CA3002774A1 - Programmable universal cell receptors and methods of using the same - Google Patents
Programmable universal cell receptors and methods of using the same Download PDFInfo
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- CA3002774A1 CA3002774A1 CA3002774A CA3002774A CA3002774A1 CA 3002774 A1 CA3002774 A1 CA 3002774A1 CA 3002774 A CA3002774 A CA 3002774A CA 3002774 A CA3002774 A CA 3002774A CA 3002774 A1 CA3002774 A1 CA 3002774A1
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61K40/10—Cellular immunotherapy characterised by the cell type used
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- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4274—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; Prostatic acid phosphatase [PAP]; Prostate-specific G-protein-coupled receptor [PSGR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70517—CD8
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C07K2319/41—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a Myc-tag
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
Landscapes
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- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US201662382691P | 2016-09-01 | 2016-09-01 | |
| US62/382,691 | 2016-09-01 | ||
| PCT/US2016/058429 WO2017070654A1 (en) | 2015-10-23 | 2016-10-24 | Programmable universal cell receptors and methods of using the same |
Publications (1)
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| CA3002774A1 true CA3002774A1 (en) | 2017-04-27 |
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| CA3002774A Abandoned CA3002774A1 (en) | 2015-10-23 | 2016-10-24 | Programmable universal cell receptors and methods of using the same |
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| US (1) | US20170112878A1 (enExample) |
| EP (1) | EP3365016A4 (enExample) |
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| AU2016341321A1 (en) * | 2015-10-23 | 2018-06-07 | Sorrento Therapeutics, Inc. | Programmable universal cell receptors and methods of using the same |
| WO2017189964A2 (en) | 2016-04-29 | 2017-11-02 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| US11326182B2 (en) | 2016-04-29 | 2022-05-10 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| WO2019010201A1 (en) * | 2017-07-03 | 2019-01-10 | Yale University | REGULATED SMALL MOLECULE ADAPTER |
| KR20200076732A (ko) * | 2017-11-03 | 2020-06-29 | 소렌토 쎄라퓨틱스, 인코포레이티드 | Cd38-지시된 키메라 항원 수용체 작제물 |
| WO2019173837A1 (en) * | 2018-03-09 | 2019-09-12 | Sorrento Therapeutics, Inc. | Dimeric antigen receptors (dar) |
| AU2020369479A1 (en) * | 2019-10-23 | 2022-05-26 | University Of Florida Research Foundation, Incorporated | Novel conjugation chemistry for catalytic antibody 38C2 |
| US20230096410A1 (en) * | 2020-03-06 | 2023-03-30 | Sorrento Therapeutics, Inc. | Innate Immunity Killer Cells Targeting PSMA Positive Tumor Cells |
| EP4225799A4 (en) * | 2020-10-12 | 2024-11-20 | Sorrento Therapeutics, Inc. | CD19-TARGETED CHIMERIC ANTIGEN RECEPTOR CONSTRUCTS |
| EP4274852A4 (en) * | 2021-01-11 | 2025-02-26 | Eutilex Co., Ltd. | BISPECIFIC EPITOP-BINDING PROTEIN WITH ANTI-4-1BB ANTIBODY AND PD-1 PROTEIN OR FRAGMENTS THEREOF AND USE THEREOF |
| CA3215938A1 (en) * | 2021-04-23 | 2022-10-27 | Henry Hongjun Ji | Dimeric antigen receptors (dars) that bind gd2 |
| WO2023154708A2 (en) * | 2022-02-10 | 2023-08-17 | The Scripps Research Institute | Car-t therapies targeted via covalently bonded adapters |
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| US6268488B1 (en) * | 1999-05-25 | 2001-07-31 | Barbas, Iii Carlos F. | Prodrug activation using catalytic antibodies |
| AU2004210088A1 (en) * | 2003-02-06 | 2004-08-19 | Micromet Ag | Trimeric polypeptide construct to induce an enduring T cell response |
| CA2696627C (en) * | 2007-08-17 | 2016-09-27 | Purdue Research Foundation | Psma binding ligand-linker conjugates and methods for using |
| EP2483301A1 (en) * | 2009-10-01 | 2012-08-08 | The United States Of America, As Represented By The Secretary, Department of Health and Human Services | Anti-vascular endothelial growth factor receptor-2 chimeric antigen receptors and use of same for the treatment of cancer |
| EP2593142B8 (en) * | 2010-07-12 | 2018-12-26 | Pfizer Healthcare Ireland | Multifunctional antibody conjugates |
| PH12013501201A1 (en) * | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| CN107188969B (zh) * | 2011-04-08 | 2021-08-27 | 美国卫生和人力服务部 | 抗-表皮生长因子受体变体iii嵌合抗原受体及其用于治疗癌症的用途 |
| WO2013044225A1 (en) * | 2011-09-22 | 2013-03-28 | The Trustees Of The University Of Pennsylvania | A universal immune receptor expressed by t cells for the targeting of diverse and multiple antigens |
| US10851178B2 (en) * | 2011-10-10 | 2020-12-01 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| AU2016341321A1 (en) * | 2015-10-23 | 2018-06-07 | Sorrento Therapeutics, Inc. | Programmable universal cell receptors and methods of using the same |
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2016
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- 2016-10-24 UY UY0001036961A patent/UY36961A/es not_active Application Discontinuation
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- 2016-10-24 JP JP2018520493A patent/JP2018537076A/ja active Pending
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Also Published As
| Publication number | Publication date |
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| WO2017070654A8 (en) | 2017-06-01 |
| EP3365016A4 (en) | 2019-07-17 |
| KR20180091820A (ko) | 2018-08-16 |
| AU2016341321A1 (en) | 2018-06-07 |
| UY36961A (es) | 2017-05-31 |
| WO2017070654A1 (en) | 2017-04-27 |
| EP3365016A1 (en) | 2018-08-29 |
| TW201726914A (zh) | 2017-08-01 |
| US20170112878A1 (en) | 2017-04-27 |
| JP2018537076A (ja) | 2018-12-20 |
| EA201890941A1 (ru) | 2018-11-30 |
| CN108883170A (zh) | 2018-11-23 |
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