CA3016576A1 - Recombinant follistatin-fc fusion proteins and use in treating duchenne muscular dystrophy - Google Patents
Recombinant follistatin-fc fusion proteins and use in treating duchenne muscular dystrophy Download PDFInfo
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- CA3016576A1 CA3016576A1 CA3016576A CA3016576A CA3016576A1 CA 3016576 A1 CA3016576 A1 CA 3016576A1 CA 3016576 A CA3016576 A CA 3016576A CA 3016576 A CA3016576 A CA 3016576A CA 3016576 A1 CA3016576 A1 CA 3016576A1
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- recombinant follistatin
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Classifications
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4707—Muscular dystrophy
- C07K14/4708—Duchenne dystrophy
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
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- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
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- Zoology (AREA)
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- General Chemical & Material Sciences (AREA)
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- Endocrinology (AREA)
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- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Prostheses (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| US201662303954P | 2016-03-04 | 2016-03-04 | |
| US62/303,954 | 2016-03-04 | ||
| PCT/US2017/020723 WO2017152090A2 (en) | 2016-03-04 | 2017-03-03 | Recombinant follistatin-fc fusion proteins and use in treating duchenne muscular dystrophy |
Publications (1)
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| CA3016576A1 true CA3016576A1 (en) | 2017-09-08 |
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| CA3016576A Abandoned CA3016576A1 (en) | 2016-03-04 | 2017-03-03 | Recombinant follistatin-fc fusion proteins and use in treating duchenne muscular dystrophy |
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| EP (1) | EP3423479A2 (enExample) |
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| KR (1) | KR20180137487A (enExample) |
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| US20180362604A1 (en) * | 2017-05-12 | 2018-12-20 | Shire Human Genetic Therapies, Inc. | Recombinant Follistatin-FC Fusion Proteins and Use in Treating Duchenne Muscular Dystrophy |
| TW201936201A (zh) | 2017-12-14 | 2019-09-16 | 美商堅固生物科技公司 | 基因之非病毒生產及遞送 |
| CN108303860B (zh) * | 2018-03-26 | 2019-11-08 | 西安电子科技大学 | 一种用于无掩模光刻扫描的分布式曝光方法 |
| WO2019191204A1 (en) * | 2018-03-28 | 2019-10-03 | Acceleron Pharma Inc. | Follistatin polypeptides for the treatment of muscle contracture |
| AU2020216361A1 (en) | 2019-01-29 | 2021-08-12 | Takeda Pharmaceutical Company Limited | Parathyroid hormone variants |
| EP4540273A1 (en) | 2022-06-15 | 2025-04-23 | UCB Biopharma SRL | Fusion protein for the prevention, treatment or amelioration of kidney diseases |
| JP2025520393A (ja) | 2022-06-15 | 2025-07-03 | ユーシービー バイオファルマ エスアールエル | フォリスタチン－ｆｃ融合タンパク質 |
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| US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
| PT1355919E (pt) | 2000-12-12 | 2011-03-02 | Medimmune Llc | Moléculas com semivida longa, composições que as contêm e suas utilizações |
| MXPA04008150A (es) * | 2002-02-21 | 2005-06-17 | Wyeth Corp | Gasp1: una proteina que contiene dominio de folistatina. |
| EP1896503B1 (en) | 2005-05-31 | 2014-10-29 | Board of Regents, The University of Texas System | IgG1 ANTIBODIES WITH MUTATED Fc PORTION FOR INCREASED BINDING TO FcRn RECEPTOR AND USES TEHEREOF |
| WO2008030367A2 (en) * | 2006-09-01 | 2008-03-13 | The General Hospital Corporation | Selective myostatin inhibitors |
| US8580922B2 (en) | 2011-03-04 | 2013-11-12 | Shire Human Genetic Therapies, Inc. | Peptide linkers for polypeptide compositions and methods for using same |
| KR20160044598A (ko) * | 2011-03-29 | 2016-04-25 | 로슈 글리카트 아게 | 항체 Fc 변이체 |
| WO2013192131A1 (en) * | 2012-06-21 | 2013-12-27 | Indiana University Research And Technology Corporation | Incretin receptor ligand polypeptide fc-region fusion polypeptides and conjugates with altered fc-effector function |
| EP3626735A1 (en) * | 2012-12-18 | 2020-03-25 | Novartis AG | Stabilized insulin-like growth factor polypeptides |
| JP6475639B2 (ja) * | 2013-01-25 | 2019-02-27 | シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド | デュシェンヌ筋ジストロフィーの治療におけるフォリスタチン |
| WO2014187807A1 (en) * | 2013-05-21 | 2014-11-27 | Arcarios B.V. | Follistatin derivatives |
| WO2015187977A1 (en) * | 2014-06-04 | 2015-12-10 | Acceleron Pharma, Inc. | Methods and compositions for treatment of disorders with follistatin polypeptides |
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Also Published As
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|---|---|
| US20200247856A1 (en) | 2020-08-06 |
| CN109153708A (zh) | 2019-01-04 |
| BR112018067747A2 (pt) | 2019-01-08 |
| IL261397A (en) | 2018-10-31 |
| MA43588A (fr) | 2021-06-02 |
| KR20180137487A (ko) | 2018-12-27 |
| WO2017152090A3 (en) | 2017-10-19 |
| EP3423479A2 (en) | 2019-01-09 |
| AU2017228475A1 (en) | 2018-09-13 |
| SG11201807400TA (en) | 2018-09-27 |
| WO2017152090A2 (en) | 2017-09-08 |
| EA201891990A1 (ru) | 2019-04-30 |
| MX2018010470A (es) | 2018-12-06 |
| JP2019509735A (ja) | 2019-04-11 |
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| Date | Code | Title | Description |
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| FZDE | Discontinued |
Effective date: 20220906 |
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| FZDE | Discontinued |
Effective date: 20220906 |