CA2988930A1 - Bacteries modifiees en vue du traitement de maladies associees a l'hyperammoniemie - Google Patents
Bacteries modifiees en vue du traitement de maladies associees a l'hyperammoniemie Download PDFInfo
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- CA2988930A1 CA2988930A1 CA2988930A CA2988930A CA2988930A1 CA 2988930 A1 CA2988930 A1 CA 2988930A1 CA 2988930 A CA2988930 A CA 2988930A CA 2988930 A CA2988930 A CA 2988930A CA 2988930 A1 CA2988930 A1 CA 2988930A1
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- engineered bacterium
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Classifications
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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- A61K35/74—Bacteria
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
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- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
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- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
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- C12N15/09—Recombinant DNA-technology
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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- C12P13/00—Preparation of nitrogen-containing organic compounds
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- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/185—Escherichia
- C12R2001/19—Escherichia coli
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
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- Medicinal Chemistry (AREA)
- Biophysics (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
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- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Plant Pathology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
L'invention concerne des bactéries génétiquement modifiées, des compositions pharmaceutiques à base de celles-ci ainsi que des méthodes de modulation et de traitement de troubles associés à l'hyperammoniémie.
Applications Claiming Priority (31)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562173706P | 2015-06-10 | 2015-06-10 | |
US201562173710P | 2015-06-10 | 2015-06-10 | |
US62/173,710 | 2015-06-10 | ||
US62/173,706 | 2015-06-10 | ||
US201562183935P | 2015-06-24 | 2015-06-24 | |
US62/183,935 | 2015-06-24 | ||
US201562184811P | 2015-06-25 | 2015-06-25 | |
US201562184770P | 2015-06-25 | 2015-06-25 | |
US62/184,770 | 2015-06-25 | ||
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US14/960,333 US9487764B2 (en) | 2014-12-05 | 2015-12-04 | Bacteria engineered to treat diseases associated with hyperammonemia |
US14/960,333 | 2015-12-04 | ||
US201662277654P | 2016-01-12 | 2016-01-12 | |
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USPCT/US16/020530 | 2016-03-02 | ||
PCT/US2016/020530 WO2016141108A1 (fr) | 2015-03-02 | 2016-03-02 | Bactéries modifiées pour traiter des maladies pour lesquelles une diminution de l'inflammation intestinale et/ou une plus grande imperméabilité de la muqueuse intestinale s'avèrent bénéfiques |
PCT/US2016/034200 WO2016200614A2 (fr) | 2015-06-10 | 2016-05-25 | Bactéries modifiées en vue du traitement de maladies associées à l'hyperammoniémie |
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JP (2) | JP6817966B2 (fr) |
AU (1) | AU2016274311A1 (fr) |
CA (1) | CA2988930A1 (fr) |
WO (1) | WO2016200614A2 (fr) |
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WO2017136795A1 (fr) | 2016-02-04 | 2017-08-10 | Synlogic, Inc. | Bactéries modifiées pour traiter des maladies associées au metabolisme du tryptophane |
AU2018272294B2 (en) * | 2017-05-24 | 2024-05-23 | Thoeris Gmbh | Use of glutamine synthetase for treating hyperammonemia |
MX2020005875A (es) * | 2017-12-05 | 2020-10-08 | Bioplx Inc | Métodos y composiciones para prevenir la infección microbiana. |
CN110446259B (zh) * | 2018-05-04 | 2022-04-15 | 大唐移动通信设备有限公司 | 一种寻呼机会的位置确定方法及通信设备 |
US20220257732A1 (en) | 2019-04-29 | 2022-08-18 | Synlogic Operating Company, Inc. | Enumeration of genetically engineered microorganisms by live cell counting techniques |
WO2020239882A1 (fr) | 2019-05-30 | 2020-12-03 | Recordati Industria Chimica E Farmaceutica S.P.A. | Formulation pharmaceutique pour l'acide carglumique |
CA3142608A1 (fr) | 2019-06-04 | 2020-12-10 | Cocoon Biotech Inc. | Produits a base de soie, formulations et procedes d'utilisation |
CN115279888B (zh) * | 2019-11-29 | 2024-04-02 | 株式会社Jinis | 具有降低血氨数值效能的菌株及包含其的用于保护神经细胞的组合物 |
US20240110191A1 (en) | 2020-12-02 | 2024-04-04 | Synlogic Operating Company, Inc. | Engineered microorganisms |
JP7260841B2 (ja) | 2021-03-31 | 2023-04-19 | 日本製鉄株式会社 | 無方向性電磁鋼板の打ち抜き方法および無方向性電磁鋼板の打ち抜き用金型 |
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JP3083315B2 (ja) * | 1990-10-29 | 2000-09-04 | 株式会社ヤクルト本社 | 血中アンモニア低下剤 |
GB9107305D0 (en) | 1991-04-08 | 1991-05-22 | Unilever Plc | Probiotic |
IT1290679B1 (it) * | 1997-02-14 | 1998-12-10 | Alfa Wassermann Spa | Uso della rifaximina e delle composizioni farmaceutiche che la contengono nel trattamento della diarrea da criptosporidiosi. |
US5989463A (en) | 1997-09-24 | 1999-11-23 | Alkermes Controlled Therapeutics, Inc. | Methods for fabricating polymer-based controlled release devices |
US6203797B1 (en) | 1998-01-06 | 2001-03-20 | Stephen C. Perry | Dietary supplement and method for use as a probiotic, for alleviating the symptons associated with irritable bowel syndrome |
EP1135461A4 (fr) | 1998-12-02 | 2003-03-26 | Univ Boston | Reseaux de genes destines a controler l'expression genetique |
EP1034787A1 (fr) | 1999-03-11 | 2000-09-13 | Société des Produits Nestlé S.A. | Souches de lactobacillus capables de prévenir la diarrhée causée des bactéries pathogènes |
US7731976B2 (en) | 2003-08-29 | 2010-06-08 | Cobb And Company, Llp | Treatment of irritable bowel syndrome using probiotic composition |
WO2009123029A1 (fr) * | 2008-03-31 | 2009-10-08 | 株式会社 大塚製薬工場 | Régulateur de niveau d’ammoniac dans le sang |
CA2926466C (fr) * | 2013-10-03 | 2021-11-16 | Frederic Bushman | Compositions comprenant un microbiome defini et procedes d'utilisation de ces compositions |
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- 2016-05-25 CA CA2988930A patent/CA2988930A1/fr not_active Abandoned
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- 2016-05-25 WO PCT/US2016/034200 patent/WO2016200614A2/fr active Application Filing
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JP2018523978A (ja) | 2018-08-30 |
WO2016200614A2 (fr) | 2016-12-15 |
JP6817966B2 (ja) | 2021-01-20 |
WO2016200614A3 (fr) | 2017-01-12 |
JP2021061846A (ja) | 2021-04-22 |
AU2016274311A1 (en) | 2018-01-18 |
EP3307879A2 (fr) | 2018-04-18 |
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