CA3030306A1 - Black seed hair growth and regrowth along with other benefits of body - Google Patents
Black seed hair growth and regrowth along with other benefits of body Download PDFInfo
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- CA3030306A1 CA3030306A1 CA3030306A CA3030306A CA3030306A1 CA 3030306 A1 CA3030306 A1 CA 3030306A1 CA 3030306 A CA3030306 A CA 3030306A CA 3030306 A CA3030306 A CA 3030306A CA 3030306 A1 CA3030306 A1 CA 3030306A1
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- hair
- black seed
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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Abstract
A composition containing black seed ingredients in water or liquid, solution or compound grows and regrows hair on body. With application of this water or liquid, solution or compound caring inherent ingredients of black seeds on body, existing or thinning hair become thick, healthy and long. Black seed possess inherent natural ingredients to grow and regrow hair. Black seed can be processed with any liquid in multiple ways to help grow and regrow hair. When black seed's inherent ingredient is fed to hair, follicles or hair roots it provides the nutritional boost that they need to grow and regrow to their natural full growth potential. Bald spots on area of body where hair existed once, starts re-growing hair once again. In addition, Black seed also possess inherent natural ingredients that can cure cancer, kill AIDS, bird flu viruses or other viruses in body. Black seed can be processed in multiple ways to deal with cancer cells. It gives nutritional boost needed to improve immune system of body. The crude oil, thymoquinone (TQ) and other oils extracted from black seeds are effective against many diseases like cancer, cardiovascular, diabetes, asthma, kidney disease, jaundice, gastrointestinal problems, anorexia, conjunctivitis, dyspepsia, rheumatism, diabetes, hypertension, intrinsic hemorrhage, paralysis, amenorrhea, anorexia, asthma, cough, bronchitis, headache, fever, influenza, eczema etc. It is also effective against cancer in blood system, lung, kidney, liver, prostate, breast, cervix, skin and other organs safely. TQ has antioxidant helps body defences, influence apoptosis and handles P13K-Akt pathway of cells.
Description
Tittle:
Black seeds hair growth and re-growth along with other benefits of body.
Description:
Background:
Today world is suffering from many diseases, some of them are uncurable.
Cancer, aids and other viruses kill many people every year. Black seed can help cure many diseases.
Hair growth and regrowth is also a dilemma in todays world. Loosing hair makes one feel uncomplete and appearance without hair is downgraded individual in society.
The oils in black seeds and thymoquinone (TQ) extracted from it are effective against many diseases in body. The ingredients in black seed can cure or heal body from multiple diseases like cancer, cardiovascular diseases, diabetes, asthma, kidney, cancer in blood system, lung, liver, prostate, breast, cervix, skin etc. TQ
has antioxidants that have ability to improve body's defense system, influence apoptosis and Akt pathway.
The covenants and attributes of black seed include: According to Iranian Journal of Basic Medical Science at Mashhad University of Medical Science. A paper was written by Fatemeh Forouzanfar, Bibi Sedigheh Fazly Bazzaz and Hosseinzadeh in year on extensive study of black seed showing chemical black seed's constituents 32% - 40% fixed oil.
Fatty acids having arachidonic, eicosadienoic, linolenic, oleic, palmitoleic, palmitic, stearic, and mydriatic acid, betasitasterol, cycloeucalenol, cycloartenol, sterol esters and sterolglucomsides.
Volatile oil (.4%-.45%) saturated fatty acids having: nigellone it is carbonyl fraction of oil, thymoquinone (TQ), thymohydroquinone (THQ), dithymoquinone, thymol, carvacrol, a and b-.
pinene, d-limonene, d-citronellol, p-cymene. Also contains: p-cymene, caravacrol, t-anethole, 4-terpineoI and longifolene.
Black seed have 2 forms of alkaloids: lsoquinoline alkaloid includes:
nigellicimine and nigellicimine n-oxide. Payrazol alkaloid includes nigellidine and nigellicine.
The nutritional composition are vitamins, carbohydrates, mineral elements, fats and proteins that include 8 or 9 essential amino acids. By sodium dedecyl sulfate polyacrylamide electrophoresis (SDSPAGE). The fractionation of whole black seeds was done which shows the band range from 94 to 100 KDA molecules mass. Black seed also have saponin and alpha hederine and in trace amount has carvone, limonene and citronellol. It also provides good number of vitamins and minerals such as Fe, Ca, K, Zn, P, Cu (3, 4).
Pharmacological effects of N. sativa seeds such as antioxidant, anti-tussive, gastroprotective, anti-anxiety, anti-ulcer, anti-asthmatic, anti-cancer, anti-inflammatory, immunomodulatory and anti-tumor properties, hepatoprotective effect, also gastric ulcer healing, tumor growth suppression, men infertility improvement, cardiovascular disorders, memory improvement, stimulate milk production, protective effects on lipid peroxidation, antibacterial activity, anti dermatophyte, antiviral activity against cytomegalovirus, have been reported for black seed.
Black seed's covenants and especially thymoquinone (TQ) posse's abilities to be anti-oxidant, anti-inflammatory, anti-cancer, anti-bacterial and anti-fungal, anti-carcinogenic, anti-schistosomiasis, anti-viral, anti-parasitic and anti-mutagenic, (TQ) is also considered safe for body. In addition, it is anti-tumor and is effective in cancer treatment in body. For example, it is effective in the diminishing the risk of atherosclerosis by decreasing the serum low density lipoprotein cholesterol level and increasing the serum high density lipoprotein cholesterol levels (Dahri et al., 2005;
Nader et al., 2010); it exerts therapeutic and protective effect in diabetes by decreasing morphological changes and preserving pancreatic beta-cell integrity (Kanter et al., 2009) and by beneficially changing the hepatic enzyme activities (Pan i and Sankaranarayanan, 2009); it is effective against hypertension (Khattab and Nagi, 2007;
Dehkordi and Kamkhah, 2008); it has a potent antihistaminic effect on airways of asthmatic patients (Boskabady et al., 2010); its components are promising agents to complement schistosomiasis specific treatment (El Shenawy et al., 2008); its oils protects kidney tissue against oxygen free radicals, preventing renal dysfunction and morphological abnormalities (Bayrak et al., 2008; Uz et al., 2008; Ragheb et al., 2009).
Other names of black seed are for black cumin, black caraway seeds, Nigella sativa etc.
Black seed's inherent ingredients are capable to grow and regrow hair in body.
They are also capable to heal body and it's internal and external organs from many diseases.
In addition, black seed is effective in healing and curing many types of cancers including but not limited to Blood Cancer, Breast Cancer, Colon Cancer, Pancreatic Cancer, Hepatic Cancer, Lung Cancer, Fibrosarcoma, Skin cancer, Renal Cancer, Prostate Cancer etc. In addition, it can heal and cure body from many viruses like AIDS, Bird Flue etc. It helps fighting viruses by bringing about higher serum levels of interferon-gamma. In addition, it raises the number of CD4 cells and raise their response, it also helps T cells and suppress macrophages. Immunity against viral infection is also raised by it. Obesity can also be controlled with this black seed ingredient. Alzymers disease can also be treated with black seed ingredients.
Black seed ingredients have anti-microbial effects on various pathogens. For example, bacteria, viruses, schistosome, fungus etc. The black seed ingredients can be applied alone or with other drugs to treat body and cure it.
Cancer in body is caused by genetic alterations and abnormal cell growth.
Black seed ingredients can kill cancer cells by acting upon cancer cells through various molecular pathways. Thymoquinone (TQ) present in black seeds influence to kill apoptotic cells in tissue caring cancer by keeping in order apoptotic genes. In addition, Anti-proliferative effect of TQ from black seeds also influence positively on myeloblastic leukemia HL-60 cells. TQ from black seed influences apoptosis and disturbs mitochondrial membrane strength. It also energizing caspases 8, 9 and 3 of HL-60 myeloblastic leukemia cells.
Similarly, TQ also have positive influence on colon cancer cell line HCT 116.
TQ also down-regulates the expression NF-kappa B-regulated anti-apoptotic (IAP-1, IAP-
Black seeds hair growth and re-growth along with other benefits of body.
Description:
Background:
Today world is suffering from many diseases, some of them are uncurable.
Cancer, aids and other viruses kill many people every year. Black seed can help cure many diseases.
Hair growth and regrowth is also a dilemma in todays world. Loosing hair makes one feel uncomplete and appearance without hair is downgraded individual in society.
The oils in black seeds and thymoquinone (TQ) extracted from it are effective against many diseases in body. The ingredients in black seed can cure or heal body from multiple diseases like cancer, cardiovascular diseases, diabetes, asthma, kidney, cancer in blood system, lung, liver, prostate, breast, cervix, skin etc. TQ
has antioxidants that have ability to improve body's defense system, influence apoptosis and Akt pathway.
The covenants and attributes of black seed include: According to Iranian Journal of Basic Medical Science at Mashhad University of Medical Science. A paper was written by Fatemeh Forouzanfar, Bibi Sedigheh Fazly Bazzaz and Hosseinzadeh in year on extensive study of black seed showing chemical black seed's constituents 32% - 40% fixed oil.
Fatty acids having arachidonic, eicosadienoic, linolenic, oleic, palmitoleic, palmitic, stearic, and mydriatic acid, betasitasterol, cycloeucalenol, cycloartenol, sterol esters and sterolglucomsides.
Volatile oil (.4%-.45%) saturated fatty acids having: nigellone it is carbonyl fraction of oil, thymoquinone (TQ), thymohydroquinone (THQ), dithymoquinone, thymol, carvacrol, a and b-.
pinene, d-limonene, d-citronellol, p-cymene. Also contains: p-cymene, caravacrol, t-anethole, 4-terpineoI and longifolene.
Black seed have 2 forms of alkaloids: lsoquinoline alkaloid includes:
nigellicimine and nigellicimine n-oxide. Payrazol alkaloid includes nigellidine and nigellicine.
The nutritional composition are vitamins, carbohydrates, mineral elements, fats and proteins that include 8 or 9 essential amino acids. By sodium dedecyl sulfate polyacrylamide electrophoresis (SDSPAGE). The fractionation of whole black seeds was done which shows the band range from 94 to 100 KDA molecules mass. Black seed also have saponin and alpha hederine and in trace amount has carvone, limonene and citronellol. It also provides good number of vitamins and minerals such as Fe, Ca, K, Zn, P, Cu (3, 4).
Pharmacological effects of N. sativa seeds such as antioxidant, anti-tussive, gastroprotective, anti-anxiety, anti-ulcer, anti-asthmatic, anti-cancer, anti-inflammatory, immunomodulatory and anti-tumor properties, hepatoprotective effect, also gastric ulcer healing, tumor growth suppression, men infertility improvement, cardiovascular disorders, memory improvement, stimulate milk production, protective effects on lipid peroxidation, antibacterial activity, anti dermatophyte, antiviral activity against cytomegalovirus, have been reported for black seed.
Black seed's covenants and especially thymoquinone (TQ) posse's abilities to be anti-oxidant, anti-inflammatory, anti-cancer, anti-bacterial and anti-fungal, anti-carcinogenic, anti-schistosomiasis, anti-viral, anti-parasitic and anti-mutagenic, (TQ) is also considered safe for body. In addition, it is anti-tumor and is effective in cancer treatment in body. For example, it is effective in the diminishing the risk of atherosclerosis by decreasing the serum low density lipoprotein cholesterol level and increasing the serum high density lipoprotein cholesterol levels (Dahri et al., 2005;
Nader et al., 2010); it exerts therapeutic and protective effect in diabetes by decreasing morphological changes and preserving pancreatic beta-cell integrity (Kanter et al., 2009) and by beneficially changing the hepatic enzyme activities (Pan i and Sankaranarayanan, 2009); it is effective against hypertension (Khattab and Nagi, 2007;
Dehkordi and Kamkhah, 2008); it has a potent antihistaminic effect on airways of asthmatic patients (Boskabady et al., 2010); its components are promising agents to complement schistosomiasis specific treatment (El Shenawy et al., 2008); its oils protects kidney tissue against oxygen free radicals, preventing renal dysfunction and morphological abnormalities (Bayrak et al., 2008; Uz et al., 2008; Ragheb et al., 2009).
Other names of black seed are for black cumin, black caraway seeds, Nigella sativa etc.
Black seed's inherent ingredients are capable to grow and regrow hair in body.
They are also capable to heal body and it's internal and external organs from many diseases.
In addition, black seed is effective in healing and curing many types of cancers including but not limited to Blood Cancer, Breast Cancer, Colon Cancer, Pancreatic Cancer, Hepatic Cancer, Lung Cancer, Fibrosarcoma, Skin cancer, Renal Cancer, Prostate Cancer etc. In addition, it can heal and cure body from many viruses like AIDS, Bird Flue etc. It helps fighting viruses by bringing about higher serum levels of interferon-gamma. In addition, it raises the number of CD4 cells and raise their response, it also helps T cells and suppress macrophages. Immunity against viral infection is also raised by it. Obesity can also be controlled with this black seed ingredient. Alzymers disease can also be treated with black seed ingredients.
Black seed ingredients have anti-microbial effects on various pathogens. For example, bacteria, viruses, schistosome, fungus etc. The black seed ingredients can be applied alone or with other drugs to treat body and cure it.
Cancer in body is caused by genetic alterations and abnormal cell growth.
Black seed ingredients can kill cancer cells by acting upon cancer cells through various molecular pathways. Thymoquinone (TQ) present in black seeds influence to kill apoptotic cells in tissue caring cancer by keeping in order apoptotic genes. In addition, Anti-proliferative effect of TQ from black seeds also influence positively on myeloblastic leukemia HL-60 cells. TQ from black seed influences apoptosis and disturbs mitochondrial membrane strength. It also energizing caspases 8, 9 and 3 of HL-60 myeloblastic leukemia cells.
Similarly, TQ also have positive influence on colon cancer cell line HCT 116.
TQ also down-regulates the expression NF-kappa B-regulated anti-apoptotic (IAP-1, IAP-
2, XIAP
BcI-2, BcI-xL, and Survivin) gene products (Sethi et al., 2008). TO induce apoptosis by the activation of c-jun NH(2)-terminal kinase and p38 mitogen-activated protein kinase pathways in pancreatic cancer cells.(Torres et al,. 2010). TQ controls and influence positively on AKT pathway and body's umbilical vein endothelial cells by supressing activeness of AKT excess signals and regulating kinase. LPS
(lipopolysaccharides a bacterial component) induced phosphorylation of pro-survival kinases AKT and was abrogated by TQ in dendric cells. (Xuan et al 2010).
Anti-oxidant enzymes are directly related to cancer sells. TQ increases anti-oxidant enzymes like super-oxides (SOD), catalase (CAT), glutathione peroxidase (GPX) and so on. Enzymes are effective against cancer cells of various kinds. TQ also decrease effects of toxic drugs used for treating cancer by up-regulating anti-oxidants in body.
Information also taken from article Anticancer Activities of Nigella Sativa written by Md Asaduzzaman Khan, Han-chun Chen and Dian-zheng Zhang. Published on line July
BcI-2, BcI-xL, and Survivin) gene products (Sethi et al., 2008). TO induce apoptosis by the activation of c-jun NH(2)-terminal kinase and p38 mitogen-activated protein kinase pathways in pancreatic cancer cells.(Torres et al,. 2010). TQ controls and influence positively on AKT pathway and body's umbilical vein endothelial cells by supressing activeness of AKT excess signals and regulating kinase. LPS
(lipopolysaccharides a bacterial component) induced phosphorylation of pro-survival kinases AKT and was abrogated by TQ in dendric cells. (Xuan et al 2010).
Anti-oxidant enzymes are directly related to cancer sells. TQ increases anti-oxidant enzymes like super-oxides (SOD), catalase (CAT), glutathione peroxidase (GPX) and so on. Enzymes are effective against cancer cells of various kinds. TQ also decrease effects of toxic drugs used for treating cancer by up-regulating anti-oxidants in body.
Information also taken from article Anticancer Activities of Nigella Sativa written by Md Asaduzzaman Khan, Han-chun Chen and Dian-zheng Zhang. Published on line July
3, 2011.
Summary:
The inherent ingredients of black seed can easily be transferred to any liquid, solution or compound. Some liquids, solutions or compounds can absorb the ingredients on room temperature and bec9me extract of black seed ingredient while other have to be heated. Like vinegar having acid in it will absorb ingredient without any heating.
Similarly, other liquid, solutions or compounds may also absorb ingredients without heating.
We can transfer black seed ingredients in liquid, solution or compound for example by putting black seeds in water. If water have higher temperature than room temperature.
The transfer of black seed ingredients may start taking place from seeds to water. The ration of black seeds and water can be 1:2, although it can vary. The less the water the higher the concentration of black seed ingredient transfer into the water. The extract may be more potent if ratio is lower. Longer time of heating them together may also affect the amount of ingredients transfer and its potency. Minimum time I
would say could be 10 to 15 minutes of heating them together to transfer ingredients, or could be less than that also.. The water becomes more darker in color as more transfer of the ingredients take place. It is optimal to heat the water and the seeds with steam to keep all ingredients of black seeds effective and alive and not to kill the ingredients with over heating. The black seeds can be separated from the water or any liquid, solution or compound after the transfer of ingredients takes place and getting its extract. The water in this invention or any liquid, solution or compound left over after separating black seeds giving the extract of ingredients that can be used to give effects of black seed ingredients and it can be used to grow and re-grow hair and/or fight diseases, cancers or viruses mentioned above in body.
This water or liquid, Solution or compound can be accompanied with other beneficial products to be more effective in achieving its intended purpose to deal with the problem of body. For example, henna leaves extract can be added by boiling them in water or liquid, solution or compound before getting extract of black seeds ingredients. And also, for example, making lotions, soaps, shampoo or any form of medicine or any kind of product can be developed with the water or liquid, solution or compound to deal with any issue of body. In addition, if we take problem of hair growth and regrowth of body, there are many oils that are very beneficial for hair growth or regrowth.
Black seed ingredients in the abstract are beneficial in reducing DHT in follicles of hair and body.
In addition, many oils have abilities to bring about good blood circulation in the area where body need to improve blood circulation to grow and regrow hair or some oils help dealing with excess DHT also and so on., for example, oils or essential oils like rosemary, lavender etc. can be added to the water or any liquid, solution or compound caring black seed abstract. Essential oils can be added in beneficial oils and then added in extract of black seeds ingredients. For example, safflower oil can be used as carrier oil, it is known for many benefits to hair and skin and its comedogenic rating is 0.
We have to keep in mind that essential oils are very strong and are safe to be used if they are under 2 percent of total and final product of our water or any liquid, solution or compound caring black seed abstract by weight. We know oil and water or other solutions or compounds may not mix well. We will have to add emulsifying agent to mix them together. There are many recipes to make lotions, soaps and various products and all percentages of items that can be added to make products are every where on internet net and in the market. They are easily accessible today. Similarly, various products can be developed to fight other diseases, cancers, or viruses by adding beneficial products or drugs to the water or liquid, solution or compound caring black seed abstract to be more effective in desired treatment of body. To make water or any liquid, solution or compound thicker we can use various products like shea butter etc.
For prolonging shelf life various preservatives may be added. We can add various products to make water or liquid, solution or compound caring black seed ingredients to make it attractive to general public and to be used conveniently as needed.
Dead skin starts covering the area where hair start to falling on body. This is due to low blood circulation on that area of the body. With time the pores are blocked with dead cells. The skin is covered with dead cells and the area becomes bald. In addition, bacteria and other fungus may also start growing along with dead skin on surface or in hair follicles. For example, Vinegar have acid in it that dissolves the dead cells and kills the bacteria and fungus and exfoliate to clear skin, pores and follicles and also clear the path for hair to grow and regrow hair once again, when used in, along with or used separately from the water or liquid, solution or compound containing caring black seed ingredients. If vinegar is not desired to be used due to any reason, other solutions or products for removal of dead skin, killing bacteria and fungus and/or exfoliating the skin or surface of body can be used that are or may be friendly to the skin.
Other products made to exfoliate and remove dead skin can also be used, they can be added to our water or liquid, solution or compound caring black seed ingredients or may be used separately and they can be alternative of vinegar also. When acids are to be used to remove dead cells and exfoliate skin, precaution must be taken to protect skin from sun light to avoid burning of the skin and other harmful effects.
Protection from sun may be done by using sun screen or using other means of protection skin from rays of sun. Other ways could be used to remove dead skin. For example, derma roller and other products could also be used to disrupt and remove outer layer of dead cells and skin on surface of body and clear the path for growth and regrowth of hair before using water or liquid, solution or compound carrying black seed ingredients.
Other remedies that solve the problem of removing dead skin, killing bacteria and fungus and exfoliating skin can also be helpful. Application of the water or liquid, solution or the compound caring black seed ingredients on the surface of the body will start growing and re-growing hair where hair was lost and bald surface appeared. The path for growth and regrowth of hair through the pores and follicles should be cleared to get better results before the water or liquid, solution or compound caring black seed ingredients is used on the surface of the body.
Cross reference:
For hair growth and regrowth:
1.
Patent 2782980 wo 2011/081861 PCT/US2010/060003 =
Hair Growth and/or Regrowth Compositions Technical Field The present disclosure relates to compositions containing certain pyrimidine compounds such as minoxidil and/or certain pyrimidine sulfate (inner salt) compounds such as minoxidil sulfate and especially compositions containing pyrimidine compounds in combination with admixtures comprising at least one antioxidant, at least one organic acid and a select fatty acid mixture. The present disclosure also relates to use of the compositions to grow hair and/or prevent hair loss in mammals and particularly in humans.
Background Various pyrimidine compounds have been suggested as being useful for growing and/or re-growing hair in mammals including humans. For example, see U.S.
Patent 4,139,619 to Chidsey, Ill, disclosure of which is incorporated herein by reference. In particular, minoxidil (6-amino- 1, 2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine is currently used commercially as a hair growth agent for use in the treatment of male pattern baldness.
More recently, the use of certain pyrimidine sulfates, such as minoxidil sulfate, have been suggested as being useful for growing hair in mammals. In particular, see U.S.
Patent 4,287,338. It is disclosed that the sulfates are faster and more potent than minoxidil in promoting hair growth. In certain situations, and/or market segments, faster and/or thicker hair growth or regrowth is a continuing desire and goal; hence, work continues in developing improved hair growth preparations.
2.
Patent 2232655 C:H ULL3Lb55 LUU3-11-L5 HERBAI¨BASED ORAL COMPOSTTION AND PROCESS FOR
PRODUCING THE SAME
Field of the Invention The present invention relates to herbal-based products, in particular to herbal-s based gums and toothpastes for promoting darkening of hair color.
Background of the Invention Chinese herbalists have over the centuries identified individual herbs that are believed to have certain beneficial effects on the human body. Included among these herbs are Radix Polygoni Multiflora, referred to by Chinese herbalists as He Shou Wu.
This herb is traditionally believed to be useful in the treatment of kidney and liver deficiencies, premature graying of the hair, relief of constipation, and skin lesions.
Another traditional herb is Rhizoma Drynariae, otherwise known as Gu Sui Bu, Which is traditionally believed to aid the liver and kidney, to assist in the healing of bone fractures, dislocations and tissue trauma, and to reduce premature balding and to promote hair growth. The physical characteristics of these herbs and their methods of preparation are described in the Encyclopedia of Chinese Medicine and Herbs, which disclosure is hereby expressly incorporated by reference. A traditional Generalization of the operation of these herbs the symptomology for which they are useful, and the activity are described in Ni, Maoshing, Chinese Herbology Made Easy, pages 138-140, 148, 149, 1 SO, and 151, A still further traditional Chinese herb is Herba Ecliptae, which has traditionally been believed to aid in restoring grayed hair to its originalcolor, and to lessen the loss of hair.
3.
= =
Patent 2652301 SYSTEM AND METHOD FOR PROMOTING HAIR GROWTH AND
IMPROVING HAIR AND SCALP HEALTH =
FIELD OF THE INVENTION
The present invention relates to the field of hair and scalp treatment, and in particular to plant extracts for promoting hair growth.
Alopecia, or hair loss, is an ongoing problem afflicting mankind and animals.
Men, woman and children can all suffer from alopecia, which can be the result of one, or a combination of, a number of factors including genetic factors, hormonal factors, surgery, trauma and stress. The universality of the occurrence of alopecia has led to continuing efforts throughout history to discover compositions for stimulating hair growth and preventing hair loss. Hair is basically composed of a tough and insoluble protein, keratin. Each hair comprises a cylindrical shaft and a root, and is contained in a follicle, which is a task-like depression in the skin. The average human head, for example, has about 100,000 hair follicles spread across the scalp. The bottom of the follicle contains a 13nger-likeprojection termed the papilla, which consists of connective tissue from which hair grows, and through which blood vessels supply the cells with nourishment. The shafts the part that extends outwards from the skin surface, whilst the root has been described as the buried part of the hair. The base of the root expands into the hair bulb, which rests upon the papilla. Cells from which the hair is produced grow in the bulb of the follicle; they are extruded in the form of fibres as the cells proliferate in the follicle. "Hair growth"
refers to the formation and elongation of the hair fibre by the dividing cells. Hair growth is not constant, however, because follicles are cycling through stages of growth, rest and regression, In most mammals, the cycle of hair growth is seasonal and is related to daylight length and hormonal activity, resulting in regular periods of shedding, or moulting. By contrast, human hair follicles generally cycle independently of one another, with each follicle apparently having its own.
Summary:
The inherent ingredients of black seed can easily be transferred to any liquid, solution or compound. Some liquids, solutions or compounds can absorb the ingredients on room temperature and bec9me extract of black seed ingredient while other have to be heated. Like vinegar having acid in it will absorb ingredient without any heating.
Similarly, other liquid, solutions or compounds may also absorb ingredients without heating.
We can transfer black seed ingredients in liquid, solution or compound for example by putting black seeds in water. If water have higher temperature than room temperature.
The transfer of black seed ingredients may start taking place from seeds to water. The ration of black seeds and water can be 1:2, although it can vary. The less the water the higher the concentration of black seed ingredient transfer into the water. The extract may be more potent if ratio is lower. Longer time of heating them together may also affect the amount of ingredients transfer and its potency. Minimum time I
would say could be 10 to 15 minutes of heating them together to transfer ingredients, or could be less than that also.. The water becomes more darker in color as more transfer of the ingredients take place. It is optimal to heat the water and the seeds with steam to keep all ingredients of black seeds effective and alive and not to kill the ingredients with over heating. The black seeds can be separated from the water or any liquid, solution or compound after the transfer of ingredients takes place and getting its extract. The water in this invention or any liquid, solution or compound left over after separating black seeds giving the extract of ingredients that can be used to give effects of black seed ingredients and it can be used to grow and re-grow hair and/or fight diseases, cancers or viruses mentioned above in body.
This water or liquid, Solution or compound can be accompanied with other beneficial products to be more effective in achieving its intended purpose to deal with the problem of body. For example, henna leaves extract can be added by boiling them in water or liquid, solution or compound before getting extract of black seeds ingredients. And also, for example, making lotions, soaps, shampoo or any form of medicine or any kind of product can be developed with the water or liquid, solution or compound to deal with any issue of body. In addition, if we take problem of hair growth and regrowth of body, there are many oils that are very beneficial for hair growth or regrowth.
Black seed ingredients in the abstract are beneficial in reducing DHT in follicles of hair and body.
In addition, many oils have abilities to bring about good blood circulation in the area where body need to improve blood circulation to grow and regrow hair or some oils help dealing with excess DHT also and so on., for example, oils or essential oils like rosemary, lavender etc. can be added to the water or any liquid, solution or compound caring black seed abstract. Essential oils can be added in beneficial oils and then added in extract of black seeds ingredients. For example, safflower oil can be used as carrier oil, it is known for many benefits to hair and skin and its comedogenic rating is 0.
We have to keep in mind that essential oils are very strong and are safe to be used if they are under 2 percent of total and final product of our water or any liquid, solution or compound caring black seed abstract by weight. We know oil and water or other solutions or compounds may not mix well. We will have to add emulsifying agent to mix them together. There are many recipes to make lotions, soaps and various products and all percentages of items that can be added to make products are every where on internet net and in the market. They are easily accessible today. Similarly, various products can be developed to fight other diseases, cancers, or viruses by adding beneficial products or drugs to the water or liquid, solution or compound caring black seed abstract to be more effective in desired treatment of body. To make water or any liquid, solution or compound thicker we can use various products like shea butter etc.
For prolonging shelf life various preservatives may be added. We can add various products to make water or liquid, solution or compound caring black seed ingredients to make it attractive to general public and to be used conveniently as needed.
Dead skin starts covering the area where hair start to falling on body. This is due to low blood circulation on that area of the body. With time the pores are blocked with dead cells. The skin is covered with dead cells and the area becomes bald. In addition, bacteria and other fungus may also start growing along with dead skin on surface or in hair follicles. For example, Vinegar have acid in it that dissolves the dead cells and kills the bacteria and fungus and exfoliate to clear skin, pores and follicles and also clear the path for hair to grow and regrow hair once again, when used in, along with or used separately from the water or liquid, solution or compound containing caring black seed ingredients. If vinegar is not desired to be used due to any reason, other solutions or products for removal of dead skin, killing bacteria and fungus and/or exfoliating the skin or surface of body can be used that are or may be friendly to the skin.
Other products made to exfoliate and remove dead skin can also be used, they can be added to our water or liquid, solution or compound caring black seed ingredients or may be used separately and they can be alternative of vinegar also. When acids are to be used to remove dead cells and exfoliate skin, precaution must be taken to protect skin from sun light to avoid burning of the skin and other harmful effects.
Protection from sun may be done by using sun screen or using other means of protection skin from rays of sun. Other ways could be used to remove dead skin. For example, derma roller and other products could also be used to disrupt and remove outer layer of dead cells and skin on surface of body and clear the path for growth and regrowth of hair before using water or liquid, solution or compound carrying black seed ingredients.
Other remedies that solve the problem of removing dead skin, killing bacteria and fungus and exfoliating skin can also be helpful. Application of the water or liquid, solution or the compound caring black seed ingredients on the surface of the body will start growing and re-growing hair where hair was lost and bald surface appeared. The path for growth and regrowth of hair through the pores and follicles should be cleared to get better results before the water or liquid, solution or compound caring black seed ingredients is used on the surface of the body.
Cross reference:
For hair growth and regrowth:
1.
Patent 2782980 wo 2011/081861 PCT/US2010/060003 =
Hair Growth and/or Regrowth Compositions Technical Field The present disclosure relates to compositions containing certain pyrimidine compounds such as minoxidil and/or certain pyrimidine sulfate (inner salt) compounds such as minoxidil sulfate and especially compositions containing pyrimidine compounds in combination with admixtures comprising at least one antioxidant, at least one organic acid and a select fatty acid mixture. The present disclosure also relates to use of the compositions to grow hair and/or prevent hair loss in mammals and particularly in humans.
Background Various pyrimidine compounds have been suggested as being useful for growing and/or re-growing hair in mammals including humans. For example, see U.S.
Patent 4,139,619 to Chidsey, Ill, disclosure of which is incorporated herein by reference. In particular, minoxidil (6-amino- 1, 2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine is currently used commercially as a hair growth agent for use in the treatment of male pattern baldness.
More recently, the use of certain pyrimidine sulfates, such as minoxidil sulfate, have been suggested as being useful for growing hair in mammals. In particular, see U.S.
Patent 4,287,338. It is disclosed that the sulfates are faster and more potent than minoxidil in promoting hair growth. In certain situations, and/or market segments, faster and/or thicker hair growth or regrowth is a continuing desire and goal; hence, work continues in developing improved hair growth preparations.
2.
Patent 2232655 C:H ULL3Lb55 LUU3-11-L5 HERBAI¨BASED ORAL COMPOSTTION AND PROCESS FOR
PRODUCING THE SAME
Field of the Invention The present invention relates to herbal-based products, in particular to herbal-s based gums and toothpastes for promoting darkening of hair color.
Background of the Invention Chinese herbalists have over the centuries identified individual herbs that are believed to have certain beneficial effects on the human body. Included among these herbs are Radix Polygoni Multiflora, referred to by Chinese herbalists as He Shou Wu.
This herb is traditionally believed to be useful in the treatment of kidney and liver deficiencies, premature graying of the hair, relief of constipation, and skin lesions.
Another traditional herb is Rhizoma Drynariae, otherwise known as Gu Sui Bu, Which is traditionally believed to aid the liver and kidney, to assist in the healing of bone fractures, dislocations and tissue trauma, and to reduce premature balding and to promote hair growth. The physical characteristics of these herbs and their methods of preparation are described in the Encyclopedia of Chinese Medicine and Herbs, which disclosure is hereby expressly incorporated by reference. A traditional Generalization of the operation of these herbs the symptomology for which they are useful, and the activity are described in Ni, Maoshing, Chinese Herbology Made Easy, pages 138-140, 148, 149, 1 SO, and 151, A still further traditional Chinese herb is Herba Ecliptae, which has traditionally been believed to aid in restoring grayed hair to its originalcolor, and to lessen the loss of hair.
3.
= =
Patent 2652301 SYSTEM AND METHOD FOR PROMOTING HAIR GROWTH AND
IMPROVING HAIR AND SCALP HEALTH =
FIELD OF THE INVENTION
The present invention relates to the field of hair and scalp treatment, and in particular to plant extracts for promoting hair growth.
Alopecia, or hair loss, is an ongoing problem afflicting mankind and animals.
Men, woman and children can all suffer from alopecia, which can be the result of one, or a combination of, a number of factors including genetic factors, hormonal factors, surgery, trauma and stress. The universality of the occurrence of alopecia has led to continuing efforts throughout history to discover compositions for stimulating hair growth and preventing hair loss. Hair is basically composed of a tough and insoluble protein, keratin. Each hair comprises a cylindrical shaft and a root, and is contained in a follicle, which is a task-like depression in the skin. The average human head, for example, has about 100,000 hair follicles spread across the scalp. The bottom of the follicle contains a 13nger-likeprojection termed the papilla, which consists of connective tissue from which hair grows, and through which blood vessels supply the cells with nourishment. The shafts the part that extends outwards from the skin surface, whilst the root has been described as the buried part of the hair. The base of the root expands into the hair bulb, which rests upon the papilla. Cells from which the hair is produced grow in the bulb of the follicle; they are extruded in the form of fibres as the cells proliferate in the follicle. "Hair growth"
refers to the formation and elongation of the hair fibre by the dividing cells. Hair growth is not constant, however, because follicles are cycling through stages of growth, rest and regression, In most mammals, the cycle of hair growth is seasonal and is related to daylight length and hormonal activity, resulting in regular periods of shedding, or moulting. By contrast, human hair follicles generally cycle independently of one another, with each follicle apparently having its own.
4.
Patent 3006576 Hair Growth Composition and Method FIELD OF THE INVENTION
The present invention relates to compositions for and methods of retarding hair lossor facilitating hair growth comprising a hair growth active, a C8-C2.4 alcohol ester of a carboxylic acid and a viscosity modifying agent comprising: a nonionic hydroxypropyl methyl cellulose and a high molecular weight carboxymethyl cellulose at a ratio of the non ionic hydroxypropmethyl cellulose to the high molecular weight carboxymethyl cellulose of greater than about 1:1.
BACKGROUND OF THE INVENTION
Alopecia, or hair loss, in its various forms is an ongoing problem afflicting mankind and animals. Men, woman and children can all suffer from alopecia, which can be result of one, or a combination of, factors including genetic factors, hormonal factors, surgery, trauma, chemotherapy, aging, certain drug side effects and stress. The universality of the occurrence of alopecia has led to continuing efforts throughout history to discover compositions for stimulating hair growth and preventing hair loss.A number of "natural"
remedies for alopecia based solely on herbs and plant extracts have been proposed. However, such compounds have proven clinically to have very little If any effect.
Accordingly, an aspect of the present invention is to provide a method for reducing hair loss and facilitate hair growth and/or providing a thicker, denser or richer hair coat Another aspect of the present disclosure is concerned with methods of using compositions comprising at least one hair growth stimulator, and at least one C8-C24 alcohol ester of a carboxylic acid. Another aspect of the present invention is improving the temperature stability of solution or gel compositions containing from about 0.1% to about 20% by weight of a hair growth or hair regrowth compound (such as minoxidil or pharmaceutically acceptable addition salts thereof); from about 0.5% to about 10% by weight of an oil phase or oily.
Patent 3006576 Hair Growth Composition and Method FIELD OF THE INVENTION
The present invention relates to compositions for and methods of retarding hair lossor facilitating hair growth comprising a hair growth active, a C8-C2.4 alcohol ester of a carboxylic acid and a viscosity modifying agent comprising: a nonionic hydroxypropyl methyl cellulose and a high molecular weight carboxymethyl cellulose at a ratio of the non ionic hydroxypropmethyl cellulose to the high molecular weight carboxymethyl cellulose of greater than about 1:1.
BACKGROUND OF THE INVENTION
Alopecia, or hair loss, in its various forms is an ongoing problem afflicting mankind and animals. Men, woman and children can all suffer from alopecia, which can be result of one, or a combination of, factors including genetic factors, hormonal factors, surgery, trauma, chemotherapy, aging, certain drug side effects and stress. The universality of the occurrence of alopecia has led to continuing efforts throughout history to discover compositions for stimulating hair growth and preventing hair loss.A number of "natural"
remedies for alopecia based solely on herbs and plant extracts have been proposed. However, such compounds have proven clinically to have very little If any effect.
Accordingly, an aspect of the present invention is to provide a method for reducing hair loss and facilitate hair growth and/or providing a thicker, denser or richer hair coat Another aspect of the present disclosure is concerned with methods of using compositions comprising at least one hair growth stimulator, and at least one C8-C24 alcohol ester of a carboxylic acid. Another aspect of the present invention is improving the temperature stability of solution or gel compositions containing from about 0.1% to about 20% by weight of a hair growth or hair regrowth compound (such as minoxidil or pharmaceutically acceptable addition salts thereof); from about 0.5% to about 10% by weight of an oil phase or oily.
5.
Patent 3006578 Hair Growth Composition and Method FIELD OF THE INVENTION
The present invention relates to compositions for and methods of retarding hair loss or facilitating hair growth comprising a hair growth active, a mixture of C12-C 15 alkyl lactates and a viscosity modifying agent comprising at least one cellulose and/or a cellulose derivative. Clear compositions are also disclosed.
BACKGROUND OF THE INVENTION
Alopecia, or hair loss, in its various forms is an ongoing problem afflicting mankind and animals. Men, woman and children can all suffer from alopecia, which can be result of one, or a combination of, factors including genetic factors, hormonal factors, surgery, trauma, chemotherapy, aging, certain drug side effects and stress. The universality of the occurrence of alopecia has led to continuing efforts throughout history to discover compositions for stimulating hair growth and preventing hair loss. A number of "natural"
remedies for alopecia based solely on herbs and plant extracts have been proposed. However, such compounds have proven clinically to have very little if any effect Accordingly, an aspect of the present invention is to provide a method for reducing hair loss and facilitate hair growth and/or providing a thicker, denser or richer hair coat. Another aspect of the present disclosure is concerned with methods of using compositions comprising at least one hair growth stimulator, and at least one C8-C24 alcohol ester of a carboxylic acid.
Another aspect of the present invention is improving the temperature stability of solution or gel compositions containing from about 0.1% to about 20% by weight of a hair growth or hair regrowth compound (such as minoxidil or pharmaceutically acceptable addition salts thereof); from about 0.5% to about 10% by weight of an oil phase or oily.
compound; from about 0% to about 60 % of a dihydric alcohol (such as propylene glycol) and from about 0 to about 65% by weight of a C2-C4 alcohol (such as ethanol).
Patent 3006578 Hair Growth Composition and Method FIELD OF THE INVENTION
The present invention relates to compositions for and methods of retarding hair loss or facilitating hair growth comprising a hair growth active, a mixture of C12-C 15 alkyl lactates and a viscosity modifying agent comprising at least one cellulose and/or a cellulose derivative. Clear compositions are also disclosed.
BACKGROUND OF THE INVENTION
Alopecia, or hair loss, in its various forms is an ongoing problem afflicting mankind and animals. Men, woman and children can all suffer from alopecia, which can be result of one, or a combination of, factors including genetic factors, hormonal factors, surgery, trauma, chemotherapy, aging, certain drug side effects and stress. The universality of the occurrence of alopecia has led to continuing efforts throughout history to discover compositions for stimulating hair growth and preventing hair loss. A number of "natural"
remedies for alopecia based solely on herbs and plant extracts have been proposed. However, such compounds have proven clinically to have very little if any effect Accordingly, an aspect of the present invention is to provide a method for reducing hair loss and facilitate hair growth and/or providing a thicker, denser or richer hair coat. Another aspect of the present disclosure is concerned with methods of using compositions comprising at least one hair growth stimulator, and at least one C8-C24 alcohol ester of a carboxylic acid.
Another aspect of the present invention is improving the temperature stability of solution or gel compositions containing from about 0.1% to about 20% by weight of a hair growth or hair regrowth compound (such as minoxidil or pharmaceutically acceptable addition salts thereof); from about 0.5% to about 10% by weight of an oil phase or oily.
compound; from about 0% to about 60 % of a dihydric alcohol (such as propylene glycol) and from about 0 to about 65% by weight of a C2-C4 alcohol (such as ethanol).
6.
Patent 2152953 COMPOSITIONS FOR TREATMENT OF THE HAIR
The present invention relates to topical compositions for the treatment of the hair which comprise a pharmaceutically acceptable oxalate of a group la or Ila metal or ammonium oxalate, disposed in a pharmaceutical acceptable carrier or diluent therefor. The pharmaceutically acceptable oxalate is preferably an oxalate selected from calcium, barium or magnesium, lithium, sodium or potassium and may include an organic plant derived oxalate.
= Extracts of red and white squill have long been repotted to have medicinal properties; white squill having the property of being a cardiac stimulant, a diuretic or emetic. These extracts have been utilised for this purpose for very many years.
We have previously described how both red and white squill extracts are useful for restoring hair loss due to conditions such as alopecia whether or not problems of seborrhoea exist The applicant has now found that a significant component of this composition, in so far as hair treatment is concerned are calcium oxalate crystals derived from the squill extract, optionally with at least some of the mucilage associated therewith.
Further tests revealed, however that the active principle of such pharmaceutical compositions was a group la or ha metal oxalate, op¨ionally with an organic oxalate and/or mucilage derived from a plant extract.
In Canadian patent 888689 there is disclosed the use of a composition for the treatment for the scalp against hair loss which essentially requires the use of an emulsion comprising bergamot oil, water and a ferrous salt including a ferrous oxalate (i.e. a group VIII metal salt).
Patent 2152953 COMPOSITIONS FOR TREATMENT OF THE HAIR
The present invention relates to topical compositions for the treatment of the hair which comprise a pharmaceutically acceptable oxalate of a group la or Ila metal or ammonium oxalate, disposed in a pharmaceutical acceptable carrier or diluent therefor. The pharmaceutically acceptable oxalate is preferably an oxalate selected from calcium, barium or magnesium, lithium, sodium or potassium and may include an organic plant derived oxalate.
= Extracts of red and white squill have long been repotted to have medicinal properties; white squill having the property of being a cardiac stimulant, a diuretic or emetic. These extracts have been utilised for this purpose for very many years.
We have previously described how both red and white squill extracts are useful for restoring hair loss due to conditions such as alopecia whether or not problems of seborrhoea exist The applicant has now found that a significant component of this composition, in so far as hair treatment is concerned are calcium oxalate crystals derived from the squill extract, optionally with at least some of the mucilage associated therewith.
Further tests revealed, however that the active principle of such pharmaceutical compositions was a group la or ha metal oxalate, op¨ionally with an organic oxalate and/or mucilage derived from a plant extract.
In Canadian patent 888689 there is disclosed the use of a composition for the treatment for the scalp against hair loss which essentially requires the use of an emulsion comprising bergamot oil, water and a ferrous salt including a ferrous oxalate (i.e. a group VIII metal salt).
7.
Patent 1270442 HAIR TONIC COMPOSITION
BACXGROUND OF THE INVENTION
1. Field of the Invention The present invention relates to a novel hair tonic composition suitable for use in preventing the generation of dandruff (or scurf) in hair and itching in the scalp and in accelerating the growth of hair. More specifically, it relates to a novel hair tonic composition containing, as an effective ingredient, an extract from dong chong xia cao.
2. Description of the Related Art The possession of a healthy and profuse head of hair throughout life is the =
=
ambition of most human beings. Various kinds of hair dressings, including hair tonic compositions, have been used for alleviating or curing epilation or depilation (i.e., the involuntary loss of hair and subsequent balding). However, present, there are no truly effective agents for allevi-ating epilation, accelerating the growth of hair, and further alleviating or curing the generation of dandruff in the hair and itching in the scale. The dong chong xia cao, which is a raw material for the hair tonic composition of the present invention, has been long known as a raw material for Chinese medicines. Dong chong xia cao was first described by Wu Iluo during the Ching dynasty in his book, Ben Cao CongXin*(Herbs from Anew).
After that it was described, for example, in Chinese publications Zhonq Yao bacidian (Encyclo¨edia of Chinese Medicine*,* and Zhong Cao Yaoxue (Chinese Herbal Medicine) and Japanese publications, Shin Tei Wakan Yaku (¨apanese and Chinese Medicine, New Ed.) by Xinpo Akamastu, and a large number of other publications relating to Chinese medicines. These publications disclose various kinds of pharmacological effects provided by dong chong xia cao, and variousprescriptions for the use of dong chong xia cao in p. 767-768, 1977 p. 12 13, 1976 p. 7p5-706, 1980
Patent 1270442 HAIR TONIC COMPOSITION
BACXGROUND OF THE INVENTION
1. Field of the Invention The present invention relates to a novel hair tonic composition suitable for use in preventing the generation of dandruff (or scurf) in hair and itching in the scalp and in accelerating the growth of hair. More specifically, it relates to a novel hair tonic composition containing, as an effective ingredient, an extract from dong chong xia cao.
2. Description of the Related Art The possession of a healthy and profuse head of hair throughout life is the =
=
ambition of most human beings. Various kinds of hair dressings, including hair tonic compositions, have been used for alleviating or curing epilation or depilation (i.e., the involuntary loss of hair and subsequent balding). However, present, there are no truly effective agents for allevi-ating epilation, accelerating the growth of hair, and further alleviating or curing the generation of dandruff in the hair and itching in the scale. The dong chong xia cao, which is a raw material for the hair tonic composition of the present invention, has been long known as a raw material for Chinese medicines. Dong chong xia cao was first described by Wu Iluo during the Ching dynasty in his book, Ben Cao CongXin*(Herbs from Anew).
After that it was described, for example, in Chinese publications Zhonq Yao bacidian (Encyclo¨edia of Chinese Medicine*,* and Zhong Cao Yaoxue (Chinese Herbal Medicine) and Japanese publications, Shin Tei Wakan Yaku (¨apanese and Chinese Medicine, New Ed.) by Xinpo Akamastu, and a large number of other publications relating to Chinese medicines. These publications disclose various kinds of pharmacological effects provided by dong chong xia cao, and variousprescriptions for the use of dong chong xia cao in p. 767-768, 1977 p. 12 13, 1976 p. 7p5-706, 1980
8.
Patent 2953957 MINOXIDIL-CONTAINING HAIR GROWTH COMPOSITION
CROSS-REFERENCE TO RELATED APPLICATIONS
The present application claims the benefit of United States provisional patent application 62/019,163, filed June 30, 2014, and United States provisional patent application 62/019,151, filed June 30, 2014, and United States provisional patent application 62/019,141, filed June 30, 2014, and United States provisional patent application 62/019,176, filed June 30, 2014, and United States provisional patent application 62/019,169, filed June 30, 2014,the entirety of which applications are hereby incorporated by reference herein as if fully set forth herein to the extent that they are not inconsistent with the present application.
FIELD OF THE INVENTION
The present invention relates to compositions for and methods of retarding hair los or facilitating hair growth comprising a hair growth active and a C8-C24 alcohol ester of acarboxylic acid.
BACKGROUND OF THE INVENTION
Alopecia, or hair loss, in its various forms is an ongoing problem afflicting mankind and animals. Men, women and children can all suffer from alopecia, which can be result of one, or a combination of, factors including genetic factors, hormonal factors, surgery, trauma, chemotherapy, aging, certain drug side effects and stress.
The universality of the occurrence of alopecia has led to continuing efforts throughout history to discover compositions for stimulating hair growth and preventing hair loss. A number of "natural" remedies for alopecia based solely on herbs and plant extracts have been proposed. However, such compounds have proven clinically to have very little if any effect. Accordingly, an aspect of the present invention is to provide method for reducing hair loss and facilitate hair growth and/or providing a thicker, denser or richer hair coat.
Patent 2953957 MINOXIDIL-CONTAINING HAIR GROWTH COMPOSITION
CROSS-REFERENCE TO RELATED APPLICATIONS
The present application claims the benefit of United States provisional patent application 62/019,163, filed June 30, 2014, and United States provisional patent application 62/019,151, filed June 30, 2014, and United States provisional patent application 62/019,141, filed June 30, 2014, and United States provisional patent application 62/019,176, filed June 30, 2014, and United States provisional patent application 62/019,169, filed June 30, 2014,the entirety of which applications are hereby incorporated by reference herein as if fully set forth herein to the extent that they are not inconsistent with the present application.
FIELD OF THE INVENTION
The present invention relates to compositions for and methods of retarding hair los or facilitating hair growth comprising a hair growth active and a C8-C24 alcohol ester of acarboxylic acid.
BACKGROUND OF THE INVENTION
Alopecia, or hair loss, in its various forms is an ongoing problem afflicting mankind and animals. Men, women and children can all suffer from alopecia, which can be result of one, or a combination of, factors including genetic factors, hormonal factors, surgery, trauma, chemotherapy, aging, certain drug side effects and stress.
The universality of the occurrence of alopecia has led to continuing efforts throughout history to discover compositions for stimulating hair growth and preventing hair loss. A number of "natural" remedies for alopecia based solely on herbs and plant extracts have been proposed. However, such compounds have proven clinically to have very little if any effect. Accordingly, an aspect of the present invention is to provide method for reducing hair loss and facilitate hair growth and/or providing a thicker, denser or richer hair coat.
9.
Patent 3000117 COMPOSITIONS AND METHODS FOR ENHANCING HAIR GROWTH, PROMOTING SKIN REGENERATION, AND WOUND HEALING
Background The non-limiting embodiments disclosed herein generally relate to compositions and methods useful for enhancing hair growth, promoting skin regeneration, and wound healing. The non-limiting embodiments disclosed herein also generally related to methods of screening for a compound capable of increasing cell proliferation. Ther are inadequate methods for regenerating skin or inducing hair growth in a subject (e.g., for treatment of a disease or condition where regenerating skin or inducing hair growth is beneficial). In addition, impaired wound healing represents a significant cause of morbidity and mortality. The wound-healing process is a complex biological process where both differentiated and stem cells as well as cytokines/chemokines, growth factors, and skin matrix components are essential for effective wound healing. Expensive growth factors are often required for cell proliferation, and even then, expansion is often not optimal. Thus, molecules which replace or enhance the actions of growth factors and allow increased expansion of cells in culture, particularly stem cells such as skin-derived precursors (SKPs) are desirable.
Thus, there is a need for molecules that promote the proliferation and self-renewal of cells, such as SKPs. These molecules may be highly advantageous for cosmetic and medical purposes (e.g., hair growth, skin regeneration, and wound healing).
Summary In a first aspect described herein, there is provided a method of promoting skin repair or wound healing, the method including administering to a subject in need thereof a composition including an effective amount of trimebutine or a pharmaceutically acceptable salt or active metabolite thereof. In certain non-limiting embodiments, the subject has a burn or an ulcer, has or previously had an infection resulting in skin loss, has undergone a surgical procedure requiring skin repair, or has an injury resulting in skin loss. In particular embodiments, the composition is administered until the wound substantially heals.
In a second aspect described herein, there is provided a method of promoting hair growth or treating a condition associated with hair loss, the method including administering to a subject in need thereof a composition including an effective amount of trimebutine or a pharmaceutically acceptable salt or active metabolite thereof. In particular non-limiting embodiments, the condition associated with hair loss is selected from the group consisting of: androgenic alopecia, alopecia areata, anagen effluvium, self-induced hair loss, telogen effluvium, scarring alopecia, hair loss as a result of chemotherapy or radiation treatment, supplementing hair transplant, priming skull, administration after hair transplant, and hair loss as a result of exposure to toxic chemicals. In certain non-limiting embodiments, the compositions is administered until a symptom of hair loss improves, wherein the symptom of hair loss is selected from the group.
Patent 3000117 COMPOSITIONS AND METHODS FOR ENHANCING HAIR GROWTH, PROMOTING SKIN REGENERATION, AND WOUND HEALING
Background The non-limiting embodiments disclosed herein generally relate to compositions and methods useful for enhancing hair growth, promoting skin regeneration, and wound healing. The non-limiting embodiments disclosed herein also generally related to methods of screening for a compound capable of increasing cell proliferation. Ther are inadequate methods for regenerating skin or inducing hair growth in a subject (e.g., for treatment of a disease or condition where regenerating skin or inducing hair growth is beneficial). In addition, impaired wound healing represents a significant cause of morbidity and mortality. The wound-healing process is a complex biological process where both differentiated and stem cells as well as cytokines/chemokines, growth factors, and skin matrix components are essential for effective wound healing. Expensive growth factors are often required for cell proliferation, and even then, expansion is often not optimal. Thus, molecules which replace or enhance the actions of growth factors and allow increased expansion of cells in culture, particularly stem cells such as skin-derived precursors (SKPs) are desirable.
Thus, there is a need for molecules that promote the proliferation and self-renewal of cells, such as SKPs. These molecules may be highly advantageous for cosmetic and medical purposes (e.g., hair growth, skin regeneration, and wound healing).
Summary In a first aspect described herein, there is provided a method of promoting skin repair or wound healing, the method including administering to a subject in need thereof a composition including an effective amount of trimebutine or a pharmaceutically acceptable salt or active metabolite thereof. In certain non-limiting embodiments, the subject has a burn or an ulcer, has or previously had an infection resulting in skin loss, has undergone a surgical procedure requiring skin repair, or has an injury resulting in skin loss. In particular embodiments, the composition is administered until the wound substantially heals.
In a second aspect described herein, there is provided a method of promoting hair growth or treating a condition associated with hair loss, the method including administering to a subject in need thereof a composition including an effective amount of trimebutine or a pharmaceutically acceptable salt or active metabolite thereof. In particular non-limiting embodiments, the condition associated with hair loss is selected from the group consisting of: androgenic alopecia, alopecia areata, anagen effluvium, self-induced hair loss, telogen effluvium, scarring alopecia, hair loss as a result of chemotherapy or radiation treatment, supplementing hair transplant, priming skull, administration after hair transplant, and hair loss as a result of exposure to toxic chemicals. In certain non-limiting embodiments, the compositions is administered until a symptom of hair loss improves, wherein the symptom of hair loss is selected from the group.
10.
Patent 2998972 TREATMENT OF ALOPECIA AREATA
FIELD OF THE INVENTION
The present invention relates to a new pharmaceutical use of 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-clipyrimidin-4-y1)-1,6-diazaspiro[3.4]octan-1-y1]-3-oxopropanenitrile.
More specifically, the present invention relates to a therapeutic or preventive agent for alopecia areata whichcontains 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-y1)-1,6-diazaspiro[3.4]octan-1-y1]-3-oxopropanenitrile.
BACKGROUND OF THE INVENTION =
Alopecia areata (AA) is an autoimmune disease that results in hair loss that ranges in presentation from circular patches on the scalp that can often undergo spontaneous resolution to complete hair loss that may persist for life. There are currently no FDA-approved treatments for AA, and treatment regimens for patients with severe disease are empiric and frequently unsatisfactory.
CITATION LISTS
Patent literature:
Patent literature 1: JP 2011-46700 A (Japan Tobacco Inc.) Patent literature 2: W02011/013785 (Japan Tobacco Inc.) Non-patent literature:
Non-patent literature 1: MCELWEE, KJ et al. Experimental induction of alopecia areata-like hair loss in C3H/HeJ mice using full-thickness skin grafts. J
Invest Dermatol. Nov 1998, Vol. 111, No. 5, pages 797-803.
SUMMARY OF THE INVENTION
A. The problem to be solved by the invention is to provide a new pharmaceutical use of 3-[(35,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-y1)-1,6-diazaspiro[3.4]octan-1-y1]-3-oxopropanenitrile.
The present inventors found for the first time that 3-[(35,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-y1)-1,6-diazaspiro[3.4]octan-1-y1]-3-oxopropanenitrile is effective for the treatment or prevention of alopecia areata and that 3-[(35,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-y1)-1,6-diazaspiro[3.4]octan-1-y1]-3-oxopropanenitrile is effective as a topical agent for treating alopecia areata or a topical agent for preventing alopecia areata, and achieved the present invention.
Patent 2998972 TREATMENT OF ALOPECIA AREATA
FIELD OF THE INVENTION
The present invention relates to a new pharmaceutical use of 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-clipyrimidin-4-y1)-1,6-diazaspiro[3.4]octan-1-y1]-3-oxopropanenitrile.
More specifically, the present invention relates to a therapeutic or preventive agent for alopecia areata whichcontains 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-y1)-1,6-diazaspiro[3.4]octan-1-y1]-3-oxopropanenitrile.
BACKGROUND OF THE INVENTION =
Alopecia areata (AA) is an autoimmune disease that results in hair loss that ranges in presentation from circular patches on the scalp that can often undergo spontaneous resolution to complete hair loss that may persist for life. There are currently no FDA-approved treatments for AA, and treatment regimens for patients with severe disease are empiric and frequently unsatisfactory.
CITATION LISTS
Patent literature:
Patent literature 1: JP 2011-46700 A (Japan Tobacco Inc.) Patent literature 2: W02011/013785 (Japan Tobacco Inc.) Non-patent literature:
Non-patent literature 1: MCELWEE, KJ et al. Experimental induction of alopecia areata-like hair loss in C3H/HeJ mice using full-thickness skin grafts. J
Invest Dermatol. Nov 1998, Vol. 111, No. 5, pages 797-803.
SUMMARY OF THE INVENTION
A. The problem to be solved by the invention is to provide a new pharmaceutical use of 3-[(35,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-y1)-1,6-diazaspiro[3.4]octan-1-y1]-3-oxopropanenitrile.
The present inventors found for the first time that 3-[(35,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-y1)-1,6-diazaspiro[3.4]octan-1-y1]-3-oxopropanenitrile is effective for the treatment or prevention of alopecia areata and that 3-[(35,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-y1)-1,6-diazaspiro[3.4]octan-1-y1]-3-oxopropanenitrile is effective as a topical agent for treating alopecia areata or a topical agent for preventing alopecia areata, and achieved the present invention.
11.
COMPOSITIONS INCLUDING AMMONIA OXIDIZING BACTERIA AND
METHODS OF USING SAME
Field of Invention The present invention relates to a composition including ammonia oxidizing bacteria to increase production of nitric oxide and nitric oxide precursors on the surface of a subject and methods of using same to reduce blood pressure, treat Alzheimer's Disease, treat obesity, and treat diabetes Type 2 in a subject, specifically By 10 administering nitric oxide to the subject. Background Beneficial bacteria have been utilized to suppress the growth of pathogenic bacteria. Bacteria and other microorganisms are ubiquitous in the environment.
The 15 discovery of pathogenic bacteria and the germ theory of disease has had a tremendous effect on health and disease states. Bacteria are a normal part of the intestinal contents of all living things. These bacteria are not pathogenic under normal conditions, and in fact improve health by rendering the normal intestinal contents less hospitable for disease causing organisms. This is accomplished in a number of ways: nutrients are consumed, 2o leaving less for pathogens; conditions are produced, such as pH, oxygen tension, which are not hospitable for pathogens; compounds are produced that are toxic to pathogens;
pathogens are consumed as food by these microorganisms; less physical space remains available for pathogens; and specific binding sites are occupied leaving fewer for pathogens. The presence of these desirable bacteria is seen as useful in preventing 25 disease states.
Fermentation of food products has been done to substitute a desired non-pathogenic strain for potential spoilage or pathogenic organisms. Brewed beverages, wine, pickled food, fermented milk products including cheese, yogurt, butter milk,sausage are all examples where desired microorganisms are deliberately inoculated into3o food products under conditions that favor their growth and inhibit the growth of spoilage and pathogenic strains. U.S.
Patents disclosing the use of specific bacteria to inhibit the growth of harmful bacteria include: U.S.
Patent No. 3,984,575 issued to Farr October 5,
COMPOSITIONS INCLUDING AMMONIA OXIDIZING BACTERIA AND
METHODS OF USING SAME
Field of Invention The present invention relates to a composition including ammonia oxidizing bacteria to increase production of nitric oxide and nitric oxide precursors on the surface of a subject and methods of using same to reduce blood pressure, treat Alzheimer's Disease, treat obesity, and treat diabetes Type 2 in a subject, specifically By 10 administering nitric oxide to the subject. Background Beneficial bacteria have been utilized to suppress the growth of pathogenic bacteria. Bacteria and other microorganisms are ubiquitous in the environment.
The 15 discovery of pathogenic bacteria and the germ theory of disease has had a tremendous effect on health and disease states. Bacteria are a normal part of the intestinal contents of all living things. These bacteria are not pathogenic under normal conditions, and in fact improve health by rendering the normal intestinal contents less hospitable for disease causing organisms. This is accomplished in a number of ways: nutrients are consumed, 2o leaving less for pathogens; conditions are produced, such as pH, oxygen tension, which are not hospitable for pathogens; compounds are produced that are toxic to pathogens;
pathogens are consumed as food by these microorganisms; less physical space remains available for pathogens; and specific binding sites are occupied leaving fewer for pathogens. The presence of these desirable bacteria is seen as useful in preventing 25 disease states.
Fermentation of food products has been done to substitute a desired non-pathogenic strain for potential spoilage or pathogenic organisms. Brewed beverages, wine, pickled food, fermented milk products including cheese, yogurt, butter milk,sausage are all examples where desired microorganisms are deliberately inoculated into3o food products under conditions that favor their growth and inhibit the growth of spoilage and pathogenic strains. U.S.
Patents disclosing the use of specific bacteria to inhibit the growth of harmful bacteria include: U.S.
Patent No. 3,984,575 issued to Farr October 5,
12.
Patent 2608651 COIVTPOSITTO'NS AND METHODS FOR THE PREVENTION AND
TREATMENT OF CONDITIONS ASSOCIATED WITH INFLAMMATION =
=
[0001] This application is entitled to and claims priority benefit under 35 U.S.C.
119(e) to U.S. Provisional application Serial No. 60/684,487 filed May 24, 2005, which is incorporated herein by reference in its entirety, 1. FIELD OF THE INVENTION
[0002] The present invention provides methods for preventing, treating, managing and/or ameliorating a condition associated with inflammation (e.g., an inflammatory disorder) or a symptom thereof, the methods comprising administering to a subject in need hereof an effective amount of a theaflavin composition and an effective amount of one or more therapies other than such a theaflavin composition.
2. BACKGROUND OF THE INVENTION
2.1 Inflammatory Disorders [0003] Inflammation plays a fundamental role in host defenses and the progression of immune-mediated diseases. The inflammatory response is initiated in response to injury (e.g., trauma, ischemia, and foreign particles) and infection (e.g., bacterial or viral infection)by a complex cascade of events, including chemical mediators (e.g., cytokines and prostaglandins) and inflammatory cells (e.g., leukocytes). The inflammatory response is characterized by increased blood flow, increased capillary permeability, and the influx of phagocytic cells. These events can result in swelling, redness, warmth (altered heat patterns), and pus formation at the site of injury or infection.
[0004] A delicate well-balanced interplay between the humoral and cellular Immune elements in the inflammatory response enables the elimination of harmful agents and the initiation of the repair of damaged tissue. When this delicately balanced interplay is disrupted, the inflammatory response may result in considerable damage to normal tissue and may be more harmful than the original insult that initiated the reaction.
In these cases of uncontrolled inflammatory responses, clinical intervention is needed to prevent tissue damage and organ dysfunction. [0005] Diseases such as rheumatoid arthritis, osteoarthritis, Crohn's disease, asthma,allergies and inflammatory bowel disease, are characterized by chronic inflammation. Current treatments for inflammatory disorders involve symptomatic medications and immunosuppressive agents to control symptoms. For example, nonsteroidal
Patent 2608651 COIVTPOSITTO'NS AND METHODS FOR THE PREVENTION AND
TREATMENT OF CONDITIONS ASSOCIATED WITH INFLAMMATION =
=
[0001] This application is entitled to and claims priority benefit under 35 U.S.C.
119(e) to U.S. Provisional application Serial No. 60/684,487 filed May 24, 2005, which is incorporated herein by reference in its entirety, 1. FIELD OF THE INVENTION
[0002] The present invention provides methods for preventing, treating, managing and/or ameliorating a condition associated with inflammation (e.g., an inflammatory disorder) or a symptom thereof, the methods comprising administering to a subject in need hereof an effective amount of a theaflavin composition and an effective amount of one or more therapies other than such a theaflavin composition.
2. BACKGROUND OF THE INVENTION
2.1 Inflammatory Disorders [0003] Inflammation plays a fundamental role in host defenses and the progression of immune-mediated diseases. The inflammatory response is initiated in response to injury (e.g., trauma, ischemia, and foreign particles) and infection (e.g., bacterial or viral infection)by a complex cascade of events, including chemical mediators (e.g., cytokines and prostaglandins) and inflammatory cells (e.g., leukocytes). The inflammatory response is characterized by increased blood flow, increased capillary permeability, and the influx of phagocytic cells. These events can result in swelling, redness, warmth (altered heat patterns), and pus formation at the site of injury or infection.
[0004] A delicate well-balanced interplay between the humoral and cellular Immune elements in the inflammatory response enables the elimination of harmful agents and the initiation of the repair of damaged tissue. When this delicately balanced interplay is disrupted, the inflammatory response may result in considerable damage to normal tissue and may be more harmful than the original insult that initiated the reaction.
In these cases of uncontrolled inflammatory responses, clinical intervention is needed to prevent tissue damage and organ dysfunction. [0005] Diseases such as rheumatoid arthritis, osteoarthritis, Crohn's disease, asthma,allergies and inflammatory bowel disease, are characterized by chronic inflammation. Current treatments for inflammatory disorders involve symptomatic medications and immunosuppressive agents to control symptoms. For example, nonsteroidal
13.
Patent 2704059 TITLE OF THE INVENTION
INCORPORATION BY REFERENCE
This application is a continuation in part of U.S. non-provisional application serial no.
11/929,015 filed on 30 October 2007 and PCT International Application No.
PCT/U52007/083006 filed on 30 October 2007, which claims priority to U.S.
Provisional application serial no. 60/855,625, filed on 30 October 2006. This application also claims priority to U.S. provisional application serial no. 61/035,653, filed on 11 March 2008. The foregoing applications, and all documents cited therein or during their prosecution ("appin cited documents) and all documents cited or referenced in the appin cited documents, and all documents cited or referenced herein ("herein cited documents"), and all documents cited or referenced in herein cited documents, together with any manufacturer's instructions, descriptions, product specifications, and product sheets for any products mentioned herein or in any document incorporated by reference herein, are hereby incorporated herein by reference, and may be employed in the practice of the invention. FIELD OF THE INVENTION
The present invention relates to antigen-antibody complexes for use as prophylactic and therapeutic vaccines for infectious diseases of AIDS. BACKGROUND OF THE
INVENTION
AIDS, or Acquired Immunodeficiency Syndrome, is caused by human immunodeficiency virus (HIV) and is characterized by several clinical features including wasting syndromes, central nervous system degeneration and profound immunosuppression that results in opportunistic infections and malignancies.
HIV is a member of the lentivirus family of animal retroviruses, which include the visna virus of sheep and the bovine, feline, and simian immunodeficiency viruses (SW). Two closely related types of HIV, Designated HIV-1 and HIV-2, have been identified thus far, of which HIV-1 is by far the most common cause of AIDS. However, HIV-2, which differs in genomic structure and antigenicity, causes a similar clinical syndrome.An infectious HIV particle consists of two identical strands of RNA, each =
approximately 9.2 kb long, packaged within a core of viral proteins. This core structure is surrounded by a phospholipid bilayer envelope derived from the host cell membrane that also includes virally-encoded membrane proteins (Abbas et al., Cellular and Molecular Immunology, 4th edition, W.B. Saunders Company, 2000, p.454). The HIV genome,
Patent 2704059 TITLE OF THE INVENTION
INCORPORATION BY REFERENCE
This application is a continuation in part of U.S. non-provisional application serial no.
11/929,015 filed on 30 October 2007 and PCT International Application No.
PCT/U52007/083006 filed on 30 October 2007, which claims priority to U.S.
Provisional application serial no. 60/855,625, filed on 30 October 2006. This application also claims priority to U.S. provisional application serial no. 61/035,653, filed on 11 March 2008. The foregoing applications, and all documents cited therein or during their prosecution ("appin cited documents) and all documents cited or referenced in the appin cited documents, and all documents cited or referenced herein ("herein cited documents"), and all documents cited or referenced in herein cited documents, together with any manufacturer's instructions, descriptions, product specifications, and product sheets for any products mentioned herein or in any document incorporated by reference herein, are hereby incorporated herein by reference, and may be employed in the practice of the invention. FIELD OF THE INVENTION
The present invention relates to antigen-antibody complexes for use as prophylactic and therapeutic vaccines for infectious diseases of AIDS. BACKGROUND OF THE
INVENTION
AIDS, or Acquired Immunodeficiency Syndrome, is caused by human immunodeficiency virus (HIV) and is characterized by several clinical features including wasting syndromes, central nervous system degeneration and profound immunosuppression that results in opportunistic infections and malignancies.
HIV is a member of the lentivirus family of animal retroviruses, which include the visna virus of sheep and the bovine, feline, and simian immunodeficiency viruses (SW). Two closely related types of HIV, Designated HIV-1 and HIV-2, have been identified thus far, of which HIV-1 is by far the most common cause of AIDS. However, HIV-2, which differs in genomic structure and antigenicity, causes a similar clinical syndrome.An infectious HIV particle consists of two identical strands of RNA, each =
approximately 9.2 kb long, packaged within a core of viral proteins. This core structure is surrounded by a phospholipid bilayer envelope derived from the host cell membrane that also includes virally-encoded membrane proteins (Abbas et al., Cellular and Molecular Immunology, 4th edition, W.B. Saunders Company, 2000, p.454). The HIV genome,
14.
Patent 2632045 INCORPORATION BY REFERENCE
This application claims priority to U.S. provisional patent application Serial No.
60/908,082 filed March 26, 2007.
The foregoing applications, and all documents cited therein or during their prosecution ("appin cited documents") and all documents cited or referenced in the appin cited documents, and all documents cited or referenced herein ("herein cited documents"),and all documents cited or referenced in herein cited documents, together with any manufacturer's instructions, descriptions, product specifications, and product sheets for any products mentioned herein or in any document incorporated by reference herein, are hereby incorporated herein by reference, and may be employed in the practice of the invention.
FIELD OF THE INVENTION
The field of the present invention relates to novel recombinant modified Ankara viral vectors (MVA) encoding HIV-1 antigens for use as HIV-1 vaccines.BACKGROUND OF
THE
INVENTION AIDS, or Acquired Immunodeficiency Syndrome, is caused by human immunodeficiency virus (HIV) and is characterized by several clinical features including wasting syndromes, central nervous system degeneration and profound immunosuppression that results in opportunistic infections and malignancies. HIV is a member of the lentivirus family of animal retroviruses, which include the virus of sheep and the bovine, feline, and simian immunodeficiency viruses (SR). Two closely related types of HIV, designatedHIV-1 and HIV-2, have been identified thus far, of which HIV-1 is by far the most common cause of AIDS. However, HIV-2, which differs in genomic structure and =
antigenicity, causes a similar clinical syndrome. An infectious HIV particle consists of two identical strands of RNA, each approximately 9.2 kb long, packaged within a core of viral proteins. This core structure is surrounded by a phospholipid bilayer envelope derived from the host cell membrane that also includes virally-encoded membrane proteins (Abbas et al., Cellular and Molecular Immunology, 4th edition, W.B. Saunders Company, 2000, p. 454).
The HIV genome has the characteristic 5'-LTR-Gag-Pol-Env-LTR-3' organization of the retrovirus family. Long terminal repeats (LTRs) at each end of the viral genome serve as binding sites for transcriptional regulatory proteins from the host and regulate viral integration into the host genome, viral gene expression, and viral replication.
Patent 2632045 INCORPORATION BY REFERENCE
This application claims priority to U.S. provisional patent application Serial No.
60/908,082 filed March 26, 2007.
The foregoing applications, and all documents cited therein or during their prosecution ("appin cited documents") and all documents cited or referenced in the appin cited documents, and all documents cited or referenced herein ("herein cited documents"),and all documents cited or referenced in herein cited documents, together with any manufacturer's instructions, descriptions, product specifications, and product sheets for any products mentioned herein or in any document incorporated by reference herein, are hereby incorporated herein by reference, and may be employed in the practice of the invention.
FIELD OF THE INVENTION
The field of the present invention relates to novel recombinant modified Ankara viral vectors (MVA) encoding HIV-1 antigens for use as HIV-1 vaccines.BACKGROUND OF
THE
INVENTION AIDS, or Acquired Immunodeficiency Syndrome, is caused by human immunodeficiency virus (HIV) and is characterized by several clinical features including wasting syndromes, central nervous system degeneration and profound immunosuppression that results in opportunistic infections and malignancies. HIV is a member of the lentivirus family of animal retroviruses, which include the virus of sheep and the bovine, feline, and simian immunodeficiency viruses (SR). Two closely related types of HIV, designatedHIV-1 and HIV-2, have been identified thus far, of which HIV-1 is by far the most common cause of AIDS. However, HIV-2, which differs in genomic structure and =
antigenicity, causes a similar clinical syndrome. An infectious HIV particle consists of two identical strands of RNA, each approximately 9.2 kb long, packaged within a core of viral proteins. This core structure is surrounded by a phospholipid bilayer envelope derived from the host cell membrane that also includes virally-encoded membrane proteins (Abbas et al., Cellular and Molecular Immunology, 4th edition, W.B. Saunders Company, 2000, p. 454).
The HIV genome has the characteristic 5'-LTR-Gag-Pol-Env-LTR-3' organization of the retrovirus family. Long terminal repeats (LTRs) at each end of the viral genome serve as binding sites for transcriptional regulatory proteins from the host and regulate viral integration into the host genome, viral gene expression, and viral replication.
15.
Patent 2901737 =, METHODS OF DIAGNOSING AND TREATING CANCER BY DETECTING AND
MANIPULATING MICROBES IN TUMORS
CROSS REFERENCE TO RELATED APPLICATIONS
[0001] This application claims the benefit of United States Provisional Patent Application no. 61/766,501, filed February 19, 2013, the subject matter of which is hereby incorporated by reference as if fully set forth herein BACKGROUND
[0002] One in eight women will be diagnosed with breast cancer in their lifetime.
It is the second leading cause of death in women, with >40,000 deaths annually (Jemal, 2010). Over the past twenty years over 5.5 billion dollars have been spent on breast cancer research. While progress has been made in treatment and screening there are still 40,000 deaths from breast cancer a year in the United States. While genes and radiation are among known breast cancer causes, the origins of a majority of breast cancer cases remain unknown (Madigan, 1995). It is important to understand how these sporadic breast cancers arise in order to develop preventative strategies against this devastating disease. The recent appreciation of the influence of microbiota on human health and disease begs the question of whether microbes play a role in sporadic breast cancers of unknown etiology.[0003] Infections and chronic inflammation have been linked to some cancers but studies of infectious causes of breast cancer have been limited to looking for specific viral signatures in invasive cancers. The breast ducts are intimately associated with cutaneous and oral microorganisms during lactation and sexual activity, and could well harbor infectious agents that contribute to carcinogenesis. It would therefore be beneficial to determine whether bacteria play a role in the development of breast cancer.
SUMMARY
[0004] In some embodiments, methods of determining that a subject has cancer or is at higher risk of developing cancer based on the level of microbes present in tumor.
Patent 2901737 =, METHODS OF DIAGNOSING AND TREATING CANCER BY DETECTING AND
MANIPULATING MICROBES IN TUMORS
CROSS REFERENCE TO RELATED APPLICATIONS
[0001] This application claims the benefit of United States Provisional Patent Application no. 61/766,501, filed February 19, 2013, the subject matter of which is hereby incorporated by reference as if fully set forth herein BACKGROUND
[0002] One in eight women will be diagnosed with breast cancer in their lifetime.
It is the second leading cause of death in women, with >40,000 deaths annually (Jemal, 2010). Over the past twenty years over 5.5 billion dollars have been spent on breast cancer research. While progress has been made in treatment and screening there are still 40,000 deaths from breast cancer a year in the United States. While genes and radiation are among known breast cancer causes, the origins of a majority of breast cancer cases remain unknown (Madigan, 1995). It is important to understand how these sporadic breast cancers arise in order to develop preventative strategies against this devastating disease. The recent appreciation of the influence of microbiota on human health and disease begs the question of whether microbes play a role in sporadic breast cancers of unknown etiology.[0003] Infections and chronic inflammation have been linked to some cancers but studies of infectious causes of breast cancer have been limited to looking for specific viral signatures in invasive cancers. The breast ducts are intimately associated with cutaneous and oral microorganisms during lactation and sexual activity, and could well harbor infectious agents that contribute to carcinogenesis. It would therefore be beneficial to determine whether bacteria play a role in the development of breast cancer.
SUMMARY
[0004] In some embodiments, methods of determining that a subject has cancer or is at higher risk of developing cancer based on the level of microbes present in tumor.
16.
Patent 2395678 ANTIMICROBIAL COMPOSITIONS AND METHODS OF USE
FIELD OF THE INVENTION
The present invention relates to compositions and methods for decreasing the infectivity, morbidity, and rate of mortality, associated with a variety of pathogens. The present invention also relates to methods and compositions for decontaminating areas samples, solutions, and foodstuffs, colonized or otherwise infected by pathogens and microorganisms.
BACKGROUND OF THE INVENTION
Pathogens such as bacteria, fungi, viruses, and bacterial spores are responsible for a plethora of human and animal ills, as well as contamination of food and biological and environmental samples. The first step in microbial infections of animals is generally attachment or colonization of skin or mucus membranes, followed by subsequent invasion and dissemination of the infectious microbe. The portals of entry of pathogenic bacteria are predominantly the skin and mucus membranes. In particular, bacteria of the Bacillus genus form stable spores that resist harsh conditions and extreme temperatures. Contamination of farmlands with B. anthracis leads toa fatal disease in domestic, agricultural, and wild animals (See e.g., Dragon and Rennie, Can.
Vet. J. 36:295 [1995]). Human infection with this organism usually results from contact with infected animals or infected animal products (See e.g., Welkos et al., Infect.
Immun. 51:795 [1986]). Human clinical syndromes include a pulmonary form that has a rapid onset.
Patent 2395678 ANTIMICROBIAL COMPOSITIONS AND METHODS OF USE
FIELD OF THE INVENTION
The present invention relates to compositions and methods for decreasing the infectivity, morbidity, and rate of mortality, associated with a variety of pathogens. The present invention also relates to methods and compositions for decontaminating areas samples, solutions, and foodstuffs, colonized or otherwise infected by pathogens and microorganisms.
BACKGROUND OF THE INVENTION
Pathogens such as bacteria, fungi, viruses, and bacterial spores are responsible for a plethora of human and animal ills, as well as contamination of food and biological and environmental samples. The first step in microbial infections of animals is generally attachment or colonization of skin or mucus membranes, followed by subsequent invasion and dissemination of the infectious microbe. The portals of entry of pathogenic bacteria are predominantly the skin and mucus membranes. In particular, bacteria of the Bacillus genus form stable spores that resist harsh conditions and extreme temperatures. Contamination of farmlands with B. anthracis leads toa fatal disease in domestic, agricultural, and wild animals (See e.g., Dragon and Rennie, Can.
Vet. J. 36:295 [1995]). Human infection with this organism usually results from contact with infected animals or infected animal products (See e.g., Welkos et al., Infect.
Immun. 51:795 [1986]). Human clinical syndromes include a pulmonary form that has a rapid onset.
17.
Patent 2395678 METHOD OF TREATING A SKIN CONDITION
WITH MALVA NEGLECTA
FIELD OF INVENTION
[0001] The present invention relates to a method of using compositions comprising plan textracts to treat a skin condition. More specifically, the present invention relates to a method of using compositions comprising extracts of Malva neglecta for improving the condition and appearance of the skin, such as by enhancing skin barrier protection, improving, reducing, inhibiting or delaying the appearance of at least one sign of aging in skin, and / or lightening skin. DESCRIPTION OF RELATED ART
[0002] Malva neglecta is typically designated a "weed." Native to the "Old World," it has been naturalized throughout North America. Malva neglecta is native to almost all of Europe, from northern Europe (e.g., Denmark, Ireland, Norway, Sweden, United Kingdom), middle Europe (e.g., Austria, Belgium), Southeastern Europe (e.g., Albania, Bulgaria, Croatia, etc.), to Southwestern Europe (e.g., France, Portugal, Spain). It is also found in Western Asia, the Arabian Peninsula, Northwestern Asia (e.g., Armenia, Georgia, Kazakhstan, Uzbekistan, Mongolia) and also in China and the Indian subcontinent. In Africa, it is found mostly in North Africa, such as Algeria and Morocco. [0003] Many Malva species are used in traditional medicinal systems around the world,including Malva neglecta. It has also been commonly used as a food. It has not been commercialized as a trade herb. It is also known by various common names - Common mallow,buttonweed, cheeseplant, cheeseweed, dwarf mallow, and roundleaf mallow.
[0004] According to Plants For A Future (http://www.pfaf.org/user/default.aspx), the online database for medicinal and edible wild plants, Malva neglecta is described for use as anti-inflammatory, anti-phlogistic, astringent, demulcent, diuretic, emollient, expectorant, laxative, poultice, purgative, and salve. [0005] The uses of Malva neglecta disclosed in Plants For A Future, as well as other knownuses of Malva neglecta described in other references, are mostly in ingested forms, except for use as an emollient or salve or poultice. Some traditional literature also describes the use of a poultice for eczema. =
Patent 2395678 METHOD OF TREATING A SKIN CONDITION
WITH MALVA NEGLECTA
FIELD OF INVENTION
[0001] The present invention relates to a method of using compositions comprising plan textracts to treat a skin condition. More specifically, the present invention relates to a method of using compositions comprising extracts of Malva neglecta for improving the condition and appearance of the skin, such as by enhancing skin barrier protection, improving, reducing, inhibiting or delaying the appearance of at least one sign of aging in skin, and / or lightening skin. DESCRIPTION OF RELATED ART
[0002] Malva neglecta is typically designated a "weed." Native to the "Old World," it has been naturalized throughout North America. Malva neglecta is native to almost all of Europe, from northern Europe (e.g., Denmark, Ireland, Norway, Sweden, United Kingdom), middle Europe (e.g., Austria, Belgium), Southeastern Europe (e.g., Albania, Bulgaria, Croatia, etc.), to Southwestern Europe (e.g., France, Portugal, Spain). It is also found in Western Asia, the Arabian Peninsula, Northwestern Asia (e.g., Armenia, Georgia, Kazakhstan, Uzbekistan, Mongolia) and also in China and the Indian subcontinent. In Africa, it is found mostly in North Africa, such as Algeria and Morocco. [0003] Many Malva species are used in traditional medicinal systems around the world,including Malva neglecta. It has also been commonly used as a food. It has not been commercialized as a trade herb. It is also known by various common names - Common mallow,buttonweed, cheeseplant, cheeseweed, dwarf mallow, and roundleaf mallow.
[0004] According to Plants For A Future (http://www.pfaf.org/user/default.aspx), the online database for medicinal and edible wild plants, Malva neglecta is described for use as anti-inflammatory, anti-phlogistic, astringent, demulcent, diuretic, emollient, expectorant, laxative, poultice, purgative, and salve. [0005] The uses of Malva neglecta disclosed in Plants For A Future, as well as other knownuses of Malva neglecta described in other references, are mostly in ingested forms, except for use as an emollient or salve or poultice. Some traditional literature also describes the use of a poultice for eczema. =
18.
The studies of medicines are a challenging opportunity for those who take interest.
The study of chemistry, medicines, applications and doses seem to vary between creatures.
NIC will progressively seek Council of Independent Nations for NIC whose primary goalis to collect and control disease. The NIC cleansing facility and the NIC
disease control facilitywill be used to provide a way in which to reach our primary goal.
The NIC cleansing facility will be a unique facility designed to collect contaminated wastes and diseases to be contained at a NIC disease control facility by means decided by Nations Independent Council. NIC will be a council of Ten independent councils. Seven of which will pertain to NIC cleansing facility and Three of which pertain to NIC disease control facility.
Meetings and schedules decided and controlled by NIC disease control facility.
The average living creature contains multiple imperfections in health which is caused by disease. It is the build up of disease that causes pain and without the means to flush out thedisease a living creature will become.overburdened by the build up of disease and increase in pain which is what causes loss of health, loss of spirit and eventually end with death. By adding certain cleansing agents it is possible to flush out the different organs of living creatures, extracting disease from the creature into concentrated toxics. The toxics are withdrawn from the organs by a combination of cleansing agents timely administered to flush and chase different diseases out of different orifices. Build ups of almost every type of disease is virtually chased outside the creature. The NIC cleansing facility will control extraction and collection.
The studies of medicines are a challenging opportunity for those who take interest.
The study of chemistry, medicines, applications and doses seem to vary between creatures.
NIC will progressively seek Council of Independent Nations for NIC whose primary goalis to collect and control disease. The NIC cleansing facility and the NIC
disease control facilitywill be used to provide a way in which to reach our primary goal.
The NIC cleansing facility will be a unique facility designed to collect contaminated wastes and diseases to be contained at a NIC disease control facility by means decided by Nations Independent Council. NIC will be a council of Ten independent councils. Seven of which will pertain to NIC cleansing facility and Three of which pertain to NIC disease control facility.
Meetings and schedules decided and controlled by NIC disease control facility.
The average living creature contains multiple imperfections in health which is caused by disease. It is the build up of disease that causes pain and without the means to flush out thedisease a living creature will become.overburdened by the build up of disease and increase in pain which is what causes loss of health, loss of spirit and eventually end with death. By adding certain cleansing agents it is possible to flush out the different organs of living creatures, extracting disease from the creature into concentrated toxics. The toxics are withdrawn from the organs by a combination of cleansing agents timely administered to flush and chase different diseases out of different orifices. Build ups of almost every type of disease is virtually chased outside the creature. The NIC cleansing facility will control extraction and collection.
19.
Patent 2857341 COMPOSITIONS CONTAINING EXTRACT OF
WITH MALVA NEGLECTA
FIELD OF INVENTION
[0001] The present invention relates to compositions comprising plant extracts for use on skin. More specifically, the present invention relates to compositions comprising extracts of MaIva neglecta for improving the condition and appearance of the skin, such as by enhancing skin barrier protection, improving, reducing, inhibiting or delaying the appearance of at least one sign of aging in skin, and / or lightening skin.
DESCRIPTION OF RELATED ART
[0002] MaIva neglecta is typically designated a "weed." Native to the "Old World," it has been naturalized throughout North America. MaIva neglecta is native to almost all of Europe, from northern Europe (e.g., Denmark, Ireland, Norway, Sweden, United Kingdom), middle Europe (e.g., Austria, Belgium), Southeastern Europe (e.g., Albania, Bulgaria, Croatia, etc.), to Southwestern Europe (e.g., France, Portugal, Spain). It is also found in Western Asia, the Arabian Peninsula, Northwestern Asia (e.g., Armenia, Georgia, Kazakhstan, Uzbekistan, Mongolia) and also in China and the Indian subcontinent. -In Africa, it is found mostly in North Africa, such as Algeria and Morocco.
[0003] Many MaIva species are used in traditional medicinal systems around the world, including MaIva neglecta. It has also been commonly used as a food. It has not been commercialized as a trade herb. It is also known by various common names -Common mallow, button weed, chees eplant, cheese weed, dwarf mallow, and round leaf mallow.[0004] According to Plants For A Future (http://www.pfalorg/user/default.aspx), the online database for medicinal and edible wild plants, MaIva neglecta is described for use as anti- =
inflammatory, anti-phlogistic, astringent, demulcent, diuretic, emollient, expectorant, laxative, poultice, purgative, and salve.[0005] The uses of MaIva neglecta disclosed in Plants For A Future, as well as other known uses of MaIva neglecta described in other references, are mostly in ingested forms, except for use as an emollient osalveorpoultice.
Some traditional literature also describes the use of a poultice for eczema.
Patent 2857341 COMPOSITIONS CONTAINING EXTRACT OF
WITH MALVA NEGLECTA
FIELD OF INVENTION
[0001] The present invention relates to compositions comprising plant extracts for use on skin. More specifically, the present invention relates to compositions comprising extracts of MaIva neglecta for improving the condition and appearance of the skin, such as by enhancing skin barrier protection, improving, reducing, inhibiting or delaying the appearance of at least one sign of aging in skin, and / or lightening skin.
DESCRIPTION OF RELATED ART
[0002] MaIva neglecta is typically designated a "weed." Native to the "Old World," it has been naturalized throughout North America. MaIva neglecta is native to almost all of Europe, from northern Europe (e.g., Denmark, Ireland, Norway, Sweden, United Kingdom), middle Europe (e.g., Austria, Belgium), Southeastern Europe (e.g., Albania, Bulgaria, Croatia, etc.), to Southwestern Europe (e.g., France, Portugal, Spain). It is also found in Western Asia, the Arabian Peninsula, Northwestern Asia (e.g., Armenia, Georgia, Kazakhstan, Uzbekistan, Mongolia) and also in China and the Indian subcontinent. -In Africa, it is found mostly in North Africa, such as Algeria and Morocco.
[0003] Many MaIva species are used in traditional medicinal systems around the world, including MaIva neglecta. It has also been commonly used as a food. It has not been commercialized as a trade herb. It is also known by various common names -Common mallow, button weed, chees eplant, cheese weed, dwarf mallow, and round leaf mallow.[0004] According to Plants For A Future (http://www.pfalorg/user/default.aspx), the online database for medicinal and edible wild plants, MaIva neglecta is described for use as anti- =
inflammatory, anti-phlogistic, astringent, demulcent, diuretic, emollient, expectorant, laxative, poultice, purgative, and salve.[0005] The uses of MaIva neglecta disclosed in Plants For A Future, as well as other known uses of MaIva neglecta described in other references, are mostly in ingested forms, except for use as an emollient osalveorpoultice.
Some traditional literature also describes the use of a poultice for eczema.
Claims
claim, water, liquid, solution or compound containing black seed inherent ingredient in a compound application to mammal and avian.
A. Composition or solution of any liquid and black seed. When it is heated black seeds transfers their inherent ingredient to the liquid and the liquid takes or absorb beneficial inherent ingredients of black seed in itself. Some liquids may not need to be heated along with black seed to transfer black seed ingredient to liquid for example vinegar.
when this liquid is applied on body existing or thinning hair become thick, healthy and long to the best capacity of their real nature. In addition, on bald spots start growing and re-growing hair again where hair existed once. Cleaning of pores and removing dead skin is important on surface of the body that need to be treated for hair growth and regrowth, this can be done by multiple ways for example acids skin peels or exfoliating to removing dead skin, various remedies to do the job may be used along or with the liquid, the solution or the compound application on body. These remedies can be included in the liquid, solution or compound caring black seed ingredients or used separately to remove dead skin and or exfoliating the pores. The path for hair to come out of follicles through the pores need to be cleared.
B. Herbs, oils, honey, seed, natural plant, Rocks, fish by products, solutions, acids, solution, element, compound, herbs, oils, honey, seeds, vegetables, fruits, plants by product, trees by product, rocks form, fish by products, animal by products, drugs and or manmade products etc that make hair growth and regrowth or fight diseases, cancers, viruses better can be added to the liquid or black seeds abstract to be more effective.
There may be multiple ways to transfer inherent ingredients of black seed with different solutions, elements and compounds.
C. This liquid, solution or compound carrying black seed inherent ingredient can be used to cure and heal other diseases in body. When this water, liquid, solution or compound reaches the infected or effected part or the organ of body it will start healing and curing the body from any diseases. Cancer and viruses can also be treated in body with this water, liquid, solution or compound caring black seed ingredients.
D. Dead skin starts covering the area where hair start falling on the surface of body. This is due to low blood circulation on that area of the body. With time the pores are blocked with dead skin and the area becomes bald. Vinegar have acid in it that dissolves the dead cells and exfoliate to clear the path for hair to grow and regrow once again, with the use of this water, liquid, solution or compound caring black seed ingredients. If vinegar is not desired to be used due to any reason. Other solutions for removal of dead skin and exfoliating the surface of body can be used. For example, Acids used in peeling skin of body may be used. Or other products made for the purpose can be alternative.
Other remedies that solve the problem of removing dead skin and exfoliating skin can also be helpful. Application of this water, liquid, solution or the compound on the surface of the body will start growing and degrowing hair where hair was lost and bald surface appeared.
E. A composition containing black seed or other name Nigella Sativa with any liquid, solution, or compound can grows and regrows hair on body. With application of this liquid, solution or compound existing or thinning hair also become thick, healthy and long. Black seed possess inherent natural ingredients to grow and regrow hair.
Black seed can be processed with any liquid in multiple ways to help grow and regrow hair.
When black seed's inherent ingredient is fed to hair, follicles or hair roots it provides the nutritional boost that they need to grow and regrow to their natural full growth potential.
Bald spots on area of body where hair existed once, starts re-growing hair once again. In addition, Black seed also possess inherent natural ingredients that can cure many diseases in various organs, cure cancer, kill AIDS, bird flu viruses or other viruses in body.
F. Black seeds may be any form that for example, powder, crushed, whole or oil etc. that transfers it's ingredients into the hosting water, liquid, solution or compound to absorb it and become abstract of black seed ingredients.
2. I claim, composition or solution containing black seed inherent ingredients in claim 1 can be in form of spray, fumes, mask, by mouth, injection or any other way inserted in body or put-upon outer surface of the body and in any way when reaches follicles and root of hair it will grow and regrow hair or get ride of any disease in body in claim 1.
A. This composition can be stand alone or mixed with any other solution, elements or compound that helps grow and regrow hair or cure any disease in body in claim 1.
3. When acid, solution, element, compound, herbs, oils, honey, seeds, vegetables, fruits, plants by product, trees by product, rocks form, fish by products, animal by products, drugs and manmade products when joined along with the compound that help immune system of body and or help hair growth, killing cancer cells or viruses will help body in claim 1.
4. I claim, this compound in claim 1 when is taken by mouth or used on the surface of the body or feeding within the body by any means and comes in contact with cancer cells, AIDS, bird flu or any other virus have positive effects in body to cure and heal it in claim 1.
5. I claim, other useful and beneficial solutions, acids, elements and compounds, herbs, oils, honey, seeds, vegetables, fruits, plants by product, trees by product, rocks form, fish by products, animal by products, drugs and manmade products etc if added in water, liquid, solution or the compound can help in better performance of the abstract of black seed ingredients in claim 1. For example, Aloe Vera will boost immune system of body if used on body in claim 1.
6. I claim, all forms of black seed are capable to do the performance in claim 1. For example, oil, powder, whole black seeds or any other form. Even fluids and organs of body can be cleaned and cured from diseases. Viruses and cancerous cells in body can be killed by using black seed inherent ingredient in claim 1.
7. I claim, even if black seed is processed differently in any way and react with any acid, solution, element, compound, herbs, oils, honey, seeds, vegetables, fruits, plants by product, trees by product, rocks form, fish by products, animal by products drug and or manmade products instead of vinegar, acids, solution or any other compound to bring black seed's inherent ingredient out to help it will perform well in claim 1.
2_ 8. l claim, instead of vinegar different solutions, acids, elements and compounds can be used that can bring out inherent ingredient of black seeds and perform well in claim 1. In addition. There can be multiple ways to get black seed stimulated to work positively by using any other solution, acids, elements, compound, herbs, oils, honey, seeds, vegetables, fruits, plants, trees by products, rocks, fish by products, animal by products, drugs and manmade products etc may be used that is capable for reacting and bring out effects of black seeds can cure and heal all internal and external organs of body from diseases, kill cancer cells, AIDS, BIRD Flu virus or any other viruses in claim 1.
9. I claim, the water, liquid, solution or compound containing black seed's ingredients when applied to the surface of the body for hair growth or regrowth will also help body to improve and will be beneficial to the body over all for example, it will maintain optimal blood pressure or maintain optimal body sugar level of the body and so on in
claim 1.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA3030306A CA3030306A1 (en) | 2019-01-16 | 2019-01-16 | Black seed hair growth and regrowth along with other benefits of body |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA3030306A CA3030306A1 (en) | 2019-01-16 | 2019-01-16 | Black seed hair growth and regrowth along with other benefits of body |
Publications (1)
Publication Number | Publication Date |
---|---|
CA3030306A1 true CA3030306A1 (en) | 2020-07-16 |
Family
ID=71608257
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA3030306A Abandoned CA3030306A1 (en) | 2019-01-16 | 2019-01-16 | Black seed hair growth and regrowth along with other benefits of body |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA3030306A1 (en) |
-
2019
- 2019-01-16 CA CA3030306A patent/CA3030306A1/en not_active Abandoned
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