CA3132472A1 - System and methods for estimation of blood flow using response surface and reduced order modeling - Google Patents

System and methods for estimation of blood flow using response surface and reduced order modeling Download PDF

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Publication number
CA3132472A1
CA3132472A1 CA3132472A CA3132472A CA3132472A1 CA 3132472 A1 CA3132472 A1 CA 3132472A1 CA 3132472 A CA3132472 A CA 3132472A CA 3132472 A CA3132472 A CA 3132472A CA 3132472 A1 CA3132472 A1 CA 3132472A1
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Canada
Prior art keywords
blood flow
vasculature
model
configurations
parameters
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Pending
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CA3132472A
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English (en)
French (fr)
Inventor
Sethuraman Sankaran
David Lesage
Charles Taylor
Nan XIAO
Hyun Jin Kim
David Spain
Michiel Schaap
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HeartFlow Inc
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HeartFlow Inc
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Publication date
Application filed by HeartFlow Inc filed Critical HeartFlow Inc
Publication of CA3132472A1 publication Critical patent/CA3132472A1/en
Pending legal-status Critical Current

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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/50—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/10—Computer-aided planning, simulation or modelling of surgical operations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/026—Measuring blood flow
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F17/00—Digital computing or data processing equipment or methods, specially adapted for specific functions
    • G06F17/10—Complex mathematical operations
    • G06F17/11—Complex mathematical operations for solving equations, e.g. nonlinear equations, general mathematical optimization problems
    • G06F17/13—Differential equations
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F30/00—Computer-aided design [CAD]
    • G06F30/20—Design optimisation, verification or simulation
    • G06F30/28—Design optimisation, verification or simulation using fluid dynamics, e.g. using Navier-Stokes equations or computational fluid dynamics [CFD]
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/60—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H30/00—ICT specially adapted for the handling or processing of medical images
    • G16H30/40—ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/10—Computer-aided planning, simulation or modelling of surgical operations
    • A61B2034/101—Computer-aided simulation of surgical operations
    • A61B2034/105—Modelling of the patient, e.g. for ligaments or bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/10—Computer-aided planning, simulation or modelling of surgical operations
    • A61B2034/107—Visualisation of planned trajectories or target regions
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F2113/00—Details relating to the application field
    • G06F2113/08—Fluids
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F2119/00—Details relating to the type or aim of the analysis or the optimisation
    • G06F2119/14—Force analysis or force optimisation, e.g. static or dynamic forces

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Primary Health Care (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Data Mining & Analysis (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Databases & Information Systems (AREA)
  • Mathematical Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Mathematical Analysis (AREA)
  • Mathematical Optimization (AREA)
  • Pure & Applied Mathematics (AREA)
  • Robotics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Computational Mathematics (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Physiology (AREA)
  • Biophysics (AREA)
  • Algebra (AREA)
  • General Engineering & Computer Science (AREA)
  • Software Systems (AREA)
  • Operations Research (AREA)
  • Computing Systems (AREA)
  • Fluid Mechanics (AREA)
  • Computer Hardware Design (AREA)
  • Evolutionary Computation (AREA)
CA3132472A 2019-05-17 2020-05-15 System and methods for estimation of blood flow using response surface and reduced order modeling Pending CA3132472A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962849489P 2019-05-17 2019-05-17
US62/849,489 2019-05-17
PCT/US2020/033239 WO2020236639A1 (en) 2019-05-17 2020-05-15 System and methods for estimation of blood flow using response surface and reduced order modeling

Publications (1)

Publication Number Publication Date
CA3132472A1 true CA3132472A1 (en) 2020-11-26

Family

ID=71069955

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3132472A Pending CA3132472A1 (en) 2019-05-17 2020-05-15 System and methods for estimation of blood flow using response surface and reduced order modeling

Country Status (8)

Country Link
US (3) US11707325B2 (https=)
EP (1) EP3970162A1 (https=)
JP (1) JP7616806B2 (https=)
KR (2) KR20260022453A (https=)
CN (1) CN113811956B (https=)
AU (1) AU2020278589A1 (https=)
CA (1) CA3132472A1 (https=)
WO (1) WO2020236639A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018515167A (ja) * 2015-04-02 2018-06-14 ハートフロー， インコーポレイテッド 血管網と潅流組織の機能的関連性を特定し可視化するシステム及び方法
US11969280B2 (en) 2020-01-07 2024-04-30 Cleerly, Inc. Systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking
US20220392065A1 (en) 2020-01-07 2022-12-08 Cleerly, Inc. Systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking
JP2023509514A (ja) 2020-01-07 2023-03-08 クリールリー、 インコーポレーテッド 医用画像分析、診断、重症度分類、意思決定、および／または疾患追跡のためのシステム、方法、およびデバイス
CA3096285A1 (en) 2020-10-16 2022-04-16 Pulsemedica Corp. Opthalmological imaging and laser delivery device, system and methods
US12406365B2 (en) 2022-03-10 2025-09-02 Cleerly, Inc. Systems, devices, and methods for non-invasive image-based plaque analysis and risk determination
US12440180B2 (en) 2022-03-10 2025-10-14 Cleerly, Inc. Systems, devices, and methods for non-invasive image-based plaque analysis and risk determination
US20250143657A1 (en) 2022-03-10 2025-05-08 Cleerly, Inc. Systems, devices, and methods for non-invasive image-based plaque analysis and risk determination
US20250217981A1 (en) 2022-03-10 2025-07-03 Cleerly, Inc. Systems, methods, and devices for image-based plaque analysis and risk determination
CN115221804B (zh) * 2022-06-08 2025-07-11 中国科学院深圳先进技术研究院 人工肺血流的流场计算方法、装置、设备及存储介质

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19814371A1 (de) * 1998-03-31 1999-10-14 Pulsion Verwaltungs Gmbh & Co Verfahren zur in-vivo Bestimmung der Compliance-Funktion und des systemischen Blutflusses eines Lebewesens und Vorrichtung zur Durchführung der Verfahren
US8200466B2 (en) * 2008-07-21 2012-06-12 The Board Of Trustees Of The Leland Stanford Junior University Method for tuning patient-specific cardiovascular simulations
US8315812B2 (en) 2010-08-12 2012-11-20 Heartflow, Inc. Method and system for patient-specific modeling of blood flow
US10328266B2 (en) * 2012-05-31 2019-06-25 Zoll Medical Corporation External pacing device with discomfort management
US10398386B2 (en) * 2012-09-12 2019-09-03 Heartflow, Inc. Systems and methods for estimating blood flow characteristics from vessel geometry and physiology
US9424395B2 (en) * 2013-03-04 2016-08-23 Heartflow, Inc. Method and system for sensitivity analysis in modeling blood flow characteristics
US9805463B2 (en) * 2013-08-27 2017-10-31 Heartflow, Inc. Systems and methods for predicting location, onset, and/or change of coronary lesions
US20150164451A1 (en) * 2013-12-18 2015-06-18 Heartflow, Inc. Systems and methods for predicting coronary plaque vulnerability from patient-specific anatomic image data
US9501622B2 (en) * 2014-03-05 2016-11-22 Heartflow, Inc. Methods and systems for predicting sensitivity of blood flow calculations to changes in anatomical geometry
US9390232B2 (en) * 2014-03-24 2016-07-12 Heartflow, Inc. Systems and methods for modeling changes in patient-specific blood vessel geometry and boundary conditions
US9594876B2 (en) 2014-11-04 2017-03-14 Heartflow, Inc. Systems and methods for simulation of occluded arteries and optimization of occlusion-based treatments
US20160196384A1 (en) 2015-01-06 2016-07-07 Siemens Aktiengesellschaft Personalized whole-body circulation in medical imaging
US10307131B2 (en) * 2015-07-17 2019-06-04 Heartflow, Inc. Systems and methods for assessing the severity of plaque and/or stenotic lesions using contrast distribution predictions and measurements
CN105326486B (zh) * 2015-12-08 2017-08-25 博动医学影像科技（上海）有限公司 血管压力差与血流储备分数的计算方法及系统
JP6829262B2 (ja) * 2016-02-26 2021-02-10 ハートフロー， インコーポレイテッド 画像ベースの患者固有の血流力学的モデルにおいて解像されていない血管を特定してモデル化するためのシステム及び方法
JP7100627B2 (ja) * 2016-09-20 2022-07-13 ハートフロー， インコーポレイテッド 次数低減モデル及び／または機械学習を使用して血流特性を推定するためのシステム及び方法
WO2020160771A1 (en) 2019-02-06 2020-08-13 Universität Zürich System and method for determining fluid flow through a subject conduit

Also Published As

Publication number Publication date
CN113811956B (zh) 2025-08-19
US20200360088A1 (en) 2020-11-19
JP7616806B2 (ja) 2025-01-17
AU2020278589A1 (en) 2022-01-06
WO2020236639A1 (en) 2020-11-26
KR102915024B1 (ko) 2026-01-21
US11707325B2 (en) 2023-07-25
US12096990B2 (en) 2024-09-24
KR20260022453A (ko) 2026-02-19
EP3970162A1 (en) 2022-03-23
CN113811956A (zh) 2021-12-17
KR20220009995A (ko) 2022-01-25
JP2022533345A (ja) 2022-07-22
US20230310085A1 (en) 2023-10-05
US20240407849A1 (en) 2024-12-12

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