CA3041587A1 - Oxazole derivatives for use as irak inhibitors and method for their preparation - Google Patents

Oxazole derivatives for use as irak inhibitors and method for their preparation Download PDF

Info

Publication number
CA3041587A1
CA3041587A1 CA3041587A CA3041587A CA3041587A1 CA 3041587 A1 CA3041587 A1 CA 3041587A1 CA 3041587 A CA3041587 A CA 3041587A CA 3041587 A CA3041587 A CA 3041587A CA 3041587 A1 CA3041587 A1 CA 3041587A1
Authority
CA
Canada
Prior art keywords
pyrazol
substituted
compound
oxazole
carboxamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3041587A
Other languages
English (en)
French (fr)
Inventor
Hui Li
Thilo Heckrodt
Yan Chen
Ryan Kelley
Darren Mcmurtrie
Kin Tso
Vanessa Taylor
Rajinder Singh
Rose Yen
Jack Maung
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rigel Pharmaceuticals Inc
Original Assignee
Rigel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rigel Pharmaceuticals Inc filed Critical Rigel Pharmaceuticals Inc
Publication of CA3041587A1 publication Critical patent/CA3041587A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA3041587A 2016-10-26 2017-10-25 Oxazole derivatives for use as irak inhibitors and method for their preparation Pending CA3041587A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662413217P 2016-10-26 2016-10-26
US62/413,217 2016-10-26
PCT/US2017/058339 WO2018089199A1 (en) 2016-10-26 2017-10-25 Oxazole derivatives for use as irak inhibitors and method for their preparation

Publications (1)

Publication Number Publication Date
CA3041587A1 true CA3041587A1 (en) 2018-05-17

Family

ID=60302473

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3041587A Pending CA3041587A1 (en) 2016-10-26 2017-10-25 Oxazole derivatives for use as irak inhibitors and method for their preparation

Country Status (9)

Country Link
US (4) US10370367B2 (enExample)
EP (1) EP3532470B1 (enExample)
JP (2) JP7170634B2 (enExample)
CN (1) CN110099899B (enExample)
CA (1) CA3041587A1 (enExample)
DK (1) DK3532470T3 (enExample)
ES (1) ES2939232T3 (enExample)
PT (1) PT3532470T (enExample)
WO (1) WO2018089199A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110862375B (zh) 2018-08-27 2022-10-25 深圳铂立健医药有限公司 吡唑化合物及其药物组合物和应用
EP4009974A1 (en) * 2019-08-08 2022-06-15 Rigel Pharmaceuticals, Inc. Compounds and method for treating cytokine release syndrome
JP2022545542A (ja) * 2019-08-30 2022-10-27 ライジェル ファーマシューティカルズ， インコーポレイテッド ピラゾール化合物、その製剤並びに化合物及び／又は製剤を使用する方法
EP4399208A4 (en) * 2021-09-08 2025-07-16 Rigel Pharmaceuticals Inc IRAK INHIBITOR FOR TREATING CYTOKINE RELEASE CONDITIONS ASSOCIATED WITH RESPIRATORY VIRUS INFECTION
ES3075943T3 (en) * 2022-03-23 2026-08-10 Rigel Pharmaceuticals Inc Pyrimid-2-yl-pyrazole compounds as irak inhibitors
CN121270516A (zh) * 2024-07-03 2026-01-06 科辉智药(深圳)新药研究中心有限公司 一种irak抑制剂化合物的晶型及其制备方法和应用

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* Cited by examiner, † Cited by third party
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US5087240A (en) 1983-08-18 1992-02-11 Drug Delivery Systems Inc. Transdermal drug patch with conductive fibers
US4921475A (en) 1983-08-18 1990-05-01 Drug Delivery Systems Inc. Transdermal drug patch with microtubes
US4738851A (en) 1985-09-27 1988-04-19 University Of Iowa Research Foundation, Inc. Controlled release ophthalmic gel formulation
US5163899A (en) 1987-03-20 1992-11-17 Drug Delivery Systems Inc. Transdermal drug delivery system
US5312325A (en) 1987-05-28 1994-05-17 Drug Delivery Systems Inc Pulsating transdermal drug delivery system
GB8804164D0 (en) 1988-02-23 1988-03-23 Tucker J M Bandage for administering physiologically active compound
US4882150A (en) 1988-06-03 1989-11-21 Kaufman Herbert E Drug delivery system
US5008110A (en) 1988-11-10 1991-04-16 The Procter & Gamble Company Storage-stable transdermal patch
US5088977A (en) 1988-12-21 1992-02-18 Drug Delivery Systems Inc. Electrical transdermal drug applicator with counteractor and method of drug delivery
US5521222A (en) 1989-09-28 1996-05-28 Alcon Laboratories, Inc. Topical ophthalmic pharmaceutical vehicles
CA2031376A1 (en) 1989-12-04 1991-06-05 Bahram Farhadieh Single layer transdermal drug administration system
US5077033A (en) 1990-08-07 1991-12-31 Mediventures Inc. Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide
DK0495421T3 (da) 1991-01-15 1996-12-09 Alcon Lab Inc Anvendelse af carragenaner i topiske ophthalmiske sammensætninger
US5352456A (en) 1991-10-10 1994-10-04 Cygnus Therapeutic Systems Device for administering drug transdermally which provides an initial pulse of drug
CA2123809A1 (en) 1991-12-18 1993-06-24 Debra L. Wilfong Multilayered barrier structures
ATE132381T1 (de) 1992-01-29 1996-01-15 Voelkl Franz Ski Ballspielschläger, insbesondere tennisschläger
IL114193A (en) 1994-06-20 2000-02-29 Teva Pharma Ophthalmic pharmaceutical compositions based on sodium alginate
ES2094688B1 (es) 1994-08-08 1997-08-01 Cusi Lab Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion.
IT1283911B1 (it) 1996-02-05 1998-05-07 Farmigea Spa Soluzioni oftalmiche viscosizzate con polisaccaridi della gomma di tamarindo
US5800807A (en) 1997-01-29 1998-09-01 Bausch & Lomb Incorporated Ophthalmic compositions including glycerin and propylene glycol
US6261547B1 (en) 1998-04-07 2001-07-17 Alcon Manufacturing, Ltd. Gelling ophthalmic compositions containing xanthan gum
US6197934B1 (en) 1998-05-22 2001-03-06 Collagenesis, Inc. Compound delivery using rapidly dissolving collagen film
EP1836188A1 (en) 2004-12-30 2007-09-26 Astex Therapeutics Limited Pyrazole derivatives as that modulate the activity of cdk, gsk and aurora kinases
JP2012254939A (ja) 2009-10-07 2012-12-27 Astellas Pharma Inc オキサゾール化合物
LT3221306T (lt) 2014-11-20 2020-03-10 Merck Patent Gmbh Heteroarilo junginiai, kaip irak inhibitoriai ir jų panaudojimas
DK3286181T3 (da) * 2015-04-22 2021-04-06 Rigel Pharmaceuticals Inc Pyrazolforbindelser og fremgangsmåde til fremstilling og anvendelse af forbindelserne
JP2019196309A (ja) 2016-09-15 2019-11-14 武田薬品工業株式会社 複素環化合物

Also Published As

Publication number Publication date
US10941140B2 (en) 2021-03-09
JP7170634B2 (ja) 2022-11-14
JP2023011795A (ja) 2023-01-24
EP3532470A1 (en) 2019-09-04
DK3532470T3 (da) 2023-02-20
JP7379640B2 (ja) 2023-11-14
CN110099899B (zh) 2024-01-02
US10370367B2 (en) 2019-08-06
US20210179601A1 (en) 2021-06-17
US20190300518A1 (en) 2019-10-03
PT3532470T (pt) 2023-02-28
US11993594B2 (en) 2024-05-28
ES2939232T3 (es) 2023-04-20
CN110099899A (zh) 2019-08-06
WO2018089199A1 (en) 2018-05-17
US20230062818A1 (en) 2023-03-02
EP3532470B1 (en) 2022-12-07
US11492349B2 (en) 2022-11-08
JP2019537577A (ja) 2019-12-26
US20180111923A1 (en) 2018-04-26

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Effective date: 20220916