CA3041605A1 - Apparatus and methods for predicting therapy outcome - Google Patents

Apparatus and methods for predicting therapy outcome Download PDF

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Publication number
CA3041605A1
CA3041605A1 CA3041605A CA3041605A CA3041605A1 CA 3041605 A1 CA3041605 A1 CA 3041605A1 CA 3041605 A CA3041605 A CA 3041605A CA 3041605 A CA3041605 A CA 3041605A CA 3041605 A1 CA3041605 A1 CA 3041605A1
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CA
Canada
Prior art keywords
subject
outcome
treating
network activity
brain network
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3041605A
Other languages
English (en)
French (fr)
Inventor
Uri ALYAGON
Abraham Zangen
Gaby S. PELL
Yiftach Roth
Ronen Segal
Amir Geva
Ziv PEREMEN
Boaz SADEH
Revital Shani-Hershkovich
Dror HAOR
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BG Negev Technologies and Applications Ltd
Brainsway Ltd
Firefly Neuroscience Ltd
Original Assignee
BG Negev Technologies and Applications Ltd
Elminda Ltd
Brainsway Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BG Negev Technologies and Applications Ltd, Elminda Ltd, Brainsway Ltd filed Critical BG Negev Technologies and Applications Ltd
Publication of CA3041605A1 publication Critical patent/CA3041605A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36025—External stimulators, e.g. with patch electrodes for treating a mental or cerebral condition
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0004—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by the type of physiological signal transmitted
    • A61B5/0006—ECG or EEG signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/16—Devices for psychotechnics; Testing reaction times ; Devices for evaluating the psychological state
    • A61B5/165—Evaluating the state of mind, e.g. depression, anxiety
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/16—Devices for psychotechnics; Testing reaction times ; Devices for evaluating the psychological state
    • A61B5/168—Evaluating attention deficit, hyperactivity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/30—Input circuits therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/369—Electroencephalography [EEG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/369—Electroencephalography [EEG]
    • A61B5/377—Electroencephalography [EEG] using evoked responses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4076—Diagnosing or monitoring particular conditions of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7271—Specific aspects of physiological measurement analysis
    • A61B5/7275—Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/004—Magnetotherapy specially adapted for a specific therapy
    • A61N2/006—Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/02—Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Psychology (AREA)
  • Developmental Disabilities (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Social Psychology (AREA)
  • Educational Technology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Artificial Intelligence (AREA)
  • Signal Processing (AREA)
  • Neurosurgery (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • Magnetic Treatment Devices (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA3041605A 2016-10-25 2017-10-25 Apparatus and methods for predicting therapy outcome Pending CA3041605A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662412598P 2016-10-25 2016-10-25
US62/412,598 2016-10-25
PCT/IL2017/051163 WO2018078619A1 (en) 2016-10-25 2017-10-25 Apparatus and methods for predicting therapy outcome

Publications (1)

Publication Number Publication Date
CA3041605A1 true CA3041605A1 (en) 2018-05-03

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA3041605A Pending CA3041605A1 (en) 2016-10-25 2017-10-25 Apparatus and methods for predicting therapy outcome

Country Status (8)

Country Link
US (1) US11400289B2 (cg-RX-API-DMAC7.html)
EP (1) EP3532162B1 (cg-RX-API-DMAC7.html)
JP (1) JP7048598B2 (cg-RX-API-DMAC7.html)
CN (1) CN110114115B (cg-RX-API-DMAC7.html)
AU (1) AU2017349924B2 (cg-RX-API-DMAC7.html)
CA (1) CA3041605A1 (cg-RX-API-DMAC7.html)
IL (1) IL266176B (cg-RX-API-DMAC7.html)
WO (1) WO2018078619A1 (cg-RX-API-DMAC7.html)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2670299A4 (en) 2011-02-03 2017-08-09 The Medical Research, Infrastructure, And Health Services Fund Of The Tel Aviv Medical Center Method and system for use in monitoring neural activity in a subject's brain
US9782585B2 (en) 2013-08-27 2017-10-10 Halo Neuro, Inc. Method and system for providing electrical stimulation to a user
EP3038700B1 (en) 2013-08-27 2020-03-11 Halo Neuro, Inc. Method and system for providing electrical stimulation to a user
US20180001107A1 (en) 2016-07-01 2018-01-04 Btl Holdings Limited Aesthetic method of biological structure treatment by magnetic field
US11247039B2 (en) 2016-05-03 2022-02-15 Btl Healthcare Technologies A.S. Device including RF source of energy and vacuum system
US11534619B2 (en) 2016-05-10 2022-12-27 Btl Medical Solutions A.S. Aesthetic method of biological structure treatment by magnetic field
US10583287B2 (en) 2016-05-23 2020-03-10 Btl Medical Technologies S.R.O. Systems and methods for tissue treatment
US10556122B1 (en) 2016-07-01 2020-02-11 Btl Medical Technologies S.R.O. Aesthetic method of biological structure treatment by magnetic field
US11141219B1 (en) 2016-08-16 2021-10-12 BTL Healthcare Technologies, a.s. Self-operating belt
CN117462844A (zh) 2017-02-02 2024-01-30 福禄神经学公司 用于经颅直流电刺激tdcs的头戴设备和包括头戴设备的系统
WO2018182534A1 (en) * 2017-03-31 2018-10-04 Agency For Science, Technology And Research A computer system for acquiring a control command
US10507324B2 (en) 2017-11-17 2019-12-17 Halo Neuro, Inc. System and method for individualizing modulation
CN108742607A (zh) * 2018-06-29 2018-11-06 南阳市中心医院 一种神经内科介入治疗装置
US12156689B2 (en) 2019-04-11 2024-12-03 Btl Medical Solutions A.S. Methods and devices for aesthetic treatment of biological structures by radiofrequency and magnetic energy
KR102609208B1 (ko) 2019-04-11 2023-12-05 비티엘 메디컬 솔루션스 에이.에스. 고주파 및 자기 에너지에 의한 생물학적 구조들의 심미적 치료를 위한 방법들 및 디바이스들
CN110537929B (zh) * 2019-08-23 2022-11-04 杭州曼安智能科技有限公司 一种基于ssvep的注意力测评方法、训练方法以及脑机接口
CN110840411B (zh) * 2019-12-06 2022-03-11 深圳市德力凯医疗设备股份有限公司 一种麻醉深度的测量装置、存储介质及电子设备
US12343157B2 (en) 2020-04-14 2025-07-01 Neurotype Inc. Assessing motivated attention with cue reactivity
US11878167B2 (en) 2020-05-04 2024-01-23 Btl Healthcare Technologies A.S. Device and method for unattended treatment of a patient
ES2993637T3 (en) 2020-05-04 2025-01-03 Btl Healthcare Technologies As Device for unattended treatment of a patient
CN111839511B (zh) * 2020-07-21 2021-08-10 浙江大学 一种磁兼容神经探针及其制备方法
WO2022056652A1 (zh) * 2020-09-15 2022-03-24 洪硕宏 评估跨颅磁刺激对忧郁症患者是否有效的辅助判断装置
CN114259239A (zh) * 2020-09-15 2022-04-01 洪硕宏 评估跨颅磁刺激对忧郁症患者是否有效的辅助判断装置
US11571541B2 (en) 2020-10-27 2023-02-07 David Richardson Hubbard, JR. Apparatus and methods of transcranial stimulation to adjust sensory cortical dendritic spine neck membrane potentials for altering consciousness
WO2022172792A1 (ja) * 2021-02-12 2022-08-18 学校法人慶應義塾 症状判定装置及び症状判定プログラム
KR20240041931A (ko) * 2021-07-06 2024-04-01 시냅티카 테라퓨틱스, 인크. 뇌 네트워크에 대해 개별 표적화된 비-침습성 자극을 제공하기 위한 시스템 및 방법
CN113545792B (zh) * 2021-07-20 2024-06-18 深圳市人民医院 一种基于tms-eeg的神经生物标记物的检测方法
EP4415812A1 (en) 2021-10-13 2024-08-21 BTL Medical Solutions a.s. Devices for aesthetic treatment of biological structures by radiofrequency and magnetic energy
US11896816B2 (en) 2021-11-03 2024-02-13 Btl Healthcare Technologies A.S. Device and method for unattended treatment of a patient
CN114081493B (zh) * 2021-12-07 2024-02-27 杭州睿笛生物科技有限公司 一种抑郁症的辅助检测评估方法
CN115644890A (zh) * 2022-11-15 2023-01-31 南京左右脑医疗科技集团有限公司 大脑状态识别方法、装置和存储介质
IL321514A (en) * 2022-12-16 2025-08-01 Graymatters Health Ltd Prognosis prediction
US11980476B1 (en) * 2023-02-16 2024-05-14 Neuralytix, Llc Intraoperative neural monitoring method
CN116510183B (zh) * 2023-06-28 2023-09-19 南昌大学第一附属医院 经颅磁刺激设备、电子设备及存储介质
CN116764106A (zh) * 2023-06-29 2023-09-19 中国医学科学院生物医学工程研究所 一种用于治疗多动症的头戴式治疗仪及治疗方法
CN117898744B (zh) * 2024-02-06 2024-07-16 中国科学院心理研究所 脑电数据分析装置、第二设备、数据采集及处理系统
US12279880B1 (en) 2024-08-09 2025-04-22 Neuralytix, Llc System and method for assessing nerve health during a spinal decompression procedure
US12279879B1 (en) 2024-08-09 2025-04-22 Neuralytix, Llc System and method for empirical assessment of nerve health during a spinal decompression procedure
US12279881B1 (en) 2024-08-09 2025-04-22 Neuralytix, Llc System and method for assessing nerve health during a spinal decompression procedure using a calculated nerve function index

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2912902A (en) 2000-10-20 2002-04-29 Us Gov Health & Human Serv Coil for magnetic stimulation and methods for using the same
US7418290B2 (en) * 2003-05-06 2008-08-26 Aspect Medical Systems, Inc. System and method of assessment of the efficacy of treatment of neurological disorders using the electroencephalogram
US7706871B2 (en) 2003-05-06 2010-04-27 Nellcor Puritan Bennett Llc System and method of prediction of response to neurological treatment using the electroencephalogram
US7976451B2 (en) 2005-06-16 2011-07-12 The United States Of America As Represented By The Department Of Health And Human Services Transcranial magnetic stimulation system and methods
EP2024901A2 (en) 2006-05-25 2009-02-18 Elminda Ltd. Neuropsychological spatiotemporal pattern recognition
WO2008070001A2 (en) 2006-12-01 2008-06-12 Beth Israel Deaconess Medical Center, Inc. Transcranial magnetic stimulation (tms) methods and apparatus
WO2009069134A2 (en) 2007-11-29 2009-06-04 Elminda Ltd. Functional analysis of neurophysiological data
WO2009069136A2 (en) 2007-11-29 2009-06-04 Elminda Ltd. Clinical applications of neuropsychological pattern analysis and modeling
US20120203130A1 (en) * 2009-07-22 2012-08-09 Armin Bernhard Tinnitus Therapy Device
US20110224571A1 (en) * 2009-11-16 2011-09-15 Alvaro Pascual-Leone Non-invasive methods for evaluating cortical plasticity impairments
CA2786380C (en) * 2010-01-18 2020-07-14 Elminda Ltd. Method and system for weighted analysis of neurophysiological data
EP2651496A4 (en) * 2010-12-14 2014-07-09 Univ California DEVICES, SYSTEMS AND METHODS OF TREATING MEDICAL DISEASES
EP2734107B1 (en) * 2011-07-20 2017-05-24 Elminda Ltd. Method and system for estimating brain concussion
US9636517B2 (en) 2012-02-13 2017-05-02 Brainsway, Ltd. Use of transcranial magnetic stimulation to modulate permeability of the blood-brain barrier
US10335606B2 (en) 2012-02-13 2019-07-02 Brainsway, Ltd. Use of transcranial magnetic stimulation to modulate permeability of the blood-brain barrier
EA201400987A3 (ru) 2012-04-06 2015-10-30 Ньюпорт Брейн Рисёч Лаборатори Инк. Rtms на гармониках биологических сигналов
KR20150085007A (ko) 2012-11-13 2015-07-22 엘마인다 리미티드 시공간 분할을 이용한 신경 생리학적 데이터 분석
US9254394B2 (en) 2013-02-21 2016-02-09 Brainsway, Ltd. Central base coils for deep transcranial magnetic stimulation
US9533168B2 (en) 2013-02-21 2017-01-03 Brainsway, Ltd. Unilateral coils for deep transcranial magnetic stimulation
US9248308B2 (en) 2013-02-21 2016-02-02 Brainsway, Ltd. Circular coils for deep transcranial magnetic stimulation
US9802058B2 (en) 2013-02-21 2017-10-31 Brainsway, Ltd. Central base coils for deep transcranial magnetic stimulation
US9808642B2 (en) 2013-02-21 2017-11-07 Brainsway, Ltd. Circular coils for deep transcranial magnetic stimulation
KR20150023364A (ko) 2013-03-15 2015-03-05 넥스팀 오와이 Ｔｍｓ 투여량 평가 및 발작 검출을 위한 방법 및 시스템
CA2965615A1 (en) 2013-11-13 2015-05-21 Elminda Ltd. Method and system for managing pain
WO2016046830A2 (en) 2014-09-28 2016-03-31 Elminda Ltd. Brain stimulation tool configuration
WO2017072777A1 (en) 2015-11-01 2017-05-04 Elminda Ltd. Method and system for estimating potential distribution on cortical surface

Also Published As

Publication number Publication date
AU2017349924A1 (en) 2019-05-23
EP3532162A1 (en) 2019-09-04
US20190247654A1 (en) 2019-08-15
JP7048598B2 (ja) 2022-04-05
IL266176A (en) 2019-06-30
EP3532162B1 (en) 2024-07-24
JP2020503084A (ja) 2020-01-30
WO2018078619A1 (en) 2018-05-03
CN110114115B (zh) 2023-06-06
IL266176B (en) 2022-08-01
US11400289B2 (en) 2022-08-02
AU2017349924B2 (en) 2024-09-12
CN110114115A (zh) 2019-08-09

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