CA3071412A1 - Dosing regimes for trans-clomiphene - Google Patents
Dosing regimes for trans-clomiphene Download PDFInfo
- Publication number
- CA3071412A1 CA3071412A1 CA3071412A CA3071412A CA3071412A1 CA 3071412 A1 CA3071412 A1 CA 3071412A1 CA 3071412 A CA3071412 A CA 3071412A CA 3071412 A CA3071412 A CA 3071412A CA 3071412 A1 CA3071412 A1 CA 3071412A1
- Authority
- CA
- Canada
- Prior art keywords
- testosterone
- clomiphene
- levels
- patient
- reduction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- GKIRPKYJQBWNGO-QPLCGJKRSA-N zuclomifene Chemical compound C1=CC(OCCN(CC)CC)=CC=C1C(\C=1C=CC=CC=1)=C(/Cl)C1=CC=CC=C1 GKIRPKYJQBWNGO-QPLCGJKRSA-N 0.000 title claims abstract description 62
- 239000000203 mixture Substances 0.000 claims abstract description 44
- 238000000034 method Methods 0.000 claims abstract description 31
- 230000009467 reduction Effects 0.000 claims abstract description 24
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 19
- 208000035475 disorder Diseases 0.000 claims abstract description 14
- 210000003205 muscle Anatomy 0.000 claims abstract description 10
- 208000000509 infertility Diseases 0.000 claims abstract description 6
- 230000036512 infertility Effects 0.000 claims abstract description 6
- 231100000535 infertility Toxicity 0.000 claims abstract description 6
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims abstract description 4
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims abstract description 4
- 230000037182 bone density Effects 0.000 claims abstract description 4
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims description 223
- 229960003604 testosterone Drugs 0.000 claims description 99
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 24
- 230000001965 increasing effect Effects 0.000 claims description 17
- 210000004698 lymphocyte Anatomy 0.000 claims description 11
- 210000004369 blood Anatomy 0.000 claims description 5
- 239000008280 blood Substances 0.000 claims description 5
- 201000003585 eunuchism Diseases 0.000 claims description 3
- 210000002307 prostate Anatomy 0.000 claims description 3
- 206010020880 Hypertrophy Diseases 0.000 claims description 2
- 206010049287 Lipodystrophy acquired Diseases 0.000 claims description 2
- 206010060862 Prostate cancer Diseases 0.000 claims description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 2
- 208000006132 lipodystrophy Diseases 0.000 claims description 2
- 208000037106 male hypogonadism Diseases 0.000 claims description 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims description 2
- 206010058359 Hypogonadism Diseases 0.000 abstract description 6
- 210000002966 serum Anatomy 0.000 description 51
- PYTMYKVIJXPNBD-OQKDUQJOSA-N 2-[4-[(z)-2-chloro-1,2-diphenylethenyl]phenoxy]-n,n-diethylethanamine;hydron;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C1=CC(OCCN(CC)CC)=CC=C1C(\C=1C=CC=CC=1)=C(/Cl)C1=CC=CC=C1 PYTMYKVIJXPNBD-OQKDUQJOSA-N 0.000 description 44
- PYTMYKVIJXPNBD-BTKVJIOYSA-N 2-[4-[(e)-2-chloro-1,2-diphenylethenyl]phenoxy]-n,n-diethylethanamine;hydron;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C1=CC(OCCN(CC)CC)=CC=C1C(\C=1C=CC=CC=1)=C(\Cl)C1=CC=CC=C1 PYTMYKVIJXPNBD-BTKVJIOYSA-N 0.000 description 40
- 230000000694 effects Effects 0.000 description 40
- 238000011282 treatment Methods 0.000 description 33
- 102000012673 Follicle Stimulating Hormone Human genes 0.000 description 24
- 108010079345 Follicle Stimulating Hormone Proteins 0.000 description 24
- 229940028334 follicle stimulating hormone Drugs 0.000 description 24
- 229940062331 androgel Drugs 0.000 description 23
- 229960003608 clomifene Drugs 0.000 description 23
- 102000009151 Luteinizing Hormone Human genes 0.000 description 21
- 108010073521 Luteinizing Hormone Proteins 0.000 description 21
- 229940040129 luteinizing hormone Drugs 0.000 description 21
- 238000002560 therapeutic procedure Methods 0.000 description 10
- 239000000902 placebo Substances 0.000 description 9
- 229940068196 placebo Drugs 0.000 description 9
- 239000003814 drug Substances 0.000 description 8
- 229940079593 drug Drugs 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 241000282520 Papio Species 0.000 description 6
- 230000001833 anti-estrogenic effect Effects 0.000 description 6
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 6
- 210000000265 leukocyte Anatomy 0.000 description 6
- 210000001550 testis Anatomy 0.000 description 6
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 5
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 5
- 230000008859 change Effects 0.000 description 5
- 230000007423 decrease Effects 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 239000000328 estrogen antagonist Substances 0.000 description 5
- 230000035558 fertility Effects 0.000 description 5
- 230000028327 secretion Effects 0.000 description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
- 102000003946 Prolactin Human genes 0.000 description 4
- 108010057464 Prolactin Proteins 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 206010003883 azoospermia Diseases 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 230000003247 decreasing effect Effects 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
- 210000004185 liver Anatomy 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 230000016087 ovulation Effects 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 229940097325 prolactin Drugs 0.000 description 4
- 230000001568 sexual effect Effects 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- 230000021595 spermatogenesis Effects 0.000 description 4
- 206010002261 Androgen deficiency Diseases 0.000 description 3
- 102000006771 Gonadotropins Human genes 0.000 description 3
- 108010086677 Gonadotropins Proteins 0.000 description 3
- 206010067125 Liver injury Diseases 0.000 description 3
- 108010089417 Sex Hormone-Binding Globulin Proteins 0.000 description 3
- 102100030758 Sex hormone-binding globulin Human genes 0.000 description 3
- 239000003098 androgen Substances 0.000 description 3
- 125000000129 anionic group Chemical group 0.000 description 3
- 229940046836 anti-estrogen Drugs 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 235000012000 cholesterol Nutrition 0.000 description 3
- 229940109239 creatinine Drugs 0.000 description 3
- 230000002939 deleterious effect Effects 0.000 description 3
- 229940011871 estrogen Drugs 0.000 description 3
- 239000000262 estrogen Substances 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000002622 gonadotropin Substances 0.000 description 3
- 210000003714 granulocyte Anatomy 0.000 description 3
- 231100000234 hepatic damage Toxicity 0.000 description 3
- 210000003016 hypothalamus Anatomy 0.000 description 3
- 230000008818 liver damage Effects 0.000 description 3
- 208000008634 oligospermia Diseases 0.000 description 3
- 230000001850 reproductive effect Effects 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- DYLIWHYUXAJDOJ-OWOJBTEDSA-N (e)-4-(6-aminopurin-9-yl)but-2-en-1-ol Chemical compound NC1=NC=NC2=C1N=CN2C\C=C\CO DYLIWHYUXAJDOJ-OWOJBTEDSA-N 0.000 description 2
- NVKAWKQGWWIWPM-ABEVXSGRSA-N 17-β-hydroxy-5-α-Androstan-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 NVKAWKQGWWIWPM-ABEVXSGRSA-N 0.000 description 2
- 208000030507 AIDS Diseases 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 208000010228 Erectile Dysfunction Diseases 0.000 description 2
- 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 description 2
- 102000001554 Hemoglobins Human genes 0.000 description 2
- 108010054147 Hemoglobins Proteins 0.000 description 2
- 101600111816 Homo sapiens Sex hormone-binding globulin (isoform 1) Proteins 0.000 description 2
- 102000004451 Pituitary Gonadotropins Human genes 0.000 description 2
- 108010081865 Pituitary Gonadotropins Proteins 0.000 description 2
- 206010059594 Secondary hypogonadism Diseases 0.000 description 2
- 102000007562 Serum Albumin Human genes 0.000 description 2
- 108010071390 Serum Albumin Proteins 0.000 description 2
- 102300044179 Sex hormone-binding globulin isoform 1 Human genes 0.000 description 2
- 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 description 2
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000000556 agonist Substances 0.000 description 2
- 238000000540 analysis of variance Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 229940046989 clomiphene citrate Drugs 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 230000002124 endocrine Effects 0.000 description 2
- 210000003979 eosinophil Anatomy 0.000 description 2
- 230000001667 episodic effect Effects 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 230000001076 estrogenic effect Effects 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 description 2
- 229940035638 gonadotropin-releasing hormone Drugs 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 238000005534 hematocrit Methods 0.000 description 2
- 231100000304 hepatotoxicity Toxicity 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 201000003368 hypogonadotropic hypogonadism Diseases 0.000 description 2
- 201000001881 impotence Diseases 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- 210000002332 leydig cell Anatomy 0.000 description 2
- 238000011866 long-term treatment Methods 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 230000036616 oligospermia Effects 0.000 description 2
- 231100000528 oligospermia Toxicity 0.000 description 2
- 230000001817 pituitary effect Effects 0.000 description 2
- 238000002203 pretreatment Methods 0.000 description 2
- 210000000582 semen Anatomy 0.000 description 2
- 230000036299 sexual function Effects 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 238000013268 sustained release Methods 0.000 description 2
- 239000012730 sustained-release form Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 150000003626 triacylglycerols Chemical class 0.000 description 2
- AKHONHCNYRUTLT-NXBFSHDWSA-N (8R,9S,10R,13S,14S,17S)-15,15,17-trihydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-one Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4(O)O)O)[C@@H]4[C@@H]3CCC2=C1 AKHONHCNYRUTLT-NXBFSHDWSA-N 0.000 description 1
- 108010082126 Alanine transaminase Proteins 0.000 description 1
- 206010012374 Depressed mood Diseases 0.000 description 1
- 206010014418 Electrolyte imbalance Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010019851 Hepatotoxicity Diseases 0.000 description 1
- 208000035150 Hypercholesterolemia Diseases 0.000 description 1
- 208000026350 Inborn Genetic disease Diseases 0.000 description 1
- 238000012313 Kruskal-Wallis test Methods 0.000 description 1
- 206010024870 Loss of libido Diseases 0.000 description 1
- 208000007466 Male Infertility Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 241001504519 Papio ursinus Species 0.000 description 1
- 206010052649 Primary hypogonadism Diseases 0.000 description 1
- 201000001880 Sexual dysfunction Diseases 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 208000024313 Testicular Neoplasms Diseases 0.000 description 1
- 206010043318 Testicular failure primary Diseases 0.000 description 1
- 206010047513 Vision blurred Diseases 0.000 description 1
- 206010000059 abdominal discomfort Diseases 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 229940030486 androgens Drugs 0.000 description 1
- 229960003473 androstanolone Drugs 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 230000002513 anti-ovulatory effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000036765 blood level Effects 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000027288 circadian rhythm Effects 0.000 description 1
- GKIRPKYJQBWNGO-OCEACIFDSA-N clomifene Chemical compound C1=CC(OCCN(CC)CC)=CC=C1C(\C=1C=CC=CC=1)=C(\Cl)C1=CC=CC=C1 GKIRPKYJQBWNGO-OCEACIFDSA-N 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 210000000918 epididymis Anatomy 0.000 description 1
- 201000010063 epididymitis Diseases 0.000 description 1
- 230000009986 erectile function Effects 0.000 description 1
- 230000003325 follicular Effects 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 208000016361 genetic disease Diseases 0.000 description 1
- 231100000024 genotoxic Toxicity 0.000 description 1
- 230000001738 genotoxic effect Effects 0.000 description 1
- 230000024924 glomerular filtration Effects 0.000 description 1
- 229940094892 gonadotropins Drugs 0.000 description 1
- 201000000079 gynecomastia Diseases 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000007686 hepatotoxicity Effects 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000007913 intrathecal administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 230000008376 long-term health Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 230000009245 menopause Effects 0.000 description 1
- 238000010197 meta-analysis Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 231100000417 nephrotoxicity Toxicity 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000011164 ossification Effects 0.000 description 1
- 230000001582 osteoblastic effect Effects 0.000 description 1
- 230000000624 ovulatory effect Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 210000003899 penis Anatomy 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 235000003784 poor nutrition Nutrition 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000007425 progressive decline Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000000541 pulsatile effect Effects 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 230000008085 renal dysfunction Effects 0.000 description 1
- 238000009256 replacement therapy Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 210000001625 seminal vesicle Anatomy 0.000 description 1
- 231100000872 sexual dysfunction Toxicity 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000003270 steroid hormone Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 229960001603 tamoxifen Drugs 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- 230000001457 vasomotor Effects 0.000 description 1
- 201000010653 vesiculitis Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/06—Anabolic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Reproductive Health (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Gynecology & Obstetrics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Pregnancy & Childbirth (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66429005P | 2005-03-22 | 2005-03-22 | |
| US60/664,290 | 2005-03-22 | ||
| CA002597700A CA2597700A1 (en) | 2005-03-22 | 2006-03-17 | Dosing regimes for trans-clomiphene |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002597700A Division CA2597700A1 (en) | 2005-03-22 | 2006-03-17 | Dosing regimes for trans-clomiphene |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3071412A1 true CA3071412A1 (en) | 2006-09-28 |
Family
ID=37024477
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3071412A Abandoned CA3071412A1 (en) | 2005-03-22 | 2006-03-17 | Dosing regimes for trans-clomiphene |
| CA002597700A Abandoned CA2597700A1 (en) | 2005-03-22 | 2006-03-17 | Dosing regimes for trans-clomiphene |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002597700A Abandoned CA2597700A1 (en) | 2005-03-22 | 2006-03-17 | Dosing regimes for trans-clomiphene |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8247456B2 (OSRAM) |
| EP (2) | EP1865938A4 (OSRAM) |
| JP (3) | JP5785680B2 (OSRAM) |
| KR (1) | KR20070114187A (OSRAM) |
| CN (1) | CN101163467B (OSRAM) |
| AU (1) | AU2006227243B2 (OSRAM) |
| BR (1) | BRPI0609389A2 (OSRAM) |
| CA (2) | CA3071412A1 (OSRAM) |
| MX (1) | MX2007010659A (OSRAM) |
| NZ (1) | NZ560551A (OSRAM) |
| PL (1) | PL383444A1 (OSRAM) |
| RU (1) | RU2413508C2 (OSRAM) |
| WO (1) | WO2006102232A2 (OSRAM) |
| ZA (1) | ZA200707774B (OSRAM) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1954807A (zh) | 2001-07-09 | 2007-05-02 | 佐纳根有限公司 | 富含反式克罗米酚的克罗米酚组合物 |
| US7737185B2 (en) | 2001-07-09 | 2010-06-15 | Repros Therapeutics Inc. | Methods and compositions with trans-clomiphene |
| KR20070114187A (ko) | 2005-03-22 | 2007-11-29 | 레프로스 쎄라피우틱스 아이엔씨. | 트랜스-클로미펜의 투약 방법 |
| WO2008052971A1 (de) | 2006-10-31 | 2008-05-08 | Basf Se | Regelung eines verfahrens zur herstellung wasserabsorbierender polymerpartikel in einer erwärmten gasphase |
| NZ591955A (en) * | 2007-10-16 | 2011-10-28 | Repros Therapeutics Inc | Trans-clomiphene for diabetes mellitus type 2 |
| TWI458478B (zh) * | 2008-11-07 | 2014-11-01 | Repros Therapeutics Inc | 用於代謝症候群與第２型糖尿病的反式氯米芬 |
| UA113291C2 (xx) | 2011-08-04 | 2017-01-10 | Метаболіти транскломіфену і їх застосування | |
| WO2013020215A1 (en) * | 2011-08-09 | 2013-02-14 | Adams Kenneth W | Use of aromatase inhibitor or estrogen blocker for increasing spermatogenesis or testosterone levels in males |
| CA2864104A1 (en) * | 2012-02-14 | 2013-08-22 | Repros Therapeutics Inc. | Selective estrogen receptor modulators with short half-lives and uses thereof |
| EP2819676B1 (en) * | 2012-02-29 | 2018-05-30 | Repros Therapeutics Inc. | Combination therapy for treating androgen deficiency |
| US10328022B2 (en) | 2012-05-31 | 2019-06-25 | Repros Therapeutics Inc. | Formulations and methods for vaginal delivery of antiprogestins |
| HK1211852A1 (en) | 2012-11-02 | 2016-06-03 | Repros Therapeutics Inc. | Methods and compositions for treating progesterone-dependent conditions |
| WO2014070523A1 (en) * | 2012-11-02 | 2014-05-08 | Repros Therapeutics Inc. | Trans-clomiphene for use in cancer therapy |
| CN105473183A (zh) * | 2013-06-05 | 2016-04-06 | 利普生物药剂公司 | 作为提高骨矿物质密度的药剂的反式克罗米芬和它的类似物 |
| KR20180112048A (ko) * | 2016-02-25 | 2018-10-11 | 아스펜 파크 파마슈티컬스 인코포레이티드 | 클로미펜 이성질체들의 경구 제형 및 이차 생식선 기능저하증 치료를 위하여 이들을 사용하는 방법 |
| EP3368506B1 (en) | 2016-04-22 | 2023-09-06 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Process for the preparation of enclomiphene citrate having needle shaped crystal habit. |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4061733A (en) | 1976-10-15 | 1977-12-06 | Narayan Vishwanath Gunjikar | Veterinary compositions for inducing estrus in animals and method |
| US4729999A (en) * | 1984-10-12 | 1988-03-08 | Bcm Technologies | Antiestrogen therapy for symptoms of estrogen deficiency |
| DE3660489D1 (en) | 1985-06-08 | 1988-09-15 | Asta Pharma Ag | Derivatives of 1,1,2,2-tetramethyl-1,2-bis(2-fluoro-4-hydroxyphenyl) ethane |
| US4820736A (en) | 1987-03-20 | 1989-04-11 | Yale University | Use of clomiphene to predict fertility in a human female |
| GB8926171D0 (en) * | 1989-11-20 | 1990-01-10 | Applied Research Systems | Treatment of infertility |
| JPH04312522A (ja) | 1991-04-08 | 1992-11-04 | Yoshiaki Kawashima | 徐放性錠剤の製造方法 |
| US5681585A (en) | 1991-12-24 | 1997-10-28 | Euro-Celtique, S.A. | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer |
| US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| US5776923A (en) | 1993-01-19 | 1998-07-07 | Endorecherche, Inc. | Method of treating or preventing osteoporosis by adminstering dehydropiandrosterone |
| GB9405304D0 (en) | 1994-03-16 | 1994-04-27 | Scherer Ltd R P | Delivery systems for hydrophobic drugs |
| CA2192708A1 (en) | 1994-06-17 | 1995-12-28 | Kenneth J. Himmelstein | In situ gel-forming delivery vehicle for bio-affecting substances, and method of use |
| DE4435368A1 (de) | 1994-09-22 | 1996-03-28 | Schering Ag | Verwendung von Aromatasehemmern zur Herstellung eines Arzneimittels zur Behandlung eines relativen Androgenmangels beim Mann |
| WO1997006787A2 (en) | 1995-08-17 | 1997-02-27 | Dyer, Alison, Margaret | Controlled release products |
| US5773031A (en) | 1996-02-27 | 1998-06-30 | L. Perrigo Company | Acetaminophen sustained-release formulation |
| IL120262A (en) | 1996-02-28 | 2001-01-28 | Pfizer | Droloxifene and derivatives thereof for use in increasing serum testosterone levels |
| JP2002511777A (ja) | 1996-10-28 | 2002-04-16 | ゼネラル ミルズ，インコーポレイテッド | 調放性粒子の埋包およびカプセル化 |
| NZ500649A (en) | 1997-04-03 | 2001-05-25 | Guilford Pharm Inc | Biodegradable terephthalate polyester-poly(phosphate) polymers, compositions, articles, and methods for making a biosorbable suture, an orthopedic appliance or bone cement for repairing injuries to bone or connective tissue |
| US6653297B1 (en) | 1997-07-03 | 2003-11-25 | Medical College Of Hampton Roads | Control of selective estrogen receptor modulators |
| RU2200732C2 (ru) * | 1997-08-12 | 2003-03-20 | Глэксо Вэллкам Инк. | Производные трифенилэтилена, способы лечения и профилактики остеопороза, рака груди и сердечно-сосудистого заболевания |
| US6342250B1 (en) | 1997-09-25 | 2002-01-29 | Gel-Del Technologies, Inc. | Drug delivery devices comprising biodegradable protein for the controlled release of pharmacologically active agents and method of making the drug delivery devices |
| US6413533B1 (en) | 1998-05-07 | 2002-07-02 | The University Of Tennessee Research Corporation | Method for chemoprevention of prostate cancer |
| AU779398B2 (en) | 1998-07-30 | 2005-01-20 | Stoller Enterprises, Inc. | Treatment of plants with salicylic acid and organic amines |
| US6291505B1 (en) | 1998-08-07 | 2001-09-18 | Chiron Corporation | Estrogen receptor modulators |
| US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| TR200200406T2 (tr) | 1999-06-11 | 2002-06-21 | Watson Pharmaceuticals, Inc. | Kadınlara oral olmayan yollarla androjenik steroidlerin uygulanması |
| CA2321321A1 (en) | 1999-09-30 | 2001-03-30 | Isotis B.V. | Polymers loaded with bioactive agents |
| US6258802B1 (en) * | 1999-10-06 | 2001-07-10 | Medical College Of Hampton Roads | Corticoid therapy |
| US20020004065A1 (en) * | 2000-01-20 | 2002-01-10 | David Kanios | Compositions and methods to effect the release profile in the transdermal administration of active agents |
| EP1289519B1 (en) * | 2000-05-26 | 2019-02-13 | Harry Fisch | Methods of treating androgen deficiency in men using clomiphene |
| US7067557B2 (en) | 2000-05-26 | 2006-06-27 | Harry Fisch | Methods of treating androgen deficiency in men using selective antiestrogens |
| PT1318837E (pt) * | 2000-08-11 | 2004-12-31 | Wyeth Corp | Metodo de tratamenton de carcinoma positivo a receptor de estrogenio |
| US6503894B1 (en) | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
| WO2002055020A2 (en) | 2000-12-11 | 2002-07-18 | Testocreme Llc | Topical testosterone formulations and associated methods |
| KR100803102B1 (ko) * | 2001-07-04 | 2008-02-13 | 니치아 카가쿠 고교 가부시키가이샤 | 질화물 반도체소자 |
| CN1954807A (zh) * | 2001-07-09 | 2007-05-02 | 佐纳根有限公司 | 富含反式克罗米酚的克罗米酚组合物 |
| US7173064B2 (en) | 2001-07-09 | 2007-02-06 | Repros Therapeutics Inc. | Methods and compositions with trans-clomiphene for treating wasting and lipodystrophy |
| US6645974B2 (en) | 2001-07-31 | 2003-11-11 | Merck & Co., Inc. | Androgen receptor modulators and methods for use thereof |
| EP1429779A2 (en) * | 2001-09-21 | 2004-06-23 | Merck & Co., Inc. | Androstanes as androgen receptor modulators |
| US20060269611A1 (en) | 2001-11-29 | 2006-11-30 | Steiner Mitchell S | Prevention and treatment of androgen-deprivation induced osteoporosis |
| US7105679B2 (en) * | 2001-12-19 | 2006-09-12 | Kanojia Ramesh M | Heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators |
| JP4312522B2 (ja) | 2003-06-30 | 2009-08-12 | 株式会社リコー | 現像剤補給方法、現像剤補給装置、及び、画像形成装置 |
| US20080242726A1 (en) * | 2004-07-14 | 2008-10-02 | Podolski Joseph S | Trans-Clomiphene for the Treatment of Benign Prostate Hypertrophy, Porstate Cancer, Hypogonadism Elevated Triglycerides and High Cholesterol |
| NZ556499A (en) | 2005-02-04 | 2011-02-25 | Repros Therapeutics Inc | Methods and materials with trans-clomiphene for the treatment of male infertility |
| EP1853298A2 (en) * | 2005-02-11 | 2007-11-14 | Regeneron Pharmaceuticals, Inc. | Therapeutic combination of a vegf antagonist (vegf trap) and an anti-hypertensive agent |
| KR20070114187A (ko) | 2005-03-22 | 2007-11-29 | 레프로스 쎄라피우틱스 아이엔씨. | 트랜스-클로미펜의 투약 방법 |
| US20080306035A1 (en) | 2005-08-05 | 2008-12-11 | Repros Therapeutics Inc. | Methods and Compositions for Treating Female Infertility Using Clomiphene |
| EP1829534A1 (en) | 2006-03-02 | 2007-09-05 | Laboratorios Del Dr. Esteve, S.A. | Use of compounds binding to the sigma receptor for the treatment of metabolic syndrome |
| NZ591955A (en) | 2007-10-16 | 2011-10-28 | Repros Therapeutics Inc | Trans-clomiphene for diabetes mellitus type 2 |
-
2006
- 2006-03-17 KR KR1020077021707A patent/KR20070114187A/ko not_active Ceased
- 2006-03-17 MX MX2007010659A patent/MX2007010659A/es active IP Right Grant
- 2006-03-17 AU AU2006227243A patent/AU2006227243B2/en not_active Ceased
- 2006-03-17 RU RU2007138867/15A patent/RU2413508C2/ru active
- 2006-03-17 US US11/815,542 patent/US8247456B2/en not_active Expired - Fee Related
- 2006-03-17 NZ NZ560551A patent/NZ560551A/en not_active IP Right Cessation
- 2006-03-17 CA CA3071412A patent/CA3071412A1/en not_active Abandoned
- 2006-03-17 CN CN2006800089841A patent/CN101163467B/zh not_active Expired - Fee Related
- 2006-03-17 PL PL383444A patent/PL383444A1/pl unknown
- 2006-03-17 EP EP06738985A patent/EP1865938A4/en not_active Ceased
- 2006-03-17 BR BRPI0609389-2A patent/BRPI0609389A2/pt active Search and Examination
- 2006-03-17 JP JP2008503069A patent/JP5785680B2/ja not_active Expired - Fee Related
- 2006-03-17 EP EP11153365A patent/EP2392322A3/en not_active Withdrawn
- 2006-03-17 WO PCT/US2006/010022 patent/WO2006102232A2/en not_active Ceased
- 2006-03-17 CA CA002597700A patent/CA2597700A1/en not_active Abandoned
-
2007
- 2007-09-11 ZA ZA200707774A patent/ZA200707774B/xx unknown
-
2012
- 2012-08-20 US US13/590,045 patent/US8519004B2/en not_active Expired - Fee Related
-
2014
- 2014-12-05 JP JP2014246454A patent/JP6270281B2/ja not_active Expired - Fee Related
-
2017
- 2017-11-17 JP JP2017221743A patent/JP2018024712A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| HK1119070A1 (en) | 2009-02-27 |
| NZ560551A (en) | 2010-02-26 |
| EP2392322A3 (en) | 2012-02-22 |
| US8247456B2 (en) | 2012-08-21 |
| US8519004B2 (en) | 2013-08-27 |
| US20120309839A1 (en) | 2012-12-06 |
| JP6270281B2 (ja) | 2018-01-31 |
| KR20070114187A (ko) | 2007-11-29 |
| AU2006227243A1 (en) | 2006-09-28 |
| CA2597700A1 (en) | 2006-09-28 |
| AU2006227243B2 (en) | 2011-10-27 |
| JP2008534503A (ja) | 2008-08-28 |
| ZA200707774B (en) | 2009-09-30 |
| WO2006102232A2 (en) | 2006-09-28 |
| RU2007138867A (ru) | 2009-04-27 |
| EP1865938A2 (en) | 2007-12-19 |
| EP2392322A2 (en) | 2011-12-07 |
| JP2015044867A (ja) | 2015-03-12 |
| CN101163467A (zh) | 2008-04-16 |
| US20090215907A1 (en) | 2009-08-27 |
| RU2413508C2 (ru) | 2011-03-10 |
| PL383444A1 (pl) | 2008-03-17 |
| JP2018024712A (ja) | 2018-02-15 |
| JP5785680B2 (ja) | 2015-09-30 |
| MX2007010659A (es) | 2007-11-08 |
| WO2006102232A3 (en) | 2007-04-12 |
| EP1865938A4 (en) | 2008-09-24 |
| BRPI0609389A2 (pt) | 2010-03-30 |
| CN101163467B (zh) | 2012-07-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US8519004B2 (en) | Dosing regimes for trans-clomiphene | |
| US10561624B2 (en) | Methods and materials for the treatment of testosterone deficiency in men | |
| AU2002318225A1 (en) | Methods and materials for the treatment of testosterone deficiency in men | |
| ZA200705906B (en) | Methods and materials with trans-clomiphene for the treatment of male infertility | |
| US7173064B2 (en) | Methods and compositions with trans-clomiphene for treating wasting and lipodystrophy | |
| US20080242726A1 (en) | Trans-Clomiphene for the Treatment of Benign Prostate Hypertrophy, Porstate Cancer, Hypogonadism Elevated Triglycerides and High Cholesterol | |
| AU2008201142B2 (en) | Methods and materials for the treatment of testosterone deficiency in men | |
| HK1164719A (en) | Dosing regimes for trans-clomiphene |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20200206 |
|
| EEER | Examination request |
Effective date: 20200206 |
|
| FZDE | Discontinued |
Effective date: 20220823 |
|
| FZDE | Discontinued |
Effective date: 20220823 |