CA3001763C - Methods and systems for analyzing tissue quality using mid-infrared spectroscopy - Google Patents

Methods and systems for analyzing tissue quality using mid-infrared spectroscopy Download PDF

Info

Publication number
CA3001763C
CA3001763C CA3001763A CA3001763A CA3001763C CA 3001763 C CA3001763 C CA 3001763C CA 3001763 A CA3001763 A CA 3001763A CA 3001763 A CA3001763 A CA 3001763A CA 3001763 C CA3001763 C CA 3001763C
Authority
CA
Canada
Prior art keywords
fixation
spectrum
sample
fixed
signature
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3001763A
Other languages
English (en)
French (fr)
Other versions
CA3001763A1 (en
Inventor
David Chafin
Michael Otter
Wolfgang Petrich
Daniel Bauer
Niels KROEGER-LUI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Ventana Medical Systems Inc
Original Assignee
F Hoffmann La Roche AG
Ventana Medical Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG, Ventana Medical Systems Inc filed Critical F Hoffmann La Roche AG
Publication of CA3001763A1 publication Critical patent/CA3001763A1/en
Application granted granted Critical
Publication of CA3001763C publication Critical patent/CA3001763C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/39Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using tunable lasers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N2001/305Fixative compositions
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/39Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using tunable lasers
    • G01N2021/396Type of laser source
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N2021/757Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated using immobilised reagents
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00Features of devices classified in G01N21/00
    • G01N2201/12Circuits of general importance; Signal processing
    • G01N2201/129Using chemometrical methods

Landscapes

  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Pathology (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA3001763A 2015-10-28 2016-10-28 Methods and systems for analyzing tissue quality using mid-infrared spectroscopy Active CA3001763C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562247609P 2015-10-28 2015-10-28
US62/247,609 2015-10-28
PCT/EP2016/076130 WO2017072320A1 (en) 2015-10-28 2016-10-28 Methods and systems for analyzing tissue quality using mid-infrared spectroscopy

Publications (2)

Publication Number Publication Date
CA3001763A1 CA3001763A1 (en) 2017-05-04
CA3001763C true CA3001763C (en) 2020-10-27

Family

ID=57233419

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3001763A Active CA3001763C (en) 2015-10-28 2016-10-28 Methods and systems for analyzing tissue quality using mid-infrared spectroscopy

Country Status (6)

Country Link
US (1) US20190369017A1 (https=)
EP (1) EP3368885B1 (https=)
JP (1) JP6676160B2 (https=)
AU (1) AU2016347631B2 (https=)
CA (1) CA3001763C (https=)
WO (1) WO2017072320A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112384786B (zh) * 2018-05-09 2024-08-23 国立研究开发法人量子科学技术研究开发机构 组织识别装置、组织识别系统、组织识别方法及记录介质
WO2020022394A1 (en) * 2018-07-24 2020-01-30 Sony Corporation Information processing apparatus and microscope for separating the fluorescence of a fluorescent reageant from the autofluorescence of a specimen
JP7520107B2 (ja) * 2019-08-28 2024-07-22 ベンタナ メディカル システムズ, インコーポレイテッド 振動分光法を使用して検体固定の持続時間および品質を評価するためのシステムおよび方法
CN114303203A (zh) * 2019-08-28 2022-04-08 文塔纳医疗系统公司 使用振动光谱法评估抗原修复和靶标修复进展定量
EP4022286A1 (en) * 2019-08-28 2022-07-06 Ventana Medical Systems, Inc. Label-free assessment of biomarker expression with vibrational spectroscopy
US11460400B2 (en) * 2020-07-07 2022-10-04 Sakura Finetek U.S.A., Inc. Use of IR spectroscopy to evaluate penetration of reagents into biological specimen
CN113030007B (zh) * 2021-02-10 2023-04-18 河南中烟工业有限责任公司 基于相似度学习算法快速检验烟用香精质量稳定性的方法
EP4437549A4 (en) * 2021-11-23 2025-09-24 Agilent Technologies Inc DIGITAL ANALYSIS OF PREANALYTICAL FACTORS IN TISSUES USED FOR HISTOLOGICAL STAINING
CN121693762A (zh) * 2023-08-16 2026-03-17 文塔纳医疗系统公司 用以确定形态学染色的生物学样本的固定状态的深度学习模型
CN119360129B (zh) * 2024-12-23 2025-03-21 浙江省测绘科学技术研究院 页岩油气井场分类方法和页岩油气开发活动监测方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040253649A1 (en) * 1998-10-21 2004-12-16 Smith Steven J. Protein quantitation with cell imaging densitometry
US20010055799A1 (en) * 1998-12-15 2001-12-27 David Baunoch Method and apparatus for automated reprocessing of tissue samples
US20060249668A1 (en) * 2005-05-05 2006-11-09 Palo Alto Research Center Incorporated Automatic detection of quality spectra
CA2604317C (en) * 2007-08-06 2017-02-28 Historx, Inc. Methods and system for validating sample images for quantitative immunoassays
CN102781226B (zh) * 2009-12-07 2015-05-20 朱伟星 通过超声波及温度控制的标准化组织样本保护
WO2011163624A1 (en) * 2010-06-25 2011-12-29 Cellmark Theranostics, Llc Method for analyzing biological specimens by spectral imaging

Also Published As

Publication number Publication date
EP3368885A1 (en) 2018-09-05
AU2016347631B2 (en) 2019-03-28
JP6676160B2 (ja) 2020-04-08
US20190369017A1 (en) 2019-12-05
WO2017072320A1 (en) 2017-05-04
AU2016347631A1 (en) 2018-04-26
EP3368885B1 (en) 2020-06-03
JP2018532116A (ja) 2018-11-01
CA3001763A1 (en) 2017-05-04

Similar Documents

Publication Publication Date Title
CA3001763C (en) Methods and systems for analyzing tissue quality using mid-infrared spectroscopy
Virkler et al. Raman spectroscopic signature of blood and its potential application to forensic body fluid identification
Verdonck et al. Characterization of human breast cancer tissues by infrared imaging
JP7047059B2 (ja) 画像処理のための自動アッセイ評価および正規化
Bonta et al. A comparison of sample preparation strategies for biological tissues and subsequent trace element analysis using LA-ICP-MS
Taylor et al. Quantification of immunohistochemistry—issues concerning methods, utility and semiquantitative assessment II
Woolman et al. Optimized mass spectrometry analysis workflow with polarimetric guidance for ex vivo and in situ sampling of biological tissues
Chlipala et al. Impact of preanalytical factors during histology processing on section suitability for digital image analysis
Leong Quantitation in immunohistology: Fact or fiction?: A discussion of variables that influence results
EP4022287B1 (en) Systems and methods for assessing specimen fixation duration and quality using vibrational spectroscopy
Das et al. Analysis of the ex-vivo transformation of semen, saliva and urine as they dry out using ATR-FTIR spectroscopy and chemometric approach
CN114270174A (zh) 使用振动光谱对生物标志物表达进行无标记评估
Bouzin et al. Digital pathology: elementary, rapid and reliable automated image analysis
JP2020530611A (ja) 染色された標本画像内で細胞を検出するための自動化された方法およびシステム
Ali et al. A simple model for cell type recognition using 2D-correlation analysis of FTIR images from breast cancer tissue
CN114303203A (zh) 使用振动光谱法评估抗原修复和靶标修复进展定量
Dolled-Filhart et al. Automated analysis of tissue microarrays
Sompuram et al. Selecting an optimal positive IHC control for verifying antigen retrieval
Guo et al. Evaluation of Minimum‐to‐Severe Global and Macrovesicular Steatosis in Human Liver Specimens: A Portable Ambient Light‐Compatible Spectroscopic Probe
Soendergaard et al. Objective quantification of immune cell infiltrates and epidermal proliferation in psoriatic skin: a comparison of digital image analysis and manual counting
Li et al. Early warning potential of banana spoilage based on 3D fluorescence data of storage room gas
Morris et al. Compatibility of staining protocols for bone tissue with Raman imaging
Andronia et al. Raman spectroscopy of the hematoxylin-eosin stained tissue
Zheng et al. Fix or Freeze? Spectral Differences Arising from Tissue Preparation in Chemical Imaging
DE102022134504A1 (de) Verfahren und gerät zur schichtdickenbestimmung histologischer schnittpräparate und konzentrationsbestimmung von biologischen substanzen in histologischen präparaten

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20181228

MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 8TH ANNIV.) - STANDARD

Year of fee payment: 8

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20240924

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT

Effective date: 20240924

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20240924

MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 9TH ANNIV.) - STANDARD

Year of fee payment: 9

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20250924

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20250924