CA3118005C - Formulation aerosolisable - Google Patents
Formulation aerosolisable Download PDFInfo
- Publication number
- CA3118005C CA3118005C CA3118005A CA3118005A CA3118005C CA 3118005 C CA3118005 C CA 3118005C CA 3118005 A CA3118005 A CA 3118005A CA 3118005 A CA3118005 A CA 3118005A CA 3118005 C CA3118005 C CA 3118005C
- Authority
- CA
- Canada
- Prior art keywords
- formulation
- nicotine
- aerosolisable
- acid
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 502
- 238000009472 formulation Methods 0.000 title claims abstract description 466
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims abstract description 232
- 229960002715 nicotine Drugs 0.000 claims abstract description 213
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims abstract description 213
- 239000002253 acid Substances 0.000 claims abstract description 193
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 124
- 229920000858 Cyclodextrin Polymers 0.000 claims description 74
- 239000000443 aerosol Substances 0.000 claims description 55
- 229940097362 cyclodextrins Drugs 0.000 claims description 47
- 238000000034 method Methods 0.000 claims description 41
- 239000000796 flavoring agent Substances 0.000 claims description 31
- 235000019634 flavors Nutrition 0.000 claims description 30
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 21
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 21
- 150000007513 acids Chemical class 0.000 claims description 17
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 17
- 239000000463 material Substances 0.000 claims description 16
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- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 7
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- 229940075582 sorbic acid Drugs 0.000 claims description 7
- JOOXCMJARBKPKM-UHFFFAOYSA-N 4-oxopentanoic acid Chemical compound CC(=O)CCC(O)=O JOOXCMJARBKPKM-UHFFFAOYSA-N 0.000 claims description 6
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- 230000001953 sensory effect Effects 0.000 claims description 6
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- 239000011976 maleic acid Substances 0.000 claims description 3
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 3
- NFLGAXVYCFJBMK-RKDXNWHRSA-N (+)-isomenthone Natural products CC(C)[C@H]1CC[C@@H](C)CC1=O NFLGAXVYCFJBMK-RKDXNWHRSA-N 0.000 claims description 2
- RADIRXJQODWKGQ-HWKANZROSA-N 2-Ethoxy-5-(1-propenyl)phenol Chemical compound CCOC1=CC=C(\C=C\C)C=C1O RADIRXJQODWKGQ-HWKANZROSA-N 0.000 claims description 2
- NFLGAXVYCFJBMK-UHFFFAOYSA-N Menthone Chemical compound CC(C)C1CCC(C)CC1=O NFLGAXVYCFJBMK-UHFFFAOYSA-N 0.000 claims description 2
- 229930007503 menthone Natural products 0.000 claims description 2
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 claims description 2
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- 235000012141 vanillin Nutrition 0.000 claims description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims 2
- 244000126002 Ziziphus vulgaris Species 0.000 claims 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 99
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 99
- 238000012360 testing method Methods 0.000 description 19
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 description 12
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- 229940035437 1,3-propanediol Drugs 0.000 description 12
- 229920000166 polytrimethylene carbonate Polymers 0.000 description 12
- 239000003571 electronic cigarette Substances 0.000 description 10
- 239000002245 particle Substances 0.000 description 9
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
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- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 4
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- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 3
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- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- HOSGXJWQVBHGLT-UHFFFAOYSA-N 6-hydroxy-3,4-dihydro-1h-quinolin-2-one Chemical group N1C(=O)CCC2=CC(O)=CC=C21 HOSGXJWQVBHGLT-UHFFFAOYSA-N 0.000 description 1
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
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- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
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- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
- A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/24—Treatment of tobacco products or tobacco substitutes by extraction; Tobacco extracts
- A24B15/241—Extraction of specific substances
- A24B15/243—Nicotine
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/10—Devices using liquid inhalable precursors
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Manufacture Of Tobacco Products (AREA)
Abstract
L'invention concerne une formulation aérosolisable comprenant (i) de l'eau en une quantité d'au moins 20% en poids sur la base de la formulation aérosolisable; (ii) de la nicotine; et (iii) un acide qui est au moins partiellement soluble dans l'eau; au moins 5% en poids de la nicotine présente dans la formulation étant sous forme protonée; et la formulation ayant un pH de 4 à 6.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1817867.3A GB201817867D0 (en) | 2018-11-01 | 2018-11-01 | Aerosolisable formulation |
GB1817867.3 | 2018-11-01 | ||
PCT/GB2019/053086 WO2020089633A1 (fr) | 2018-11-01 | 2019-10-31 | Formulation aérosolisable |
Publications (2)
Publication Number | Publication Date |
---|---|
CA3118005A1 CA3118005A1 (fr) | 2020-05-07 |
CA3118005C true CA3118005C (fr) | 2024-03-26 |
Family
ID=64655382
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA3118005A Active CA3118005C (fr) | 2018-11-01 | 2019-10-31 | Formulation aerosolisable |
Country Status (13)
Country | Link |
---|---|
US (1) | US20230270154A1 (fr) |
EP (1) | EP3873241A1 (fr) |
JP (2) | JP2022506073A (fr) |
KR (1) | KR20210074307A (fr) |
CN (1) | CN113260261A (fr) |
AU (1) | AU2019371078B2 (fr) |
BR (1) | BR112021008570A2 (fr) |
CA (1) | CA3118005C (fr) |
GB (1) | GB201817867D0 (fr) |
IL (1) | IL282617A (fr) |
MX (1) | MX2021005164A (fr) |
UA (1) | UA127838C2 (fr) |
WO (1) | WO2020089633A1 (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB202013489D0 (en) | 2020-08-27 | 2020-10-14 | Nicoventures Holdings Ltd | Consumable |
US11771132B2 (en) | 2020-08-27 | 2023-10-03 | Rai Strategic Holdings, Inc. | Atomization nozzle for aerosol delivery device |
US11771136B2 (en) | 2020-09-28 | 2023-10-03 | Rai Strategic Holdings, Inc. | Aerosol delivery device |
CN114983001A (zh) * | 2021-03-02 | 2022-09-02 | 深圳雾灵科技有限公司 | 一种烟草产品的添加剂及其制备方法和应用 |
CN113940440A (zh) * | 2021-09-30 | 2022-01-18 | 深圳市真味生物科技有限公司 | 一种高效传输的电子雾化液 |
WO2023214678A1 (fr) * | 2022-05-04 | 2023-11-09 | 주식회사 케이티앤지 | Produit de génération d'aérosol et système de génération d'aérosol |
KR20230166197A (ko) * | 2022-05-30 | 2023-12-07 | 주식회사 케이티앤지 | 에어로졸 발생 물품 및 에어로졸 발생 시스템 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0201669D0 (sv) * | 2002-06-03 | 2002-06-03 | Pharmacia Ab | New formulation and use thereof |
US7767698B2 (en) * | 2002-06-03 | 2010-08-03 | Mcneil Ab | Formulation and use thereof |
SE536491C2 (sv) * | 2012-03-26 | 2013-12-27 | Bionicotine Ab | Påse innehållande nikotin och en tuggummikomposition |
GB201215273D0 (en) * | 2012-08-28 | 2012-10-10 | Kind Consumer Ltd | Nicotine composition |
CN117137195A (zh) * | 2013-05-06 | 2023-12-01 | 尤尔实验室有限公司 | 用于气溶胶装置的烟碱盐调配物及其方法 |
KR102665932B1 (ko) * | 2013-12-05 | 2024-05-13 | 쥴 랩스, 인크. | 에어로졸 장치를 위한 니코틴 액제 및 그 방법 |
TWI664918B (zh) * | 2014-05-21 | 2019-07-11 | 瑞士商菲利浦莫里斯製品股份有限公司 | 可感應加熱的菸草產品 |
GB201413835D0 (en) * | 2014-08-05 | 2014-09-17 | Nicoventures Holdings Ltd | Electronic vapour provision system |
GB2535427A (en) * | 2014-11-07 | 2016-08-24 | Nicoventures Holdings Ltd | Solution |
GB201508671D0 (en) * | 2015-05-20 | 2015-07-01 | British American Tobacco Co | Aerosol generating material and devices including the same |
US10327472B2 (en) * | 2015-09-25 | 2019-06-25 | Altria Client Services Llc | Pre-vaporization formulation for controlling acidity in an e-vaping device |
DE102015117811A1 (de) * | 2015-10-20 | 2017-04-20 | Chv Pharma Gmbh & Co. Kg | Inhalator sowie wirkstoffhaltige Zubereitung für einen Inhalator |
US20180199618A1 (en) * | 2016-09-27 | 2018-07-19 | Bond Street Manufacturing Llc | Vaporizable Tobacco Wax Compositions and Container thereof |
EP3574902A1 (fr) * | 2018-06-01 | 2019-12-04 | Yatzz Limited | Formulation de nicotine et mode d'administration |
-
2018
- 2018-11-01 GB GBGB1817867.3A patent/GB201817867D0/en not_active Ceased
-
2019
- 2019-10-31 BR BR112021008570-0A patent/BR112021008570A2/pt unknown
- 2019-10-31 CA CA3118005A patent/CA3118005C/fr active Active
- 2019-10-31 JP JP2021523231A patent/JP2022506073A/ja active Pending
- 2019-10-31 WO PCT/GB2019/053086 patent/WO2020089633A1/fr unknown
- 2019-10-31 KR KR1020217012898A patent/KR20210074307A/ko not_active Application Discontinuation
- 2019-10-31 MX MX2021005164A patent/MX2021005164A/es unknown
- 2019-10-31 US US17/290,652 patent/US20230270154A1/en active Pending
- 2019-10-31 AU AU2019371078A patent/AU2019371078B2/en active Active
- 2019-10-31 CN CN201980087212.9A patent/CN113260261A/zh active Pending
- 2019-10-31 EP EP19798361.2A patent/EP3873241A1/fr active Pending
- 2019-10-31 UA UAA202102266A patent/UA127838C2/uk unknown
-
2021
- 2021-04-25 IL IL282617A patent/IL282617A/en unknown
-
2023
- 2023-06-20 JP JP2023101027A patent/JP2023120357A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
IL282617A (en) | 2021-06-30 |
UA127838C2 (uk) | 2024-01-17 |
US20230270154A1 (en) | 2023-08-31 |
KR20210074307A (ko) | 2021-06-21 |
JP2023120357A (ja) | 2023-08-29 |
JP2022506073A (ja) | 2022-01-17 |
WO2020089633A1 (fr) | 2020-05-07 |
BR112021008570A2 (pt) | 2021-08-03 |
AU2019371078A1 (en) | 2021-05-27 |
CA3118005A1 (fr) | 2020-05-07 |
AU2019371078B2 (en) | 2022-07-14 |
MX2021005164A (es) | 2021-07-15 |
CN113260261A (zh) | 2021-08-13 |
GB201817867D0 (en) | 2018-12-19 |
EP3873241A1 (fr) | 2021-09-08 |
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