CA3077084A1 - Regulatory t cell epitopes - Google Patents

Regulatory t cell epitopes Download PDF

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Publication number
CA3077084A1
CA3077084A1 CA3077084A CA3077084A CA3077084A1 CA 3077084 A1 CA3077084 A1 CA 3077084A1 CA 3077084 A CA3077084 A CA 3077084A CA 3077084 A CA3077084 A CA 3077084A CA 3077084 A1 CA3077084 A1 CA 3077084A1
Authority
CA
Canada
Prior art keywords
cells
regulatory
seq
aspects
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3077084A
Other languages
English (en)
French (fr)
Inventor
William Martin
Amy S. Rosenberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Food And Drug Administration
Epivax Inc
Original Assignee
Food And Drug Administration
Epivax Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Food And Drug Administration, Epivax Inc filed Critical Food And Drug Administration
Publication of CA3077084A1 publication Critical patent/CA3077084A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA3077084A 2017-10-05 2018-10-05 Regulatory t cell epitopes Pending CA3077084A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762568630P 2017-10-05 2017-10-05
US201762568625P 2017-10-05 2017-10-05
US62/568,625 2017-10-05
US62/568,630 2017-10-05
US201862729792P 2018-09-11 2018-09-11
US62/729,792 2018-09-11
PCT/US2018/054595 WO2019071116A1 (en) 2017-10-05 2018-10-05 T REGULATORY LYMPHOCYTE EPITOPES

Publications (1)

Publication Number Publication Date
CA3077084A1 true CA3077084A1 (en) 2019-04-11

Family

ID=65994377

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3077084A Pending CA3077084A1 (en) 2017-10-05 2018-10-05 Regulatory t cell epitopes

Country Status (6)

Country Link
US (2) US11441122B2 (https=)
EP (1) EP3691673A4 (https=)
JP (2) JP7274472B2 (https=)
AU (1) AU2018346681B2 (https=)
CA (1) CA3077084A1 (https=)
WO (1) WO2019071116A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4126901A4 (en) * 2020-03-27 2024-04-10 Epivax, Inc. Regulatory t cell epitopes
JP2023520989A (ja) * 2020-03-27 2023-05-23 エピバックス・インコーポレーテッド １型糖尿病の予防および治療に有用なｔレジトープ構築物
AU2021350011A1 (en) * 2020-09-25 2023-05-11 Epivax, Inc. Retro-inverso regulatory t cell epitopes
GB202100194D0 (en) * 2021-01-07 2021-02-24 Cambridge Entpr Ltd Inhibition of T-Cell activity

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US5328470A (en) 1989-03-31 1994-07-12 The Regents Of The University Of Michigan Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
EP0815262A4 (en) 1995-03-24 2000-08-23 Scripps Research Inst Methods for identifying a factor v gene mutation
AU2002249779A1 (en) 2000-12-01 2002-08-12 Regents Of The University Of Minnesota Method to treat hemophilia
WO2003087161A1 (en) * 2002-04-18 2003-10-23 Merck Patent Gmbh Modified factor viii
CN1720326A (zh) * 2002-10-01 2006-01-11 株式会社载体研究所 通过抑制tap活性增强mhcⅰ类分子对外来表位的展示的方法
EP1598367A1 (en) 2004-05-18 2005-11-23 ZLB Behring GmbH Modified coagulation factors with enhanced stability and their derivatives
JP2009528293A (ja) 2006-02-23 2009-08-06 ザ チルドレンズ ホスピタル オブ フィラデルフィア 様々な形態の活性型第ｖ因子を用いた止血を調節する組成物及び方法
AU2007284651B2 (en) * 2006-08-09 2014-03-20 Institute For Systems Biology Organ-specific proteins and methods of their use
EP2450368A1 (en) 2007-01-30 2012-05-09 Epivax, Inc. Regulatory t cell epitopes, compositions and uses thereof
MX374963B (es) * 2011-04-29 2025-03-06 Selecta Biosciences Inc Nanoportadores sintéticos tolerogénicos para reducir las respuestas de anticuerpos.
EP2968499A4 (en) * 2013-03-15 2016-11-30 Haplomics Inc COMPOSITIONS AND METHODS FOR THE IMMUNO-TOLERANCE INDUCTION FOR FACTOR VIII SPATIAL THERAPIES IN PERSONS WITH HEMOPHILIA A
AR101185A1 (es) * 2014-07-11 2016-11-30 Novo Nordiks As Anticuerpos anti-factor v o factor v activado
JP2018517405A (ja) * 2015-05-04 2018-07-05 エピバックス インコーポレーテッド インフルエンザａ／上海／２／２０１３ ｈ７配列の改変ｈ７赤血球凝集素糖タンパク質
US20210093735A1 (en) 2018-04-26 2021-04-01 The University Of North Carolina At Chapel Hill Methods and compositions for treatment of hemophilia

Also Published As

Publication number Publication date
US12275956B2 (en) 2025-04-15
EP3691673A4 (en) 2021-06-09
US20230212512A1 (en) 2023-07-06
JP2023106434A (ja) 2023-08-01
AU2018346681A1 (en) 2020-04-16
US11441122B2 (en) 2022-09-13
AU2018346681B2 (en) 2024-02-22
US20200308542A1 (en) 2020-10-01
JP2021503276A (ja) 2021-02-12
WO2019071116A1 (en) 2019-04-11
JP7274472B2 (ja) 2023-05-16
EP3691673A1 (en) 2020-08-12

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