CA3118689A1 - Artificial expression constructs for selectively modulating gene expression in excitatory cortical neurons - Google Patents

Artificial expression constructs for selectively modulating gene expression in excitatory cortical neurons Download PDF

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Publication number
CA3118689A1
CA3118689A1 CA3118689A CA3118689A CA3118689A1 CA 3118689 A1 CA3118689 A1 CA 3118689A1 CA 3118689 A CA3118689 A CA 3118689A CA 3118689 A CA3118689 A CA 3118689A CA 3118689 A1 CA3118689 A1 CA 3118689A1
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ehgt
seq
cell
cells
expression
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French (fr)
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Lucas T. GRAYBUCK
Bosiljka Tasic
Tanya DAIGLE
Jonathan Ting
Hongkui Zeng
Brian Edward KALMBACH
John K. Mich
Erik HESS
Edward Sebastian LEIN
Boaz P. LEVI
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Allen Institute
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Allen Institute
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
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    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
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    • C—CHEMISTRY; METALLURGY
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
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  • Wood Science & Technology (AREA)
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  • General Engineering & Computer Science (AREA)
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  • Molecular Biology (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA3118689A 2018-11-05 2019-11-05 Artificial expression constructs for selectively modulating gene expression in excitatory cortical neurons Pending CA3118689A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201862755988P 2018-11-05 2018-11-05
US62/755,988 2018-11-05
US201962806684P 2019-02-15 2019-02-15
US201962806600P 2019-02-15 2019-02-15
US62/806,684 2019-02-15
US62/806,600 2019-02-15
US201962872021P 2019-07-09 2019-07-09
US62/872,021 2019-07-09
PCT/US2019/059927 WO2020097121A1 (en) 2018-11-05 2019-11-05 Artificial expression constructs for selectively modulating gene expression in excitatory cortical neurons

Publications (1)

Publication Number Publication Date
CA3118689A1 true CA3118689A1 (en) 2020-05-14

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CA3118689A Pending CA3118689A1 (en) 2018-11-05 2019-11-05 Artificial expression constructs for selectively modulating gene expression in excitatory cortical neurons

Country Status (6)

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US (2) US12703873B2 (enExample)
EP (1) EP3877529A4 (enExample)
JP (3) JP7590962B2 (enExample)
AU (2) AU2019375975B2 (enExample)
CA (1) CA3118689A1 (enExample)
WO (1) WO2020097121A1 (enExample)

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CA3142948A1 (en) 2019-02-15 2020-08-20 Allen Institute Artificial expression constructs for selectively modulating gene expression in selected neuronal cell populations
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WO2021248085A2 (en) * 2020-06-04 2021-12-09 Allen Institute Artificial expression constructs for selectively modulating gene expression in inhibitory neocortical neurons
EP4185303A4 (en) * 2020-07-24 2024-10-30 University of Massachusetts Dna-binding domain transactivators and uses thereof
US20230302158A1 (en) * 2020-08-14 2023-09-28 Allen Institute Artificial expression constructs for modulating gene expression in striatal neurons
GB202013940D0 (en) 2020-09-04 2020-10-21 Synpromics Ltd Regulatory nucleic acid sequences
EP4244366A4 (en) * 2020-11-10 2024-12-25 Allen Institute Artificial expression constructs for modulating gene expression in chandelier cells
EP4277524A4 (en) * 2021-01-13 2025-06-04 Duke University Compositions for and methods of improving fluid flux in the brain
US20240182923A1 (en) * 2021-03-30 2024-06-06 Allen Institute Artificial expression constructs for modulating gene expression in claustrum neurons
AU2022276538A1 (en) * 2021-05-21 2023-11-09 Allen Institute Artificial expression constructs for modulating gene expression in neurons within the thalamus
CN113736734B (zh) * 2021-09-23 2022-10-25 中山大学中山眼科中心 一种用于灵长类动物神经元分离的试剂盒及方法
WO2023108021A1 (en) * 2021-12-07 2023-06-15 Allen Institute Artificial expression constructs for modulating gene expression in neocortical layer 4 or layer 5 intratelencephalic neurons
AU2023226080A1 (en) * 2022-02-24 2024-10-03 Allen Institute Artificial expression constructs for modulating gene expression in dopaminergic neurons
CN114752624B (zh) * 2022-04-08 2025-04-15 中国海洋大学 一种侏儒蛤卵子的电穿孔方法
WO2024011224A2 (en) * 2022-07-08 2024-01-11 The Trustees Of Columbia University In The City Of New York Regulatory element for cell type specific expression of genes in spinal motor neurons
WO2024238448A2 (en) * 2023-05-12 2024-11-21 Temple University - Of The Commonwealth System Of Higher Education Chimeric capsid recombinant adeno-associated virus with bbb penetration and microglia targeting (aav-bm)
CN117346715B (zh) * 2023-12-04 2024-03-08 成都深瑞同华科技有限公司 一种配电网架空线路弧垂测定方法、系统及存储介质

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EP3877529A4 (en) 2023-01-25
JP2026021360A (ja) 2026-02-10
EP3877529A1 (en) 2021-09-15
AU2025242185A1 (en) 2025-10-30
JP2022513426A (ja) 2022-02-08
WO2020097121A1 (en) 2020-05-14
AU2019375975B2 (en) 2025-07-10
JP7590962B2 (ja) 2024-11-27
US20210395780A1 (en) 2021-12-23
JP2025024092A (ja) 2025-02-19
JP7774695B2 (ja) 2025-11-21
AU2019375975A1 (en) 2021-06-17
US20250236886A1 (en) 2025-07-24
US12703873B2 (en) 2026-08-11

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