CA3016488C - Dosage regimen for the treatment of acute exacerbations of chronic obstructive pulmonary disease - Google Patents

Dosage regimen for the treatment of acute exacerbations of chronic obstructive pulmonary disease Download PDF

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Publication number
CA3016488C
CA3016488C CA3016488A CA3016488A CA3016488C CA 3016488 C CA3016488 C CA 3016488C CA 3016488 A CA3016488 A CA 3016488A CA 3016488 A CA3016488 A CA 3016488A CA 3016488 C CA3016488 C CA 3016488C
Authority
CA
Canada
Prior art keywords
pyrazol
amino
pharmaceutically acceptable
methylbenzamide
dose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3016488A
Other languages
English (en)
French (fr)
Other versions
CA3016488A1 (en
Inventor
Colin ORFORD
Cyril Clarke
Colm Farrell
Jacqueline PARKIN
Stefan De Buck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mereo Biopharma 1 Ltd
Original Assignee
Mereo Biopharma 1 Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mereo Biopharma 1 Ltd filed Critical Mereo Biopharma 1 Ltd
Publication of CA3016488A1 publication Critical patent/CA3016488A1/en
Application granted granted Critical
Publication of CA3016488C publication Critical patent/CA3016488C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA3016488A 2016-03-08 2016-03-08 Dosage regimen for the treatment of acute exacerbations of chronic obstructive pulmonary disease Active CA3016488C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/GB2016/050636 WO2017153702A1 (en) 2016-03-08 2016-03-08 Dosage regimen for the treatment of acute exacerbations of chronic obstructive pulmonary disease

Publications (2)

Publication Number Publication Date
CA3016488A1 CA3016488A1 (en) 2017-09-14
CA3016488C true CA3016488C (en) 2023-04-11

Family

ID=55586330

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3016488A Active CA3016488C (en) 2016-03-08 2016-03-08 Dosage regimen for the treatment of acute exacerbations of chronic obstructive pulmonary disease

Country Status (9)

Country Link
US (2) US10603306B2 (https=)
JP (1) JP6741774B2 (https=)
KR (2) KR102762199B1 (https=)
AU (1) AU2016397047B2 (https=)
BR (1) BR112018067454A2 (https=)
CA (1) CA3016488C (https=)
MX (1) MX385717B (https=)
RU (1) RU2713203C1 (https=)
WO (1) WO2017153702A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102762199B1 (ko) * 2016-03-08 2025-02-07 메레오 바이오파마 1 리미티드 만성 폐쇄성 폐 질환의 급성 악화 치료를 위한 투약법
GB201612238D0 (en) 2016-07-14 2016-08-31 Mereo Biopharma 1 Ltd Method for producing a polymorphic form of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-Yl]-n-cyclopropyl-4-methylbenzamide
GB201612240D0 (en) 2016-07-14 2016-08-31 Mereo Biopharma 1 Ltd Method for producing a polymorphic form of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-n-cyclopropyl-4-methylbenzamide
JP7280627B2 (ja) * 2017-12-11 2023-05-24 メレオ バイオファーマ １ リミテッド 慢性閉塞性肺疾患の急性増悪の処置における３－［５－アミノ－４－（３－シアノベンゾイル）－ピラゾール－１－イル］－ｎ－シクロプロピル－４－メチルベンズアミドの使用
AU2018381874B2 (en) 2017-12-11 2024-08-15 Mereo Biopharma 1 Limited Use of 3-(5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl)-N-cyclopropyl-4-methylbenzamide in the prevention or reduction of acute exacerbations of chronic obstructive pulmonary disease

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9501841D0 (en) 1995-01-31 1995-03-22 Co Ordinated Drug Dev Improvements in and relating to carrier particles for use in dry powder inhalers
US6598603B1 (en) 1997-12-31 2003-07-29 Astra Aktiebolag Method for treating respiratory diseases
PL2298743T3 (pl) * 2003-06-26 2013-02-28 Novartis Ag Inhibitory kinaz P38 na bazie 5-członowych heterocykli
TW201705980A (zh) 2004-04-09 2017-02-16 艾伯維生物技術有限責任公司 用於治療ＴＮＦα相關失調症之多重可變劑量療法
GB0409703D0 (en) 2004-04-30 2004-06-02 Vectura Ltd Pharmaceutical compositions
US20050277602A1 (en) 2004-05-21 2005-12-15 Grunstein Michael M Methods employing agonists of P38 map kinase for the treatment of asthma
CA2640665A1 (en) 2006-02-10 2007-08-16 Pfizer Products Inc. Pyridinone pyrazole urea and pyrimidinone pyrazole urea derivatives
GB0603684D0 (en) 2006-02-23 2006-04-05 Novartis Ag Organic compounds
WO2013139809A1 (en) * 2012-03-20 2013-09-26 Novartis Ag Use of a pyrazole derivative in the treatment of acute exacerbations of chronic obstructive pulmonary disease
KR102762199B1 (ko) * 2016-03-08 2025-02-07 메레오 바이오파마 1 리미티드 만성 폐쇄성 폐 질환의 급성 악화 치료를 위한 투약법
BR112018067784A2 (pt) * 2016-03-08 2019-01-15 Mereo Biopharma 1 Ltd regime de dosagem para o tratamento de exacerbações agudas de condições inflamatórias

Also Published As

Publication number Publication date
JP6741774B2 (ja) 2020-08-19
AU2016397047B2 (en) 2022-04-07
CA3016488A1 (en) 2017-09-14
MX2018010782A (es) 2019-01-10
KR20240101698A (ko) 2024-07-02
US10603306B2 (en) 2020-03-31
US20200281896A1 (en) 2020-09-10
AU2016397047A1 (en) 2018-09-06
BR112018067454A2 (pt) 2019-01-15
JP2019507786A (ja) 2019-03-22
US20190060279A1 (en) 2019-02-28
RU2713203C1 (ru) 2020-02-04
MX385717B (es) 2025-03-18
US11129810B2 (en) 2021-09-28
KR20180118667A (ko) 2018-10-31
WO2017153702A1 (en) 2017-09-14
KR102762199B1 (ko) 2025-02-07

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