CA3021573A1 - Systems and methods for generating therapeutic electric fields for capture of nervous system targets - Google Patents
Systems and methods for generating therapeutic electric fields for capture of nervous system targets Download PDFInfo
- Publication number
- CA3021573A1 CA3021573A1 CA3021573A CA3021573A CA3021573A1 CA 3021573 A1 CA3021573 A1 CA 3021573A1 CA 3021573 A CA3021573 A CA 3021573A CA 3021573 A CA3021573 A CA 3021573A CA 3021573 A1 CA3021573 A1 CA 3021573A1
- Authority
- CA
- Canada
- Prior art keywords
- electrodes
- blood vessel
- cathode
- separation distance
- electric field
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 230000005684 electric field Effects 0.000 title claims description 36
- 230000001225 therapeutic effect Effects 0.000 title description 15
- 238000000034 method Methods 0.000 title description 13
- 210000000653 nervous system Anatomy 0.000 title description 7
- 210000005036 nerve Anatomy 0.000 claims abstract description 72
- 210000004204 blood vessel Anatomy 0.000 claims abstract description 41
- 230000004007 neuromodulation Effects 0.000 claims abstract description 18
- 230000002889 sympathetic effect Effects 0.000 claims abstract description 11
- 230000001734 parasympathetic effect Effects 0.000 claims abstract description 7
- 238000000926 separation method Methods 0.000 claims description 21
- 230000003213 activating effect Effects 0.000 claims 6
- 230000002792 vascular Effects 0.000 abstract description 5
- 230000000638 stimulation Effects 0.000 abstract description 4
- 230000004044 response Effects 0.000 description 13
- 230000000747 cardiac effect Effects 0.000 description 10
- 238000002560 therapeutic procedure Methods 0.000 description 10
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 238000013507 mapping Methods 0.000 description 5
- 239000000758 substrate Substances 0.000 description 5
- 238000003491 array Methods 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 210000005037 parasympathetic nerve Anatomy 0.000 description 4
- 230000001154 acute effect Effects 0.000 description 3
- 230000002051 biphasic effect Effects 0.000 description 3
- 210000003129 brachiocephalic vein Anatomy 0.000 description 3
- 210000005166 vasculature Anatomy 0.000 description 3
- 230000004913 activation Effects 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 210000002620 vena cava superior Anatomy 0.000 description 2
- 239000004642 Polyimide Substances 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000005137 deposition process Methods 0.000 description 1
- 238000009795 derivation Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000000004 hemodynamic effect Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 238000003698 laser cutting Methods 0.000 description 1
- 238000013187 longer-term treatment Methods 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000004126 nerve fiber Anatomy 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 229920001721 polyimide Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- 210000002073 venous valve Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36146—Control systems specified by the stimulation parameters
- A61N1/36182—Direction of the electrical field, e.g. with sleeve around stimulating electrode
- A61N1/36185—Selection of the electrode configuration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0551—Spinal or peripheral nerve electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36114—Cardiac control, e.g. by vagal stimulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36114—Cardiac control, e.g. by vagal stimulation
- A61N1/36117—Cardiac control, e.g. by vagal stimulation for treating hypertension
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36135—Control systems using physiological parameters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36146—Control systems specified by the stimulation parameters
- A61N1/36182—Direction of the electrical field, e.g. with sleeve around stimulating electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/375—Constructional arrangements, e.g. casings
- A61N1/37516—Intravascular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/056—Transvascular endocardial electrode systems
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physiology (AREA)
- Biophysics (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Electrotherapy Devices (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562146802P | 2015-04-13 | 2015-04-13 | |
| US62/146,802 | 2015-04-13 | ||
| PCT/US2016/027363 WO2016168357A1 (en) | 2015-04-13 | 2016-04-13 | Systems and methods for generating therapeutic electric fields for capture of nervous system targets |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3021573A1 true CA3021573A1 (en) | 2016-10-20 |
Family
ID=57126066
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3021573A Abandoned CA3021573A1 (en) | 2015-04-13 | 2016-04-13 | Systems and methods for generating therapeutic electric fields for capture of nervous system targets |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11185699B2 (enExample) |
| EP (1) | EP3319689A4 (enExample) |
| JP (1) | JP2018514265A (enExample) |
| AU (2) | AU2016248118A1 (enExample) |
| CA (1) | CA3021573A1 (enExample) |
| WO (1) | WO2016168357A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008070189A2 (en) | 2006-12-06 | 2008-06-12 | The Cleveland Clinic Foundation | Method and system for treating acute heart failure by neuromodulation |
| WO2013134543A1 (en) | 2012-03-08 | 2013-09-12 | Medtronic Ardian Luxembourg Sarl | Immune system neuromodulation and associated systems and methods |
| US20190069949A1 (en) | 2014-12-03 | 2019-03-07 | Metavention, Inc. | Systems and methods for modulatng nerves or other tissue |
| CA3015372A1 (en) | 2016-03-09 | 2017-09-14 | CARDIONOMIC, Inc. | Cardiac contractility neurostimulation systems and methods |
| US10524859B2 (en) | 2016-06-07 | 2020-01-07 | Metavention, Inc. | Therapeutic tissue modulation devices and methods |
| AU2018333929A1 (en) | 2017-09-13 | 2020-04-09 | CARDIONOMIC, Inc. | Neurostimulation systems and methods for affecting cardiac contractility |
| EP3758791B1 (en) * | 2018-03-02 | 2024-04-24 | Medtronic, Inc. | Implantable medical electrode assemblies and devices |
| EP3836859B1 (en) | 2018-08-13 | 2025-03-05 | Cardionomic, Inc. | Systems for affecting cardiac contractility and/or relaxation |
| AU2020269601A1 (en) | 2019-05-06 | 2021-12-02 | CARDIONOMIC, Inc. | Systems and methods for denoising physiological signals during electrical neuromodulation |
| US12569686B2 (en) | 2020-06-16 | 2026-03-10 | Cardionomix, Inc. | Chronically implantable systems and methods for affecting cardiac contractility and/or relaxation |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7653438B2 (en) * | 2002-04-08 | 2010-01-26 | Ardian, Inc. | Methods and apparatus for renal neuromodulation |
| US9026228B2 (en) * | 2004-10-21 | 2015-05-05 | Medtronic, Inc. | Transverse tripole neurostimulation lead, system and method |
| WO2008092246A1 (en) | 2007-01-29 | 2008-08-07 | Simon Fraser University | Transvascular nerve stimulation apparatus and methods |
| US8792991B2 (en) * | 2008-04-29 | 2014-07-29 | Medtronic, Inc. | Therapy program modification based on therapy guidelines |
| JP2012519574A (ja) * | 2009-03-09 | 2012-08-30 | カーディアック ペースメイカーズ， インコーポレイテッド | リンパ管に埋め込み可能な電極を含む自律神経調整のためのシステム |
| US8577468B2 (en) * | 2011-09-30 | 2013-11-05 | Nyxoah SA | Apparatus and method for extending implant life using a dual power scheme |
| US8494654B2 (en) * | 2010-09-22 | 2013-07-23 | Boston Scientific Neuromodulation Corporation | Systems and methods for making and using paddle leads with adjustable spacing between adjacent electrodes |
| US9446240B2 (en) * | 2011-07-11 | 2016-09-20 | Interventional Autonomics Corporation | System and method for neuromodulation |
| CA2878396A1 (en) * | 2011-07-11 | 2013-02-28 | Interventional Autonomics Corporation | System and method for neuromodulation |
| EP3287067B1 (en) * | 2011-11-07 | 2019-10-30 | Medtronic Ardian Luxembourg S.à.r.l. | Endovascular nerve monitoring devices and associated systems |
| EP2822645B1 (en) * | 2012-03-05 | 2017-05-03 | Simon Fraser University | Transvascular nerve stimulation apparatus |
| US9833608B2 (en) * | 2012-11-20 | 2017-12-05 | NeuroTronik IP Holding (Jersey) Limited | Positioning methods for intravascular electrode arrays for neuromodulation |
| US9175276B2 (en) | 2013-02-12 | 2015-11-03 | Novozymes, Inc. | Polypeptides having endoglucanase activity and polynucleotides encoding same |
-
2016
- 2016-04-13 WO PCT/US2016/027363 patent/WO2016168357A1/en not_active Ceased
- 2016-04-13 AU AU2016248118A patent/AU2016248118A1/en not_active Abandoned
- 2016-04-13 CA CA3021573A patent/CA3021573A1/en not_active Abandoned
- 2016-04-13 EP EP16836078.2A patent/EP3319689A4/en not_active Withdrawn
- 2016-04-13 JP JP2017553423A patent/JP2018514265A/ja active Pending
-
2017
- 2017-10-17 US US15/786,536 patent/US11185699B2/en not_active Expired - Fee Related
-
2020
- 2020-10-07 AU AU2020250217A patent/AU2020250217B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU2020250217A1 (en) | 2020-11-05 |
| EP3319689A4 (en) | 2019-05-08 |
| US11185699B2 (en) | 2021-11-30 |
| WO2016168357A1 (en) | 2016-10-20 |
| US20200269052A1 (en) | 2020-08-27 |
| AU2020250217B2 (en) | 2021-04-29 |
| WO2016168357A8 (en) | 2018-03-22 |
| EP3319689A1 (en) | 2018-05-16 |
| AU2016248118A1 (en) | 2018-02-22 |
| JP2018514265A (ja) | 2018-06-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2020250217B2 (en) | Systems and methods for generating therapeutic electric fields for capture of nervous system targets | |
| EP3870275B1 (en) | Neurostimulation artefact minimisation | |
| US8688233B2 (en) | System and method for spinal cord stimulation to treat motor disorders | |
| JP6538149B2 (ja) | 多重電界を使用する後角刺激の強化 | |
| US7603178B2 (en) | Electrical stimulation lead, system, and method | |
| US9855428B2 (en) | Active implantable medical device with automatic optimization of the configuration of a multi-electrode stimulation lead | |
| US20140316496A1 (en) | Intravascular Electrode Arrays for Neuromodulation | |
| JP2023543301A (ja) | 腫瘍治療電場を形成するための植込み可能アレイ | |
| US20070197892A1 (en) | Non-planar multi-channel electrode array | |
| JP2012508624A (ja) | 多重化複数電極神経刺激装置 | |
| US11395921B2 (en) | Intravascular electrode arrays for neuromodulation | |
| US8706240B2 (en) | Method for direct modulation of the spinothalamic tract | |
| JP2018527066A (ja) | 干渉電流での脊髄刺激 | |
| JP2013523278A (ja) | 指向性リード線アセンブリ | |
| KR20090039747A (ko) | 션트 게이트를 가지는 바이 플래너 전극 | |
| JP5746323B2 (ja) | 神経構造を電気的に刺激するための３次元レイアウトを有するインプラント | |
| US20140039572A1 (en) | System and method for treating depression and epilepsy | |
| AU2024250227A1 (en) | System for lead placement by evoked potential | |
| CN223787946U (zh) | 电极触点、植入式电极及神经刺激系统 | |
| Anderson et al. | Defining the impact of deep brain stimulation contact size and shape on neural selectivity | |
| DL et al. | International Journal of Computational & Neural Engineering (IJCNE) ISSN 2572-7389 | |
| Djilas et al. | Influence of encapsulation tissue reaction on the volume of tissue activated with deep-brain stimulation electrodes: A simulation study |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20220301 |