CA3039376A1 - Reversibly protected thiolated electrophilic fatty acids as prodrugs - Google Patents
Reversibly protected thiolated electrophilic fatty acids as prodrugs Download PDFInfo
- Publication number
- CA3039376A1 CA3039376A1 CA3039376A CA3039376A CA3039376A1 CA 3039376 A1 CA3039376 A1 CA 3039376A1 CA 3039376 A CA3039376 A CA 3039376A CA 3039376 A CA3039376 A CA 3039376A CA 3039376 A1 CA3039376 A1 CA 3039376A1
- Authority
- CA
- Canada
- Prior art keywords
- fatty acid
- thiolated
- carbon
- fatty acids
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/01—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to acyclic carbon atoms
- C07C205/03—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662404368P | 2016-10-05 | 2016-10-05 | |
| US62/404,368 | 2016-10-05 | ||
| PCT/US2017/055149 WO2018067705A1 (en) | 2016-10-05 | 2017-10-04 | Reversibly protected thiolated electrophilic fatty acids as prodrugs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3039376A1 true CA3039376A1 (en) | 2018-04-12 |
Family
ID=61832194
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3039376A Pending CA3039376A1 (en) | 2016-10-05 | 2017-10-04 | Reversibly protected thiolated electrophilic fatty acids as prodrugs |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US10744106B2 (https=) |
| EP (1) | EP3522884B1 (https=) |
| JP (1) | JP2019529501A (https=) |
| CN (1) | CN109803648A (https=) |
| CA (1) | CA3039376A1 (https=) |
| ES (1) | ES2982757T3 (https=) |
| WO (1) | WO2018067705A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118845745A (zh) * | 2024-09-25 | 2024-10-29 | 浙江大学医学院附属第二医院 | 辛酸钠在制备治疗脓毒症药物中的应用 |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10765652B2 (en) | 2016-10-05 | 2020-09-08 | University of Pittsburgh—of the Commonwealth System of Higher Education | Reversible nitroxide derivatives of nitroalkenes that mediate nitrosating and alkylating reactions |
| CN112996493A (zh) | 2018-11-14 | 2021-06-18 | 高等教育联邦系统-匹兹堡大学 | 作为rad51抑制剂的亲电试剂和亲电前药 |
| WO2021242758A1 (en) * | 2020-05-26 | 2021-12-02 | Imara Inc. | Improved nitro-fatty acid oral dose regimens |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2679224A1 (en) | 2007-08-01 | 2014-01-01 | University of Pittsburgh of the Commonwealth System of Higher Education | Nitro oleic acid modulation of type II diabetes |
| WO2010014889A2 (en) | 2008-08-01 | 2010-02-04 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Nitro fatty acids as regiomers and related mimetics |
| EP2459189A4 (en) | 2009-07-31 | 2013-01-16 | Univ Pittsburgh | FATTY ACIDS AS ANTI-INFLAMMATORY AGENTS |
| EP2809317A4 (en) | 2012-02-03 | 2015-07-22 | Univ Pittsburgh | FATTY ACIDS AS ANTI-INFLAMMATORY ACTIVE SUBSTANCES |
| EP3440045B1 (en) | 2016-03-04 | 2025-08-20 | University of Pittsburgh- Of the Commonwealth System of Higher Education | Prevention, treatment and reversal of disease using therapeutically effective amounts of dicarboxylic acid compounds |
| US10765652B2 (en) | 2016-10-05 | 2020-09-08 | University of Pittsburgh—of the Commonwealth System of Higher Education | Reversible nitroxide derivatives of nitroalkenes that mediate nitrosating and alkylating reactions |
-
2017
- 2017-10-04 JP JP2019517823A patent/JP2019529501A/ja active Pending
- 2017-10-04 EP EP17859121.0A patent/EP3522884B1/en active Active
- 2017-10-04 CN CN201780062044.9A patent/CN109803648A/zh active Pending
- 2017-10-04 ES ES17859121T patent/ES2982757T3/es active Active
- 2017-10-04 US US16/339,702 patent/US10744106B2/en active Active
- 2017-10-04 WO PCT/US2017/055149 patent/WO2018067705A1/en not_active Ceased
- 2017-10-04 CA CA3039376A patent/CA3039376A1/en active Pending
-
2020
- 2020-07-23 US US16/937,263 patent/US20200352890A1/en not_active Abandoned
-
2023
- 2023-05-22 US US18/200,344 patent/US20230321022A1/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118845745A (zh) * | 2024-09-25 | 2024-10-29 | 浙江大学医学院附属第二医院 | 辛酸钠在制备治疗脓毒症药物中的应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3522884B1 (en) | 2024-05-29 |
| US20230321022A1 (en) | 2023-10-12 |
| EP3522884C0 (en) | 2024-05-29 |
| EP3522884A1 (en) | 2019-08-14 |
| ES2982757T3 (es) | 2024-10-17 |
| WO2018067705A1 (en) | 2018-04-12 |
| US10744106B2 (en) | 2020-08-18 |
| CN109803648A (zh) | 2019-05-24 |
| US20200352890A1 (en) | 2020-11-12 |
| EP3522884A4 (en) | 2020-05-27 |
| US20190282527A1 (en) | 2019-09-19 |
| JP2019529501A (ja) | 2019-10-17 |
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| US9663444B2 (en) | Heteroatom containing substituted fatty acids | |
| US20150094292A1 (en) | Topical compositions containing nitro fatty acids | |
| KR20100106958A (ko) | 신장 보호제로서 중쇄 길이 지방산 및 글리세라이드 | |
| AU2021205027A1 (en) | Prevention, treatment and reversal of disease using therapeutically effective amounts of activated fatty acids | |
| US20150183754A1 (en) | Fatty acid inhibitors | |
| US11491128B2 (en) | Reversible nitroxide derivatives of nitroalkenes that mediate nitrosating and alkylating reactions | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20220930 |
|
| P11 | Amendment of application requested |
Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-P100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT RECEIVED - RESPONSE TO EXAMINER'S REQUISITION Effective date: 20240718 |
|
| B12 | Application deemed to be withdrawn, abandoned or lapsed |
Free format text: ST27 STATUS EVENT CODE: N-2-6-B10-B12-B303 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: DEEMED ABANDONED - FAILURE TO RESPOND TO AN EXAMINER'S REQUISITION Effective date: 20240913 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: N-6-6-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT Effective date: 20241219 |
|
| P11 | Amendment of application requested |
Free format text: ST27 STATUS EVENT CODE: N-6-6-P10-P11-P102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT DETERMINED COMPLIANT Effective date: 20250212 |
|
| P13 | Application amended |
Free format text: ST27 STATUS EVENT CODE: N-6-6-P10-P13-X000 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: APPLICATION AMENDED Effective date: 20250212 |
|
| U13 | Renewal or maintenance fee not paid |
Free format text: ST27 STATUS EVENT CODE: N-2-6-U10-U13-U300 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: DEEMED ABANDONED - FAILURE TO RESPOND TO MAINTENANCE FEE NOTICE Effective date: 20251111 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT Effective date: 20251117 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: N-6-6-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT Effective date: 20260106 |
|
| U13 | Renewal or maintenance fee not paid |
Free format text: ST27 STATUS EVENT CODE: N-2-6-U10-U13-U300 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: DEEMED ABANDONED - FAILURE TO RESPOND TO MAINTENANCE FEE NOTICE Effective date: 20260407 |