CA3005236C - Heterocyclic compounds for the inhibition and treatment of sphingosine-1-phosphate mediated diseases - Google Patents

Heterocyclic compounds for the inhibition and treatment of sphingosine-1-phosphate mediated diseases Download PDF

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Publication number
CA3005236C
CA3005236C CA3005236A CA3005236A CA3005236C CA 3005236 C CA3005236 C CA 3005236C CA 3005236 A CA3005236 A CA 3005236A CA 3005236 A CA3005236 A CA 3005236A CA 3005236 C CA3005236 C CA 3005236C
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optionally substituted
compound
formula
another embodiment
group
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French (fr)
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CA3005236A1 (en
Inventor
Raju Mohan
Jason Harris
John Nuss
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Oppilan Pharma Ltd Great Britain
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Oppilan Pharma Ltd Great Britain
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245Oxadiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433Thidiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA3005236A 2015-11-13 2016-11-11 Heterocyclic compounds for the inhibition and treatment of sphingosine-1-phosphate mediated diseases Active CA3005236C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562255041P 2015-11-13 2015-11-13
US62/255,041 2015-11-13
PCT/US2016/061676 WO2017083756A1 (en) 2015-11-13 2016-11-11 Heterocyclic compounds for the treatment of disease

Publications (2)

Publication Number Publication Date
CA3005236A1 CA3005236A1 (en) 2017-05-18
CA3005236C true CA3005236C (en) 2024-02-20

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CA3005236A Active CA3005236C (en) 2015-11-13 2016-11-11 Heterocyclic compounds for the inhibition and treatment of sphingosine-1-phosphate mediated diseases

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US (4) US10683291B2 (cg-RX-API-DMAC7.html)
EP (2) EP4163281A1 (cg-RX-API-DMAC7.html)
JP (3) JP6933384B2 (cg-RX-API-DMAC7.html)
KR (1) KR102720397B1 (cg-RX-API-DMAC7.html)
CN (2) CN114149424B (cg-RX-API-DMAC7.html)
AU (2) AU2016353348A1 (cg-RX-API-DMAC7.html)
BR (1) BR112018009745B1 (cg-RX-API-DMAC7.html)
CA (1) CA3005236C (cg-RX-API-DMAC7.html)
DK (1) DK3373931T3 (cg-RX-API-DMAC7.html)
ES (1) ES2932049T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20221417T1 (cg-RX-API-DMAC7.html)
HU (1) HUE060594T2 (cg-RX-API-DMAC7.html)
IL (1) IL259297B2 (cg-RX-API-DMAC7.html)
LT (1) LT3373931T (cg-RX-API-DMAC7.html)
MX (1) MX382092B (cg-RX-API-DMAC7.html)
PL (1) PL3373931T3 (cg-RX-API-DMAC7.html)
PT (1) PT3373931T (cg-RX-API-DMAC7.html)
RS (1) RS63837B1 (cg-RX-API-DMAC7.html)
RU (1) RU2727194C2 (cg-RX-API-DMAC7.html)
SI (1) SI3373931T1 (cg-RX-API-DMAC7.html)
SM (1) SMT202300062T1 (cg-RX-API-DMAC7.html)
WO (1) WO2017083756A1 (cg-RX-API-DMAC7.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3373931T (pt) 2015-11-13 2022-12-06 Oppilan Pharma Ltd Compostos heterocíclicos para o tratamento de doenças
WO2018211323A1 (en) * 2017-05-17 2018-11-22 Oppilan Pharma Ltd. Hetercyclic compounds for the treatment of disease
EP3625230A1 (en) * 2017-05-17 2020-03-25 Oppilan Pharma Ltd. Prodrugs for the treatment of disease
GB201815018D0 (en) * 2018-09-14 2018-10-31 Univ Oxford Innovation Ltd Enantiomeric compounds
JP2025524598A (ja) * 2022-07-06 2025-07-30 オピラン ファーマ リミテッド S1p受容体モジュレーターの結晶形態
EP4649080A1 (en) * 2023-01-13 2025-11-19 Oppilan Pharma Ltd. Preparation of an s1p receptor modulator

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US4772597A (en) * 1983-10-14 1988-09-20 Pfizer Inc. 2-azacycloalkylthiopenem derivatives
JP2007528872A (ja) * 2003-10-01 2007-10-18 メルク エンド カムパニー インコーポレーテッド S1p受容体アゴニストとしての3,5−アリール置換、ヘテロアリール置換またはシクロアルキル置換された1,2,4−オキサジアゾール化合物
GB0511684D0 (en) * 2005-06-08 2005-07-13 Novartis Ag Organic compounds
KR20080014009A (ko) * 2005-06-08 2008-02-13 노파르티스 아게 폴리시클릭 옥사디아졸 또는 이속사졸, 및 이들의 s1p수용체 리간드로서의 용도
RU2425832C2 (ru) * 2006-04-03 2011-08-10 Астеллас Фарма Инк. Гетеросоединение
JP2010513283A (ja) 2006-12-15 2010-04-30 アボット・ラボラトリーズ 新規なオキサジアゾール化合物
US20110207704A1 (en) 2006-12-15 2011-08-25 Abbott Laboratories Novel Oxadiazole Compounds
US20100160369A1 (en) * 2008-12-04 2010-06-24 Exelixis, Inc. S1P1 Agonists and Methods of Making And Using
US20100249071A1 (en) 2009-03-30 2010-09-30 Exelixis, Inc. Modulators of S1P and Methods of Making And Using
US9011494B2 (en) 2009-09-24 2015-04-21 Warsaw Orthopedic, Inc. Composite vertebral rod system and methods of use
ES2665461T3 (es) 2009-11-13 2018-04-25 Celgene International Ii Sàrl Moduladores del receptor esfingosina 1-fosfato y métodos de síntesis quiral
EP2595969B1 (en) * 2010-07-20 2015-04-22 Bristol-Myers Squibb Company Substituted 3-phenyl-1,2,4-oxadiazole compounds
AU2012325916A1 (en) 2011-10-20 2014-05-01 Glaxosmithkline Llc Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators
MX2016006936A (es) * 2013-11-27 2016-10-05 Genentech Inc Benzamidas sustituidas y metodos para usarlas.
PT3373931T (pt) 2015-11-13 2022-12-06 Oppilan Pharma Ltd Compostos heterocíclicos para o tratamento de doenças

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Publication number Publication date
RS63837B1 (sr) 2023-01-31
CN114149424B (zh) 2025-05-13
JP2023017862A (ja) 2023-02-07
MX2018005987A (es) 2018-11-29
HUE060594T2 (hu) 2023-03-28
KR20180095811A (ko) 2018-08-28
SI3373931T1 (sl) 2023-02-28
IL259297B2 (en) 2023-03-01
US20220227767A1 (en) 2022-07-21
EP3373931A4 (en) 2019-04-03
CN114149424A (zh) 2022-03-08
LT3373931T (lt) 2023-03-10
CN108463222A (zh) 2018-08-28
JP2018535261A (ja) 2018-11-29
BR112018009745A2 (pt) 2018-11-06
US20230339944A1 (en) 2023-10-26
CA3005236A1 (en) 2017-05-18
JP7174963B2 (ja) 2022-11-18
JP2021191753A (ja) 2021-12-16
BR112018009745B1 (pt) 2023-09-26
RU2018121416A (ru) 2019-12-13
CN108463222B (zh) 2021-10-22
JP6933384B2 (ja) 2021-09-08
HRP20221417T1 (hr) 2023-02-03
ES2932049T3 (es) 2023-01-09
DK3373931T3 (da) 2022-11-28
AU2021202945A1 (en) 2021-06-03
AU2021202945B2 (en) 2022-06-23
KR102720397B1 (ko) 2024-10-21
IL259297A (en) 2018-07-31
IL259297B (en) 2022-11-01
EP3373931B1 (en) 2022-09-28
PL3373931T3 (pl) 2023-02-06
SMT202300062T1 (it) 2023-03-17
AU2016353348A1 (en) 2018-07-05
MX382092B (es) 2025-03-04
EP3373931A1 (en) 2018-09-19
EP4163281A1 (en) 2023-04-12
US10683291B2 (en) 2020-06-16
BR112018009745A8 (pt) 2019-02-26
US20190241556A1 (en) 2019-08-08
US20200325135A1 (en) 2020-10-15
JP7445325B2 (ja) 2024-03-07
RU2727194C2 (ru) 2020-07-21
RU2018121416A3 (cg-RX-API-DMAC7.html) 2019-12-17
WO2017083756A1 (en) 2017-05-18
PT3373931T (pt) 2022-12-06

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