CA3141422A1 - Targeted gene editing constructs and methods of using the same - Google Patents

Targeted gene editing constructs and methods of using the same Download PDF

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Publication number
CA3141422A1
CA3141422A1 CA3141422A CA3141422A CA3141422A1 CA 3141422 A1 CA3141422 A1 CA 3141422A1 CA 3141422 A CA3141422 A CA 3141422A CA 3141422 A CA3141422 A CA 3141422A CA 3141422 A1 CA3141422 A1 CA 3141422A1
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Prior art keywords
nucleic acid
amino acid
sequence
modified
protein
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CA3141422A
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English (en)
French (fr)
Inventor
Avencia Sanchez-mejias Garcia
Marc Guell Cargol
Dimitrie IVANCIC DJERMANOVIC
Maria Pallares Masmitja
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Universitat Pompeu Fabra
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Universitat Pompeu Fabra
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
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    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
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    • C12N2800/00—Nucleic acids vectors
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    • C12N2800/90—Vectors containing a transposable element

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  • Crystallography & Structural Chemistry (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
CA3141422A 2019-06-11 2020-06-11 Targeted gene editing constructs and methods of using the same Pending CA3141422A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962860186P 2019-06-11 2019-06-11
US62/860,186 2019-06-11
PCT/IB2020/055507 WO2020250181A1 (en) 2019-06-11 2020-06-11 Targeted gene editing constructs and methods of using the same

Publications (1)

Publication Number Publication Date
CA3141422A1 true CA3141422A1 (en) 2020-12-17

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA3141422A Pending CA3141422A1 (en) 2019-06-11 2020-06-11 Targeted gene editing constructs and methods of using the same

Country Status (11)

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US (1) US20220235379A1 (enExample)
EP (1) EP3983541A1 (enExample)
JP (1) JP7830129B2 (enExample)
KR (1) KR102990253B1 (enExample)
CN (1) CN114026240A (enExample)
AU (1) AU2020290790B2 (enExample)
BR (1) BR112021024828A2 (enExample)
CA (1) CA3141422A1 (enExample)
IL (1) IL288794A (enExample)
MX (1) MX2021015157A (enExample)
WO (1) WO2020250181A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024094224A3 (zh) * 2022-12-12 2024-06-27 上海精缮生物科技有限责任公司 一种PBase蛋白、融合蛋白、核酸和基因整合系统及应用

Families Citing this family (17)

* Cited by examiner, † Cited by third party
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JP7419168B2 (ja) * 2020-06-10 2024-01-22 株式会社東芝 改変型ｐｉｇｇｙＢａｃトランスポゼースのポリペプチド、それをコードするポリヌクレオチド、導入キャリア、キット、細胞のゲノムに目的配列を組込む方法及び細胞製造方法
WO2022129430A1 (en) * 2020-12-16 2022-06-23 Universitat Pompeu Fabra Therapeutic lama2 payload for treatment of congenital muscular dystrophy
AU2021403660A1 (en) 2020-12-16 2023-07-06 Universitat Pompeu Fabra Programmable transposases and uses thereof
AU2022272723A1 (en) * 2021-05-14 2023-11-30 Becton, Dickinson And Company Methods for making libraries for nucleic acid sequencing
AU2022273536A1 (en) * 2021-05-14 2023-11-16 Becton, Dickinson And Company Multiplexed unbiased nucleic acid amplification method
FR3124522B1 (fr) * 2021-06-25 2025-02-28 Cherbonneau Francois Composition et méthode permettant l’édition génomique
WO2023060089A2 (en) * 2021-10-04 2023-04-13 Poseida Therapeutics, Inc. Transposases and uses thereof
AU2022425534A1 (en) * 2021-12-30 2024-07-04 Regel Therapeutics, Inc. Compositions for modulating expression of sodium voltage-gated channel alpha subunit 1 and uses thereof
WO2023141504A2 (en) * 2022-01-19 2023-07-27 Genomeminer, Inc. (Formally Tupac Bio, Inc.) Dcas9-integrase for targeted genome editing
US20250158010A1 (en) 2022-02-15 2025-05-15 Lg Energy Solution, Ltd. Apparatus for manufacturing secondary battery and method for manufacturing secondary battery using the same
CN116218904B (zh) * 2022-11-03 2025-04-15 国药中生生物技术研究院有限公司 一种可提高工程化细胞外泌体中特定核酸分子载量的方法及其应用
EP4504923A4 (en) * 2023-03-27 2025-12-31 Beijing Astragenomics Tech Co Ltd ISOLATED TRANSPOSASE AND ITS USE
WO2024227131A1 (en) * 2023-04-27 2024-10-31 Rensselaer Polytechnic Institute Recombinant enzyme for the accurate insertion of dna sequences in eukaryotic cells
WO2024246338A2 (en) 2023-06-01 2024-12-05 Integra Therapeutics Novel transposases and uses thereof
WO2025212757A2 (en) * 2024-04-03 2025-10-09 Buck Institute For Research On Aging Cas enabled targeted transposition
WO2026087488A1 (en) 2024-10-21 2026-04-30 Integra Therapeutics Gene editing tools and compositions for cell engineering
CN119842638A (zh) * 2025-01-20 2025-04-18 天津大学 融合酶突变体及其在氟代白藜芦醇合成中的应用

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AU2003268022B2 (en) * 2002-07-24 2009-02-05 Manoa Biosciences Inc. Transposon-based vectors and methods of nucleic acid integration
US9783790B2 (en) * 2011-07-15 2017-10-10 The Johns Hopkins University Trichoplusia ni piggybac transposases with reduced integration activity
US20170114333A1 (en) * 2014-04-11 2017-04-27 The Johns Hopkins University Improvements to eukaryotic transposase mutants and transposon end compositions for modifying nucleic acids and methods for production and use in the generation of sequencing libraries
EP4600366A3 (en) 2015-03-31 2025-10-22 SOHM, Inc. Cas 9 retroviral integrase systems for targeted incorporation of a dna sequence into a genome of a cell
CA3004665C (en) * 2015-12-14 2021-08-24 GenomeFrontier Therapeutics, Inc. Transposon system, kit comprising the same, and uses thereof
WO2018175872A1 (en) * 2017-03-24 2018-09-27 President And Fellows Of Harvard College Methods of genome engineering by nuclease-transposase fusion proteins

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024094224A3 (zh) * 2022-12-12 2024-06-27 上海精缮生物科技有限责任公司 一种PBase蛋白、融合蛋白、核酸和基因整合系统及应用

Also Published As

Publication number Publication date
JP7830129B2 (ja) 2026-03-16
WO2020250181A1 (en) 2020-12-17
AU2020290790B2 (en) 2026-02-19
KR102990253B1 (ko) 2026-07-10
MX2021015157A (es) 2022-03-17
AU2020290790A1 (en) 2022-01-27
JP2022540318A (ja) 2022-09-15
CN114026240A (zh) 2022-02-08
BR112021024828A2 (pt) 2022-01-25
EP3983541A1 (en) 2022-04-20
KR20220019794A (ko) 2022-02-17
IL288794A (en) 2022-02-01
US20220235379A1 (en) 2022-07-28

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