06-19 The Broad Institute, Inc. Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains
IL239344B2 (en) 2012-12-12 2024-06-01 Broad Inst Inc Systems engineering, methods and optimal guiding components for sequence manipulation
US20180237800A1 (en) * 2015-09-21 2018-08-23 The Regents Of The University Of California Compositions and methods for target nucleic acid modification
WO2017056095A1 (en) * 2015-09-30 2017-04-06 Ramot At Tel-Aviv University Ltd. Polyaminated polyglutamic acid-containing compounds and uses thereof for delivering oligonucleotides
WO2018094356A2 (en) * 2016-11-18 2018-05-24 Genedit Inc. Compositions and methods for target nucleic acid modification
WO2021217082A1 (en) * 2020-04-23 2021-10-28 Genedit Inc. Polymer with cationic and hydrophobic side chains

Also Published As

Publication number Publication date
KR20220013570A (ko) 2022-02-04
JP7805789B2 (ja) 2026-01-26
WO2020243370A1 (en) 2020-12-03
AU2020282798A1 (en) 2021-12-16
EP3976015A1 (en) 2022-04-06
JP2022534245A (ja) 2022-07-28
US20220340712A1 (en) 2022-10-27

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