CA3101264A1 - Chromatography valve for fluid analysis - Google Patents
Chromatography valve for fluid analysis Download PDFInfo
- Publication number
- CA3101264A1 CA3101264A1 CA3101264A CA3101264A CA3101264A1 CA 3101264 A1 CA3101264 A1 CA 3101264A1 CA 3101264 A CA3101264 A CA 3101264A CA 3101264 A CA3101264 A CA 3101264A CA 3101264 A1 CA3101264 A1 CA 3101264A1
- Authority
- CA
- Canada
- Prior art keywords
- cartridge
- valve according
- chromatography
- ports
- channel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000012530 fluid Substances 0.000 title claims abstract description 111
- 238000004587 chromatography analysis Methods 0.000 title claims abstract description 79
- 238000004458 analytical method Methods 0.000 title claims abstract description 14
- 238000000034 method Methods 0.000 claims abstract description 20
- 230000005465 channeling Effects 0.000 claims abstract description 4
- 230000003068 static effect Effects 0.000 claims description 122
- 238000010926 purge Methods 0.000 claims description 56
- 238000005070 sampling Methods 0.000 claims description 39
- 238000007789 sealing Methods 0.000 claims description 38
- 238000004891 communication Methods 0.000 claims description 37
- 238000003825 pressing Methods 0.000 claims description 24
- 238000010438 heat treatment Methods 0.000 claims description 9
- 239000012535 impurity Substances 0.000 claims description 7
- 239000011248 coating agent Substances 0.000 claims description 6
- 238000000576 coating method Methods 0.000 claims description 6
- 239000002245 particle Substances 0.000 claims description 4
- 230000006835 compression Effects 0.000 claims description 2
- 238000007906 compression Methods 0.000 claims description 2
- 239000000463 material Substances 0.000 description 22
- 238000004519 manufacturing process Methods 0.000 description 6
- 238000002347 injection Methods 0.000 description 5
- 239000007924 injection Substances 0.000 description 5
- 239000012159 carrier gas Substances 0.000 description 4
- 239000007789 gas Substances 0.000 description 4
- 230000008016 vaporization Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 2
- 239000000919 ceramic Substances 0.000 description 2
- 239000000356 contaminant Substances 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 229920003223 poly(pyromellitimide-1,4-diphenyl ether) Polymers 0.000 description 2
- 238000010146 3D printing Methods 0.000 description 1
- 239000004696 Poly ether ether ketone Substances 0.000 description 1
- 239000004642 Polyimide Substances 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- JUPQTSLXMOCDHR-UHFFFAOYSA-N benzene-1,4-diol;bis(4-fluorophenyl)methanone Chemical compound OC1=CC=C(O)C=C1.C1=CC(F)=CC=C1C(=O)C1=CC=C(F)C=C1 JUPQTSLXMOCDHR-UHFFFAOYSA-N 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000004868 gas analysis Methods 0.000 description 1
- 239000002241 glass-ceramic Substances 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- 238000011017 operating method Methods 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920002530 polyetherether ketone Polymers 0.000 description 1
- 229920001721 polyimide Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000007779 soft material Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
- G01N30/20—Injection using a sampling valve
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K11/00—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves
- F16K11/02—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit
- F16K11/06—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit comprising only sliding valves, i.e. sliding closure elements
- F16K11/065—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit comprising only sliding valves, i.e. sliding closure elements with linearly sliding closure members
- F16K11/0655—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit comprising only sliding valves, i.e. sliding closure elements with linearly sliding closure members with flat slides
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K11/00—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves
- F16K11/02—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit
- F16K11/06—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit comprising only sliding valves, i.e. sliding closure elements
- F16K11/072—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit comprising only sliding valves, i.e. sliding closure elements with pivoted closure members
- F16K11/074—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit comprising only sliding valves, i.e. sliding closure elements with pivoted closure members with flat sealing faces
- F16K11/0743—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit comprising only sliding valves, i.e. sliding closure elements with pivoted closure members with flat sealing faces with both the supply and the discharge passages being on one side of the closure plates
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K49/00—Means in or on valves for heating or cooling
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K49/00—Means in or on valves for heating or cooling
- F16K49/002—Electric heating means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
- G01N30/20—Injection using a sampling valve
- G01N2030/202—Injection using a sampling valve rotary valves
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
- G01N30/20—Injection using a sampling valve
- G01N2030/207—Injection using a sampling valve with metering cavity, e.g. sample loop
- G01N2030/208—Injection using a sampling valve with metering cavity, e.g. sample loop with more than one cavity
Landscapes
- General Engineering & Computer Science (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Multiple-Way Valves (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862679244P | 2018-06-01 | 2018-06-01 | |
| US62/679,244 | 2018-06-01 | ||
| PCT/CA2019/050759 WO2019227231A1 (en) | 2018-06-01 | 2019-05-31 | Chromatography valve for fluid analysis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3101264A1 true CA3101264A1 (en) | 2019-12-05 |
Family
ID=68696596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3101264A Pending CA3101264A1 (en) | 2018-06-01 | 2019-05-31 | Chromatography valve for fluid analysis |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11885774B2 (https=) |
| EP (1) | EP3803376B1 (https=) |
| JP (1) | JP7464536B2 (https=) |
| CA (1) | CA3101264A1 (https=) |
| WO (1) | WO2019227231A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7728262B2 (ja) * | 2019-12-18 | 2025-08-22 | メカニック アナリティク インコーポレイテッド | パルスパージダイヤフラム弁および関連する方法 |
| US12553867B2 (en) | 2020-12-15 | 2026-02-17 | Mecanique Analytique Inc. | Variable load chromatography valve for fluid analysis |
| US12320441B1 (en) * | 2021-02-08 | 2025-06-03 | Schivo Medical Limited | Centering electronic rotary valve |
| CN115015442B (zh) * | 2022-07-19 | 2023-11-14 | 国网安徽省电力有限公司电力科学研究院 | 基于梯度油样校验法的实验室气相色谱仪校验装置及方法 |
| DE102023119806A1 (de) * | 2023-07-26 | 2025-01-30 | Hochschule Aalen, Körperschaft des öffentlichen Rechts | Vorrichtung zum Transfer einer Flüssigkeitsprobe innerhalb eines mikrofluidischen Systems |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3267736A (en) * | 1964-01-20 | 1966-08-23 | Cons Electrodynamics Corp | Chromatographic sampling valve |
| JPS4632560Y1 (https=) * | 1966-07-15 | 1971-11-10 | ||
| US3916465A (en) * | 1972-10-26 | 1975-11-04 | Hooker Chemicals Plastics Corp | Multi-stream gas chromatographic method and apparatus |
| US6193213B1 (en) * | 1999-03-05 | 2001-02-27 | Valco Instruments Company, Inc. | Variable pressure loading system utilizing combined spring and fluid pressure |
| US6910503B2 (en) * | 2001-05-25 | 2005-06-28 | Upchurch Scientific, Inc. | Methods and apparatus for micro-fluidic analytical chemistry |
| JP2007523307A (ja) | 2004-02-19 | 2007-08-16 | ウオーターズ・インベストメンツ・リミテツド | ピンバルブアセンブリ |
| CA2577824C (en) * | 2004-08-25 | 2012-02-07 | Systeme Analytique Inc. | Rotary valve and analytical chromatographic system using the same |
| US7216528B2 (en) * | 2005-02-22 | 2007-05-15 | Mecanique Analytique Inc. | Diaphragm-sealed valve, analytical chromatographic system and method using the same |
| US7544293B2 (en) * | 2005-09-26 | 2009-06-09 | Semba Inc. | Valve and process for interrupted continuous flow chromatography |
| US7377291B2 (en) * | 2005-12-28 | 2008-05-27 | Serveron Corporation | Multiport rotary valve |
| US7740705B2 (en) * | 2006-03-08 | 2010-06-22 | Tokyo Electron Limited | Exhaust apparatus configured to reduce particle contamination in a deposition system |
| WO2009073966A1 (en) * | 2007-12-12 | 2009-06-18 | Mecanique Analytique Inc. | Diaphragm-sealed valve with process purging groove |
| US8876081B2 (en) | 2009-07-13 | 2014-11-04 | Idex Health & Science Llc | Rotary shear valve assembly with a polymer insert device |
| DE102010042265A1 (de) | 2010-10-11 | 2012-04-12 | PARltec GmbH | Ventil, Vorrichtung mit Ventil, Verwendung des Ventils in der Vorrichtung, Mikropumpe mit Ventil, Verneblersystem mit Ventil und Dosier-/Mischvorrichtung mit Ventil |
| US20130206653A1 (en) | 2010-10-29 | 2013-08-15 | John E. Brann | Modular Multiple-Column Chromatography Cartridge |
| JP2016509242A (ja) * | 2013-03-11 | 2016-03-24 | メカニック・アナリティック・インコーポレーテッド | 密封組立体を備えるダイヤフラム弁、これを含むクロマトグラフシステム、及びその作動方法 |
| JP5928376B2 (ja) * | 2013-03-15 | 2016-06-01 | 株式会社島津製作所 | 流路切換バルブ |
| JP5928375B2 (ja) * | 2013-03-15 | 2016-06-01 | 株式会社島津製作所 | 流路切換バルブ |
| US9739383B2 (en) | 2014-07-29 | 2017-08-22 | Idex Health & Science Llc | Multi-path selector valve |
| JP2016173249A (ja) | 2015-03-16 | 2016-09-29 | 王子ホールディングス株式会社 | サンプル供給装置 |
| US10520477B2 (en) * | 2016-12-09 | 2019-12-31 | Idex Health & Science Llc | High pressure valve with multi-piece stator assembly |
-
2019
- 2019-05-31 EP EP19812086.7A patent/EP3803376B1/en active Active
- 2019-05-31 WO PCT/CA2019/050759 patent/WO2019227231A1/en not_active Ceased
- 2019-05-31 JP JP2020565800A patent/JP7464536B2/ja active Active
- 2019-05-31 US US17/058,017 patent/US11885774B2/en active Active
- 2019-05-31 CA CA3101264A patent/CA3101264A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2021525363A (ja) | 2021-09-24 |
| EP3803376A4 (en) | 2022-03-16 |
| US20210199625A1 (en) | 2021-07-01 |
| EP3803376B1 (en) | 2024-04-03 |
| WO2019227231A1 (en) | 2019-12-05 |
| EP3803376A1 (en) | 2021-04-14 |
| JP7464536B2 (ja) | 2024-04-09 |
| US11885774B2 (en) | 2024-01-30 |
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