CA3120160A1 - Proteines chimeres de liaison au recepteur destinees a etre utilisees dans des vecteurs pour delivrer des bacteries - Google Patents

Proteines chimeres de liaison au recepteur destinees a etre utilisees dans des vecteurs pour delivrer des bacteries Download PDF

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Publication number
CA3120160A1
CA3120160A1 CA3120160A CA3120160A CA3120160A1 CA 3120160 A1 CA3120160 A1 CA 3120160A1 CA 3120160 A CA3120160 A CA 3120160A CA 3120160 A CA3120160 A CA 3120160A CA 3120160 A1 CA3120160 A1 CA 3120160A1
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CA
Canada
Prior art keywords
rbp
virus
seq
terminal
terminal domain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3120160A
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English (en)
Inventor
Jesus FERNANDEZ-RODRIGUEZ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eligo Bioscience
Original Assignee
Eligo Bioscience
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2019/082640 external-priority patent/WO2020109339A1/fr
Application filed by Eligo Bioscience filed Critical Eligo Bioscience
Publication of CA3120160A1 publication Critical patent/CA3120160A1/fr
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10311—Siphoviridae
    • C12N2795/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10311—Siphoviridae
    • C12N2795/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2795/10342—Use of virus, viral particle or viral elements as a vector virus or viral particle as vehicle, e.g. encapsulating small organic molecule
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10311—Siphoviridae
    • C12N2795/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2795/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Vecteurs pour délivrer des bactéries destinés à être utilisés pour un transfert efficace d'une charge utile souhaitée dans une cellule bactérienne cible. Plus particulièrement, la présente invention concerne des vecteurs pour délivrer des bactéries ayant des plages d'hôte souhaitées sur la base de la présence d'une protéine de liaison au récepteur chimérique (RBP) composée d'une fusion entre l'extrémité N-terminale d'une RBP dérivée d'un bactériophage du type lambda et de l'extrémité C-terminale d'un RBP différent et/ou la présence d'un récepteur ramifié modifié se liant aux polypeptides à sous-unités multiples ("RBP ramifié").
CA3120160A 2018-12-21 2019-12-23 Proteines chimeres de liaison au recepteur destinees a etre utilisees dans des vecteurs pour delivrer des bacteries Pending CA3120160A1 (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201862783258P 2018-12-21 2018-12-21
US62/783,258 2018-12-21
US201962802777P 2019-02-08 2019-02-08
US62/802,777 2019-02-08
US16/696,769 2019-11-26
EPPCT/EP2019/082640 2019-11-26
PCT/EP2019/082640 WO2020109339A1 (fr) 2018-11-27 2019-11-26 Protéines chimères de liaison au récepteur destinées à être utilisées dans des vecteurs pour délivrer des bactéries
US16/696,769 US11661443B2 (en) 2018-11-27 2019-11-26 Chimeric receptor binding proteins for use in bacterial delivery vehicles
PCT/EP2019/086990 WO2020128108A1 (fr) 2018-12-21 2019-12-23 Protéines chimères de liaison au récepteur destinées à être utilisées dans des vecteurs pour délivrer des bactéries

Publications (1)

Publication Number Publication Date
CA3120160A1 true CA3120160A1 (fr) 2020-06-25

Family

ID=71101098

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3120160A Pending CA3120160A1 (fr) 2018-12-21 2019-12-23 Proteines chimeres de liaison au recepteur destinees a etre utilisees dans des vecteurs pour delivrer des bacteries

Country Status (7)

Country Link
EP (1) EP3898953A1 (fr)
JP (1) JP2022514700A (fr)
KR (1) KR20210107053A (fr)
CN (1) CN113498435A (fr)
CA (1) CA3120160A1 (fr)
IL (1) IL283796A (fr)
WO (1) WO2020128108A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11584781B2 (en) 2019-12-30 2023-02-21 Eligo Bioscience Chimeric receptor binding proteins resistant to proteolytic degradation
TR202014396A2 (tr) * 2020-09-10 2022-03-21 Univ Yildiz Teknik Mikroorganizma hedefli, antimikrobiyal bileşen/bileşenler içeren nanoformülasyonlar.
WO2022144381A1 (fr) * 2020-12-30 2022-07-07 Eligo Bioscience Modulation du microbiome d'un hôte par administration de charges utiles d'adn à étalement réduit à un minimum
EP4342538A1 (fr) * 2022-09-20 2024-03-27 Technische Universität München Production simultanée de protéines structurelles de bactériophages hétérologues dans un système d'expression acellulaire
US20240158760A1 (en) * 2022-11-10 2024-05-16 Laboratory Corporation Of America Holdings Synthetic phage with recombinant tail-spike proteins and related methods
CN116003531B (zh) * 2022-12-28 2023-09-05 山东省农业科学院畜牧兽医研究所 噬菌体受体结合蛋白po86在大肠杆菌o抗原血清型分型鉴定中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10660943B2 (en) 2013-02-07 2020-05-26 The Rockefeller University Sequence specific antimicrobials
JP6842417B2 (ja) * 2014-12-16 2021-03-17 シー３ジェイ セラピューティクス インコーポレイテッド インビトロウイルスゲノム工学のための組成物及びその方法

Also Published As

Publication number Publication date
WO2020128108A1 (fr) 2020-06-25
IL283796A (en) 2021-07-29
CN113498435A (zh) 2021-10-12
JP2022514700A (ja) 2022-02-14
KR20210107053A (ko) 2021-08-31
EP3898953A1 (fr) 2021-10-27

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