CA3102955A1 - Multistrain population control systems and methods - Google Patents

Multistrain population control systems and methods Download PDF

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Publication number
CA3102955A1
CA3102955A1 CA3102955A CA3102955A CA3102955A1 CA 3102955 A1 CA3102955 A1 CA 3102955A1 CA 3102955 A CA3102955 A CA 3102955A CA 3102955 A CA3102955 A CA 3102955A CA 3102955 A1 CA3102955 A1 CA 3102955A1
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Canada
Prior art keywords
toxin
strain
bacterial strain
hours
bacterial
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Pending
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CA3102955A
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English (en)
French (fr)
Inventor
Jeff HASTY
Michael Julius LIAO
Muhammad Omar Din
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University of California San Diego UCSD
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University of California San Diego UCSD
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Publication of CA3102955A1 publication Critical patent/CA3102955A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P39/00—Processes involving microorganisms of different genera in the same process, simultaneously
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K2035/11—Medicinal preparations comprising living procariotic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K2035/11—Medicinal preparations comprising living procariotic cells
    • A61K2035/115—Probiotics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185—Escherichia
    • C12R2001/19—Escherichia coli

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA3102955A 2018-06-08 2019-06-07 Multistrain population control systems and methods Pending CA3102955A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862682755P 2018-06-08 2018-06-08
US62/682,755 2018-06-08
PCT/US2019/036179 WO2019237083A1 (en) 2018-06-08 2019-06-07 Multistrain population control systems and methods

Publications (1)

Publication Number Publication Date
CA3102955A1 true CA3102955A1 (en) 2019-12-12

Family

ID=68770625

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3102955A Pending CA3102955A1 (en) 2018-06-08 2019-06-07 Multistrain population control systems and methods

Country Status (6)

Country Link
US (2) US11896626B2 (https=)
EP (1) EP3801582A4 (https=)
JP (1) JP2021526802A (https=)
CN (1) CN112601536B (https=)
CA (1) CA3102955A1 (https=)
WO (1) WO2019237083A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107709558B (zh) 2015-04-09 2022-05-13 加利福尼亚大学董事会 用于治疗物的产生和释放的工程化细菌
EP3801582A4 (en) * 2018-06-08 2022-07-06 The Regents of the University of California SYSTEMS AND METHODS FOR REGULATING MULTI-STRAINS POPULATIONS
WO2021119436A1 (en) * 2019-12-13 2021-06-17 The Regents Of The University Of California Compositions and methods of using inducible signaling for tunable dyanmics in microbial communities
KR102575631B1 (ko) * 2023-03-07 2023-09-06 천준영 미세조류 생화학적 봉쇄 방법
KR102562275B1 (ko) * 2023-03-07 2023-07-31 천준영 미세조류의 생화학적 봉쇄 방법 및 이를 적용한 유전자 조작된 미세조류 이용 하폐수 정화 방법
EP4724111A2 (en) * 2023-06-08 2026-04-15 The Trustees Of Columbia University In The City Of New York Intracellular delivery of therapeutic cargos and viral rnas by engineered salmonella

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JP2003532698A (ja) * 2000-05-10 2003-11-05 プリンストン ユニバーシティ 細菌の増殖および病理発生を調節するための化合物ならびに方法
US8858930B2 (en) * 2004-10-26 2014-10-14 Chengru Zhu Live attenuated bacterial vaccine to reduce or inhibit carriage and shedding of enterohemorrhagic Escherichia coli in cattle
EP1655370A1 (en) 2004-11-05 2006-05-10 Gesellschaft für Biotechnologische Forschung Bacterial vector
WO2008045333A2 (en) 2006-10-05 2008-04-17 Tyco Healthcare Group Lp Flexible endoscopic stitching devices
EP2114992A2 (en) * 2007-01-09 2009-11-11 Yissum Research Development Company, of The Hebrew University of Jerusalem Anti-bacterial peptides and methods of treating diseases using same
WO2010022260A2 (en) * 2008-08-20 2010-02-25 University Of Medicine And Dentistry Of New Jersey Novel toxin-antitoxin system
EP2182068A1 (en) 2008-10-28 2010-05-05 DKFZ Deutsches Krebsforschungszentrum Use of bacteria for the sensing and killing of cancer cells
CN201362719Y (zh) 2009-01-15 2009-12-16 北京航空航天大学 一种实现细胞间振荡子同步的电路结构
JP5612269B2 (ja) * 2009-04-24 2014-10-22 花王株式会社 歯周病マーカー
WO2011150421A2 (en) 2010-05-28 2011-12-01 The Arizona Board Of Regents For And On Behalf Of Arizona State University Recombinant bacterium to decrease tumor growth
US8942321B2 (en) 2010-09-22 2015-01-27 Qualcomm Incorporated Efficient compressed sensing channel estimation for single-carrier communication systems
WO2013003597A1 (en) * 2011-06-30 2013-01-03 Exxonmobil Research And Engineering Company Regulation of toxin and antitoxin genes for biological containment
US9603877B2 (en) 2011-08-31 2017-03-28 Nanyang Technological University Isolated nucleotide molecule and method of sensing and killing of pathogenic microorganism
US9044020B2 (en) 2011-08-31 2015-06-02 Nanyang Technological University Isolated nucleotide molecule and method of sensing and killing of pathogenic microorganism
CA2884816A1 (en) 2012-09-13 2014-03-20 Massachusetts Institute Of Technology Programmable drug delivery profiles of tumor-targeted bacteria
SE537235C2 (sv) 2012-09-21 2015-03-10 Valeas Recycling Ab Förfarande och arrangemang för återvinning av förångningsbara ämnen ur en slagg medelst plasmainducerad förångning
WO2014098767A1 (en) 2012-12-21 2014-06-26 Nanyang Technological University Programmable synthetic lysis system for controlled release of macromolecules
US9593339B1 (en) * 2013-02-14 2017-03-14 David Gordon Bermudes Bacteria carrying bacteriophage and protease inhibitors for the treatment of disorders and methods of treatment
KR20210100224A (ko) * 2014-04-15 2021-08-13 에이오바이오미 엘엘씨 암모니아-산화 니트로소모나스 유트로파 균주 d23
KR101647491B1 (ko) 2014-06-25 2016-08-11 전남대학교산학협력단 유도자 불요구성 자가세포농도 인식 자가 유도시스템 및 그의 용도
CN104131018A (zh) 2014-07-31 2014-11-05 厦门大学 一种细胞内蛋白自诱导表达的方法
CN107709558B (zh) 2015-04-09 2022-05-13 加利福尼亚大学董事会 用于治疗物的产生和释放的工程化细菌
IL294171A (en) * 2016-05-25 2022-08-01 Mybiotics Pharma Ltd Composition and methods for microbiota therapy
US20210284953A1 (en) 2017-05-19 2021-09-16 The Regents Of The University Of California Synthetic quorum-regulated lysis
EP3801582A4 (en) * 2018-06-08 2022-07-06 The Regents of the University of California SYSTEMS AND METHODS FOR REGULATING MULTI-STRAINS POPULATIONS
WO2021119436A1 (en) 2019-12-13 2021-06-17 The Regents Of The University Of California Compositions and methods of using inducible signaling for tunable dyanmics in microbial communities

Also Published As

Publication number Publication date
US11896626B2 (en) 2024-02-13
CN112601536B (zh) 2024-01-09
US20240350559A1 (en) 2024-10-24
US20210169941A1 (en) 2021-06-10
EP3801582A4 (en) 2022-07-06
EP3801582A1 (en) 2021-04-14
JP2021526802A (ja) 2021-10-11
WO2019237083A1 (en) 2019-12-12
CN112601536A (zh) 2021-04-02

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