CA3139062A1 - Kcnt1 inhibitors and methods of use - Google Patents

Kcnt1 inhibitors and methods of use Download PDF

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Publication number
CA3139062A1
CA3139062A1 CA3139062A CA3139062A CA3139062A1 CA 3139062 A1 CA3139062 A1 CA 3139062A1 CA 3139062 A CA3139062 A CA 3139062A CA 3139062 A CA3139062 A CA 3139062A CA 3139062 A1 CA3139062 A1 CA 3139062A1
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Canada
Prior art keywords
pharmaceutical composition
disease
group
6alkyl
condition associated
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CA3139062A
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English (en)
French (fr)
Inventor
Gabriel Martinez Botella
Andrew Mark Griffin
Paul S. Charifson
Kiran Reddy
Michael Kristopher Mathieu KAHLIG
Brian Edward Marron
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Praxis Precision Medicines Inc
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Praxis Precision Medicines Inc
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Publication of CA3139062A1 publication Critical patent/CA3139062A1/en
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    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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