CA2999511C - Compositions and methods for prevention and treatment of corneal haze and scarring - Google Patents

Compositions and methods for prevention and treatment of corneal haze and scarring Download PDF

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Publication number
CA2999511C
CA2999511C CA2999511A CA2999511A CA2999511C CA 2999511 C CA2999511 C CA 2999511C CA 2999511 A CA2999511 A CA 2999511A CA 2999511 A CA2999511 A CA 2999511A CA 2999511 C CA2999511 C CA 2999511C
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Canada
Prior art keywords
amino acid
hgf
seq
acid sequence
agent
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Active
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CA2999511A
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English (en)
French (fr)
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CA2999511A1 (en
Inventor
Sunil Chauhan
Reza Dana
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Schepens Eye Research Institute Inc
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Schepens Eye Research Institute Inc
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Publication of CA2999511A1 publication Critical patent/CA2999511A1/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1833—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
CA2999511A 2015-09-11 2016-09-09 Compositions and methods for prevention and treatment of corneal haze and scarring Active CA2999511C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562217611P 2015-09-11 2015-09-11
US62/217,611 2015-09-11
PCT/US2016/050945 WO2017044743A1 (en) 2015-09-11 2016-09-09 Compositions and methods for prevention and treatment of corneal haze and scarring

Publications (2)

Publication Number Publication Date
CA2999511A1 CA2999511A1 (en) 2017-03-16
CA2999511C true CA2999511C (en) 2024-01-23

Family

ID=58240852

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2999511A Active CA2999511C (en) 2015-09-11 2016-09-09 Compositions and methods for prevention and treatment of corneal haze and scarring

Country Status (7)

Country Link
US (4) US10449234B2 (https=)
EP (2) EP3347034B1 (https=)
JP (4) JP6929273B2 (https=)
AU (3) AU2016320905B2 (https=)
CA (1) CA2999511C (https=)
ES (1) ES2983338T3 (https=)
WO (1) WO2017044743A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2999511C (en) 2015-09-11 2024-01-23 The Schepens Eye Research Institute, Inc. Compositions and methods for prevention and treatment of corneal haze and scarring
WO2019155833A1 (ja) * 2018-02-07 2019-08-15 学校法人日本医科大学 改良型アデノ随伴ウイルスベクター
EP3863715A4 (en) * 2018-10-09 2022-08-24 The Board of Trustees of the Leland Stanford Junior University MODIFIED FIBROBLASTIC GROWTH FACTOR VARIANTS COMBINED WITH MODIFIED HEPATOCYTE GROWTH FACTOR VARIANTS FOR THERAPY
WO2020185689A1 (en) * 2019-03-08 2020-09-17 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Multilayer drug delivery coating for contact lens
EP3962511A4 (en) * 2019-04-29 2023-01-18 The Board of Trustees of the Leland Stanford Junior University METHODS OF OCULAR TREATMENT USING A GENETICALLY MODIFIED HEPATOCYTE GROWTH FACTOR DIMERIC FRAGMENT
EP4574211A3 (en) 2021-05-14 2025-09-10 Claris Biotherapeutics, Inc. Compositions of growth factor for the treatment of eye disease

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6566098B1 (en) * 1990-09-14 2003-05-20 The United States Of America As Represented By The Department Of Health And Human Services DNA encoding truncated hepatocyte growth factor variants
US5703047A (en) * 1992-09-21 1997-12-30 Board Of Regents, The University Of Texas System Methods and treatments for corneal healing with growth factors
US5589451A (en) 1992-09-21 1996-12-31 Board Of Regents, The University Of Texas System Methods and treaments for corneal healing with hepatocyte and keratinocyte growth factors
JP3962097B2 (ja) * 1994-03-18 2007-08-22 敏一 中村 免疫抑制剤による副作用の軽減剤
US20020136721A1 (en) * 1998-02-17 2002-09-26 Schwall Ralph H. Hepatocyte growth factor receptor antagonists and uses thereof
AU2745599A (en) 1998-03-05 1999-09-20 Senju Pharmaceutical Co., Ltd. Pharmaceutical composition for prophylaxis and therapy of diseases associated with ocular fundus tissue cytopathy
US20030148950A1 (en) * 2001-10-09 2003-08-07 Li Xin Kringle domain 1 of human hepatocyte growth factor and uses therefor
US7202066B2 (en) * 2002-01-29 2007-04-10 Carrington Laboratories, Inc. Combination of a growth factor and a protease enzyme
AU2003270118A1 (en) * 2002-08-30 2004-03-19 F. Hoffmann-La Roche Ag Scatter factor/hepatocyte growth factor antagonist nk4 for the treatment of glioma
US8575099B2 (en) * 2006-04-20 2013-11-05 Osaka University Agent for treating polyglutamine aggregation-caused disease or suppressing onset thereof
JP5093783B2 (ja) * 2006-04-20 2012-12-12 クリングルファーマ株式会社 Ｈｇｆ前駆体蛋白質改変体及びその活性型蛋白質
US20070167935A1 (en) * 2007-01-19 2007-07-19 Serdarevic Olivia N Methods and compositions for optimizing the outcomes of refractive laser surgery of the cornea
US9556248B2 (en) * 2010-03-19 2017-01-31 The Board Of Trustees Of The Leland Stanford Junior University Hepatocyte growth factor fragments that function as potent met receptor agonists and antagonists
HRP20191711T1 (hr) 2011-03-14 2019-12-13 Drug Delivery Solutions Ltd Oftalmološki pripravak
US8999938B2 (en) * 2013-06-21 2015-04-07 Gnt Llc Ophthalmic lipophilic drug delivery vehicle formulations
CA2999511C (en) 2015-09-11 2024-01-23 The Schepens Eye Research Institute, Inc. Compositions and methods for prevention and treatment of corneal haze and scarring

Also Published As

Publication number Publication date
EP3347034A4 (en) 2019-05-08
HK1258026A1 (en) 2019-11-01
EP4417259A3 (en) 2024-10-23
WO2017044743A1 (en) 2017-03-16
US11759499B2 (en) 2023-09-19
US20180256685A1 (en) 2018-09-13
US20210299219A1 (en) 2021-09-30
JP2025181979A (ja) 2025-12-11
AU2021286438A1 (en) 2022-01-20
CA2999511A1 (en) 2017-03-16
JP2018526412A (ja) 2018-09-13
EP3347034B1 (en) 2024-05-29
AU2016320905A1 (en) 2018-04-05
JP2021181472A (ja) 2021-11-25
EP3347034A1 (en) 2018-07-18
EP3347034C0 (en) 2024-05-29
JP6929273B2 (ja) 2021-09-01
US10449234B2 (en) 2019-10-22
AU2021286438B2 (en) 2024-12-05
US20200121758A1 (en) 2020-04-23
AU2025201563A1 (en) 2025-03-27
JP2023179739A (ja) 2023-12-19
ES2983338T3 (es) 2024-10-22
EP4417259A2 (en) 2024-08-21
US20240123032A1 (en) 2024-04-18
AU2016320905B2 (en) 2021-10-07

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