CA3090505A1 - Antifolates gamma-polyglutamates et utilisations associees - Google Patents
Antifolates gamma-polyglutamates et utilisations associees Download PDFInfo
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- CA3090505A1 CA3090505A1 CA3090505A CA3090505A CA3090505A1 CA 3090505 A1 CA3090505 A1 CA 3090505A1 CA 3090505 A CA3090505 A CA 3090505A CA 3090505 A CA3090505 A CA 3090505A CA 3090505 A1 CA3090505 A1 CA 3090505A1
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- antifolate
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Abstract
L'invention concerne d'une manière générale des antifolates gamma-polyglutamatés, des formulations contenant des liposomes remplis d'antifolates gamma-polyglutamatés, des procédés de préparation d'antifolates gamma-polyglutamatés et des formulations contenant des liposomes, et des méthodes d'utilisation d'antifolates gamma-polyglutamatés et des formulations contenant des liposomes pour le traitement de troubles hyperprolifératifs (par exemple, du cancer) et de troubles du système immunitaire (par exemple, d'une inflammation et d'une maladie auto-immune telle que la polyarthrite rhumatoïde).<i /> <i />
Applications Claiming Priority (29)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862627733P | 2018-02-07 | 2018-02-07 | |
US201862627732P | 2018-02-07 | 2018-02-07 | |
US62/627,732 | 2018-02-07 | ||
US62/627,733 | 2018-02-07 | ||
US201862630824P | 2018-02-14 | 2018-02-14 | |
US201862630620P | 2018-02-14 | 2018-02-14 | |
US201862630613P | 2018-02-14 | 2018-02-14 | |
US201862630751P | 2018-02-14 | 2018-02-14 | |
US201862630652P | 2018-02-14 | 2018-02-14 | |
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US20180236098A1 (en) | 2016-08-12 | 2018-08-23 | L.E.A.F. Holdings Group Llc | Alpha and gamma-d polyglutamated antifolates and uses thereof |
CA3090387A1 (fr) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Pralatrexate alpha-polyglutamate et utilisations associees |
WO2019157138A1 (fr) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Pémétrexed alpha-polyglutamaté et utilisations associées |
EP3755335A4 (fr) * | 2018-02-14 | 2022-06-22 | L.E.A.F Holdings Group LLC | Tétrahydrofolates gamma polyglutamiques et leurs utilisations |
CA3090875A1 (fr) | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Lometrexol gamma polyglutamique et ses utilisations |
CN111936145A (zh) * | 2018-02-14 | 2020-11-13 | L.E.A.F.控股集团公司 | γ聚谷氨酸化氨甲蝶呤及其用途 |
EP3752158A4 (fr) * | 2018-02-14 | 2022-03-09 | L.E.A.F Holdings Group LLC | Aminoptérine gamma polyglutamique et ses utilisations |
CN114555127A (zh) * | 2019-08-06 | 2022-05-27 | L.E.A.F.控股集团公司 | 制备聚谷氨酸化抗叶酸剂的方法以及它们的组合物的用途 |
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EP2437596B1 (fr) * | 2009-06-03 | 2017-05-03 | Ex-Tek, LLC | Compositions de traitement cutané |
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WO2018031980A1 (fr) * | 2016-08-12 | 2018-02-15 | L.E.A.F. Holdings Group Llc | Antifolates de polyglutamates et leurs utilisations. |
JP2019524885A (ja) | 2016-08-12 | 2019-09-05 | エル.イー.エー.エフ. ホールディングス グループ エルエルシーL.E.A.F. Holdings Group Llc | ポリグルタミン酸化抗葉酸剤およびその使用 |
US20190231690A1 (en) * | 2017-11-08 | 2019-08-01 | L.E.A.F. Holdings Group Llc | Platinum complexes and uses thereof |
WO2019157138A1 (fr) * | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Pémétrexed alpha-polyglutamaté et utilisations associées |
WO2019157121A1 (fr) * | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Lométrexol alpha-polyglutamaté et utilisations associées |
EP3749320A4 (fr) * | 2018-02-07 | 2022-03-09 | L.E.A.F Holdings Group LLC | Aminoptérine alpha-polyglutamatée et utilisations associées |
EP3749318A4 (fr) * | 2018-02-07 | 2022-07-06 | L.E.A.F Holdings Group LLC | Raltitrexed gamma-polyglutamaté et utilisations associées |
CA3090509A1 (fr) * | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Methotrexate alpha-polyglutamate et utilisations associees |
EP3749311A4 (fr) * | 2018-02-07 | 2022-07-06 | L.E.A.F Holdings Group LLC | Compositions de pémétrexed polyglutamaté gamma et leurs utilisations |
CA3090387A1 (fr) * | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Pralatrexate alpha-polyglutamate et utilisations associees |
CN111867593A (zh) * | 2018-02-07 | 2020-10-30 | L.E.A.F.控股集团公司 | α聚谷氨酸化抗叶酸剂及其用途 |
CA3090506A1 (fr) * | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Tetrahydrofolates alpha polyglutames et leurs utilisations |
US20210169884A1 (en) * | 2018-02-07 | 2021-06-10 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated raltitrexed and uses thereof |
CN111936145A (zh) * | 2018-02-14 | 2020-11-13 | L.E.A.F.控股集团公司 | γ聚谷氨酸化氨甲蝶呤及其用途 |
WO2019160736A1 (fr) * | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Pralatrexate gamma-polyglutamaté et utilisations associées |
CA3090875A1 (fr) * | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Lometrexol gamma polyglutamique et ses utilisations |
EP3755335A4 (fr) * | 2018-02-14 | 2022-06-22 | L.E.A.F Holdings Group LLC | Tétrahydrofolates gamma polyglutamiques et leurs utilisations |
EP3752158A4 (fr) * | 2018-02-14 | 2022-03-09 | L.E.A.F Holdings Group LLC | Aminoptérine gamma polyglutamique et ses utilisations |
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WO2019157148A1 (fr) | 2019-08-15 |
EP3749321A1 (fr) | 2020-12-16 |
CN111936147A (zh) | 2020-11-13 |
JP7490240B2 (ja) | 2024-05-27 |
EP3749321A4 (fr) | 2022-03-09 |
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