CA3032123A1 - Automated drug delivery systems and methods - Google Patents
Automated drug delivery systems and methods Download PDFInfo
- Publication number
- CA3032123A1 CA3032123A1 CA3032123A CA3032123A CA3032123A1 CA 3032123 A1 CA3032123 A1 CA 3032123A1 CA 3032123 A CA3032123 A CA 3032123A CA 3032123 A CA3032123 A CA 3032123A CA 3032123 A1 CA3032123 A1 CA 3032123A1
- Authority
- CA
- Canada
- Prior art keywords
- actuator
- syringe
- cup
- controller
- drug delivery
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000012377 drug delivery Methods 0.000 title claims abstract description 46
- 238000000034 method Methods 0.000 title abstract description 46
- 239000000463 material Substances 0.000 claims abstract description 36
- 239000012530 fluid Substances 0.000 claims description 49
- 239000003814 drug Substances 0.000 claims description 34
- 229940079593 drug Drugs 0.000 claims description 33
- 238000004891 communication Methods 0.000 claims description 22
- 230000008878 coupling Effects 0.000 claims description 16
- 238000010168 coupling process Methods 0.000 claims description 16
- 238000005859 coupling reaction Methods 0.000 claims description 16
- 238000001802 infusion Methods 0.000 abstract description 44
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 14
- 238000007913 intrathecal administration Methods 0.000 description 8
- 238000002347 injection Methods 0.000 description 7
- 239000007924 injection Substances 0.000 description 7
- 238000010586 diagram Methods 0.000 description 5
- 238000003032 molecular docking Methods 0.000 description 5
- 230000029058 respiratory gaseous exchange Effects 0.000 description 5
- 238000003860 storage Methods 0.000 description 5
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
- 210000003169 central nervous system Anatomy 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 238000009593 lumbar puncture Methods 0.000 description 4
- 210000004556 brain Anatomy 0.000 description 3
- 210000000038 chest Anatomy 0.000 description 3
- 230000008602 contraction Effects 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000003384 imaging method Methods 0.000 description 3
- 238000003780 insertion Methods 0.000 description 3
- 230000037431 insertion Effects 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 230000010349 pulsation Effects 0.000 description 3
- 229920000049 Carbon (fiber) Polymers 0.000 description 2
- 206010007953 Central nervous system lymphoma Diseases 0.000 description 2
- 206010010904 Convulsion Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- 208000018737 Parkinson disease Diseases 0.000 description 2
- 208000002552 acute disseminated encephalomyelitis Diseases 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 description 2
- 239000003990 capacitor Substances 0.000 description 2
- 229910002092 carbon dioxide Inorganic materials 0.000 description 2
- 239000004917 carbon fiber Substances 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 238000012790 confirmation Methods 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- -1 e.g. Substances 0.000 description 2
- 206010015037 epilepsy Diseases 0.000 description 2
- 238000001415 gene therapy Methods 0.000 description 2
- 208000003906 hydrocephalus Diseases 0.000 description 2
- 108010072166 idursulfase Proteins 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 2
- 238000000520 microinjection Methods 0.000 description 2
- 208000005340 mucopolysaccharidosis III Diseases 0.000 description 2
- 208000011045 mucopolysaccharidosis type 3 Diseases 0.000 description 2
- 201000006417 multiple sclerosis Diseases 0.000 description 2
- 208000016800 primary central nervous system lymphoma Diseases 0.000 description 2
- 206010063401 primary progressive multiple sclerosis Diseases 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 230000000541 pulsatile effect Effects 0.000 description 2
- 238000005086 pumping Methods 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 150000003384 small molecules Chemical class 0.000 description 2
- 208000002320 spinal muscular atrophy Diseases 0.000 description 2
- 230000001360 synchronised effect Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 210000000115 thoracic cavity Anatomy 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 238000012800 visualization Methods 0.000 description 2
- MKJIEFSOBYUXJB-HOCLYGCPSA-N (3S,11bS)-9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one Chemical compound C1CN2C[C@H](CC(C)C)C(=O)C[C@H]2C2=C1C=C(OC)C(OC)=C2 MKJIEFSOBYUXJB-HOCLYGCPSA-N 0.000 description 1
- DUHUCHOQIDJXAT-OLVMNOGESA-N 3-hydroxy-(3-α,5-α)-Pregnane-11,20-dione Chemical compound C([C@@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)C)[C@@]2(C)CC1=O DUHUCHOQIDJXAT-OLVMNOGESA-N 0.000 description 1
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 208000022526 Canavan disease Diseases 0.000 description 1
- 229910000531 Co alloy Inorganic materials 0.000 description 1
- 229910000684 Cobalt-chrome Inorganic materials 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 1
- 201000007547 Dravet syndrome Diseases 0.000 description 1
- 208000024412 Friedreich ataxia Diseases 0.000 description 1
- 208000023105 Huntington disease Diseases 0.000 description 1
- 102100029199 Iduronate 2-sulfatase Human genes 0.000 description 1
- 102000004627 Iduronidase Human genes 0.000 description 1
- 108010003381 Iduronidase Proteins 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
- HBBGRARXTFLTSG-UHFFFAOYSA-N Lithium ion Chemical compound [Li+] HBBGRARXTFLTSG-UHFFFAOYSA-N 0.000 description 1
- 206010051696 Metastases to meninges Diseases 0.000 description 1
- 208000036572 Myoclonic epilepsy Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 206010030312 On and off phenomenon Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 239000004696 Poly ether ether ketone Substances 0.000 description 1
- 208000036758 Postinfectious cerebellitis Diseases 0.000 description 1
- 208000025816 Sanfilippo syndrome type A Diseases 0.000 description 1
- 206010073677 Severe myoclonic epilepsy of infancy Diseases 0.000 description 1
- 208000034799 Tauopathies Diseases 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- WAIPAZQMEIHHTJ-UHFFFAOYSA-N [Cr].[Co] Chemical compound [Cr].[Co] WAIPAZQMEIHHTJ-UHFFFAOYSA-N 0.000 description 1
- 229940022705 aldurazyme Drugs 0.000 description 1
- 229960003305 alfaxalone Drugs 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 230000000692 anti-sense effect Effects 0.000 description 1
- JUPQTSLXMOCDHR-UHFFFAOYSA-N benzene-1,4-diol;bis(4-fluorophenyl)methanone Chemical compound OC1=CC=C(O)C=C1.C1=CC(F)=CC=C1C(=O)C1=CC=C(F)C=C1 JUPQTSLXMOCDHR-UHFFFAOYSA-N 0.000 description 1
- 229940049706 benzodiazepine Drugs 0.000 description 1
- 150000001557 benzodiazepines Chemical class 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000010952 cobalt-chrome Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 108050003126 conotoxin Proteins 0.000 description 1
- 229960004397 cyclophosphamide Drugs 0.000 description 1
- 230000000881 depressing effect Effects 0.000 description 1
- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 description 1
- 229960003529 diazepam Drugs 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 229940012882 elaprase Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002641 enzyme replacement therapy Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000002594 fluoroscopy Methods 0.000 description 1
- 238000010362 genome editing Methods 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229960002396 idursulfase Drugs 0.000 description 1
- 238000009169 immunotherapy Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000011810 insulating material Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 150000002605 large molecules Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000004973 liquid crystal related substance Substances 0.000 description 1
- 229910001416 lithium ion Inorganic materials 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000004705 lumbosacral region Anatomy 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 229960000485 methotrexate Drugs 0.000 description 1
- DDLIGBOFAVUZHB-UHFFFAOYSA-N midazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NC=C2CN=C1C1=CC=CC=C1F DDLIGBOFAVUZHB-UHFFFAOYSA-N 0.000 description 1
- 229960003793 midazolam Drugs 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 201000002273 mucopolysaccharidosis II Diseases 0.000 description 1
- 208000022018 mucopolysaccharidosis type 2 Diseases 0.000 description 1
- 208000036710 mucopolysaccharidosis type 3A Diseases 0.000 description 1
- 208000012226 mucopolysaccharidosis type IIIA Diseases 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 230000000174 oncolytic effect Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000003534 oscillatory effect Effects 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 101150086837 pic gene Proteins 0.000 description 1
- 229920002530 polyetherether ketone Polymers 0.000 description 1
- APGDTXUMTIZLCJ-CGVGKPPMSA-N prednisolone succinate Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)COC(=O)CCC(O)=O)[C@@H]4[C@@H]3CCC2=C1 APGDTXUMTIZLCJ-CGVGKPPMSA-N 0.000 description 1
- 229950004597 prednisolone succinate Drugs 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 208000005809 status epilepticus Diseases 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 210000002330 subarachnoid space Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229960005333 tetrabenazine Drugs 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 description 1
- 229960000303 topotecan Drugs 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
- A61M5/14546—Front-loading type injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3202—Devices for protection of the needle before use, e.g. caps
- A61M5/3204—Needle cap remover, i.e. devices to dislodge protection cover from needle or needle hub, e.g. deshielding devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M2005/14513—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons with secondary fluid driving or regulating the infusion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
- A61M2205/3344—Measuring or controlling pressure at the body treatment site
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
- A61M2205/502—User interfaces, e.g. screens or keyboards
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
- A61M2205/52—General characteristics of the apparatus with microprocessors or computers with memories providing a history of measured variating parameters of apparatus or patient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/10—Trunk
- A61M2210/1003—Spinal column
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/04—Heartbeat characteristics, e.g. ECG, blood pressure modulation
- A61M2230/06—Heartbeat rate only
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2046—Media being expelled from injector by gas generation, e.g. explosive charge
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medical Treatment And Welfare Office Work (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662368797P | 2016-07-29 | 2016-07-29 | |
| US62/368,797 | 2016-07-29 | ||
| US201662369361P | 2016-08-01 | 2016-08-01 | |
| US62/369,361 | 2016-08-01 | ||
| PCT/US2017/044286 WO2018022955A1 (en) | 2016-07-29 | 2017-07-28 | Automated drug delivery systems and methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3032123A1 true CA3032123A1 (en) | 2018-02-01 |
Family
ID=61012379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3032123A Pending CA3032123A1 (en) | 2016-07-29 | 2017-07-28 | Automated drug delivery systems and methods |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10828424B2 (enExample) |
| EP (1) | EP3490638A4 (enExample) |
| JP (2) | JP2019521809A (enExample) |
| CN (1) | CN109862928B (enExample) |
| AU (2) | AU2017302599B2 (enExample) |
| CA (1) | CA3032123A1 (enExample) |
| WO (1) | WO2018022955A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4917538B2 (ja) | 2004-09-03 | 2012-04-18 | エル・オー・エム・ラボラトリーズ・インコーポレイテッド | 格納可能な針を備えた使い捨て空気圧式安全注射器 |
| US8062864B2 (en) * | 2007-05-21 | 2011-11-22 | Alderbio Holdings Llc | Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies |
| CN104936639A (zh) * | 2013-01-29 | 2015-09-23 | 赛诺菲-安万特德国有限公司 | 电子模块和药物输送装置 |
| WO2016183123A1 (en) * | 2015-05-11 | 2016-11-17 | Alcyone Lifesciences, Inc. | Drug delivery systems and methods |
| DE102015118011A1 (de) * | 2015-10-22 | 2017-04-27 | Human Med Ag | Vorrichtung zur Transplantation von Körperfett |
| GB2556616B (en) * | 2016-07-21 | 2019-09-25 | Cipher Surgical Ltd | Scope assembly |
| US10675438B2 (en) | 2017-11-15 | 2020-06-09 | Alcyone Lifesciences, Inc. | Therapy specific, pre-programmed auto injection device |
| WO2019209800A1 (en) | 2018-04-23 | 2019-10-31 | The Trustees Of Columbia University In The City Of New York | Fluid responsive devices and methods |
| US11480561B2 (en) | 2018-08-14 | 2022-10-25 | Cardiac Pacemakers, Inc. | Systems and methods for monitoring immunotherapy toxicity |
| US10940290B2 (en) | 2018-08-27 | 2021-03-09 | Alcyone Lifesciences, Inc. | Fluid delivery systems and methods |
| US10926024B2 (en) | 2018-10-04 | 2021-02-23 | Corvictus Llc | Emergency medical intervention device |
| EP3903859B1 (en) * | 2018-12-27 | 2025-09-24 | Daicel Corporation | Needleless injector |
| US12048830B2 (en) * | 2019-03-07 | 2024-07-30 | Kpr U.S., Llc | Delivery of fluid from a syringe |
| US10646660B1 (en) * | 2019-05-16 | 2020-05-12 | Milestone Scientific, Inc. | Device and method for identification of a target region |
| DE102019123870A1 (de) * | 2019-09-05 | 2021-03-11 | Pharmpur Gmbh | Stiftartiges Spritzensystem |
| US11738154B2 (en) * | 2019-09-11 | 2023-08-29 | Altaviz, Llc | Micro-volume injectors with dose guidance and methods for use |
| FR3109318B1 (fr) * | 2020-04-15 | 2023-11-10 | Syrengy | Seringue d’injection |
| DE202020106870U1 (de) * | 2020-11-30 | 2022-03-03 | Pharmpur Gmbh | Stiftartige Spritzenvorrichtung und Spritzensystem |
| CN112957566A (zh) * | 2021-01-28 | 2021-06-15 | 四川省肿瘤医院 | 一种脉冲式注射器助力装置 |
| EP4326365A4 (en) * | 2021-05-19 | 2025-03-12 | Alcyone Therapeutics, Inc. | FLUID DELIVERY SYSTEMS AND TREATMENT METHODS |
| US20250000495A1 (en) * | 2021-11-15 | 2025-01-02 | Fundació Hospital Universitari Vall D'hebron - Institut De Recerca | Syringe driving systems |
| WO2024019938A1 (en) | 2022-07-18 | 2024-01-25 | Medphlow, Llc | Integrated cartridge assembly for administration of drugs |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4666430A (en) * | 1984-12-05 | 1987-05-19 | I-Flow Corporation | Infusion pump |
| US4707906A (en) * | 1986-03-25 | 1987-11-24 | Posey John T | Method of attaching tube to a tube holder |
| AU609843B2 (en) * | 1987-06-19 | 1991-05-09 | University Of Melbourne, The | Infusion pump |
| US5151093A (en) | 1990-10-29 | 1992-09-29 | Alza Corporation | Osmotically driven syringe with programmable agent delivery |
| WO1997000091A1 (fr) * | 1995-06-14 | 1997-01-03 | Berney Jean Claude | Piston de seringue avec transmission lineaire |
| DE19742632A1 (de) * | 1997-09-26 | 1999-04-08 | Fresenius Medical Care De Gmbh | Pump- und Dosiervorrichtung |
| DE19859811C2 (de) * | 1998-12-23 | 2001-05-10 | Hilekes Guido | Kontrastmittelinjektionssystem |
| WO2002064194A1 (en) * | 2001-02-14 | 2002-08-22 | Acist Medical Systems, Inc. | Fluid injector system |
| US6547432B2 (en) * | 2001-07-16 | 2003-04-15 | Stryker Instruments | Bone cement mixing and delivery device for injection and method thereof |
| US6929619B2 (en) | 2002-08-02 | 2005-08-16 | Liebel-Flarshiem Company | Injector |
| US7632245B1 (en) | 2003-08-18 | 2009-12-15 | Medrad, Inc. | Devices, systems and methods for delivery of a fluid into a patient during a magnetic resonance procedure |
| US20050177111A1 (en) * | 2004-02-06 | 2005-08-11 | Shaul Ozeri | Miniature infusion pump |
| JP5089991B2 (ja) * | 2004-02-18 | 2012-12-05 | アレス トレイディング ソシエテ アノニム | 液状薬剤を注射する手持ち型電子制御式注射器械 |
| DE502005003349D1 (de) | 2004-06-24 | 2008-04-30 | E Z Em Inc | Hydraulisches injektionssystem und verfarhren zur injektion |
| NZ560516A (en) * | 2005-02-01 | 2010-12-24 | Intelliject Inc | A delivery system where a medicant is automatically delivered on activation as well as a recorded instruction |
| US7302960B2 (en) * | 2005-10-26 | 2007-12-04 | Smiths Medical Asd, Inc. | Momentary high pressure valve |
| US8096449B2 (en) | 2006-07-17 | 2012-01-17 | Medmix Systems Ag | Dispensing appliance for a multiple cartridge |
| CA2656569A1 (en) * | 2006-07-19 | 2008-06-26 | Mallinckrodt Inc. | Radiation shielded syringe assembly and uses thereof |
| US7618409B2 (en) * | 2006-12-21 | 2009-11-17 | Milestone Scientific, Inc | Computer controlled drug delivery system with dynamic pressure sensing |
| US20090004063A1 (en) | 2007-06-29 | 2009-01-01 | Symyx Technologies, Inc. | Apparatus and method for actuating a syringe |
| EP2263720B1 (en) * | 2007-08-20 | 2012-06-13 | Mallinckrodt LLC | Fluid driven medical injectors |
| MX2010002935A (es) * | 2007-09-17 | 2010-08-09 | Satish Sundar | Bombas de infusion de alta precision. |
| BRPI0817907B8 (pt) | 2007-10-02 | 2021-06-22 | Lamodel Ltd | aparelho para administrar uma substância a um indivíduo |
| WO2009058353A1 (en) * | 2007-11-02 | 2009-05-07 | The Cleveland Clinic Foundation | Device for increasing cerebral blood flow |
| CA2728871C (en) * | 2008-06-26 | 2017-01-17 | Gambro Lundia Ab | Methods and devices for monitoring the integrity of a fluid connection |
| EP2393534B1 (en) | 2009-02-05 | 2015-03-25 | Sanofi-Aventis Deutschland GmbH | Medicament delivery devices |
| US9289544B2 (en) * | 2009-12-28 | 2016-03-22 | Gambro Lundia Ab | Method and device for detecting a configuration of withdrawal and return devices |
| US8397578B2 (en) * | 2010-06-03 | 2013-03-19 | Medtronic, Inc. | Capacitive pressure sensor assembly |
| WO2012024106A2 (en) | 2010-08-17 | 2012-02-23 | University Of Florida Research Foundation, Inc. | Central site photoplethysmography, medication administration, and safety |
| CN103338799B (zh) * | 2010-11-29 | 2016-01-13 | 赛诺菲-安万特德国有限公司 | 药物递送装置 |
| US8535268B2 (en) * | 2010-12-22 | 2013-09-17 | Alcon Research, Ltd. | Device for at least one of injection or aspiration |
| US20130274577A1 (en) * | 2012-04-16 | 2013-10-17 | PicoLife Technologies | Medication Delivery Device and Related Methods of Use |
| EP2844330B1 (en) * | 2012-04-24 | 2020-06-03 | The Queen Elizabeth Hospital King's Lynn NHS Foundation Trust | A device for performing regional anesthesia |
| US9956341B2 (en) * | 2012-07-03 | 2018-05-01 | Milestone Scientific, Inc. | Drug infusion with pressure sensing and non-continuous flow for identification of and injection into fluid-filled anatomic spaces |
| KR101200374B1 (ko) | 2012-08-24 | 2012-11-14 | 대한민국 | 어류용 자동 연속 주사장치 |
| US9539384B2 (en) | 2012-09-28 | 2017-01-10 | Animas Corporation | Telescoping piston drive for medical infusion device |
| US9451729B2 (en) * | 2013-12-23 | 2016-09-20 | Dell Products, L.P. | Modular application of peripheral panels as expansion sleeves and cable management components within a rack-based information handling system |
| DE102014012171B4 (de) * | 2014-08-18 | 2018-11-08 | Edwin Kreuzeder | Vorrichtung zum Auspressen von viskosen Massen aus Behältern |
| US10806396B2 (en) * | 2015-01-26 | 2020-10-20 | Alcyone Lifesciences, Inc. | Drug delivery methods with tracer |
| DK3081263T3 (da) * | 2015-04-17 | 2020-03-16 | P&X Medical Nv | Sammensætninger og redskaber til behandling af glaukom |
| WO2016183123A1 (en) | 2015-05-11 | 2016-11-17 | Alcyone Lifesciences, Inc. | Drug delivery systems and methods |
| AR108963A1 (es) * | 2016-04-13 | 2018-10-17 | Merial Inc | Dispositivo de inyección con mecanismo de accionamiento para administrar múltiples formulaciones líquidas, tales como vacunas |
-
2017
- 2017-07-28 US US15/662,416 patent/US10828424B2/en not_active Expired - Fee Related
- 2017-07-28 WO PCT/US2017/044286 patent/WO2018022955A1/en not_active Ceased
- 2017-07-28 CA CA3032123A patent/CA3032123A1/en active Pending
- 2017-07-28 EP EP17835317.3A patent/EP3490638A4/en not_active Withdrawn
- 2017-07-28 JP JP2019504096A patent/JP2019521809A/ja active Pending
- 2017-07-28 CN CN201780046833.3A patent/CN109862928B/zh active Active
- 2017-07-28 AU AU2017302599A patent/AU2017302599B2/en active Active
-
2020
- 2020-11-09 US US16/949,661 patent/US20210052820A1/en not_active Abandoned
-
2022
- 2022-04-21 JP JP2022069994A patent/JP2022089998A/ja active Pending
- 2022-12-01 AU AU2022279517A patent/AU2022279517A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN109862928A (zh) | 2019-06-07 |
| JP2022089998A (ja) | 2022-06-16 |
| CN109862928B (zh) | 2022-06-14 |
| EP3490638A1 (en) | 2019-06-05 |
| JP2019521809A (ja) | 2019-08-08 |
| US20180028761A1 (en) | 2018-02-01 |
| US20210052820A1 (en) | 2021-02-25 |
| US10828424B2 (en) | 2020-11-10 |
| EP3490638A4 (en) | 2020-01-22 |
| WO2018022955A1 (en) | 2018-02-01 |
| AU2017302599B2 (en) | 2022-09-01 |
| AU2017302599A1 (en) | 2019-01-24 |
| AU2022279517A1 (en) | 2023-02-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20210052820A1 (en) | Automated Drug Delivery Systems And Methods | |
| AU2020286295B2 (en) | Drug delivery systems and methods | |
| US20230173224A1 (en) | Drug Delivery Systems and Methods | |
| US10653442B2 (en) | Drug delivery systems and methods | |
| US9233203B2 (en) | Medical needles for damping motion | |
| US20240408306A1 (en) | Modulated power injector with input device | |
| KR102764673B1 (ko) | 무선 조절형 주사 보조장치 및 그에 대한 사용 방법 | |
| US20230050388A1 (en) | Applicator with dosing unit | |
| WO2025038547A1 (en) | Micro-injection system and methods | |
| WO2022203745A1 (en) | Modulated power injector with input device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20220720 |
|
| EEER | Examination request |
Effective date: 20220720 |
|
| EEER | Examination request |
Effective date: 20220720 |
|
| EEER | Examination request |
Effective date: 20220720 |
|
| EEER | Examination request |
Effective date: 20220720 |