CA3022195C - Compounds for modulating aquaporins - Google Patents

Compounds for modulating aquaporins Download PDF

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Publication number
CA3022195C
CA3022195C CA3022195A CA3022195A CA3022195C CA 3022195 C CA3022195 C CA 3022195C CA 3022195 A CA3022195 A CA 3022195A CA 3022195 A CA3022195 A CA 3022195A CA 3022195 C CA3022195 C CA 3022195C
Authority
CA
Canada
Prior art keywords
thiadiazol
triazol
acetamide
ethy1
pheny1
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3022195A
Other languages
English (en)
French (fr)
Other versions
CA3022195A1 (en
Inventor
Johan Evenas
Joakim Larsson
Klaus DREISCH
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Apoglyx AB
Original Assignee
Apoglyx AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apoglyx AB filed Critical Apoglyx AB
Publication of CA3022195A1 publication Critical patent/CA3022195A1/en
Application granted granted Critical
Publication of CA3022195C publication Critical patent/CA3022195C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA3022195A 2016-04-28 2017-04-28 Compounds for modulating aquaporins Active CA3022195C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16167378 2016-04-28
EP16167378.5 2016-04-28
PCT/EP2017/060148 WO2017186893A1 (en) 2016-04-28 2017-04-28 Compounds for modulating aquaporins

Publications (2)

Publication Number Publication Date
CA3022195A1 CA3022195A1 (en) 2017-11-02
CA3022195C true CA3022195C (en) 2024-02-13

Family

ID=55854711

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3022195A Active CA3022195C (en) 2016-04-28 2017-04-28 Compounds for modulating aquaporins

Country Status (12)

Country Link
US (1) US10730865B2 (https=)
EP (1) EP3448853B1 (https=)
JP (1) JP6921118B2 (https=)
CA (1) CA3022195C (https=)
DK (1) DK3448853T3 (https=)
ES (1) ES2902409T3 (https=)
HR (1) HRP20212031T1 (https=)
HU (1) HUE057193T2 (https=)
LT (1) LT3448853T (https=)
PL (1) PL3448853T3 (https=)
PT (1) PT3448853T (https=)
WO (1) WO2017186893A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111393444B (zh) * 2019-01-02 2022-10-28 上海迪赛诺化学制药有限公司 一种阿巴卡韦羟基醋酸酯的制备方法
WO2025137265A1 (en) 2023-12-20 2025-06-26 Saint Michael's College, Inc. Methods and compositions for reducing gliaptosis: macroglia-induced neuronal cell death
CN118001408B (zh) * 2024-04-08 2024-06-25 北京大学 一种水通道蛋白9磷酸化抑制剂的用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US333792A (en) * 1886-01-05 Stop watch
WO2004089367A1 (en) * 2003-04-11 2004-10-21 Novo Nordisk A/S Pharmaceutical use of substituted 1,2,4-triazoles
GB0704394D0 (en) * 2007-03-07 2007-04-11 Senexis Ltd Compounds
CA2965873C (en) 2014-10-29 2023-02-21 Apoglyx Ab Derivatives of 2-(1,2,4-triazol-3-ylsulfanyl)-n-1,3,4-thiadiazol-2-yl acetamide which are useful for the treatment of inter alia diabetes

Also Published As

Publication number Publication date
JP6921118B2 (ja) 2021-08-18
EP3448853A1 (en) 2019-03-06
EP3448853B1 (en) 2021-11-17
US20190127360A1 (en) 2019-05-02
LT3448853T (lt) 2022-01-10
HUE057193T2 (hu) 2022-04-28
PL3448853T3 (pl) 2022-02-28
ES2902409T3 (es) 2022-03-28
CA3022195A1 (en) 2017-11-02
US10730865B2 (en) 2020-08-04
PT3448853T (pt) 2021-12-30
JP2019516677A (ja) 2019-06-20
DK3448853T3 (da) 2021-12-06
HRP20212031T1 (hr) 2022-04-01
WO2017186893A1 (en) 2017-11-02

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