CA3100065A1 - Methods and apparatus for multi-modal prediction using a trained statistical model - Google Patents

Methods and apparatus for multi-modal prediction using a trained statistical model Download PDF

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Publication number
CA3100065A1
CA3100065A1 CA3100065A CA3100065A CA3100065A1 CA 3100065 A1 CA3100065 A1 CA 3100065A1 CA 3100065 A CA3100065 A CA 3100065A CA 3100065 A CA3100065 A CA 3100065A CA 3100065 A1 CA3100065 A1 CA 3100065A1
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modality
data
encoder
gene
training
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French (fr)
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Jonathan M. Rothberg
Henri Lichenstein
Umut ESER
Michael Meyer
Marylens HERNANDEZ
Tian Xu
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Quantum Si Inc
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Quantum Si Inc
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    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20Supervised data analysis
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00ICT programming tools or database systems specially adapted for bioinformatics
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16CCOMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/30Prediction of properties of chemical compounds, compositions or mixtures
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16CCOMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/70Machine learning, data mining or chemometrics

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  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
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  • Bioinformatics & Computational Biology (AREA)
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  • General Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Evolutionary Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Data Mining & Analysis (AREA)
  • Chemical & Material Sciences (AREA)
  • Databases & Information Systems (AREA)
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  • Artificial Intelligence (AREA)
  • Crystallography & Structural Chemistry (AREA)
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  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
CA3100065A 2018-05-30 2019-05-08 Methods and apparatus for multi-modal prediction using a trained statistical model Pending CA3100065A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862678083P 2018-05-30 2018-05-30
US201862678094P 2018-05-30 2018-05-30
US62/678,094 2018-05-30
US62/678,083 2018-05-30
PCT/US2019/031260 WO2019231624A2 (en) 2018-05-30 2019-05-08 Methods and apparatus for multi-modal prediction using a trained statistical model

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CA3100065A1 true CA3100065A1 (en) 2019-12-05

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CA3100065A Pending CA3100065A1 (en) 2018-05-30 2019-05-08 Methods and apparatus for multi-modal prediction using a trained statistical model

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EP (1) EP3803884A2 (https=)
JP (1) JP7490576B2 (https=)
KR (1) KR20210018333A (https=)
CN (1) CN112513990A (https=)
AU (1) AU2019276730A1 (https=)
BR (1) BR112020023429A2 (https=)
CA (1) CA3100065A1 (https=)
MX (1) MX2020012899A (https=)
WO (1) WO2019231624A2 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022006676A1 (en) * 2020-07-09 2022-01-13 Mcmaster University Machine learning prediction of biological effect in multicellular animals from microorganism transcriptional fingerprint patterns in non-inhibitory chemical challenge
CN114334038A (zh) * 2021-12-31 2022-04-12 杭州师范大学 一种基于异质网络嵌入模型的疾病药物预测方法
CN114792573A (zh) * 2022-04-18 2022-07-26 北京百度网讯科技有限公司 药物联用的效果预测方法、模型训练方法、装置及设备
CN119830148A (zh) * 2024-11-14 2025-04-15 安徽理工大学 基于自监督空间学习的跨模态轴承故障诊断方法
WO2026076576A1 (en) * 2024-10-08 2026-04-16 Huawei Technologies Co., Ltd. Devices and methods for in-network learning for dynamic wireless networks

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201904887D0 (en) * 2019-04-05 2019-05-22 Lifebit Biotech Ltd Lifebit al
JP7332238B2 (ja) * 2020-03-10 2023-08-23 エスアールアイ インターナショナル タスク固有のデータ利用のための物理学により誘導されたディープマルチモーダル埋め込みのための方法及び装置
CN111540405B (zh) * 2020-04-29 2023-07-07 新疆大学 一种基于快速网络嵌入的疾病基因预测方法
CN111627515B (zh) * 2020-05-29 2023-07-18 上海商汤智能科技有限公司 药物推荐方法、装置、电子设备及介质
CN111950295A (zh) * 2020-08-10 2020-11-17 北京嘀嘀无限科技发展有限公司 一种训练自然语言处理模型的方法和系统
CN112151127A (zh) * 2020-09-04 2020-12-29 牛张明 基于分子语义向量的无监督学习药物虚拟筛选方法和系统
KR20230137869A (ko) * 2020-09-25 2023-10-05 리누스 헬스 인코포레이티드 기계 학습 보조 인지 평가 및 치료를 위한 시스템들 및 방법들
US11756572B2 (en) 2020-12-02 2023-09-12 Google Llc Self-supervised speech representations for fake audio detection
CN112700277B (zh) * 2020-12-30 2024-05-28 北京爱笔科技有限公司 用户行为数据的处理方法和多行为序列转化模型训练方法
US12579111B2 (en) * 2020-12-31 2026-03-17 International Business Machines Corporation Cross-domain structural mapping in machine learning processing
CN112862727B (zh) * 2021-03-16 2023-06-23 上海壁仞智能科技有限公司 一种跨模态图像转换方法及装置
CN113223655B (zh) * 2021-05-07 2023-05-12 西安电子科技大学 基于变分自编码器的药物-疾病关联预测方法
JP7674636B2 (ja) * 2021-09-27 2025-05-12 オムロン株式会社 モデル生成方法、データ提示方法、データ生成方法、推定方法、モデル生成装置、データ提示装置、データ生成装置、及び推定装置
CN113869417B (zh) * 2021-09-28 2025-11-14 清华大学 基于自监督和多模态的基因数据模型训练方法及装置
CN113987345A (zh) * 2021-10-27 2022-01-28 北京百度网讯科技有限公司 数据处理的方法、装置、设备、存储介质及程序产品
CN114049930B (zh) * 2021-11-12 2024-07-16 东南大学 一种基于异质网络表示学习的中药药方重定位方法
CN114429787B (zh) * 2021-12-30 2023-04-18 北京百度网讯科技有限公司 组学数据处理方法、装置、电子设备和存储介质
CN114613450B (zh) * 2022-03-09 2025-09-19 平安科技(深圳)有限公司 药物分子的性质预测方法、装置、存储介质及计算机设备
CN114626480B (zh) * 2022-03-22 2024-12-13 国网智能电网研究院有限公司 多源异构数据特征提取装置、方法、存储介质及电子设备
WO2023193935A1 (en) * 2022-04-08 2023-10-12 NEC Laboratories Europe GmbH Method and system for predicting gene expression perturbations
KR102841093B1 (ko) * 2022-04-18 2025-07-31 한양대학교 산학협력단 모달리티의 고유 특성을 보존하는 멀티미디어 추천 방법 및 시스템
CN118158425A (zh) * 2022-11-30 2024-06-07 华为技术有限公司 图像压缩系统、图像处理方法和编解码方法及电子设备
CN115587257B (zh) * 2022-12-13 2023-04-07 阿里巴巴(中国)有限公司 模型超参数优化方法、存储介质和电子设备
KR20240108318A (ko) * 2022-12-30 2024-07-09 건국대학교 글로컬산학협력단 머신 러닝 기반 메타 분석을 이용하여 계산된 일치된 가중치 연결 점수의 앙상블에 의한 신약 재창출 후보군 예측 방법 및 장치
CN116524997B (zh) * 2023-05-04 2024-07-16 电子科技大学 基于经典-量子混合神经网络实现药物相互作用结果的预测系统
CN116244484B (zh) * 2023-05-11 2023-08-08 山东大学 一种面向不平衡数据的联邦跨模态检索方法及系统
WO2024263011A1 (ko) * 2023-06-23 2024-12-26 주식회사 엘지 경영개발원 멀티태스킹 모델 학습 방법 및 이를 기초로 학습된 머신러닝 모델을 이용한 멀티태스킹 수행 방법
WO2025015037A1 (en) * 2023-07-10 2025-01-16 Symphony Diagnostics, Inc. Systems and methods for animal health assessment, surveillance, and enhancement
CN117133436A (zh) * 2023-10-17 2023-11-28 哈尔滨工业大学(深圳)(哈尔滨工业大学深圳科技创新研究院) 基于多源数据融合的药物疾病关联预测方法、装置及设备
WO2025105524A1 (ko) * 2023-11-15 2025-05-22 엘지전자 주식회사 인공 지능 서버 및 그의 동작 방법
CN118352085B (zh) * 2024-06-14 2024-09-17 之江实验室 基于多时间点多模态脑影像数据的脑疾病病程预测系统
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Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6202049B1 (en) 1999-03-09 2001-03-13 Matsushita Electric Industrial Co., Ltd. Identification of unit overlap regions for concatenative speech synthesis system
JP5229478B2 (ja) 2008-12-25 2013-07-03 日本電気株式会社 統計モデル学習装置、統計モデル学習方法、およびプログラム
JP2013211616A (ja) 2012-03-30 2013-10-10 Sony Corp 端末装置、端末制御方法、プログラム、および情報処理システム
US20160170982A1 (en) * 2014-12-16 2016-06-16 Yahoo! Inc. Method and System for Joint Representations of Related Concepts
JP2019512758A (ja) 2016-01-15 2019-05-16 株式会社Preferred Networks マルチモーダル生成機械学習のためのシステムおよび方法
GB201615051D0 (en) 2016-09-05 2016-10-19 Kheiron Medical Tech Ltd Multi-modal medical image procesing
CN107545151B (zh) * 2017-09-01 2020-10-16 中南大学 一种基于低秩矩阵填充的药物重定位方法

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022006676A1 (en) * 2020-07-09 2022-01-13 Mcmaster University Machine learning prediction of biological effect in multicellular animals from microorganism transcriptional fingerprint patterns in non-inhibitory chemical challenge
CN114334038A (zh) * 2021-12-31 2022-04-12 杭州师范大学 一种基于异质网络嵌入模型的疾病药物预测方法
CN114334038B (zh) * 2021-12-31 2024-05-14 杭州师范大学 一种基于异质网络嵌入模型的疾病药物预测方法
CN114792573A (zh) * 2022-04-18 2022-07-26 北京百度网讯科技有限公司 药物联用的效果预测方法、模型训练方法、装置及设备
WO2026076576A1 (en) * 2024-10-08 2026-04-16 Huawei Technologies Co., Ltd. Devices and methods for in-network learning for dynamic wireless networks
CN119830148A (zh) * 2024-11-14 2025-04-15 安徽理工大学 基于自监督空间学习的跨模态轴承故障诊断方法

Also Published As

Publication number Publication date
EP3803884A2 (en) 2021-04-14
WO2019231624A3 (en) 2020-03-19
AU2019276730A1 (en) 2020-12-10
JP7490576B2 (ja) 2024-05-27
KR20210018333A (ko) 2021-02-17
MX2020012899A (es) 2021-02-26
BR112020023429A2 (pt) 2021-02-23
JP2021526259A (ja) 2021-09-30
WO2019231624A2 (en) 2019-12-05
CN112513990A (zh) 2021-03-16

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