CA3036597C - Systems, methods, and gene signatures for predicting a biological status of an individual - Google Patents

Systems, methods, and gene signatures for predicting a biological status of an individual Download PDF

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Publication number
CA3036597C
CA3036597C CA3036597A CA3036597A CA3036597C CA 3036597 C CA3036597 C CA 3036597C CA 3036597 A CA3036597 A CA 3036597A CA 3036597 A CA3036597 A CA 3036597A CA 3036597 C CA3036597 C CA 3036597C
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Prior art keywords
genes
score
computer
data set
lrrn3
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English (en)
French (fr)
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CA3036597A1 (en
Inventor
Carine Poussin
Vincenzo BELCASTRO
Florian Martin
Stephanie Boue
Manuel Claude Peitsch
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Philip Morris Products SA
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Philip Morris Products SA
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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F42/00—Simulated smoking devices other than electrically operated; Component parts thereof; Manufacture or testing thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H70/00—ICT specially adapted for the handling or processing of medical references
    • G16H70/60—ICT specially adapted for the handling or processing of medical references relating to pathologies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Bioethics (AREA)
  • Evolutionary Computation (AREA)
  • Artificial Intelligence (AREA)
  • Software Systems (AREA)
  • Primary Health Care (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CA3036597A 2016-09-14 2017-05-30 Systems, methods, and gene signatures for predicting a biological status of an individual Active CA3036597C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662394551P 2016-09-14 2016-09-14
US62/394551 2016-09-14
PCT/EP2017/063073 WO2018050299A1 (en) 2016-09-14 2017-05-30 Systems, methods, and gene signatures for predicting a biological status of an individual

Publications (2)

Publication Number Publication Date
CA3036597A1 CA3036597A1 (en) 2018-03-22
CA3036597C true CA3036597C (en) 2023-03-28

Family

ID=59021473

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3036597A Active CA3036597C (en) 2016-09-14 2017-05-30 Systems, methods, and gene signatures for predicting a biological status of an individual

Country Status (8)

Country Link
US (1) US20190244677A1 (enExample)
EP (1) EP3513344A1 (enExample)
JP (2) JP7022119B2 (enExample)
KR (2) KR102685289B1 (enExample)
CN (1) CN109643584A (enExample)
CA (1) CA3036597C (enExample)
MX (1) MX2019002316A (enExample)
WO (1) WO2018050299A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102517328B1 (ko) * 2021-03-31 2023-04-04 주식회사 크라우드웍스 작업툴을 이용한 이미지 내 세포 분별에 관한 작업 수행 방법 및 프로그램
CN113159571B (zh) * 2021-04-20 2024-08-27 中国农业大学 一种跨境外来物种风险等级判定及智能识别方法及系统
CN116103392B (zh) * 2021-11-09 2026-06-26 中国医学科学院药物研究所 标志物sema6b在制备结直肠癌诊断及预后预测产品中的用途
JP2025529273A (ja) * 2022-09-02 2025-09-04 コーセプト セラピューティクス， インコーポレイテッド 選択的グルココルチコイド受容体調節を評価する方法、並びにグルココルチコイド受容体調節から利益を得る可能性が高い患者を特定及び治療する方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2316973A1 (en) * 2003-06-10 2011-05-04 The Trustees Of Boston University Detection methods for disorders of the lung
JP2006314315A (ja) 2005-05-10 2006-11-24 Synergenz Bioscience Ltd 肺の機能と異常を調べるための方法と組成物
JP2009529329A (ja) * 2006-03-09 2009-08-20 トラスティーズ オブ ボストン ユニバーシティ 鼻腔上皮細胞の遺伝子発現プロファイルを用いた、肺疾患のための診断および予後診断の方法
US20100055689A1 (en) 2008-03-28 2010-03-04 Avrum Spira Multifactorial methods for detecting lung disorders
EP3831954A3 (en) * 2008-11-17 2021-10-13 Veracyte, Inc. Methods and compositions of molecular profiling for disease diagnostics
JP2012518997A (ja) 2009-02-26 2012-08-23 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション 喫煙未経験者におけるマイクロｒｎａ、ならびに関連する材料および方法
US20120245952A1 (en) * 2011-03-23 2012-09-27 University Of Rochester Crowdsourcing medical expertise
US20150178462A1 (en) * 2011-08-29 2015-06-25 Cardiodx, Inc. Methods and Compositions for Determining Smoking Status
US10329618B2 (en) * 2012-09-06 2019-06-25 Duke University Diagnostic markers for platelet function and methods of use
US11127486B2 (en) * 2013-12-16 2021-09-21 Philip Morris Products S.A. Systems and methods for predicting a smoking status of an individual
EP3916110A1 (en) * 2014-07-14 2021-12-01 Veracyte, Inc. Methods for evaluating lung cancer status
CN114606309A (zh) * 2014-11-05 2022-06-10 威拉赛特公司 使用机器学习和高维转录数据的诊断系统和方法

Also Published As

Publication number Publication date
JP7275334B2 (ja) 2023-05-17
WO2018050299A1 (en) 2018-03-22
CA3036597A1 (en) 2018-03-22
EP3513344A1 (en) 2019-07-24
JP7022119B2 (ja) 2022-02-17
KR20190046940A (ko) 2019-05-07
BR112019004920A2 (pt) 2019-06-04
KR20220103819A (ko) 2022-07-22
CN109643584A (zh) 2019-04-16
KR102685289B1 (ko) 2024-07-16
US20190244677A1 (en) 2019-08-08
KR102421109B1 (ko) 2022-07-14
MX2019002316A (es) 2019-06-24
JP2019532410A (ja) 2019-11-07
JP2022062189A (ja) 2022-04-19

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