CA3116406A1 - Culture de lymphocytes infiltrant les tumeurs issus d'une digestion de tumeur - Google Patents
Culture de lymphocytes infiltrant les tumeurs issus d'une digestion de tumeur Download PDFInfo
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Mycology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Les lymphocytes infiltrant les tumeurs (TIL) sont des cellules immunitaires qui ont quitté la circulation sanguine et migré dans une tumeur. Les TIL ont été utilisés en thérapie de transfert adoptif autoplastique pour le traitement du cancer. L'invention concerne des méthodes permettant une expansion rapide des lymphocytes infiltrant les tumeurs en utilisant des cellules tumorales provenant d'une digestion enzymatique.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862735451P | 2018-09-24 | 2018-09-24 | |
| US62/735,451 | 2018-09-24 | ||
| PCT/US2019/052681 WO2020068816A1 (fr) | 2018-09-24 | 2019-09-24 | Culture de lymphocytes infiltrant les tumeurs issus d'une digestion de tumeur |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3116406A1 true CA3116406A1 (fr) | 2020-04-02 |
Family
ID=69953544
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3116406A Pending CA3116406A1 (fr) | 2018-09-24 | 2019-09-24 | Culture de lymphocytes infiltrant les tumeurs issus d'une digestion de tumeur |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20220002673A1 (fr) |
| EP (1) | EP3856208A4 (fr) |
| CA (1) | CA3116406A1 (fr) |
| WO (1) | WO2020068816A1 (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022221525A1 (fr) * | 2021-04-16 | 2022-10-20 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Culture de lymphocytes infiltrant les tumeurs issus d'une digestion de tumeur |
| WO2023167977A2 (fr) * | 2022-03-02 | 2023-09-07 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Culture de lymphocytes infiltrant les tumeurs issus d'un produit de digestion de tumeur |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120244133A1 (en) * | 2011-03-22 | 2012-09-27 | The United States of America, as represented by the Secretary, Department of Health and | Methods of growing tumor infiltrating lymphocytes in gas-permeable containers |
| US10233425B2 (en) * | 2013-09-16 | 2019-03-19 | The Trustees Of The University Of Pennsylvania | CD137 enrichment for efficient tumor infiltrating lymphocyte selection |
| EP3154350B1 (fr) * | 2014-04-10 | 2024-03-27 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Expansion améliorée des lymphocytes infiltrants des tumeurs pour thérapie cellulaire adoptive |
| WO2018204761A1 (fr) * | 2017-05-05 | 2018-11-08 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Procédé rapide de culture de lymphocytes infiltrant les tumeurs |
| WO2022221525A1 (fr) * | 2021-04-16 | 2022-10-20 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Culture de lymphocytes infiltrant les tumeurs issus d'une digestion de tumeur |
-
2019
- 2019-09-24 EP EP19866416.1A patent/EP3856208A4/fr active Pending
- 2019-09-24 US US17/279,327 patent/US20220002673A1/en active Pending
- 2019-09-24 CA CA3116406A patent/CA3116406A1/fr active Pending
- 2019-09-24 WO PCT/US2019/052681 patent/WO2020068816A1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20220002673A1 (en) | 2022-01-06 |
| EP3856208A1 (fr) | 2021-08-04 |
| EP3856208A4 (fr) | 2022-07-06 |
| WO2020068816A1 (fr) | 2020-04-02 |
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