CA3123293A1 - Systeme de distribution sous-pie-merienne et procedes d'utilisation - Google Patents
Systeme de distribution sous-pie-merienne et procedes d'utilisation Download PDFInfo
- Publication number
- CA3123293A1 CA3123293A1 CA3123293A CA3123293A CA3123293A1 CA 3123293 A1 CA3123293 A1 CA 3123293A1 CA 3123293 A CA3123293 A CA 3123293A CA 3123293 A CA3123293 A CA 3123293A CA 3123293 A1 CA3123293 A1 CA 3123293A1
- Authority
- CA
- Canada
- Prior art keywords
- delivery system
- subpial
- frame
- reservoir
- disposed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims description 33
- 239000000758 substrate Substances 0.000 claims abstract description 38
- 210000000278 spinal cord Anatomy 0.000 claims description 30
- 239000012530 fluid Substances 0.000 claims description 20
- 210000000988 bone and bone Anatomy 0.000 claims description 16
- 239000000126 substance Substances 0.000 claims description 11
- 239000013598 vector Substances 0.000 claims description 9
- 239000003814 drug Substances 0.000 claims description 8
- 229940079593 drug Drugs 0.000 claims description 8
- 238000004891 communication Methods 0.000 claims description 7
- 238000002684 laminectomy Methods 0.000 claims description 5
- 241000700605 Viruses Species 0.000 claims description 4
- 239000003102 growth factor Substances 0.000 claims description 4
- 239000013612 plasmid Substances 0.000 claims description 4
- -1 cells Substances 0.000 claims description 3
- 230000003213 activating effect Effects 0.000 claims description 2
- 230000037452 priming Effects 0.000 claims description 2
- 238000010586 diagram Methods 0.000 description 22
- 241001465754 Metazoa Species 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 6
- 238000002347 injection Methods 0.000 description 6
- 239000007924 injection Substances 0.000 description 6
- 238000007913 intrathecal administration Methods 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 239000006285 cell suspension Substances 0.000 description 5
- 230000033001 locomotion Effects 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- 229910001220 stainless steel Inorganic materials 0.000 description 5
- 239000010935 stainless steel Substances 0.000 description 5
- 238000001356 surgical procedure Methods 0.000 description 5
- 108700011259 MicroRNAs Proteins 0.000 description 4
- 108091027967 Small hairpin RNA Proteins 0.000 description 4
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 4
- 239000002679 microRNA Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 239000004055 small Interfering RNA Substances 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 description 3
- 210000004556 brain Anatomy 0.000 description 3
- 230000000295 complement effect Effects 0.000 description 3
- 210000003205 muscle Anatomy 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 239000010936 titanium Substances 0.000 description 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 2
- 241000713772 Human immunodeficiency virus 1 Species 0.000 description 2
- 108091034117 Oligonucleotide Proteins 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 2
- 239000000074 antisense oligonucleotide Substances 0.000 description 2
- 238000012230 antisense oligonucleotides Methods 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 210000000576 arachnoid Anatomy 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 210000001951 dura mater Anatomy 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 229910052719 titanium Inorganic materials 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 241000700198 Cavia Species 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 208000000094 Chronic Pain Diseases 0.000 description 1
- 241000699800 Cricetinae Species 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 241000282575 Gorilla Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 208000008238 Muscle Spasticity Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241000282579 Pan Species 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 241000282405 Pongo abelii Species 0.000 description 1
- 241000288906 Primates Species 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 238000004873 anchoring Methods 0.000 description 1
- 230000008499 blood brain barrier function Effects 0.000 description 1
- 210000001218 blood-brain barrier Anatomy 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 238000013265 extended release Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 210000002418 meninge Anatomy 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 210000001178 neural stem cell Anatomy 0.000 description 1
- 230000000926 neurological effect Effects 0.000 description 1
- 230000009972 noncorrosive effect Effects 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 210000000578 peripheral nerve Anatomy 0.000 description 1
- 210000003446 pia mater Anatomy 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 210000004044 posterior horn cell Anatomy 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000002693 spinal anesthesia Methods 0.000 description 1
- 210000001032 spinal nerve Anatomy 0.000 description 1
- 210000000273 spinal nerve root Anatomy 0.000 description 1
- 208000005198 spinal stenosis Diseases 0.000 description 1
- 238000002672 stereotactic surgery Methods 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000033912 thigmotaxis Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/34—Trocars; Puncturing needles
- A61B17/3401—Puncturing needles for the peridural or subarachnoid space or the plexus, e.g. for anaesthesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/02—Surgical instruments, devices or methods, e.g. tourniquets for holding wounds open; Tractors
- A61B17/0206—Surgical instruments, devices or methods, e.g. tourniquets for holding wounds open; Tractors with antagonistic arms as supports for retractor elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/02—Surgical instruments, devices or methods, e.g. tourniquets for holding wounds open; Tractors
- A61B17/0293—Surgical instruments, devices or methods, e.g. tourniquets for holding wounds open; Tractors with ring member to support retractor elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/34—Trocars; Puncturing needles
- A61B17/3403—Needle locating or guiding means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/34—Trocars; Puncturing needles
- A61B17/3478—Endoscopic needles, e.g. for infusion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/10—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges for stereotaxic surgery, e.g. frame-based stereotaxis
- A61B90/11—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges for stereotaxic surgery, e.g. frame-based stereotaxis with guides for needles or instruments, e.g. arcuate slides or ball joints
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/50—Supports for surgical instruments, e.g. articulated arms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/0105—Steering means as part of the catheter or advancing means; Markers for positioning
- A61M25/0113—Mechanical advancing means, e.g. catheter dispensers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00477—Coupling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/34—Trocars; Puncturing needles
- A61B17/3403—Needle locating or guiding means
- A61B2017/3405—Needle locating or guiding means using mechanical guide means
- A61B2017/3407—Needle locating or guiding means using mechanical guide means including a base for support on the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/34—Trocars; Puncturing needles
- A61B17/3403—Needle locating or guiding means
- A61B2017/3405—Needle locating or guiding means using mechanical guide means
- A61B2017/3409—Needle locating or guiding means using mechanical guide means including needle or instrument drives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/50—Supports for surgical instruments, e.g. articulated arms
- A61B90/57—Accessory clamps
- A61B2090/571—Accessory clamps for clamping a support arm to a bed or other supports
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M2025/0007—Epidural catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/20—Pathogenic agents
- A61M2202/206—Viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/10—Trunk
- A61M2210/1003—Spinal column
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2250/00—Specially adapted for animals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pathology (AREA)
- Anesthesiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Surgical Instruments (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
La présente invention concerne un système d'administration sous la pie-mère comprend : a) une plateforme; b) un manipulateur attaché au rail de la plateforme; c) un assemblage d'aiguille attaché à un coupleur du manipulateur; d) un réservoir fixé à une extrémité distale du corps allongé de l'assemblage d'aiguille pour contenir un substrat avant l'administration du substrat par l'ouverture de l'aiguille.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962790616P | 2019-01-10 | 2019-01-10 | |
| US62/790,616 | 2019-01-10 | ||
| PCT/US2020/013059 WO2020146718A1 (fr) | 2019-01-10 | 2020-01-10 | Système de distribution sous-pie-mérienne et procédés d'utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3123293A1 true CA3123293A1 (fr) | 2020-07-16 |
Family
ID=71521225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3123293A Pending CA3123293A1 (fr) | 2019-01-10 | 2020-01-10 | Systeme de distribution sous-pie-merienne et procedes d'utilisation |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10980566B2 (fr) |
| EP (1) | EP3908198A4 (fr) |
| JP (1) | JP7373226B2 (fr) |
| KR (1) | KR20210114013A (fr) |
| CN (1) | CN113260317B (fr) |
| CA (1) | CA3123293A1 (fr) |
| WO (1) | WO2020146718A1 (fr) |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5292722A (en) | 1992-11-06 | 1994-03-08 | Brigham And Women's Hospital | Intravenous solution that diminishes body protein loss |
| US5643286A (en) * | 1994-06-24 | 1997-07-01 | Cytotherapeutics, Inc. | Microdrive for use in stereotactic surgery |
| AU3146495A (en) * | 1994-07-22 | 1996-02-22 | Eastern Washington University | Methods for stereotactic implantation |
| US20020007145A1 (en) | 1998-10-23 | 2002-01-17 | Timothy Stivland | Catheter having improved bonding region |
| JP2003530131A (ja) * | 1999-03-07 | 2003-10-14 | ディスクレ リミテッド | コンピューターを利用する手術方法及び装置 |
| US6613026B1 (en) | 1999-12-08 | 2003-09-02 | Scimed Life Systems, Inc. | Lateral needle-less injection apparatus and method |
| CA2404160A1 (fr) | 2000-03-27 | 2001-10-04 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Identification de nouveaux transporteurs de gaba humains |
| AU2001285327A1 (en) | 2000-09-01 | 2002-03-22 | Lexicon Genetics Incorporated | Human gaba transporter protein and polynucleotides encoding the same |
| US6579281B2 (en) | 2000-10-11 | 2003-06-17 | Popcab, Llc | Instrument stabilizer for through-a-port surgery |
| US20030195633A1 (en) | 2001-05-04 | 2003-10-16 | Hyde Edward R. | Magnetic array implant and prosthesis insert |
| US7011647B2 (en) | 2001-07-13 | 2006-03-14 | Scimed Life Systems, Inc. | Introducer sheath |
| US20070142748A1 (en) | 2002-04-19 | 2007-06-21 | Ajay Deshmukh | Tissue penetration device |
| US20030199085A1 (en) | 2002-04-22 | 2003-10-23 | Abraham Berger | Transportation of stem cells |
| US7666177B2 (en) | 2003-09-15 | 2010-02-23 | James Guest | Method and system for cellular transplantation in the spinal cord |
| WO2006047554A2 (fr) | 2004-10-22 | 2006-05-04 | Diagnostic Ultrasound Corporation | Appareil et procede pour insertion et retrait guides par l'image d'une canule ou d'une aiguille |
| WO2006050211A2 (fr) | 2004-10-28 | 2006-05-11 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Therapie genique a base de proteine decarboxylase d'acide glutamique a administration peripherique pour lutter contre la douleur engendree par un traumatisme medullaire |
| US8172855B2 (en) * | 2004-11-24 | 2012-05-08 | Abdou M S | Devices and methods for inter-vertebral orthopedic device placement |
| US20070213292A1 (en) | 2005-08-10 | 2007-09-13 | The Rockefeller University | Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof |
| US20100023021A1 (en) | 2005-12-27 | 2010-01-28 | Flaherty J Christopher | Biological Interface and Insertion |
| KR20080007968A (ko) | 2006-07-19 | 2008-01-23 | 연세대학교 산학협력단 | Ｇａｄ65를 발현하는 재조합 벡터를 포함하는 신경병증성통증 완화용 조성물 |
| PT3146982T (pt) | 2006-10-03 | 2019-10-31 | Genzyme Corp | Terapia génica para esclerose lateral amiotrófica e outros distúrbios da medula espinal |
| ITUD20060223A1 (it) | 2006-10-23 | 2008-04-24 | De Longhi Spa | Dispositivo mobile per il riscaldamento di ambienti |
| DE202006019649U1 (de) | 2006-12-22 | 2007-08-16 | Brainlab Ag | Navigierte Applikationsführung für gezielte Spinalarzneimittelzufuhr |
| EP2126131A2 (fr) | 2007-03-08 | 2009-12-02 | Genizon Biosciences, Inc. | Cartographie des gènes de l'homme associés avec la schizophrénie |
| US9011410B2 (en) | 2007-05-03 | 2015-04-21 | The Regents Of The University Of California | Spinal multisegmental cell and drug delivery system |
| WO2009091514A2 (fr) | 2008-01-14 | 2009-07-23 | I-V Access Technology, Inc. | Appareil pour accès vasculaire périphérique |
| EP2274041B1 (fr) * | 2008-04-04 | 2016-06-08 | The Cleveland Clinic Foundation | Plateforme rachidienne d'administration d'un agent thérapeutique à une cible de moelle épinière |
| EP2337517B1 (fr) | 2008-07-03 | 2013-01-09 | The Cleveland Clinic Foundation | Canule spinale flottante |
| WO2010071832A1 (fr) | 2008-12-19 | 2010-06-24 | Nationwide Children's Hospital | Administration de polynucléotides à travers la barrière hémato-encéphalique à l'aide de aav9 recombinant |
| US8901097B2 (en) | 2009-11-08 | 2014-12-02 | Quark Pharmaceuticals, Inc. | Methods for delivery of siRNA to the spinal cord and therapies arising therefrom |
| JP2012000390A (ja) | 2010-06-21 | 2012-01-05 | Olympus Corp | 投薬チューブおよび薬剤投与装置 |
| JPWO2012029535A1 (ja) | 2010-08-31 | 2013-10-28 | テルモ株式会社 | 医療用装置 |
| WO2012050907A2 (fr) | 2010-09-28 | 2012-04-19 | The Regents Of The University Of California | Agonistes de gaba dans le traitement de troubles associés au syndrome métabolique et combinaisons de gaba dans le traitement ou la prophylaxie du diabète de type i |
| CN103328038A (zh) | 2010-12-01 | 2013-09-25 | 史拜诺莫度雷森公司 | 向神经解剖结构直接递送药剂 |
| MX367842B (es) | 2012-02-07 | 2019-09-09 | Global Bio Therapeutics Inc | Método compartimentado de administración de ácidos nucleicos y composiciones y usos del mismo. |
| US20130289399A1 (en) * | 2012-04-27 | 2013-10-31 | Vertiflex, Inc. | Decompression systems and methods of using the same |
| US20150224331A1 (en) | 2012-09-24 | 2015-08-13 | The Regents Of The University Of California | Spinal cord pulsation-cancelation injection system |
| US20150343038A1 (en) | 2013-01-23 | 2015-12-03 | The Regents Of The University Of California | Method and composition for treating spasticity |
| GB201308917D0 (en) | 2013-05-17 | 2013-07-03 | Renishaw Plc | Delivery |
| US10688285B2 (en) | 2015-01-30 | 2020-06-23 | The Regents Of The University Of California | Spinal subpial gene delivery system |
| JP2018506530A (ja) | 2015-01-30 | 2018-03-08 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 脊柱軟膜下遺伝子送達システム |
| WO2017095753A1 (fr) * | 2015-12-01 | 2017-06-08 | Invivo Therapeutics Corporation | Compositions et procédés de préparation d'un milieu injectable à administrer dans le système nerveux central |
| JP6949867B2 (ja) | 2016-03-28 | 2021-10-13 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ | 神経の過剰興奮を治療するための方法および組成物 |
-
2020
- 2020-01-10 CA CA3123293A patent/CA3123293A1/fr active Pending
- 2020-01-10 US US16/954,146 patent/US10980566B2/en active Active
- 2020-01-10 WO PCT/US2020/013059 patent/WO2020146718A1/fr unknown
- 2020-01-10 JP JP2021539125A patent/JP7373226B2/ja active Active
- 2020-01-10 KR KR1020217024705A patent/KR20210114013A/ko unknown
- 2020-01-10 EP EP20738538.6A patent/EP3908198A4/fr active Pending
- 2020-01-10 CN CN202080006984.8A patent/CN113260317B/zh active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN113260317A (zh) | 2021-08-13 |
| JP7373226B2 (ja) | 2023-11-02 |
| CN113260317B (zh) | 2024-05-07 |
| US10980566B2 (en) | 2021-04-20 |
| EP3908198A1 (fr) | 2021-11-17 |
| EP3908198A4 (fr) | 2022-09-14 |
| KR20210114013A (ko) | 2021-09-17 |
| WO2020146718A1 (fr) | 2020-07-16 |
| JP2022516746A (ja) | 2022-03-02 |
| US20200397467A1 (en) | 2020-12-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2274041B1 (fr) | Plateforme rachidienne d'administration d'un agent thérapeutique à une cible de moelle épinière | |
| US7181289B2 (en) | Epidural nerve root access catheter and treatment methods | |
| US7329262B2 (en) | Stereoguide for clamping neurosurgical instruments | |
| JP4465493B2 (ja) | 大脳内適用用カテーテルおよびガイドチューブ | |
| US20150224331A1 (en) | Spinal cord pulsation-cancelation injection system | |
| JP6456924B2 (ja) | 医療処置のための固定装置及び方法 | |
| US8715240B2 (en) | Apparatus and method for convection enhanced therapeutic delivery | |
| PT1787592E (pt) | Dispositivo e sistema para administrar um material endurecível num osso | |
| EP2337517B1 (fr) | Canule spinale flottante | |
| WO2003002170A2 (fr) | Catheter pour administration de medicaments a invasion minimale | |
| US20040243101A1 (en) | Minimally invasive drug delivery catheter | |
| US10980566B2 (en) | Subpial delivery system and methods of use | |
| US20010049518A1 (en) | Method of delivering a beneficial agent employing a steerable catheter | |
| Grondin et al. | Chronic intracerebral delivery of trophic factors via a programmable pump as a treatment for parkinsonism | |
| RU2651129C1 (ru) | Способ направленной одноуровневой эпидуральной анестезии | |
| Kastler et al. | Lumbar Sympathetic Block and Neurolysis: Computed Tomography | |
| Dalgic et al. | Experimental Endoscopic Cordotomy in the Sheep Model |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20220909 |
|
| EEER | Examination request |
Effective date: 20220909 |
|
| EEER | Examination request |
Effective date: 20220909 |
|
| EEER | Examination request |
Effective date: 20220909 |
|
| EEER | Examination request |
Effective date: 20220909 |
|
| EEER | Examination request |
Effective date: 20220909 |