CA3045756A1 - Hiv binding agents - Google Patents
Hiv binding agents Download PDFInfo
- Publication number
- CA3045756A1 CA3045756A1 CA3045756A CA3045756A CA3045756A1 CA 3045756 A1 CA3045756 A1 CA 3045756A1 CA 3045756 A CA3045756 A CA 3045756A CA 3045756 A CA3045756 A CA 3045756A CA 3045756 A1 CA3045756 A1 CA 3045756A1
- Authority
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- Canada
- Prior art keywords
- seq
- binding agent
- antibody
- amino acid
- hiv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1036—Retroviridae, e.g. leukemia viruses
- C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
- C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562263618P | 2015-12-05 | 2015-12-05 | |
| US62/263,618 | 2015-12-05 | ||
| PCT/IB2016/057367 WO2017093985A1 (en) | 2015-12-05 | 2016-12-05 | Hiv binding agents |
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| CA3045756A1 true CA3045756A1 (en) | 2017-06-08 |
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| CA3045756A Abandoned CA3045756A1 (en) | 2015-12-05 | 2016-12-05 | Hiv binding agents |
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| US (2) | US10730933B2 (enExample) |
| EP (1) | EP3383902A1 (enExample) |
| JP (1) | JP2019509046A (enExample) |
| CN (1) | CN108779168A (enExample) |
| CA (1) | CA3045756A1 (enExample) |
| WO (1) | WO2017093985A1 (enExample) |
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| US10730933B2 (en) | 2015-12-05 | 2020-08-04 | Centre Hospitalier Universitaire Vaudois | HIV binding agents |
| WO2020012435A1 (en) * | 2018-07-13 | 2020-01-16 | Lausanne University Hospital | Hiv binding agents |
| WO2020082045A1 (en) * | 2018-10-19 | 2020-04-23 | University Of Maryland, College Park | Multispecfic anti-hiv antibodies |
| JP7678790B2 (ja) * | 2019-07-15 | 2025-05-16 | ローザンヌ ユニヴァーシティ ホスピタル | Ｈｉｖ結合剤 |
| CN115963260B (zh) * | 2022-06-27 | 2025-05-23 | 珠海碳云晶芯智能科技有限公司 | 多肽芯片及其在艾滋病诊断产品制备中的应用 |
Family Cites Families (43)
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| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| DK169582B1 (da) | 1986-06-23 | 1994-12-12 | Squibb Bristol Myers Co | Humant monoklonalt antistof, der er i stand til at reagere med en epitop på LAV/HTLV-III kappeglycoproteinet gp41, cellelinier, som producerer sådant antistof, farmaceutisk præparat indeholdende antistoffet samt fremgangsmåde til bestemmelse af nærværelsen af LAV/HTLV-III i en biologisk prøve og fremgangsmåde til separering af specifikke antigendeterminanter af LAV/HTLV-III under anvendelse af ant |
| US5087557A (en) | 1986-06-23 | 1992-02-11 | Genetic Systems Corporation | Human monoclonal antibody to lymphadenopathy-associated virus |
| EP0681026A1 (en) | 1987-03-02 | 1995-11-08 | Whitehead Institute For Biomedical Research | Recombinant mycobacterial vaccine |
| US5504005A (en) | 1987-03-02 | 1996-04-02 | Albert Einstein College Of Medicine Of Yeshiva University | Recombinant mycobacterial vaccine |
| ATE135743T1 (de) | 1987-11-13 | 1996-04-15 | Hermann Katinger | Monoklonale menschliche antikörper gegen hiv-i |
| US5831034A (en) | 1987-11-13 | 1998-11-03 | Hermann Katinger | Human monoclonal anti-HIV-I-antibodies |
| AU608413B2 (en) | 1988-03-30 | 1991-03-28 | Abbott Laboratories | Mouse monoclonal antibody (5-21-3) to human immunodeficiency virus gp41 protein |
| US5298419A (en) | 1988-03-31 | 1994-03-29 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Human hybridomas and monoclonal antibodies which bind both gp41 and gp120 envelope proteins of human immunodeficiency virus |
| JPH0292298A (ja) | 1988-09-30 | 1990-04-03 | Olympus Optical Co Ltd | Ｈｉｖ構成蛋白に対するモノクローナル抗体 |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| JPH04505099A (ja) | 1989-02-28 | 1992-09-10 | ニューヨーク ユニバーシィティ | ヒト免疫不全ウイルスに対するヒトモノクローン抗体 |
| US5731189A (en) | 1989-02-28 | 1998-03-24 | New York University | Human monoclonal antibodies to human immunodeficiency virus |
| WO1990014363A1 (en) | 1989-05-19 | 1990-11-29 | Amgen Inc. | Metalloproteinase inhibitor |
| US6008044A (en) | 1989-08-24 | 1999-12-28 | Bioclonetics | Human monoclonal antibodies directed against the transmembrane glycoprotein (gp41) of human immunodeficiency virus-1 (HIV-1) and detection of antibodies against epitope (GCSGKLIC) |
| US5459060A (en) | 1989-08-24 | 1995-10-17 | Bioclonetics Incorporated | Human monoclonal antibodies directed against the transmembrane glycoprotein (gp41) of human immunodeficiency virus-1 (HIV-1) |
| EP0511300A4 (en) | 1990-01-16 | 1993-05-26 | Replgien Corporation | Monoclonal antibody specific for non-immunodominant epitope of hiv proteins |
| WO1991013157A1 (en) | 1990-02-26 | 1991-09-05 | Commonwealth Scientific And Industrial Research Organisation | Shuttle plasmid for escherichia coli and mycobacteria |
| GB9015888D0 (en) | 1990-07-19 | 1990-09-05 | Smithkline Biolog | Vectors |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| CA2089661C (en) | 1990-08-29 | 2007-04-03 | Nils Lonberg | Transgenic non-human animals capable of producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
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| WO2006050219A2 (en) | 2004-10-29 | 2006-05-11 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Broadly cross-reactive hiv-1 neutralizing human monoclonal antibodies |
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| BR112014010823B1 (pt) * | 2011-11-07 | 2021-02-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | anticorpos que se ligam a gp41 e neutralizam o vírus da imunodeficiência humana tipo 1 (hiv-1), seus usos, molécula de ácido nucleico, vetor de expressão, composição, kit, bem como métodos de detecção de infecção pelo hiv-1 e de teste de imunógeno potencial |
| WO2015103549A1 (en) | 2014-01-03 | 2015-07-09 | The United States Of America, As Represented By The Secretary Department Of Health And Human Services | Neutralizing antibodies to hiv-1 env and their use |
| US10730933B2 (en) | 2015-12-05 | 2020-08-04 | Centre Hospitalier Universitaire Vaudois | HIV binding agents |
-
2016
- 2016-12-05 US US15/780,821 patent/US10730933B2/en not_active Expired - Fee Related
- 2016-12-05 JP JP2018548300A patent/JP2019509046A/ja active Pending
- 2016-12-05 WO PCT/IB2016/057367 patent/WO2017093985A1/en not_active Ceased
- 2016-12-05 EP EP16819370.4A patent/EP3383902A1/en not_active Withdrawn
- 2016-12-05 CN CN201680080738.0A patent/CN108779168A/zh active Pending
- 2016-12-05 CA CA3045756A patent/CA3045756A1/en not_active Abandoned
-
2020
- 2020-06-26 US US16/912,886 patent/US20210009661A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017093985A1 (en) | 2017-06-08 |
| EP3383902A1 (en) | 2018-10-10 |
| JP2019509046A (ja) | 2019-04-04 |
| US20190345234A1 (en) | 2019-11-14 |
| WO2017093985A4 (en) | 2017-07-27 |
| CN108779168A (zh) | 2018-11-09 |
| US20210009661A1 (en) | 2021-01-14 |
| US10730933B2 (en) | 2020-08-04 |
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