CA3074258A1 - Therapeutic metal complexes and ligands and methods of making and using same - Google Patents
Therapeutic metal complexes and ligands and methods of making and using same Download PDFInfo
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- CA3074258A1 CA3074258A1 CA3074258A CA3074258A CA3074258A1 CA 3074258 A1 CA3074258 A1 CA 3074258A1 CA 3074258 A CA3074258 A CA 3074258A CA 3074258 A CA3074258 A CA 3074258A CA 3074258 A1 CA3074258 A1 CA 3074258A1
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- Prior art keywords
- aliphatic
- compound
- heteroaliphatic
- heteroaryl
- aryl
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
- C07F1/005—Compounds containing elements of Groups 1 or 11 of the Periodic Table without C-Metal linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/34—Copper; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
- C07F1/08—Copper compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762553714P | 2017-09-01 | 2017-09-01 | |
| US62/553,714 | 2017-09-01 | ||
| PCT/US2018/049163 WO2019046761A1 (en) | 2017-09-01 | 2018-08-31 | THERAPEUTIC METAL COMPLEXES AND LIGANDS, METHODS OF MAKING AND USING SAME |
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| Publication Number | Publication Date |
|---|---|
| CA3074258A1 true CA3074258A1 (en) | 2019-03-07 |
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| CA3074258A Pending CA3074258A1 (en) | 2017-09-01 | 2018-08-31 | Therapeutic metal complexes and ligands and methods of making and using same |
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| JP2020532538A (ja) * | 2017-09-01 | 2020-11-12 | オレゴン ステイト ユニバーシティー | 治療用金属錯体およびリガンドならびにその作成および使用の方法 |
| BR112022001301A2 (pt) * | 2019-07-25 | 2022-04-12 | Als Therapy Development Inst | Cuptsm para o tratamento de distúrbios neurodegenerativos |
| JP2023544965A (ja) | 2020-08-26 | 2023-10-26 | エイエルエス・セラピー・デヴェロップメント・インスティテュート | 神経変性障害の治療のための銅錯体 |
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| NL7403524A (en) | 1959-09-15 | 1974-05-27 | Pharmaceutical compsn. - contg. alpha-dithiosemicarbazone active against trichomonas vaginalis | |
| US4107210A (en) | 1976-09-07 | 1978-08-15 | The Dow Chemical Company | Synthesis of alpha-diketones |
| CA2166676C (en) * | 1995-01-09 | 2007-05-01 | Yasuhisa Fujibayashi | Diagnostic agent for hypoxia or mitochondrial dysfunction comprising radioactive copper complex of dithiosemicarbazone derivative or diamine diol schiff base derivative |
| GB0617299D0 (en) * | 2006-09-01 | 2006-10-11 | Isis Innovation | Compounds for imaging and therapy |
| EP2099441A4 (en) | 2006-11-20 | 2010-04-28 | Univ Melbourne | METAL DISPENSER AND ITS THERAPEUTIC USES |
| AU2009326867B2 (en) * | 2008-12-12 | 2015-10-29 | The University Of Melbourne | Process for the preparation of asymmetrical bis(thiosemicarbazones) |
| ES2778038T3 (es) * | 2013-11-11 | 2020-08-07 | Collaborative Medicinal Development Llc | Complejos metálicos y métodos de tratamiento |
| WO2017070752A1 (en) * | 2015-10-29 | 2017-05-04 | The University Of Queensland | Imaging agents |
| WO2017214546A1 (en) * | 2016-06-10 | 2017-12-14 | University Of Louisville Research Foundation, Inc. | Compounds, related compositions, catalysts, electrochemical cells, fuel cells, their preparation and their uses |
| WO2018204564A1 (en) * | 2017-05-04 | 2018-11-08 | University Of Louisville Research Foundation, Inc. | Thiosemicarbazone derivatives as anti-cancer agents |
| JP2020532538A (ja) * | 2017-09-01 | 2020-11-12 | オレゴン ステイト ユニバーシティー | 治療用金属錯体およびリガンドならびにその作成および使用の方法 |
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2018
- 2018-08-31 JP JP2020512506A patent/JP2020532538A/ja active Pending
- 2018-08-31 CN CN201880065301.9A patent/CN111278835A/zh active Pending
- 2018-08-31 CA CA3074258A patent/CA3074258A1/en active Pending
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Also Published As
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| IL272895B2 (en) | 2025-06-01 |
| IL272895A (en) | 2020-04-30 |
| AU2018325283B2 (en) | 2023-11-16 |
| US12403159B2 (en) | 2025-09-02 |
| US20230172977A1 (en) | 2023-06-08 |
| JP2024001064A (ja) | 2024-01-09 |
| WO2019046761A1 (en) | 2019-03-07 |
| JP2020532538A (ja) | 2020-11-12 |
| US11596651B2 (en) | 2023-03-07 |
| AU2018325283A1 (en) | 2020-03-12 |
| EP3676271A1 (en) | 2020-07-08 |
| US20200188430A1 (en) | 2020-06-18 |
| IL272895B1 (en) | 2025-02-01 |
| CN111278835A (zh) | 2020-06-12 |
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