CA3040344A1 - Treatment of cholangiocarcinoma with tpcs-2a induced photochemical internalisation of gemcitabine - Google Patents
Treatment of cholangiocarcinoma with tpcs-2a induced photochemical internalisation of gemcitabine Download PDFInfo
- Publication number
- CA3040344A1 CA3040344A1 CA3040344A CA3040344A CA3040344A1 CA 3040344 A1 CA3040344 A1 CA 3040344A1 CA 3040344 A CA3040344 A CA 3040344A CA 3040344 A CA3040344 A CA 3040344A CA 3040344 A1 CA3040344 A1 CA 3040344A1
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- CA
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- Prior art keywords
- gemcitabine
- cytotoxic agent
- dose
- tpcs2a
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
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- A—HUMAN NECESSITIES
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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- A61K33/243—Platinum; Compounds thereof
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- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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Landscapes
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- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| GB1704719.2 | 2017-03-24 | ||
| GBGB1704719.2A GB201704719D0 (en) | 2017-03-24 | 2017-03-24 | Method |
| PCT/EP2017/076257 WO2018069536A1 (en) | 2016-10-14 | 2017-10-13 | Treatment of cholangiocarcinoma with tpcs-2a induced photochemical internalisation of gemcitabine |
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| CA3040344A1 true CA3040344A1 (en) | 2018-04-19 |
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| GB201913121D0 (en) * | 2019-09-11 | 2019-10-23 | Seald As | Compositions and methods for treatment of cholangiocarcinoma |
| GB202301312D0 (en) | 2023-01-30 | 2023-03-15 | Pci Biotech As | Method and product |
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| NO180167C (no) | 1994-09-08 | 1997-02-26 | Photocure As | Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosol |
| GB9905911D0 (en) | 1999-03-15 | 1999-05-05 | Photocure As | Method |
| CN100558903C (zh) | 2000-11-29 | 2009-11-11 | Pci生物技术联合股份有限公司 | 将分子输递进胞质溶胶的光化学内化法 |
| GB0121023D0 (en) * | 2001-08-30 | 2001-10-24 | Norwegian Radium Hospital Res | Compound |
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| ES2841941T3 (es) | 2021-07-12 |
| AU2017342086A1 (en) | 2019-05-09 |
| JP2019530718A (ja) | 2019-10-24 |
| PL3525783T3 (pl) | 2021-04-19 |
| KR20190068573A (ko) | 2019-06-18 |
| RU2019109682A3 (enExample) | 2021-02-15 |
| CN110022874A (zh) | 2019-07-16 |
| EP3525783B1 (en) | 2020-12-16 |
| WO2018069536A1 (en) | 2018-04-19 |
| RU2019109682A (ru) | 2020-11-16 |
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