CA3005695A1 - Methods for predicting response to anti-tnf therapy - Google Patents

Methods for predicting response to anti-tnf therapy Download PDF

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Publication number
CA3005695A1
CA3005695A1 CA3005695A CA3005695A CA3005695A1 CA 3005695 A1 CA3005695 A1 CA 3005695A1 CA 3005695 A CA3005695 A CA 3005695A CA 3005695 A CA3005695 A CA 3005695A CA 3005695 A1 CA3005695 A1 CA 3005695A1
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CA
Canada
Prior art keywords
subject
target molecule
expression
sample
tnf therapy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA3005695A
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English (en)
French (fr)
Inventor
Helen Louise WRIGHT
Robert John Moots
Steven William Edwards
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Liverpool
Original Assignee
University of Liverpool
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Liverpool filed Critical University of Liverpool
Publication of CA3005695A1 publication Critical patent/CA3005695A1/en
Abandoned legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/10Signal processing, e.g. from mass spectrometry [MS] or from PCR
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/30ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/136Screening for pharmacological compounds
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Software Systems (AREA)
  • Artificial Intelligence (AREA)
  • Evolutionary Computation (AREA)
  • Bioethics (AREA)
  • Signal Processing (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Primary Health Care (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA3005695A 2015-12-03 2016-12-02 Methods for predicting response to anti-tnf therapy Abandoned CA3005695A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1521357.2 2015-12-03
GBGB1521357.2A GB201521357D0 (en) 2015-12-03 2015-12-03 Methods for predicting response to anti-TNF therapy
PCT/GB2016/053798 WO2017093750A1 (en) 2015-12-03 2016-12-02 Methods for predicting response to anti-tnf therapy

Publications (1)

Publication Number Publication Date
CA3005695A1 true CA3005695A1 (en) 2017-06-08

Family

ID=55234362

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3005695A Abandoned CA3005695A1 (en) 2015-12-03 2016-12-02 Methods for predicting response to anti-tnf therapy

Country Status (8)

Country Link
US (1) US20190367984A1 (enExample)
EP (1) EP3384044A1 (enExample)
JP (1) JP2018537100A (enExample)
CN (1) CN108291261A (enExample)
AU (1) AU2016364003A1 (enExample)
CA (1) CA3005695A1 (enExample)
GB (1) GB201521357D0 (enExample)
WO (1) WO2017093750A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2018113694A (ru) 2015-09-17 2019-10-17 Эмджен Инк. Прогноз клинического ответа на антагонисты ил-23 с использованием биомаркеров сигнального пути ил-23
EP3654993A4 (en) * 2017-07-17 2021-08-25 The Broad Institute, Inc. CELL ATLAS OF HEALTHY HUMAN COLUMN AND HUMAN COLUMN WITH COLITIS ULCEROSA
CN108047327B (zh) * 2017-11-29 2020-08-07 中国医学科学院北京协和医院 一种检测骨关节炎的生物标志物及其应用
WO2019159186A1 (en) * 2018-02-19 2019-08-22 Genefron Ltd. Methods of determining response to tnf alpha blockers
EP3765634A4 (en) 2018-03-16 2021-12-01 Scipher Medicine Corporation METHODS AND SYSTEMS FOR PREDICTING THE RESPONSE TO ANTI-TNF THERAPIES
SG11202104882WA (en) * 2018-11-15 2021-06-29 Ampel Biosolutions Llc Machine learning disease prediction and treatment prioritization
JP2022541125A (ja) 2019-06-27 2022-09-22 サイファー メディシン コーポレーション 患者を層別化するための分類子の開発
CA3152279A1 (en) * 2019-10-04 2021-04-08 The Regents Of The University Of Michigan Methods for determining responsiveness to anti-tumor necrosis factor therapy in the treatment of psoriasis
CA3199737A1 (en) * 2020-11-30 2022-06-02 Tobin Dickerson Microneedle devices and methods, and skin condition assays
US20220291238A1 (en) * 2021-03-12 2022-09-15 Janssen Biotech, Inc. Methods for Predicting Treatment Response in Ulcerative Colitis
CN113373218A (zh) * 2021-08-04 2021-09-10 杭州浙大迪迅生物基因工程有限公司 一组检测人嗜酸性粒细胞阳离子蛋白mRNA表达的引物组和试剂盒
CN116559453A (zh) * 2022-11-22 2023-08-08 杭州广科安德生物科技有限公司 一种用于肺癌检测的生物标志物
WO2026047197A1 (en) * 2024-08-30 2026-03-05 Sanofi Biotechnology Differential biomarkers for anti-interleukin-6 and anti-tumor necrosis factor-α treatment response in rheumatoid arthritis

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2658171A1 (en) * 2006-07-13 2008-01-17 Source Precision Medicine, Inc. D/B/A Source Mdx Gene expression profiling for identification, monitoring and treatment of multiple sclerosis
WO2008132176A2 (en) * 2007-04-27 2008-11-06 Universite Catholique De Louvain Method for evaluating the response of an individual to tnf blocking therapy
BRPI0812461A2 (pt) * 2007-06-08 2017-06-13 Biogen Idec Inc método de prever a resposta de um indivíduo a uma terapia, método de tratamento de um distúrbio imunológico, composição e kit
EP2192197A1 (en) * 2008-11-27 2010-06-02 Vereniging voor christelijk hoger onderwijs, wetenschappelijk onderzoek en patiëntenzorg Predicting clinical response to treatment with a soluble tnf-antagonist or tnf, or a tnf receptor agonist
CN102597268B (zh) * 2009-09-03 2017-09-22 弗·哈夫曼-拉罗切有限公司 用于治疗、诊断和监控类风湿性关节炎的方法
US20130042333A1 (en) * 2011-05-06 2013-02-14 Jean-Gabriel JUDDE Markers for cancer prognosis and therapy and methods of use
HU230680B1 (hu) * 2012-10-19 2017-08-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Diagnosztikai eljárás
US9809854B2 (en) * 2012-11-15 2017-11-07 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Biomarkers for disease activity and clinical manifestations systemic lupus erythematosus

Also Published As

Publication number Publication date
CN108291261A (zh) 2018-07-17
GB201521357D0 (en) 2016-01-20
WO2017093750A1 (en) 2017-06-08
JP2018537100A (ja) 2018-12-20
US20190367984A1 (en) 2019-12-05
AU2016364003A1 (en) 2018-06-28
EP3384044A1 (en) 2018-10-10

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20220602

FZDE Discontinued

Effective date: 20220602