CA3074809A1 - Fiber reinforced biocomposite threaded implants - Google Patents
Fiber reinforced biocomposite threaded implants Download PDFInfo
- Publication number
- CA3074809A1 CA3074809A1 CA3074809A CA3074809A CA3074809A1 CA 3074809 A1 CA3074809 A1 CA 3074809A1 CA 3074809 A CA3074809 A CA 3074809A CA 3074809 A CA3074809 A CA 3074809A CA 3074809 A1 CA3074809 A1 CA 3074809A1
- Authority
- CA
- Canada
- Prior art keywords
- implant
- range
- fibers
- optionally
- layers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007943 implant Substances 0.000 title claims abstract description 490
- 239000000835 fiber Substances 0.000 title claims abstract description 263
- 239000011173 biocomposite Substances 0.000 title claims abstract description 70
- 229920000642 polymer Polymers 0.000 claims abstract description 132
- 239000000203 mixture Substances 0.000 claims abstract description 80
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 62
- 239000011707 mineral Substances 0.000 claims abstract description 62
- 230000002787 reinforcement Effects 0.000 claims abstract description 34
- 239000002131 composite material Substances 0.000 claims description 69
- 210000000988 bone and bone Anatomy 0.000 claims description 55
- 229920001577 copolymer Polymers 0.000 claims description 55
- 239000011159 matrix material Substances 0.000 claims description 36
- 238000009826 distribution Methods 0.000 claims description 31
- 239000012783 reinforcing fiber Substances 0.000 claims description 28
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 claims description 27
- 229920001432 poly(L-lactide) Polymers 0.000 claims description 26
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 25
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 24
- 238000004804 winding Methods 0.000 claims description 24
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 22
- 229920000331 Polyhydroxybutyrate Polymers 0.000 claims description 16
- 229920002988 biodegradable polymer Polymers 0.000 claims description 16
- 239000004621 biodegradable polymer Substances 0.000 claims description 16
- 230000000399 orthopedic effect Effects 0.000 claims description 16
- 239000005015 poly(hydroxybutyrate) Substances 0.000 claims description 16
- 229920001897 terpolymer Polymers 0.000 claims description 14
- -1 tyrosine carbonates Chemical class 0.000 claims description 14
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 12
- OZJPLYNZGCXSJM-UHFFFAOYSA-N 5-valerolactone Chemical compound O=C1CCCCO1 OZJPLYNZGCXSJM-UHFFFAOYSA-N 0.000 claims description 11
- 229920001610 polycaprolactone Polymers 0.000 claims description 11
- 229920002635 polyurethane Polymers 0.000 claims description 11
- 239000004814 polyurethane Substances 0.000 claims description 11
- 230000003014 reinforcing effect Effects 0.000 claims description 11
- 239000000377 silicon dioxide Substances 0.000 claims description 11
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 9
- KKCBUQHMOMHUOY-UHFFFAOYSA-N Na2O Inorganic materials [O-2].[Na+].[Na+] KKCBUQHMOMHUOY-UHFFFAOYSA-N 0.000 claims description 9
- 239000001913 cellulose Chemical class 0.000 claims description 9
- 229920002678 cellulose Chemical class 0.000 claims description 9
- RBMHUYBJIYNRLY-UHFFFAOYSA-N 2-[(1-carboxy-1-hydroxyethyl)-hydroxyphosphoryl]-2-hydroxypropanoic acid Chemical compound OC(=O)C(O)(C)P(O)(=O)C(C)(O)C(O)=O RBMHUYBJIYNRLY-UHFFFAOYSA-N 0.000 claims description 8
- 239000002557 mineral fiber Substances 0.000 claims description 8
- 229920001434 poly(D-lactide) Polymers 0.000 claims description 8
- 229920001184 polypeptide Polymers 0.000 claims description 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 8
- 230000000750 progressive effect Effects 0.000 claims description 8
- 230000002441 reversible effect Effects 0.000 claims description 8
- 229920001244 Poly(D,L-lactide) Polymers 0.000 claims description 7
- 229920001710 Polyorthoester Polymers 0.000 claims description 7
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 7
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 7
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims description 7
- 102000004169 proteins and genes Human genes 0.000 claims description 7
- 108090000623 proteins and genes Proteins 0.000 claims description 7
- YFHICDDUDORKJB-UHFFFAOYSA-N trimethylene carbonate Chemical compound O=C1OCCCO1 YFHICDDUDORKJB-UHFFFAOYSA-N 0.000 claims description 7
- 239000002253 acid Substances 0.000 claims description 6
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims description 6
- 229910052681 coesite Inorganic materials 0.000 claims description 6
- 229910052906 cristobalite Inorganic materials 0.000 claims description 6
- 229910052682 stishovite Inorganic materials 0.000 claims description 6
- 229910052905 tridymite Inorganic materials 0.000 claims description 6
- 229920001661 Chitosan Polymers 0.000 claims description 5
- 102000008186 Collagen Human genes 0.000 claims description 5
- 108010035532 Collagen Proteins 0.000 claims description 5
- 229920001436 collagen Polymers 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 5
- 150000004676 glycans Chemical class 0.000 claims description 5
- 229920000117 poly(dioxanone) Polymers 0.000 claims description 5
- 229920001282 polysaccharide Polymers 0.000 claims description 5
- 239000005017 polysaccharide Substances 0.000 claims description 5
- ALRHLSYJTWAHJZ-UHFFFAOYSA-N 3-hydroxypropionic acid Chemical compound OCCC(O)=O ALRHLSYJTWAHJZ-UHFFFAOYSA-N 0.000 claims description 4
- JJTUDXZGHPGLLC-IMJSIDKUSA-N 4511-42-6 Chemical compound C[C@@H]1OC(=O)[C@H](C)OC1=O JJTUDXZGHPGLLC-IMJSIDKUSA-N 0.000 claims description 4
- 229920001651 Cyanoacrylate Polymers 0.000 claims description 4
- 102000009123 Fibrin Human genes 0.000 claims description 4
- 108010073385 Fibrin Proteins 0.000 claims description 4
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 4
- 229920000954 Polyglycolide Polymers 0.000 claims description 4
- 229920000388 Polyphosphate Polymers 0.000 claims description 4
- 229920002472 Starch Chemical class 0.000 claims description 4
- 150000007513 acids Chemical class 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 4
- 229950003499 fibrin Drugs 0.000 claims description 4
- 239000001630 malic acid Substances 0.000 claims description 4
- 235000006408 oxalic acid Nutrition 0.000 claims description 4
- 239000005014 poly(hydroxyalkanoate) Substances 0.000 claims description 4
- 229920000515 polycarbonate Polymers 0.000 claims description 4
- 239000004417 polycarbonate Substances 0.000 claims description 4
- 229920000728 polyester Polymers 0.000 claims description 4
- 229920006149 polyester-amide block copolymer Polymers 0.000 claims description 4
- 229920002643 polyglutamic acid Polymers 0.000 claims description 4
- 229920000903 polyhydroxyalkanoate Polymers 0.000 claims description 4
- 239000001205 polyphosphate Substances 0.000 claims description 4
- 235000011176 polyphosphates Nutrition 0.000 claims description 4
- 235000012239 silicon dioxide Nutrition 0.000 claims description 4
- 239000008107 starch Chemical class 0.000 claims description 4
- 235000019698 starch Nutrition 0.000 claims description 4
- 235000000346 sugar Nutrition 0.000 claims description 4
- 150000008163 sugars Chemical class 0.000 claims description 4
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 3
- VKSWWACDZPRJAP-UHFFFAOYSA-N 1,3-dioxepan-2-one Chemical compound O=C1OCCCCO1 VKSWWACDZPRJAP-UHFFFAOYSA-N 0.000 claims description 3
- VPVXHAANQNHFSF-UHFFFAOYSA-N 1,4-dioxan-2-one Chemical compound O=C1COCCO1 VPVXHAANQNHFSF-UHFFFAOYSA-N 0.000 claims description 3
- SJDLIJNQXLJBBE-UHFFFAOYSA-N 1,4-dioxepan-2-one Chemical compound O=C1COCCCO1 SJDLIJNQXLJBBE-UHFFFAOYSA-N 0.000 claims description 3
- AOLNDUQWRUPYGE-UHFFFAOYSA-N 1,4-dioxepan-5-one Chemical compound O=C1CCOCCO1 AOLNDUQWRUPYGE-UHFFFAOYSA-N 0.000 claims description 3
- 229930185605 Bisphenol Natural products 0.000 claims description 3
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 3
- 229920002732 Polyanhydride Polymers 0.000 claims description 3
- 239000004642 Polyimide Substances 0.000 claims description 3
- 229940061720 alpha hydroxy acid Drugs 0.000 claims description 3
- 150000001280 alpha hydroxy acids Chemical class 0.000 claims description 3
- IISBACLAFKSPIT-UHFFFAOYSA-N bisphenol A Chemical compound C=1C=C(O)C=CC=1C(C)(C)C1=CC=C(O)C=C1 IISBACLAFKSPIT-UHFFFAOYSA-N 0.000 claims description 3
- 229920002674 hyaluronan Polymers 0.000 claims description 3
- 229960003160 hyaluronic acid Drugs 0.000 claims description 3
- 229920001308 poly(aminoacid) Polymers 0.000 claims description 3
- 229920001721 polyimide Polymers 0.000 claims description 3
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 3
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 claims description 3
- 229940045110 chitosan Drugs 0.000 claims description 2
- 229960005188 collagen Drugs 0.000 claims description 2
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims 1
- 229910052593 corundum Inorganic materials 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 1
- 229910001845 yogo sapphire Inorganic materials 0.000 claims 1
- 239000000463 material Substances 0.000 description 55
- 230000000670 limiting effect Effects 0.000 description 30
- 238000006731 degradation reaction Methods 0.000 description 26
- 230000015556 catabolic process Effects 0.000 description 23
- 210000001519 tissue Anatomy 0.000 description 23
- 208000027418 Wounds and injury Diseases 0.000 description 18
- 239000004626 polylactic acid Substances 0.000 description 17
- 238000002513 implantation Methods 0.000 description 16
- 239000003365 glass fiber Substances 0.000 description 14
- 238000004519 manufacturing process Methods 0.000 description 13
- 206010017076 Fracture Diseases 0.000 description 12
- 238000005452 bending Methods 0.000 description 12
- 239000004633 polyglycolic acid Substances 0.000 description 12
- 229950008885 polyglycolic acid Drugs 0.000 description 12
- 239000011521 glass Substances 0.000 description 11
- 208000010392 Bone Fractures Diseases 0.000 description 10
- 230000006835 compression Effects 0.000 description 10
- 238000007906 compression Methods 0.000 description 10
- 230000001054 cortical effect Effects 0.000 description 10
- 230000004580 weight loss Effects 0.000 description 10
- 239000000945 filler Substances 0.000 description 9
- 230000008569 process Effects 0.000 description 9
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 9
- 239000012763 reinforcing filler Substances 0.000 description 8
- 229910052751 metal Inorganic materials 0.000 description 7
- 239000002184 metal Substances 0.000 description 7
- 239000002861 polymer material Substances 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 230000009286 beneficial effect Effects 0.000 description 6
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 6
- 230000007423 decrease Effects 0.000 description 6
- 230000006870 function Effects 0.000 description 6
- 238000003780 insertion Methods 0.000 description 6
- 230000037431 insertion Effects 0.000 description 6
- 238000005297 material degradation process Methods 0.000 description 6
- 239000004632 polycaprolactone Substances 0.000 description 6
- 230000035876 healing Effects 0.000 description 5
- 238000001727 in vivo Methods 0.000 description 5
- 230000001965 increasing effect Effects 0.000 description 5
- 239000002952 polymeric resin Substances 0.000 description 5
- 230000002829 reductive effect Effects 0.000 description 5
- 229920003002 synthetic resin Polymers 0.000 description 5
- 239000000654 additive Substances 0.000 description 4
- 230000000996 additive effect Effects 0.000 description 4
- 239000001506 calcium phosphate Substances 0.000 description 4
- 229920006237 degradable polymer Polymers 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 239000011152 fibreglass Substances 0.000 description 4
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 4
- 238000000338 in vitro Methods 0.000 description 4
- 238000011068 loading method Methods 0.000 description 4
- 239000000178 monomer Substances 0.000 description 4
- 230000000278 osteoconductive effect Effects 0.000 description 4
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 4
- 238000001356 surgical procedure Methods 0.000 description 4
- 238000013459 approach Methods 0.000 description 3
- 239000005312 bioglass Substances 0.000 description 3
- 239000012620 biological material Substances 0.000 description 3
- 229910000389 calcium phosphate Inorganic materials 0.000 description 3
- 235000011010 calcium phosphates Nutrition 0.000 description 3
- 239000000919 ceramic Substances 0.000 description 3
- 238000000748 compression moulding Methods 0.000 description 3
- 239000007822 coupling agent Substances 0.000 description 3
- 239000007857 degradation product Substances 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 239000003733 fiber-reinforced composite Substances 0.000 description 3
- 230000009969 flowable effect Effects 0.000 description 3
- 230000001976 improved effect Effects 0.000 description 3
- 230000002757 inflammatory effect Effects 0.000 description 3
- 238000001746 injection moulding Methods 0.000 description 3
- 230000010354 integration Effects 0.000 description 3
- 238000003754 machining Methods 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 150000002739 metals Chemical class 0.000 description 3
- 238000013001 point bending Methods 0.000 description 3
- 230000036316 preload Effects 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 238000007634 remodeling Methods 0.000 description 3
- 229920005989 resin Polymers 0.000 description 3
- 239000011347 resin Substances 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 210000004872 soft tissue Anatomy 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 2
- 239000004696 Poly ether ether ketone Substances 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 238000012668 chain scission Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000003776 cleavage reaction Methods 0.000 description 2
- 208000031513 cyst Diseases 0.000 description 2
- 230000023753 dehiscence Effects 0.000 description 2
- 238000001125 extrusion Methods 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 150000002484 inorganic compounds Chemical class 0.000 description 2
- 229910010272 inorganic material Inorganic materials 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 229920005615 natural polymer Polymers 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 230000008520 organization Effects 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 238000011056 performance test Methods 0.000 description 2
- 229920002530 polyetherether ketone Polymers 0.000 description 2
- 238000012667 polymer degradation Methods 0.000 description 2
- 229920006254 polymer film Polymers 0.000 description 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 2
- 239000004810 polytetrafluoroethylene Substances 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 238000010079 rubber tapping Methods 0.000 description 2
- 230000007017 scission Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- KZNICNPSHKQLFF-UHFFFAOYSA-N succinimide Chemical compound O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 description 2
- 210000002435 tendon Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 238000010146 3D printing Methods 0.000 description 1
- 208000027502 Ankle fracture Diseases 0.000 description 1
- 206010065687 Bone loss Diseases 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- 208000024779 Comminuted Fractures Diseases 0.000 description 1
- 229920002430 Fibre-reinforced plastic Polymers 0.000 description 1
- 206010023215 Joint effusion Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 206010073853 Osteochondral fracture Diseases 0.000 description 1
- 206010069135 Periprosthetic fracture Diseases 0.000 description 1
- 229910001069 Ti alloy Inorganic materials 0.000 description 1
- 239000004699 Ultra-high molecular weight polyethylene Substances 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 239000005313 bioactive glass Substances 0.000 description 1
- 239000000560 biocompatible material Substances 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000037118 bone strength Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 239000000412 dendrimer Substances 0.000 description 1
- 229920000736 dendritic polymer Polymers 0.000 description 1
- 238000000113 differential scanning calorimetry Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000005553 drilling Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 239000011151 fibre-reinforced plastic Substances 0.000 description 1
- 238000009730 filament winding Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000005242 forging Methods 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 230000009477 glass transition Effects 0.000 description 1
- 229920000578 graft copolymer Polymers 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 210000003041 ligament Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000005226 mechanical processes and functions Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229910001092 metal group alloy Inorganic materials 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000002113 nanodiamond Substances 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 229920002463 poly(p-dioxanone) polymer Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 239000000622 polydioxanone Substances 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 230000006340 racemization Effects 0.000 description 1
- 229920005604 random copolymer Polymers 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 229910001256 stainless steel alloy Inorganic materials 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 229960002317 succinimide Drugs 0.000 description 1
- 230000003319 supportive effect Effects 0.000 description 1
- 230000003746 surface roughness Effects 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 229920000785 ultra high molecular weight polyethylene Polymers 0.000 description 1
- 238000000196 viscometry Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
- B29D1/00—Producing articles with screw-threads
- B29D1/005—Producing articles with screw-threads fibre reinforced
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws or setting implements
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/84—Fasteners therefor or fasteners being internal fixation devices
- A61B17/86—Pins or screws or threaded wires; nuts therefor
- A61B17/866—Material or manufacture
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/446—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L31/125—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L31/128—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix containing other specific inorganic fillers not covered by A61L31/126 or A61L31/127
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C70/00—Shaping composites, i.e. plastics material comprising reinforcements, fillers or preformed parts, e.g. inserts
- B29C70/04—Shaping composites, i.e. plastics material comprising reinforcements, fillers or preformed parts, e.g. inserts comprising reinforcements only, e.g. self-reinforcing plastics
- B29C70/06—Fibrous reinforcements only
- B29C70/08—Fibrous reinforcements only comprising combinations of different forms of fibrous reinforcements incorporated in matrix material, forming one or more layers, and with or without non-reinforced layers
- B29C70/081—Combinations of fibres of continuous or substantial length and short fibres
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C70/00—Shaping composites, i.e. plastics material comprising reinforcements, fillers or preformed parts, e.g. inserts
- B29C70/04—Shaping composites, i.e. plastics material comprising reinforcements, fillers or preformed parts, e.g. inserts comprising reinforcements only, e.g. self-reinforcing plastics
- B29C70/28—Shaping operations therefor
- B29C70/30—Shaping by lay-up, i.e. applying fibres, tape or broadsheet on a mould, former or core; Shaping by spray-up, i.e. spraying of fibres on a mould, former or core
- B29C70/32—Shaping by lay-up, i.e. applying fibres, tape or broadsheet on a mould, former or core; Shaping by spray-up, i.e. spraying of fibres on a mould, former or core on a rotating mould, former or core
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C70/00—Shaping composites, i.e. plastics material comprising reinforcements, fillers or preformed parts, e.g. inserts
- B29C70/04—Shaping composites, i.e. plastics material comprising reinforcements, fillers or preformed parts, e.g. inserts comprising reinforcements only, e.g. self-reinforcing plastics
- B29C70/28—Shaping operations therefor
- B29C70/30—Shaping by lay-up, i.e. applying fibres, tape or broadsheet on a mould, former or core; Shaping by spray-up, i.e. spraying of fibres on a mould, former or core
- B29C70/34—Shaping by lay-up, i.e. applying fibres, tape or broadsheet on a mould, former or core; Shaping by spray-up, i.e. spraying of fibres on a mould, former or core and shaping or impregnating by compression, i.e. combined with compressing after the lay-up operation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C70/00—Shaping composites, i.e. plastics material comprising reinforcements, fillers or preformed parts, e.g. inserts
- B29C70/68—Shaping composites, i.e. plastics material comprising reinforcements, fillers or preformed parts, e.g. inserts by incorporating or moulding on preformed parts, e.g. inserts or layers, e.g. foam blocks
- B29C70/86—Incorporated in coherent impregnated reinforcing layers, e.g. by winding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws or setting implements
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/84—Fasteners therefor or fasteners being internal fixation devices
- A61B17/86—Pins or screws or threaded wires; nuts therefor
- A61B17/8625—Shanks, i.e. parts contacting bone tissue
- A61B17/863—Shanks, i.e. parts contacting bone tissue with thread interrupted or changing its form along shank, other than constant taper
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws or setting implements
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/84—Fasteners therefor or fasteners being internal fixation devices
- A61B17/86—Pins or screws or threaded wires; nuts therefor
- A61B17/864—Pins or screws or threaded wires; nuts therefor hollow, e.g. with socket or cannulated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00004—(bio)absorbable, (bio)resorbable or resorptive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2267/00—Use of polyesters or derivatives thereof as reinforcement
- B29K2267/04—Polyesters derived from hydroxycarboxylic acids
- B29K2267/043—PGA, i.e. polyglycolic acid or polyglycolide
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2001/00—Articles provided with screw threads
- B29L2001/007—Screws
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Surgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Composite Materials (AREA)
- Heart & Thoracic Surgery (AREA)
- Mechanical Engineering (AREA)
- Medical Informatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Materials Engineering (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762555070P | 2017-09-07 | 2017-09-07 | |
| US62/555,070 | 2017-09-07 | ||
| PCT/IB2018/056809 WO2019049062A1 (en) | 2017-09-07 | 2018-09-06 | FIBER REINFORCED BIOCOMPOSITE IMPLANTS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3074809A1 true CA3074809A1 (en) | 2019-03-14 |
Family
ID=65634933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3074809A Pending CA3074809A1 (en) | 2017-09-07 | 2018-09-06 | Fiber reinforced biocomposite threaded implants |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11317957B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3678566B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP7430393B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102758177B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN111050677B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2018327272B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3074809A1 (cg-RX-API-DMAC7.html) |
| FI (1) | FI3678566T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL272499B2 (cg-RX-API-DMAC7.html) |
| SG (1) | SG11201912595WA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2019049062A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11291483B2 (en) | 2010-10-20 | 2022-04-05 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants |
| US11058796B2 (en) | 2010-10-20 | 2021-07-13 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications |
| US10010609B2 (en) | 2013-05-23 | 2018-07-03 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants |
| BR112017012508B1 (pt) | 2014-12-26 | 2022-04-12 | Ossio Ltd | Implante médico |
| US11553953B1 (en) * | 2019-09-10 | 2023-01-17 | Joseph T. Robbins | Bone screw system and method |
| US11857234B2 (en) * | 2020-04-16 | 2024-01-02 | Field Orthopaedics Pty Ltd | Orthopaedic bone stabilisation device |
| AU2020443729A1 (en) * | 2020-04-22 | 2022-12-08 | Arctic Biomaterials Oy | Preparation of a fiber-reinforced implant |
| CN113576712A (zh) | 2020-04-30 | 2021-11-02 | 财团法人工业技术研究院 | 组织修复装置及其的使用方法 |
| TWI762291B (zh) * | 2020-04-30 | 2022-04-21 | 財團法人工業技術研究院 | 組織修復裝置及其之使用方法 |
| KR102395813B1 (ko) * | 2020-08-11 | 2022-05-11 | 재단법인 오송첨단의료산업진흥재단 | 골다공증 치료를 위한 골 형성 촉진 폴리머 융합 임플란트 |
| US12383246B2 (en) | 2020-10-12 | 2025-08-12 | Abbott Cardiovascular Systems, Inc. | Vessel closure device with improved safety and tract hemostasis |
| CN112315605B (zh) * | 2020-11-03 | 2021-12-21 | 吉林大学 | 一种植入式骨囊肿开窗引流系统 |
| RU2748905C1 (ru) * | 2020-11-06 | 2021-06-01 | Общество с ограниченной ответственностью "МЕДПРОФИ" | Способ индивидуализации дентальных имплантатов с применением лазерной абляции и диагностики 5 типов плотности костной ткани |
| WO2022104114A1 (en) * | 2020-11-13 | 2022-05-19 | 206 Ortho, Inc. | Elongated composite for an implant |
| CN113398325B (zh) * | 2021-06-11 | 2023-04-21 | 叶川 | 用于增强螺钉稳定性和诱导骨再生的纤维膜及其制备方法 |
| IL294542A (en) | 2021-07-19 | 2023-02-01 | Ossio Ltd | A device with a tube for inserting implants with an adjustable insertion depth |
| EP4373419A4 (en) * | 2021-07-19 | 2025-06-11 | Ossio Ltd. | FIBER-REINFORCED MEDICAL BIOCOMPOSITE IMPLANTS WITH DEFORMABLE PROJECTIONS AND METHODS OF USE THEREOF |
| US11957391B2 (en) | 2021-11-01 | 2024-04-16 | Warsaw Orthopedic, Inc. | Bone screw having an overmold of a shank |
| EP4440449A1 (en) * | 2021-11-30 | 2024-10-09 | Ossio Ltd. | Non-swivel suture anchor for knotless fixation of tissue |
| US12471973B2 (en) * | 2021-12-17 | 2025-11-18 | Trilliant Surgical Llc | Threaded implant for bone fixation and related methods |
| KR20250024085A (ko) * | 2022-07-29 | 2025-02-18 | 가부시키가이샤 스파인테크 | 뼈 나사 |
| IL320172A (en) * | 2022-11-16 | 2025-06-01 | Ossio Ltd | Fiber-reinforced orthopedic compression staple |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61253334A (ja) * | 1985-03-01 | 1986-11-11 | Toyota Motor Corp | アルミナ繊維及び鉱物繊維強化金属複合材料 |
| US4750905A (en) * | 1985-07-10 | 1988-06-14 | Harrington Arthritis Research Center | Beam construction and method |
| US4978360A (en) | 1986-03-03 | 1990-12-18 | Zimmer, Inc. | Method of manufacturing a composite implant prosthesis |
| US5192330A (en) * | 1987-01-20 | 1993-03-09 | Smith & Nephew Richards, Inc. | Orthopedic device of biocompatible polymer with oriented fiber reinforcement |
| US5064439A (en) | 1987-01-20 | 1991-11-12 | Richards Medical Company | Orthopedic device of biocompatible polymer with oriented fiber reinforcement |
| DE3734108A1 (de) | 1987-10-06 | 1989-04-20 | Mecron Med Prod Gmbh | Marknagel fuer die behandlung von knochenbruechen |
| DE3831657A1 (de) | 1988-09-17 | 1990-03-22 | Boehringer Ingelheim Kg | Vorrichtung zur osteosynthese und verfahren zu ihrer herstellung |
| US6171338B1 (en) | 1988-11-10 | 2001-01-09 | Biocon, Oy | Biodegradable surgical implants and devices |
| US5209888A (en) * | 1988-12-16 | 1993-05-11 | Fukuvi Chemical Industry Co., Ltd. | Method for producing frp screw-like fastening elements |
| ATE138554T1 (de) | 1990-02-14 | 1996-06-15 | Man Ceramics Gmbh | Knochenimplantat |
| US5181930A (en) * | 1991-04-10 | 1993-01-26 | Pfizer Hospital Products Group, Inc. | Composite orthopedic implant |
| US5507814A (en) | 1994-03-30 | 1996-04-16 | Northwestern University | Orthopedic implant with self-reinforced mantle |
| AU3635095A (en) | 1994-09-20 | 1996-04-09 | Smith & Nephew Richards Inc. | Composite threaded component and method of manufacture |
| US6602293B1 (en) | 1996-11-01 | 2003-08-05 | The Johns Hopkins University | Polymeric composite orthopedic implant |
| AU738334B2 (en) * | 1997-05-30 | 2001-09-13 | Osteobiologics, Inc. | Fiber-reinforced, porous, biodegradable implant device |
| DE19823737C2 (de) | 1998-05-27 | 2003-05-15 | Sepitec Foundation Vaduz | Verbundwerkstoff aus Polymer- oder Keramikmaterialien |
| US6306140B1 (en) * | 2001-01-17 | 2001-10-23 | Synthes (Usa) | Bone screw |
| CN101420991A (zh) * | 2003-11-20 | 2009-04-29 | 血管技术国际股份公司 | 聚合物组合物及其使用方法 |
| FI20055194L (fi) | 2005-04-27 | 2006-10-28 | Bioretec Oy | Bioabsorboituva ja bioaktiivinen komposiittimateriaali ja menetelmä komposiitin valmistamiseksi |
| FI124017B (fi) | 2006-06-30 | 2014-01-31 | Stick Tech Oy | Kovettavat kuitulujitetut komposiitit ja menetelmä aplikaatio-orientuneiden kuitulujitettujen komposiittien valmistamiseksi |
| WO2008095046A2 (en) | 2007-01-30 | 2008-08-07 | Loma Vista Medical, Inc., | Biological navigation device |
| FI20075246A7 (fi) | 2007-04-12 | 2009-01-30 | Bioretec Oy | Lääketieteellinen väline |
| DE102007020951A1 (de) | 2007-05-04 | 2008-11-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren und Vorrichtung zur Reinigung eines resorbierbaren Polyesters |
| JP5939563B2 (ja) | 2008-08-11 | 2016-06-22 | フィブラリン コーポレイションＦｉｂｒａｌｉｇｎ Ｃｏｒｐ． | バイオコンポジット及びその製造方法 |
| US9456890B2 (en) | 2009-01-15 | 2016-10-04 | The Curators Of The University Of Missouri | Scaffold for bone and tissue repair in mammals |
| CN102355863B (zh) | 2009-01-16 | 2014-09-17 | 卡波菲克斯整形有限公司 | 复合材料骨植入物 |
| CN101531821A (zh) * | 2009-04-17 | 2009-09-16 | 山东大学 | 玻璃纤维增强聚酯矿物复合材料及其制备方法 |
| PL2243500T3 (pl) | 2009-04-23 | 2012-06-29 | Purac Biochem Bv | Biozgodny kompozyt i jego zastosowanie |
| EP2243749B1 (en) | 2009-04-23 | 2015-04-08 | PURAC Biochem BV | Resorbable and biocompatible fibre glass compositions and their uses |
| WO2010128039A1 (en) | 2009-05-07 | 2010-11-11 | Dsm Ip Assets B.V. | Biodegradable composite comprising a biodegradable polymer and a glass fiber |
| US10154867B2 (en) * | 2010-06-07 | 2018-12-18 | Carbofix In Orthopedics Llc | Multi-layer composite material bone screw |
| CN101942709B (zh) | 2010-09-26 | 2012-01-04 | 东华大学 | 一种含多壁碳纳米管的cs/pva 复合纳米纤维及其制备方法 |
| CA2841336A1 (fr) | 2011-07-13 | 2012-01-19 | Cadorel, Catherine | Piece composite pour implantation endo-osseuse et procede de fabrication d'une telle piece |
| US9090029B2 (en) | 2012-02-06 | 2015-07-28 | Warsaw Orthopedic, Inc. | Pultrusion process for preparing composites having low percentage of fibers and articles made from same |
| US8735504B2 (en) | 2012-05-02 | 2014-05-27 | Warsaw Orthopedic, Inc. | Methods for preparing polymers having low residual monomer content |
| US9179541B1 (en) | 2014-07-10 | 2015-11-03 | International Business Machines Corporation | Surface-mount connector structure for embedded optical and electrical traces |
| BR112017012508B1 (pt) * | 2014-12-26 | 2022-04-12 | Ossio Ltd | Implante médico |
| US10617458B2 (en) * | 2015-12-23 | 2020-04-14 | Carbofix In Orthopedics Llc | Multi-layer composite material bone screw |
| EP3320877B1 (de) | 2016-11-14 | 2021-05-26 | Andreas Schwitalla | Implantat aus faserverstärktem kunststoff |
| JP7315145B2 (ja) | 2018-03-06 | 2023-07-26 | ディーエスエム アイピー アセッツ ビー．ブイ． | 骨伝導性繊維、このような骨伝導性繊維を含む医療用インプラント、及び製造方法 |
| US11896736B2 (en) | 2020-07-13 | 2024-02-13 | Globus Medical, Inc | Biomaterial implants and methods of making the same |
-
2018
- 2018-09-06 JP JP2020511984A patent/JP7430393B2/ja active Active
- 2018-09-06 AU AU2018327272A patent/AU2018327272B2/en active Active
- 2018-09-06 KR KR1020207009847A patent/KR102758177B1/ko active Active
- 2018-09-06 EP EP18853365.7A patent/EP3678566B1/en active Active
- 2018-09-06 FI FIEP18853365.7T patent/FI3678566T3/fi active
- 2018-09-06 IL IL272499A patent/IL272499B2/en unknown
- 2018-09-06 CN CN201880057783.3A patent/CN111050677B/zh active Active
- 2018-09-06 CA CA3074809A patent/CA3074809A1/en active Pending
- 2018-09-06 US US16/637,363 patent/US11317957B2/en active Active
- 2018-09-06 SG SG11201912595WA patent/SG11201912595WA/en unknown
- 2018-09-06 WO PCT/IB2018/056809 patent/WO2019049062A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU2018327272A1 (en) | 2020-01-30 |
| JP2020533046A (ja) | 2020-11-19 |
| JP7430393B2 (ja) | 2024-02-13 |
| KR102758177B1 (ko) | 2025-01-22 |
| EP3678566B1 (en) | 2024-09-04 |
| IL272499B2 (en) | 2024-09-01 |
| CN111050677A (zh) | 2020-04-21 |
| EP3678566A4 (en) | 2021-06-02 |
| IL272499A (en) | 2020-03-31 |
| EP3678566A1 (en) | 2020-07-15 |
| KR20200052330A (ko) | 2020-05-14 |
| US11317957B2 (en) | 2022-05-03 |
| FI3678566T3 (fi) | 2024-11-28 |
| CN111050677B (zh) | 2023-06-20 |
| US20210369314A1 (en) | 2021-12-02 |
| SG11201912595WA (en) | 2020-01-30 |
| AU2018327272B2 (en) | 2023-12-21 |
| IL272499B1 (en) | 2024-05-01 |
| WO2019049062A1 (en) | 2019-03-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2018327272B2 (en) | Fiber reinforced biocomposite threaded implants | |
| US12239766B2 (en) | Continuous-fiber reinforced biocomposite medical implants | |
| US11491264B2 (en) | Fiber reinforced biocomposite medical implants with high mineral content | |
| CN111629694B (zh) | 纤维束增强的生物复合材料医用植入物 | |
| US20250135075A1 (en) | Fiber-reinforced biocomposite medical implants with deformable protrusions and methods of use thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20230901 |