CA3008840A1 - Bispecific antibody platform - Google Patents
Bispecific antibody platform Download PDFInfo
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- CA3008840A1 CA3008840A1 CA3008840A CA3008840A CA3008840A1 CA 3008840 A1 CA3008840 A1 CA 3008840A1 CA 3008840 A CA3008840 A CA 3008840A CA 3008840 A CA3008840 A CA 3008840A CA 3008840 A1 CA3008840 A1 CA 3008840A1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/66—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a swap of domains, e.g. CH3-CH2, VH-CL or VL-CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
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- Public Health (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562269664P | 2015-12-18 | 2015-12-18 | |
| US62/269,664 | 2015-12-18 | ||
| PCT/US2016/066865 WO2017106462A1 (en) | 2015-12-18 | 2016-12-15 | Bispecific antibody platform |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3008840A1 true CA3008840A1 (en) | 2017-06-22 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3008840A Pending CA3008840A1 (en) | 2015-12-18 | 2016-12-15 | Bispecific antibody platform |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11447575B2 (enExample) |
| EP (1) | EP3389710A1 (enExample) |
| JP (2) | JP7138046B2 (enExample) |
| KR (1) | KR20180100136A (enExample) |
| CN (1) | CN108601830B (enExample) |
| AU (1) | AU2016370821A1 (enExample) |
| CA (1) | CA3008840A1 (enExample) |
| MA (1) | MA44054A (enExample) |
| WO (1) | WO2017106462A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2017315146A1 (en) * | 2016-08-26 | 2019-04-11 | Sanofi | Multispecific antibodies facilitating selective light chain pairing |
| WO2019028125A1 (en) | 2017-08-01 | 2019-02-07 | Ab Studio Inc. | Bispecific antibodies and uses thereof |
| CN110028588A (zh) * | 2018-01-11 | 2019-07-19 | 上海细胞治疗研究院 | 抗原-Fc融合蛋白及其检测阳性CAR-T细胞的应用 |
| CA3117409A1 (en) | 2018-10-29 | 2020-05-07 | Biogen Ma Inc. | Humanized and stabilized fc5 variants for enhancement of blood brain barrier transport |
| WO2020131697A2 (en) | 2018-12-17 | 2020-06-25 | Revitope Limited | Twin immune cell engager |
| CN113660956B (zh) | 2019-01-28 | 2024-10-29 | Ab诊疗公司 | 双特异性抗体及其用途 |
| CN113692416B (zh) * | 2019-03-25 | 2024-11-08 | 施慧达药业集团(吉林)有限公司 | 蛋白质异二聚体及其用途 |
| BR112022002012A2 (pt) * | 2019-08-15 | 2022-06-07 | Regeneron Pharma | Moléculas multispecíficas de ligação a antígeno para células-alvo e usos das mesma |
| MX2022002239A (es) * | 2019-08-23 | 2022-03-22 | Igm Biosciences Inc | Glicovariantes de igm. |
| KR20220071210A (ko) * | 2019-09-25 | 2022-05-31 | 우니베르지테트 스튜트가르트 | 변형된 ehd2 도메인을 포함하는 결합 모듈 |
| WO2021139758A1 (zh) * | 2020-01-09 | 2021-07-15 | 江苏恒瑞医药股份有限公司 | 新型多肽复合物 |
| CN113307879A (zh) * | 2020-02-27 | 2021-08-27 | 启愈生物技术(上海)有限公司 | 一种taa/ctla-4/il15三功能融合蛋白及其应用 |
| CN113563473A (zh) * | 2020-04-29 | 2021-10-29 | 三生国健药业（上海）股份有限公司 | 四价双特异性抗体、其制备方法和用途 |
| IL301926A (en) * | 2020-11-06 | 2023-06-01 | Amgen Inc | Antigen binding domain with reduced clipping rate |
| JP2024517907A (ja) * | 2021-05-14 | 2024-04-23 | 江蘇恒瑞医薬股▲ふん▼有限公司 | 抗原結合分子 |
| JP2024527977A (ja) | 2021-07-27 | 2024-07-26 | ノヴァブ， インコーポレイテッド | 免疫エフェクター機能を有する操作されたｖｌｒｂ抗体 |
| WO2024073482A1 (en) * | 2022-09-28 | 2024-04-04 | Dren Bio, Inc. | Multispecific antibodies and methods of use thereof |
| WO2025042806A2 (en) | 2023-08-21 | 2025-02-27 | Modernatx, Inc. | C-met binding antibodies, nucleic acids encoding same, and methods of use |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US20090162359A1 (en) * | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
| CA2824824A1 (en) * | 2011-02-28 | 2012-09-07 | F. Hoffmann-La Roche Ag | Monovalent antigen binding proteins |
| WO2013012733A1 (en) * | 2011-07-15 | 2013-01-24 | Biogen Idec Ma Inc. | Heterodimeric fc regions, binding molecules comprising same, and methods relating thereto |
| WO2013156054A1 (en) | 2012-04-16 | 2013-10-24 | Universität Stuttgart | The igm and ige heavy chain domain 2 as covalently linked homodimerization modules for the generation of fusion proteins with dual specificity |
| RU2014149681A (ru) * | 2012-05-24 | 2016-07-20 | Ф. Хоффманн-Ля Рош Аг | Антитела с множественной специфичностью |
| AU2014337135B2 (en) * | 2013-10-18 | 2019-09-19 | Regeneron Pharmaceuticals, Inc. | Methods and compositions comprising a combination of a VEGF antagonist and an anti-CTLA-4 antibody |
| US10982008B2 (en) * | 2014-12-05 | 2021-04-20 | Merck Patent Gmbh | Domain-exchanged antibody |
| WO2017011342A1 (en) | 2015-07-10 | 2017-01-19 | Abbvie Inc. | Igm-or-ige-modified binding proteins and uses thereof |
| AU2017315146A1 (en) * | 2016-08-26 | 2019-04-11 | Sanofi | Multispecific antibodies facilitating selective light chain pairing |
| WO2020131697A2 (en) * | 2018-12-17 | 2020-06-25 | Revitope Limited | Twin immune cell engager |
-
2016
- 2016-12-15 CN CN201680081272.6A patent/CN108601830B/zh active Active
- 2016-12-15 KR KR1020187020661A patent/KR20180100136A/ko not_active Abandoned
- 2016-12-15 EP EP16820131.7A patent/EP3389710A1/en active Pending
- 2016-12-15 MA MA044054A patent/MA44054A/fr unknown
- 2016-12-15 JP JP2018531487A patent/JP7138046B2/ja active Active
- 2016-12-15 WO PCT/US2016/066865 patent/WO2017106462A1/en not_active Ceased
- 2016-12-15 CA CA3008840A patent/CA3008840A1/en active Pending
- 2016-12-15 AU AU2016370821A patent/AU2016370821A1/en not_active Abandoned
- 2016-12-15 US US16/061,903 patent/US11447575B2/en active Active
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2021
- 2021-06-01 JP JP2021092180A patent/JP2021121642A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| MA44054A (fr) | 2018-10-24 |
| CN108601830B (zh) | 2023-02-03 |
| KR20180100136A (ko) | 2018-09-07 |
| JP2019502694A (ja) | 2019-01-31 |
| JP7138046B2 (ja) | 2022-09-15 |
| WO2017106462A1 (en) | 2017-06-22 |
| AU2016370821A1 (en) | 2018-07-12 |
| US20190048098A1 (en) | 2019-02-14 |
| JP2021121642A (ja) | 2021-08-26 |
| US11447575B2 (en) | 2022-09-20 |
| EP3389710A1 (en) | 2018-10-24 |
| CN108601830A (zh) | 2018-09-28 |
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